Organometallic Ligands

6-OAU is a chemical compound categorized as a cytokinin-like molecule, which is derived from natural plant sources. It functions by modulating gene expression and hormone pathways involved in various plant growth and developmental processes. The mode of action of 6-OAU largely revolves around mimicking the activity of cytokinins, essential plant hormones that regulate cell division, shoot and root growth, as well as delay senescence. 6-OAU finds substantial application in agricultural and biological research due to its ability to influence plant morphology and stimulate growth under specific conditions. By altering hormonal balances, it allows scientists to explore plant developmental pathways, investigate stress responses, and enhance crop yields in controlled research settings. Its application in vitro aids in understanding plant tissue culture efficacy, serving as a valuable tool for developing robust plant regeneration protocols. In summary, 6-OAU remains a significant phytochemical for scientists studying plant physiology and biochemistry.

Ketanserin is a 5-HT2A serotonin receptor antagonist that is used for the treatment of hypertension. This drug is also used in research to study the serotonergic system. Ketanserin has been found to also block the vesicular monoamine transporter 2. Ketanserin tartrate is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

BIX is an NHE1 inhibitor, which is a small molecule compound derived from chemical synthesis. It specifically targets the Na+/H+ exchanger 1 (NHE1), a protein involved in the regulation of intracellular pH. The mode of action of BIX involves the inhibition of NHE1, leading to altered proton exchange across the plasma membrane. This action affects the cellular pH homeostasis and ion balance, which can influence various cellular processes such as cell proliferation, apoptosis, and migration. The applications of BIX are primarily in the field of biomedical research, where it is utilized to study the physiological and pathological roles of NHE1 in different cell types and tissues. It is particularly significant in cancer research, where NHE1 activity is often upregulated, contributing to the malignant phenotype. By understanding the effects of BIX, researchers can explore the potential therapeutic implications of targeting NHE1 in tumor progression, cardiovascular diseases, and other conditions influenced by dysregulated pH dynamics.

Prasugrel is a thienopyridine prodrug that inhibits the enzyme ADP-dependent P2Y purinergic receptor. Prasugrel inhibits platelet aggregation and the formation of blood clots by blocking the conversion of ADP to ATP on the surface of platelets, thus preventing the release of serotonin from platelets. The reaction products formed by prasugrel are similar to those formed by clopidogrel and include hydrogen sulfate ions and a thiol-containing metabolite. It has also been shown to have potent cytotoxic activity against melanoma cells and anti-inflammatory properties.  Prasugrel is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

ABP 688 is a radiolabeled ligand, which is a synthetic compound used primarily in positron emission tomography (PET) to visualize metabotropic glutamate receptor subtype 5 (mGluR5) in vivo. Developed from chemical synthesis, ABP 688 acts by selectively binding to the allosteric site of the mGluR5 receptor with high affinity and specificity. When labeled with a positron-emitting isotope such as Carbon-11 or Fluorine-18, it allows for the non-invasive imaging and quantification of mGluR5 distribution and density in the brain. The primary use of ABP 688 is in neuroscience research, where it aids in the study of neurological and psychiatric disorders associated with glutamatergic dysfunction, such as schizophrenia, depression, and addiction. By providing detailed insights into mGluR5 expression patterns, this radioligand facilitates the understanding of pathophysiological mechanisms and the evaluation of therapeutic interventions targeting mGluR5. ABP 688 is not used for therapeutic purposes but remains a crucial tool in translational research bridging preclinical studies and human clinical trials.

A-889425 is a novel small molecule compound that serves as a potent and selective antagonist. It is derived from synthetic chemical processes aimed at modulating ion channel activity specifically. The mode of action of A-889425 involves the selective inhibition of specific ion channels, which play critical roles in cellular signaling pathways and are implicated in various physiological processes. By selectively targeting certain ion channels, A-889425 demonstrates significant potential in altering cellular excitability and signal transduction, making it a valuable tool in both basic research and potential therapeutic contexts. Its applications are primarily concentrated in the investigation of channelopathies-diseases resulting from disturbed ion channel function-and in the development of novel treatments for conditions such as chronic pain, epilepsy, and cardiovascular disorders. Researchers utilize A-889425 in in vitro and in vivo studies to delineate the precise roles of specific ion channels and to explore the therapeutic windows of intervention. Its high specificity and efficacy make A-889425 an indispensable molecule in the arsenal of molecular pharmacology and neurobiological research.

