Polycyclic Aromatic Hydrocarbons (PAHs)

Stability Hygroscopic Applications 1,2,3,4-Tetrahydro-1-[(4-hydroxyphenyl)methyl]-hydrobromide-(1S)-6,7-isoquinolinediol has been used in the preparation of (-)-Higenamine (H325800) References Ho, C.L., Ko, J.L., Chen, C.M.: J. Chinese Biochem. Soc., 14, 94 (1985)

Applications Occurs in coal tar. Is formed during distillation of coal, in very small amount during distillation or pyrolysis of many fats and oils. Chrysene is one of the basic polycyclic aromatic hydrocarbon (PAH) which is toxic environmental pollutant and consistently exposed to sunlight. However, little information is available on its photogenotoxicity.  The objective of the present study was to analyze the effects of Chrysene, under environmental intensity of UVB (0.6 mW/cm2) in human skin epidermal cell line (HaCaT). Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Anderson, D., et al.: Mutat. Res., 307, 261 (1994), Diamond, S., et al.: Environ. Toxicol. Chem., 25, 3015 (2006), Fotakis, G., et al.: Toxicol. Lett., 160, 171 (2006),

Applications 2-Nitrodibenzothiophene is a nitrated polycyclic aromatic hydrocarbon (PAH). 2-Nitrodibenzothiophene is removed from coal by hydrogenation in Tetralin. References Watanabe, T. et al.: Mut. Res. Gen. Toxicol. Environ. Mutagen., 388, 67 (1997); Gundermann, K.D.: U. S. Environ. Prot. Agency, Off. Res. Dev., 133 (1976);

Applications A metabolite of Phenanthrene (P294800(P)), which is a polycyclic aromatic hydrocarbon; an environmental pollutant. References Boyland, E., et al.: Biochem. J., 84, 564 (1962); Hamada, S., et al.: Mutat. Res., 495, 127 (2001); Shimada, T., et al.: Drug Metab. Dispos., 29, 1176 (2001); Moennikes, O., et al.: Cancer Res., 64, 4707 (2004); Albig, A., et al.: Mol. Biol. Cell., 16, 609 (2005); Di Toro, D. et al.: Environ. Toxicol. Chem., 19, 1971 (2000); Vines, C. et al.: Aquat. Toxicol., 51, 225 (2000); Incardona, J. et al.: Toxicol. Appl. Pharmacol., 196, 191 (2004); Junghans, M., et al.: Aquat. Toxicol., 76, 93 (2006);

Applications 6-Ethylchrysene is a persistent organic pollutant (POP). It is a derivative of chrysene (C428000) which is considered as a carcinogen. References Bratberg, M., et al.: Chemosphere, 90, 2157 (2013); Hecht, S., et al.: J. Natl. Cancer Inst., 53, 1121 (1974)