Coumarins

4-Phenyl-7,8-dihydroxycoumarin (7,8-Dihydroxy-4-phenylcoumarin) inhibits the activity of Staphylococcus aureus DNA helicase

Herniarin (Ayapanin) is a natural coumarin with antitumor effect.

Imperatorin, a biologically active furanocoumarin from the roots of Angelica dahurica (Umbelliferae), can induce apoptosis in human promyelocytic leukaemia, HL-60 cells,

Lactone

5-Methoxysuberenone is a chemical constituent of the root bark of Toddalia asiatica (L.) Lam. (T. aculeata Pers.), Rutaceae.

Lactone

Scopoletin exhibits antifungal, anti-allergic, anti-aging, and hypouricemic activities, it exerts anti-RA action probably through suppressing IL-6 production from fibroblast-like synoviocytes via MAPK/PKC/CREB pathways. Scopoletin can ameliorate alcohol-induced hepatic lipid accumulation by modulating AMPK-SREBP pathway-mediated lipogenesis in mice fed a high-fat diet.

Lactone

Phellopterin: partial central benzodiazepine receptor agonist, cytotoxic at 40-400 μM on RAW264.7 cells, inhibits VCAM-1, affects monocyte adhesion.

Nodakenin, a coumarin isolated from the roots of Angelica biserrata (Shan et Yuan) Yuan etShan, possesses neuroprotective, antiaggregatory, antibacterial, and memory

Psoralen crosslinking between human immunodeficiency virus type 1 RNA and primer tRNA3(Lys).

'Alloimperatorin fights HL-60 leukemia by inducing apoptosis, disrupting cell cycle, and halting migration; it also enhances erythrocyte hemolysis.'

Isoscopoletin analytical standard provided with chromatographic purity, to be used as reference material for qualitative determination.

M04062 - beta-Alanine 7-amino-4-methylcoumarin trifluoroacetate salt

M03628 - Carboxyumbelliferyl-Å-D-Galactopyranoside (CUG)

Scopoletin is a naturally occurring coumarin derivative, which is primarily isolated from plants such as those in the Solanaceae and Asteraceae families. It exhibits a diverse range of biological activities due to its multifaceted mode of action, which includes antioxidant, anti-inflammatory, and antimicrobial properties. As a phytochemical, scopoletin can modulate various biochemical pathways, influencing both enzymatic and receptor-mediated processes. Scopoletin is widely studied for its therapeutic potential in reducing oxidative stress and modulating the immune response, making it a subject of interest in the development of treatments for conditions characterized by inflammation and microbial infections. Additionally, its ability to inhibit certain enzymes and interact with neurotransmitter systems suggests potential applications in neurology and metabolic research. As a scientific compound, scopoletin continues to be an important molecule for further research, contributing to a deeper understanding of plant-based bioactive compounds and their effects on human health.

Lactone

LC3-mHTT-IN-AN2 (5,7-Dihydroxy-4-phenylcoumarin) is found in the plant Passiflora serratodigitata with the antibacterial activity.

Bergaptol is a naturally occurring furanocoumarin, which is a compound derived from plants, particularly from the Rutaceae family such as bergamot and other citrus species. It is primarily characterized by its chemical structure containing a furan ring fused to a coumarin moiety. Bergaptol acts primarily through its interaction with biological systems by inhibiting certain enzymatic activities and interfering with the biological pathways that involve reactive oxygen species. This compound exhibits antioxidant properties, reducing oxidative stress by scavenging free radicals and thereby protecting cells from damage. Bergaptol is utilized in various fields of research due to its potential therapeutic effects. It is studied for its anti-inflammatory properties, making it valuable in exploring treatments for conditions associated with chronic inflammation. Furthermore, its role in modulating enzymatic pathways has implications in cancer research, as it can influence cell proliferation and apoptosis. In the field of dermatology, it is investigated for its properties in managing skin disorders and pigmentation issues. Bergaptol’s versatility as a biologically active compound makes it a significant subject of study in pharmacology and biochemistry.