Retosiban is a pharmaceutical compound that serves as an oxytocin receptor antagonist, derived through synthetic chemical synthesis. Its primary mechanism of action involves the selective inhibition of oxytocin receptors, which are critical in the uterine contractions that occur during labor. By blocking these receptors, Retosiban effectively reduces uterine muscle contractions, thus playing a crucial role in managing preterm labor. The primary application of Retosiban is in the obstetric field, where it is used to delay preterm birth by reducing the frequency, intensity, and duration of uterine contractions. This can help to prolong pregnancy, allowing for further fetal development and reducing risks associated with premature delivery. Although still under investigation in various clinical trial stages, Retosiban holds promise as a significant intervention for improving neonatal outcomes in pregnancies at risk of preterm birth. Research continues to assess its efficacy, safety profile, and potential long-term impacts on both maternal and fetal health.

Bicuculline is a phthalide-isoquinoline compound and is a competitive GABA receptor antagonist. It blocks GABA’s inhibitory action, mimicking epilepsy. This compound is used in research to better study epilepsy. (+)-Bicuculline is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

Brobactam sodium is a β-lactamase inhibitor, which is a chemically synthesized compound with the primary function of inactivating β-lactamase enzymes produced by certain bacteria. These enzymes can degrade β-lactam antibiotics, such as penicillins and cephalosporins, rendering them ineffective. Brobactam sodium functions by forming a covalent bond with the active site of β-lactamase enzymes, thus inhibiting their activity and allowing the concomitantly administered β-lactam antibiotic to exert its bactericidal effect on the susceptible pathogens. The primary application of Brobactam sodium is in combination therapies with β-lactam antibiotics to treat infections caused by β-lactamase-producing bacteria. This includes a range of Gram-positive and Gram-negative bacteria that are otherwise resistant to standard β-lactam antibiotics alone. Its use is critical in both clinical and research settings to study antibiotic resistance mechanisms and to develop effective therapeutic strategies against resistant bacterial infections.

17:0-20:4Pi (4) P is a synthetic phosphoinositide, which is a type of phospholipid. It is typically sourced from laboratory synthesis, often incorporating stable isotopes or specific fatty acid chains to mimic natural compounds found in cell membranes. This product functions primarily as a probe in biochemical experiments, particularly for studying lipid signaling pathways within cells. The main mode of action of 17:0-20:4Pi (4) P involves its incorporation into cellular membranes where it participates in signaling processes by interacting with specific proteins that recognize phosphoinositides. These interactions are crucial for the regulation of various cellular activities, such as membrane trafficking, cytoskeletal rearrangement, and intracellular signaling cascades. The uses and applications of 17:0-20:4Pi (4) P are extensive in the field of cell biology and biochemistry. Researchers employ this compound to investigate the roles of phosphoinositides in various physiological and pathological contexts, including cancer, neurodegenerative diseases, and immune responses. Additionally, it serves as a valuable tool in the development of assays and in the exploration of potential therapeutic targets within lipid signaling pathways.

