Polycyclic Aromatic Hydrocarbons (PAHs)

Applications 2,3-Benzoperylene is a potent mutagen. It can be used as a standard in determination of polycyclic aromatic hydrocarbons (PAH’s). References Durant, J., et al.: Mutat. Res-Genet. Tox., 446, 1 (1999); Schubert, P., et al.: Analyt. Chem.m 75, 234 (2003)

Applications Labelled analogue of Dibenz[a,h]anthracene, a polycyclic aromatic hydrocarbon (PAH) and a known carcinogen. Dibenz[a,h]anthracene has produced positive results in bacterial DNA damage and mutagenicity assays and in mammalian cell DNA damage, mutagenicity and cell transformation assays. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Farmer, P.B. et al.: Mutat. Res. Re. Mutat. Res., 544, 397 (2003); Leadon, S. et al.: Carcinogenesis, 16, 3021 (1995); Andrews, A.W. et al.: Mutat. Res., 51, 311 (1978); Kaden, D.A. et al.: Cancer Res., 39, 4152 (1979);

Applications 4,5-Methanochrysene shows moderate degree of carcinogenic activity. As a polycyclic aromatic hydrocarbon (PAH), it is considered as a pollutant. References Dunlap, C., et al.: Cancer Res., 3, 606(1943); Rice, J., et al.: Carcinogenesis, 9, 2275 (1988); Fabacher, D., et al.: Arch. Environ. Con. Tox., 21, 17 (1991)

Applications 5-Methylbenz[a]anthracene is a monomethylated polycyclic aromatic hydrocarbon with carcinogenic activity. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Majumdar, R. et al.: Mutat. Res. Lett., 175, 1 (1986); Smith, I.A. et al.: Int. J. Quant. Chem. Quant. Biol. Symp., 5, 311 (1978); Wislocki, P.G. et al.: Carcinogenesis, 3, 215 (1982);

Applications 1-Hydroxypyrene-d9 is found in humane urine after exposure to coal tar and a coal derived product. References Jongeneelen, F.J., et al.: Int. Arch. Occup. Environ. Health, 57, 47 (1985)

Applications Polycyclic aromatic hydrocarbons (PAHs) and their PAH-DNA adducts in lung tissues, and their ability to mutate the Ki-ras oncogene in PAH-induced tumors. Seven PAHs were studied: cyclopenta[cd]pyrene (CPP), benzo[a]pyrene (B[a]P), benzo[b]fluoranthene (B[b]F), dibenz[a,h]anthracene (DBA), 5-methylchrysene (5MC), benz[j]aceanthrylene (B[j]A), and dibenzo[a,l]pyrene (DB[a,l]P). References Nesnow, S., et al.: Cancer Lett., 73, 73 (1993), Herzog, C., et al.: Cancer Res., 54, 4007 (1994), Prahalad, A., et al.: Carcinogenesis, 18, 1955 (1997),

Stability Moisture Sensitive Applications Phorate Oxon Sulfone is a major metabolite of Phorate (P353500), an inhibitor of acetylcholinesterase and pseudocholinesterase. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Boshoff, P.R., et al.: J. Agr. Food Chem., 27, 626 (1979),

Applications 2-Methylnaphthalene-D10 is a labelled analogue of 2-Methylnaphthalene (M323130). 2-​Methylnaphthalene is a polycyclic aromatic hydrocarbon (PAH) that has been used as an indicator of smoke exposure in food and packaging materials. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Johnston, J.J., et. al.: J. Agr. Food Chem., 42, 1954 (1994)

Applications 3-Chloroacenaphthene is a chloro derivative of Acenaphthene (D448330); a polycyclic aromatic hydrocarbon serving as a carcinogenic agent. References Hansen, B., et al.: Environ. Toxicol. Chem., 18, 772 (1999); Czub, G., et al.: Environ. Sci. Technol., 38, 2406 (2004)

Applications Octachloronapthalene is a polychlorinated napththalene (PCN) produced via industrial thermal processes. It is a chemical pollutant present in the environment. References Liu, G. et al.: Chemos., 118, 112 (2015); Pena-Abaurrea, M. et al.: Env. Sci. Tech., 48, 9591 (2014);

Applications Labelled Dibenzo[a,l]pyrene (D416945). An active metabolite from inhalation and dermal exposure to polycyclic aromatics hydrocarbons in hot mix asphalt paving workers. DBC is the most potent tumorigen that has been identified to date. Dibenzo[def,p]chrysene (DBC) is a carcinogen and should be handled with appropriate caution. References Anderson, L., et al.: Toxicol. Appl. Pharmacol., 199, 85 (2004), Yu, Z., et al.: Cancer Res., 66, 755 (2006), Shen, J., et al.: Toxicol. Sci., 95, 313 (2007),