Dalbergin, a bone-conserving agent like estradiol, may treat postmenopausal osteoporosis and protects against skin photoaging.

Natural glycoside

5,7-Dihydroxy-4-methylcoumarin monohydrate is an organic chemical compound, specifically a type of coumarin derivative. Coumarins are a class of naturally occurring aromatic compounds that are found in various plant sources, such as tonka beans, sweet clover, and other botanicals. This particular compound, with its distinct hydroxyl and methyl groups, falls under the broader category of hydroxycoumarins, which are of significant interest in biochemical research due to their various functional properties. The mode of action of 5,7-Dihydroxy-4-methylcoumarin involves its ability to participate in biochemical reactions, particularly those involving enzyme inhibition and free radical scavenging. The presence of hydroxyl groups enhances its potential as an antioxidant, facilitating interactions that can neutralize reactive oxygen species. In scientific research, 5,7-Dihydroxy-4-methylcoumarin monohydrate is primarily utilized in studies exploring its antioxidant properties, enzyme inhibitory effects, and potential therapeutic applications. It serves as a valuable tool in understanding biochemical pathways and the development of pharmacologically active compounds. Its role in modulating enzyme activities and oxidative stress response mechanisms makes it a significant subject of academic and clinical investigations.

M05817 - 7-Methoxycoumarin

M04111 - Glycine 7-amido-4-methylcoumarin hydrobromide salt

Lactone

Sparstolonin B is a TLR2 and TLR4 antagonist with anti-HIV, anti-cancer, anti-tumor and anti-inflammatory activities,.

Byakangelicol is a naturally occurring furanocoumarin, which is a type of organic compound found predominantly in the roots of certain plants, such as Angelica dahurica. This compound is synthesized through the plant's secondary metabolic pathways, primarily as a defense mechanism against herbivores and pathogens. Byakangelicol exerts its biological effects primarily through the inhibition of various enzymatic pathways, such as cytochrome P450s and monoamine oxidase, which are key in processes like drug metabolism and neurotransmitter regulation. The diverse applications of Byakangelicol include its use in scientific research as an investigational compound to study enzyme interactions and its potential therapeutic effects. Its ability to modulate enzyme activity makes it a candidate for further exploration in areas like anti-cancer research, due to its purported activity in influencing cell cycle dynamics and apoptosis. Furthermore, its anti-inflammatory and antioxidant properties offer promise in the development of treatments for conditions linked to oxidative stress and inflammatory responses. Researchers continue to explore its full potential and scope within pharmacological and toxicological domains.

6-Methylcoumarin (Toncarine) (6MC) is a semisynthetic coumarin with important in vitro and in vivo anti-inflammatory activity.

Lactone

Fluorescent dye used in diagnostic culture media

Citropten analytical standard provided with w/w absolute assay, to be used for quantitative titration.

Heraclenin: anticoagulant, anti-inflammatory, mutagenic in C. reinhardii, induces apoptosis in leukemia, clastogenic, antiplasmodial, and antimicrobial.

7-Methoxycoumarin is a fluorescent compound, which is a derivative of coumarin. It is synthesized through chemical modification processes of natural coumarin, typically sourced from plant extracts of the Apiaceae and Rutaceae families. The mode of action of 7-Methoxycoumarin involves its ability to fluoresce when exposed to ultraviolet light. This property is derived from its aromatic structure, which allows it to absorb light and subsequently emit it at a longer wavelength. This characteristic makes it a valuable probe for monitoring biological interactions and quantifying biochemical processes. In research and industrial settings, 7-Methoxycoumarin is widely utilized for its fluorescent properties. It is commonly employed in enzyme assays, where it acts as a substrate that releases a fluorescent product upon enzymatic action. Additionally, it is used in the study of enzyme kinetics, drug discovery, and cellular imaging. Its application extends to the development of light-responsive materials and sensors. The compound's ability to provide real-time feedback in biological systems is pivotal for advancing our understanding of complex biochemical pathways.