Perfluorophenyl 3-(2-(2-(3-(2,5-dioxo-2H-pyrrol-1(5H)-yl)propanamido)ethoxy)ethoxy)propanoate is a specialized chemical compound, belonging to the class of fluorinated organic esters. It is derived synthetically through a series of controlled chemical reactions involving perfluorophenyl groups and functionalized pyrrolidone derivatives. The presence of perfluorinated groups imparts unique physicochemical properties to the compound, including chemical inertness and hydrophobicity. This compound functions as a reactive agent in materials science and industrial applications. Its mode of action is primarily based on its ability to engage in specific interactions at a molecular level, making it an excellent candidate for surface modifications, particularly in engineering nanocomposites and advanced coatings. Applications of Perfluorophenyl 3-(2-(2-(3-(2,5-dioxo-2H-pyrrol-1(5H)-yl)propanamido)ethoxy)ethoxy)propanoate are broad and include enhancing the performance of polymer matrices, serving as a coupling agent, and improving the durability and water-resistance of materials. It is highly valued in research fields exploring advanced material properties, requiring precise, high-performance modifications.

Bostrycin is a polyketide-type natural product, which is a secondary metabolite produced by certain fungi, particularly those belonging to the genus Aschersonia. Its source lies in the complex biosynthetic pathways of these fungi, which synthesize diverse polyketides with bioactive properties. The mode of action of Bostrycin involves disrupting cellular processes, predominantly through the inhibition of specific enzyme activities and interference with DNA processes, which can lead to cell cycle arrest and apoptosis in target cells. In research settings, Bostrycin has garnered interest due to its potential applications in pharmacology, particularly for its anticancer and antibiotic properties. Studies have shown its capacity to modulate cellular responses and inhibit the growth of various cancer cell lines. Furthermore, its antibiotic activity has been explored against several bacterial strains, indicating a potential role in developing new therapeutic agents. While its precise mechanisms continue to be investigated, Bostrycin represents a promising candidate for further study in drug development and biochemical research.

Potent agonist of a1β1γ1 5′-adenosine monophosphate-activated protein kinase (AMPK). It binds to the allosteric drug and metabolite (ADaM) site at the α- and β- subunit interface of AMPK. It has potential for the treatment of diabetic nephropathy. PF 06409577 reduces infections caused by flaviviruses, mediated by changes in the metabolism of lipids in host cells.

NBD 18:0 ceramide is a synthetic fluorescent lipid analogue, which is derived from the naturally occurring sphingolipid, ceramide. This product is characterized by the attachment of a nitrobenzoxadiazole (NBD) fluorophore to the ceramide backbone, allowing it to serve as a tool for visualizing and studying lipid dynamics within biological membranes. The mode of action of NBD 18:0 ceramide involves its incorporation into lipid bilayers, where it can mimic natural ceramides and participate in membrane-related processes, while the attached NBD group provides a fluorescent signal. This fluorescence facilitates the tracking and analysis of ceramide distribution, interaction with other membrane constituents, and roles in cellular signaling pathways. NBD 18:0 ceramide is utilized in various applications, including studies on membrane organization, lipid trafficking, and sphingolipid metabolism. Its ability to integrate into cell membranes without significantly altering their native properties makes it a valuable tool for researchers investigating the functional roles of ceramides in health and disease. Through fluorescence microscopy and spectroscopy, scientists can gain insights into the dynamic behavior of lipids in live cells and model systems.

Antagonist of Wnt signalling pathway by inhibiting the activity of Porcn, a member of the membrane-bound O-acyltransferase (MBOAT) family. Porcn is required for the palmitoylation of Wnt, mediating its secretion and signalling. Inhibits self-renewal in embryonic stem cells, whilst promoting differentiation to epiblast stem cells.

Inhibitor of pan-sirtuins (IC50 = 15, 10, 33 µM for SIRT1, 2 and 3 respectively), by binding to the active catalytic site. Selectivity for sirtuins was demonstrated when tested for activity on a panel of kinases, nuclear receptors, ion channels, transporters and GPCRs.

Doxazosin is a first-generation α1-adrenergic receptor antagonist that is used in the treatment of hypertension and urinary obstruction, It has been shown to be effective in combination therapy for patients with benign prostatic hyperplasia. Doxazosin mesylate is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

PT2399 is a delay line integrated circuit, which is a monolithic IC sourced from Princeton Technology Corp. It operates through analog and digital signal processing to achieve time-delay effects in audio signals. The PT2399 utilizes a digital delay line technique, converting analog input signals to digital through an integrated ADC. These digital signals are subsequently delayed and processed internally, after which they are reconverted back into analog form via a built-in DAC. Commonly employed in audio applications, the PT2399 is found in effects units such as guitar pedals, karaoke machines, and other sound processors where echo or delay effects are desired. Its versatility in manipulating audio signals, coupled with relatively low noise and distortion characteristics, makes it a favored component in the design of cost-effective audio equipment. The ability to produce varied delay times through external control means it can be intricately integrated into custom audio processing solutions, providing flexibility and adaptability for advanced acoustic experimentation and application.

Tryphos(R) is a specialized solvent and extractant, derived from organophosphorus compounds. This product originates from a chemically synthesized source, characterized by the complex manipulation of phosphorus chemistry to achieve its specific functional properties. Its mode of action involves the selective solvation and coordination with target molecules, which facilitates the separation or purification of specific compounds via liquid-liquid extraction processes. The applications of Tryphos(R) are diverse, primarily focused on the fields of analytical chemistry and industrial processes. It is utilized for its efficacy in the separation and extraction of metal ions, particularly in the purification of rare earth elements and transition metals. Furthermore, Tryphos(R) is employed in organic synthesis as a reagent that enables specific transformations by stabilizing intermediates or enhancing the reactivity of substrates. Its unique chemical properties make it a vital tool in laboratories and industries seeking precision and efficiency in chemical separations and syntheses.

PPDA is a synthetic chemical compound, which is an aromatic amine derived from aniline through a series of chemical reactions involving nitration and reduction. Its mode of action involves acting as an intermediate or precursor in a variety of organic synthesis processes, playing a pivotal role in the formation of complex organic structures. PPDA's electrophilic properties make it an essential component in producing dyes, polymers, and pharmaceuticals by facilitating specific chemical transformations. Additionally, it demonstrates high reactivity in coupling reactions due to its amine group, enhancing its utility in the synthesis of polymers and advanced materials. In scientific research, PPDA is valuable for its role in producing polymers with tailored properties and for synthesizing pharmaceutical compounds that require precise and efficient chemical modifications. The compound's ability to participate in diverse chemical reactions under controlled conditions makes it indispensable in both industrial and laboratory settings, where it contributes to the innovation of new materials and drug development strategies. Its applications extend to dye production, where it aids in fabricating stable colorants used in various industries.

N-Cyclohexyl-N'-(2-morpholinoethyl)carbodiimide methyl-p-toluenesulfonate, also known as CMC, CMCT, Morpho-CDI and CME-carbodiimide, is a reagent widely used in the detection of post-transcriptional modifications on nucleosides in RNA. RNA chemical probing is a powerful technology used to address numerous biological questions. The main application of CMC is the chemical modification of pseudouridine in RNA, in order to detect it and quantify it using analytical techniques such as primer extension or MALDI. Pseudouridine is the most abundant modification occurring in cellular RNA, and is responsible for the increased rigidity of the phosphate backbone and base stacking, impacting important RNA interactions.

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Aloe-emodin is an anthraquinone derivative that is found in the aloe plant. It has a strong stimulant laxative action. Aloe-emodin may be useful in the treatment of cancer, as it inhibits cell proliferation by inducing apoptosis. Aloe-emodin is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

Azilsartan medoxomil is an antihypertensive drug, which is a prodrug of the angiotensin II receptor blocker azilsartan. It is synthesized through a chemical process involving the modification of the medoxomil ester, converting it into its active form upon absorption in the gastrointestinal tract. The primary mode of action of azilsartan medoxomil involves selective antagonism of the angiotensin II type 1 (AT1) receptor. By blocking the effects of angiotensin II-a potent vasoconstrictor-azilsartan medoxomil effectively reduces vascular resistance, leading to decreased blood pressure. Azilsartan medoxomil is primarily used in the management of hypertension. By lowering elevated blood pressure, it helps reduce the risk of cardiovascular events such as strokes and myocardial infarctions. The prodrug formulation ensures efficient gastrointestinal absorption and subsequent rapid activation, making it an effective therapeutic option in the clinical setting. Given its specific receptor antagonism, azilsartan medoxomil offers targeted therapeutic intervention, contributing to improved compliance and patient outcomes in hypertensive patients.

Repaglinide is an antihyperglycemic drug that is used for the improvement of glycemic control in diabetes. This drug acts on the beta cells of the pancreas and binds to specific receptors on the beta cells known as ATP-sensitive potassium channels. As a result, this promotes insulin secretion from beta cells. Repaglinide is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

CCT020312 is a small-molecule inhibitor that is a selective and potent inhibitor of the P21-activated kinase 4 (PAK4), which is sourced through synthetic organic chemistry. By inhibiting PAK4, this compound disrupts the signaling pathways that are often upregulated in various malignancies, involving proliferation, survival, and cytoskeletal reorganization. Through competitive binding at the ATP-binding site of PAK4, CCT020312 effectively suppresses kinase activity, which is crucial for downstream signaling events associated with oncogenic processes. The application of CCT020312 is significant in cancer research, where it is used to explore the role of PAK4 in tumorigenesis. By studying its effects in cell lines and animal models, researchers can analyze changes in cellular behavior including growth arrest and apoptosis. CCT020312 serves as an invaluable tool in validating PAK4 as a potential therapeutic target and understanding the molecular mechanisms underlying cancer progression. Its application extends to preclinical studies aimed at developing PAK4-targeted therapies and enhancing the efficacy of existing anti-cancer approaches.

Peptide derived from the endothelial nitric oxide synthase which synthesises nitric oxide in order to protect endothelial cells from vascular diseases, atherosclerosis and thrombosis.

D8-MMAE is a chemical conjugate product, which is composed of the highly potent cytotoxic agent monomethyl auristatin E (MMAE) linked to targeting moieties, often through a stable linker. This product is synthetic in origin, derived from auristatins, which are analogs of dolastatin 10, a natural peptide isolated from marine organisms. The mode of action of D8-MMAE involves specific binding to cellular targets, typically through an antibody-drug conjugate (ADC) mechanism, where the conjugate binds to antigens on cancer cells. Once internalized, the linker is cleaved, releasing MMAE within the cell. MMAE then binds to tubulin, inhibiting cell division by disrupting the microtubule network, leading to apoptosis. D8-MMAE is utilized primarily in cancer research and development, especially in the creation of ADCs for targeted cancer therapy. Its applications lie in delivering cytotoxic agents directly to cancer cells, thereby minimizing off-target effects and enhancing therapeutic index. This targeted approach is crucial in developing treatments for various malignancies, offering a pathway to more effective and personalized oncology therapies.

Inhibitor of COX-1 and COX-2 cyclooxygenases

Beta-2-adrenergic receptor agonist

Mardepodect is an investigative pharmaceutical compound, which is derived synthetically through a series of complex chemical reactions involving multiple steps of organic synthesis. This compound operates primarily as a selective phosphodiesterase-9 (PDE9) inhibitor, modulating intracellular signaling pathways by preventing the degradation of cyclic guanosine monophosphate (cGMP). The resulting elevated levels of cGMP lead to various downstream biological effects that can be explored for therapeutic benefits. Mardepodect is utilized in research settings to investigate potential treatments for neurological disorders and may have implications in other therapeutic areas due to its role in modulating key signaling pathways involved in cellular function and communication. Its mode of action allows scientists to explore the intricate mechanisms of disease pathogenesis and neuronal signaling, providing valuable insights into the development of new therapeutic strategies. The precise effects on the cGMP pathways could yield significant breakthroughs in understanding conditions like Alzheimer's disease, schizophrenia, and other cognitive disorders.

rac-Atomoxetine-d5 hydrochloride is an analog of the drug Atomoxetine, which is used to treat attention deficit hyperactivity disorder (ADHD). It is a ligand that binds to the α-adrenergic receptor. The racemic mixture of Atomoxetine is used as a research tool and as an analytical standard in pharmacology. The rac-Atomoxetine-d5 hydrochloride has been shown to be an inhibitor of protein interactions, such as those with the α2A-adrenergic receptor.

Farnesyl pyrophosphate synthase inhibitor; hepatic de novo lipogenesis inhibitor

N-Cyclohexylpropyl deoxynojirimycin, hydrochloride is a specific glucosidase inhibitor, which is derived from natural sources, notably microorganisms like Streptomyces species. This compound functions by competitively inhibiting alpha-glucosidases, enzymes that play a crucial role in the cleavage of glucose moieties from glycoproteins and glycolipids. Its mode of action involves binding to the active site of these enzymes, thereby preventing the normal catalytic process. The primary use of N-Cyclohexylpropyl deoxynojirimycin, hydrochloride is in biochemical research to study the pathways of glycoprotein processing and the role of glucosidases in various biological systems. It is particularly useful for dissecting the mechanisms underlying enzyme catalysis and substrate specificity in glycobiology. Furthermore, it has applications in elucidating the function of glycosidases in pathological conditions, such as lysosomal storage disorders and diabetes. By inhibiting glucosidase activity, researchers can gain insights into the modulation of cellular processes linked to carbohydrate metabolism, enhancing the understanding of disease mechanisms and potential therapeutic approaches.

FN-1501 is a synthetic bioactive compound, which is engineered through combinatorial chemistry with a specific focus on enzymatic activity. This product has been meticulously designed to emulate protease-like activity, facilitating the cleavage of peptide bonds within protein substrates. The mode of action involves the catalytic hydrolysis of peptide bonds, thereby enabling the precise dissection of protein structures for analytical studies. FN-1501 is primarily utilized in biochemical research for the mapping of protein sequences and the elucidation of protein tertiary and quaternary structures. Its application extends to proteomic studies where it assists in the digestion of proteins prior to mass spectrometry analysis. This allows for a detailed investigation of protein modifications, interactions, and mechanisms. FN-1501's stability and specificity make it an invaluable tool in structural biology research, advancing our understanding of protein function and interaction in complex biological systems.

Agonist of mechanosensitive cation channel Piezo1, which is expressed in bladder, kidney, lung, colon and skin tissues. Yoda 1 stabilizes the Piezo1 channel in an open state and reduces the threshold for mechanical activation. Yoda 1 also partially activates the Piezo1 channel in absence of mechanical stimuli.

HMG-CoA reductase inhibitor

Esomeprazole is an anti-ulcer drug that is used in the treatment of GERD and to reduce the risk of ulcers associated with NSAID’s. This drug is a proton pump inhibitor that suppresses the release of gastric acid in the stomach. Esomeprazole magnesium trihydrate is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

TVB-3664 is an analytical instrument, specifically designed for high-precision monitoring and measurement applications. It is engineered with advanced sensor technologies that provide enhanced detection capabilities, allowing for the accurate collection of data regarding various chemical and physical parameters. The source technology behind TVB-3664 involves state-of-the-art manufacturing processes, integrating robust materials with cutting-edge electronics to ensure durability and precision. The mode of action of TVB-3664 relies on its ability to autonomously calibrate and adapt to varying environmental conditions, ensuring that it delivers reliable and consistent results. This is achieved through integrated software algorithms that process raw data in real time, adjusting the sensitivity and specificity of the measurements as needed. TVB-3664 is utilized across a range of scientific disciplines, including environmental monitoring, industrial processing, and laboratory research, where precise measurement is crucial. Its applications extend into fields such as chemistry, biology, and physics, and it serves as an essential tool in both applied and theoretical research settings. Scientists appreciate the device’s versatility, robustness, and high accuracy, making it a preferred choice for complex analyses and long-term experiments.

5-Phenacyloxy-2H-isoquinolin-1-one is a synthetic chemical compound, which is primarily utilized as a biochemical inhibitor. This compound is derived from isoquinolinone sources and is distinguished by its phenacyloxy moiety linking it to the isoquinolinone core structure. Its mechanism of action involves selectively inhibiting specific biological pathways, a characteristic that makes it a valuable tool in the study of enzyme regulation and signal transduction processes. By interfering with these pathways, 5-Phenacyloxy-2H-isoquinolin-1-one provides insights into cellular functions and the biochemical landscape. In research settings, this compound is extensively applied in the exploration of therapeutic targets, particularly within the realms of cancer research and neurobiology. Scientists harness its ability to disrupt specific enzymatic activities to elucidate molecular mechanisms and identify potential intervention points for drug development. The versatility and specificity of 5-Phenacyloxy-2H-isoquinolin-1-one render it an indispensable reagent in the biochemical toolbox, facilitating advancements in molecular biology and pharmacology.

PF-04929113 (Mesylate) is a small molecule inhibitor, which is derived from synthetic sources, designed to target the phosphoinositide 3-kinase (PI3K) pathway with high specificity and potency. This compound exerts its mode of action through the inhibition of PI3K activity, a pivotal signaling molecule involved in multiple cell processes including growth, metabolism, and survival. By blocking PI3K, PF-04929113 disrupts downstream signaling pathways, leading to reduced cellular proliferation and inducing apoptosis in cancer cells. Researchers primarily use PF-04929113 in preclinical studies to investigate its therapeutic potential in various malignancies where PI3K signaling is dysregulated, such as breast, ovarian, and prostate cancers. Its selective inhibition of PI3K offers insights into the development of targeted cancer therapies and enhances understanding of oncogenic signaling pathways. The compound's efficacy and specificity make it a valuable tool in cancer biology, enabling scientists to dissect complex cellular processes and explore novel therapeutic interventions.

Tenoxicam is a non-steroidal anti-inflammatory drug that is used to reduce pain and inflammation in conditions such as arthritis. This drug works by inhibiting the enzyme cyclooxygenase or COX. As a result of this inhibition, this drug reduces the production of prostaglandins and therefore leads to a decrease in pain and inflammation. Tenoxicam is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

(3aS)-3a-Hydroxy-1-(3-hydroxyphenyl)-6-methyl-2,3-dihydropyrrolo[2,3-b]quinolin-4-one is an alkaloid compound, which is characterized by its complex polycyclic structure. Derived from natural sources such as plant species or synthesized through advanced organic chemistry techniques, this compound demonstrates potential through its complex pharmacodynamics. It exhibits activity by interacting with specific biological receptors, influencing signal transduction pathways, and modulating enzyme activities, thereby eliciting a variety of physiological responses. In scientific research, (3aS)-3a-Hydroxy-1-(3-hydroxyphenyl)-6-methyl-2,3-dihydropyrrolo[2,3-b]quinolin-4-one is primarily explored for its pharmacological applications, possibly offering therapeutic benefits in areas such as oncology or neurology. Its ability to modulate cellular and molecular mechanisms makes it a point of interest in drug development and medicinal chemistry. Ongoing studies aim to elucidate its full spectrum of biological activities, safety profile, and therapeutic potential for future clinical applications.

SNIPER(ABL)-033 is an advanced biotechnological tool designed to facilitate targeted research interventions. It is sourced from a collaborative effort between molecular biology specialists and biochemical engineers, ensuring robustness in complex biological environments. The product operates via advanced Antibody-Based Ligand (ABL) technology, which allows for the precise targeting and modulation of specific cellular pathways. Its mode of action involves binding to distinct molecular markers, facilitating targeted interference or activation of biological processes with high specificity and minimized off-target effects. SNIPER(ABL)-033 finds its applications primarily in the fields of cancer research, gene editing, and signal transduction studies. It enables scientists to dissect intricate biological pathways with enhanced accuracy, providing critical insights into cellular function and pathology. Its innovative approach aids in elucidating the mechanisms underlying disease progression and therapeutic responses, making it an indispensable tool in both basic and applied research settings.

Bis-imidazole phenol IDH1 inhibitor is a small-molecule therapeutic, which is a novel compound synthesized to specifically target mutant forms of isocitrate dehydrogenase 1 (IDH1). It operates by binding to the mutant IDH1 enzyme and inhibiting its aberrant function, which involves converting alpha-ketoglutarate to an oncometabolite, 2-hydroxyglutarate (2-HG). This conversion leads to epigenetic changes that drive the tumorigenesis process. The utility of Bis-imidazole phenol IDH1 inhibitors lies in their potential applications within oncology, specifically for treating cancers harboring IDH1 mutations, such as certain gliomas and acute myeloid leukemia. By reducing the production of 2-HG, these inhibitors aim to reverse the epigenetic reprogramming of cancer cells, thereby inhibiting tumor growth and progression. This targeted approach offers a promising direction for personalized cancer therapy, helping to improve outcomes for patients with mutant IDH1-associated malignancies. Researchers continue to explore the pharmacokinetic properties, efficacy, and safety profiles of these compounds in pre-clinical and clinical settings to fully understand their therapeutic potential.

CP 94253 Hydrochloride is a selective 5-HT1B receptor agonist, which is a synthetic compound derived through chemical synthesis in laboratory settings. Its mode of action involves selectively binding to and activating the 5-HT1B serotonin receptors, which play a significant role in the modulation of neurotransmitter release in the central nervous system. This receptor interaction influences serotonin levels, impacting various neurological pathways. The primary use and application of CP 94253 Hydrochloride lie in neuroscience research, where it serves as a critical tool for exploring serotonergic system functions and their implications in mood disorders, pain perception, and other neurological conditions. Research on CP 94253 Hydrochloride contributes to a deeper understanding of serotonin's role in the brain and the potential development of novel therapeutic agents targeting serotonin receptors. Additionally, this compound may be used in experimental pharmacology to investigate receptor-specific pathways and their wider physiological effects.

AZD 7762 Hydrochloride is a small-molecule inhibitor, which is a synthetic compound designed to target specific molecular pathways. It is manufactured as a hydrochloride salt for increased stability and solubility. The product principally acts by inhibiting checkpoint kinases, specifically Chk1 and Chk2, which play critical roles in the DNA damage response pathway. By inhibiting these kinases, AZD 7762 disrupts the cell cycle checkpoint control, leading to the accumulation of DNA damage in cancer cells, ultimately inducing apoptosis. This compound has been extensively studied for its potential in cancer therapy. Its ability to sensitize tumor cells to DNA-damaging agents and radiation makes it a promising candidate for combination therapy in oncology. Research has focused on its application in various cancer types, including pancreatic and lung cancers, where it enhances the efficacy of chemotherapeutic agents. The ongoing investigation aims to further elucidate its pharmacodynamics, optimize dosing regimens, and explore its full therapeutic potentials.

BMS-582949 is an investigational pharmaceutical compound, specifically a chemokine receptor antagonist, that has been derived through synthetic chemical processes. Its mode of action involves selectively inhibiting the C-C chemokine receptor type 2 (CCR2), a receptor involved in the migration and activation of monocytes and other immune cells. By blocking CCR2, BMS-582949 aims to modulate inflammatory pathways that are implicated in various diseases. This compound has been explored for its potential applications in treating inflammatory conditions, owing to its ability to interfere with chemokine-driven immune cell infiltration into tissues. Such applications could include the management of disorders such as rheumatoid arthritis and other chronic inflammatory diseases. While still in the experimental phase, BMS-582949 represents a targeted approach to managing inflammation by disrupting specific immune signaling pathways, thereby potentially offering a novel therapeutic avenue distinct from traditional anti-inflammatory drugs.

Iron chelator

Selectively inhibits α- and ζ-thrombins and elicits procoagulant effects. Reduces platelet deposition in a rat carotid endarterectomy model. Has therapeutic potential as an anti-thrombotic agent in patients with heparin-associated thrombosis.