Cytoskeletal Signaling
Cytoskeletal signaling inhibitors are compounds that disrupt the signaling pathways regulating the cytoskeleton, which is crucial for cell shape, motility, division, and intracellular transport. These inhibitors are used to study the dynamics of cytoskeletal proteins, such as actin and tubulin, and their role in processes like cell migration, adhesion, and cancer metastasis. Cytoskeletal signaling inhibitors are valuable in research on cell biology, cancer, and neurobiology. At CymitQuimica, we offer a comprehensive range of high-quality cytoskeletal signaling inhibitors to support your research in these areas.
Products of "Cytoskeletal Signaling"
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PKCθ pseudosubstrate peptide inhibitor,myristoylated
Myristoylated PKCθ pseudosubstrate peptide inhibitor is a synthetic peptide utilized to investigate the mechanism of action of protein kinase C theta (PKCθ) [1Formula:C105H184N36O21SPurity:98%Color and Shape:SolidMolecular weight:2318.88Miransertib
CAS:Miransertib (ARQ-092) is an orally bioavailable, selective, and potent allosteric Akt inhibitor.Formula:C27H24N6Purity:98.83% - ≥95%Color and Shape:SolidMolecular weight:432.52Ref: TM-T3467
1mg52.00€5mg97.00€10mg169.00€25mg344.00€50mg567.00€100mg908.00€500mg1,795.00€1mL*10mM (DMSO)114.00€Defactinib hydrochloride
CAS:Defactinib hydrochloride (PF 04554878 hydrochloride) is a novel inhibitor of FAK.Formula:C20H22ClF3N8O3SPurity:98.06% - 98.78%Color and Shape:SolidMolecular weight:546.95Midostaurin
CAS:PKC412(Midostaurin (PKC412); CGP41231; CGP41251) is a broad spectrum protein kinase inhibitor.Formula:C35H30N4O4Purity:100% - 99.47%Color and Shape:SolidMolecular weight:570.64Ref: TM-T3211
1mg51.00€5mg88.00€10mg126.00€25mg216.00€50mg328.00€100mg487.00€500mg1,093.00€1mL*10mM (DMSO)96.00€LY3372689
CAS:LY3372689 (Formulaic Ia) is an orally active O-GlcNAcase (OGA) enzyme inhibitor for tau protein-based disorders including Alzheimer's disease.Formula:C16H22FN5O3SPurity:99.27% - 99.45%Color and Shape:SolidMolecular weight:383.44Ref: TM-T61661
1mg99.00€5mg235.00€10mg354.00€25mg635.00€50mg935.00€100mg1,415.00€1mL*10mM (DMSO)259.00€Multi-kinase inhibitor 1
CAS:Multi-kinase inhibitor 1 (Multi-kinase inhibitor I) is a Multi-kinase inhibitor.Formula:C20H17F3N4O3Purity:99.34%Color and Shape:SolidMolecular weight:418.37FRAX597
CAS:FRAX597 is an effective, ATP-competitive inhibitor of group I PAKs, and for PAK1(IC50=8 nM), PAK2(IC50=13 nM), and PAK3 (IC50=19 nM).Formula:C29H28ClN7OSPurity:97.34% - 99.85%Color and Shape:SolidMolecular weight:558.1Ansamitocin P 3'
CAS:Ansamitocin P 3' (Maytansinol butyrate) is an antibody-drug conjugate cytotoxin with antitumor activity.Formula:C32H43ClN2O9Purity:98.16% - 99.16%Color and Shape:SolidMolecular weight:635.14Ref: TM-T1910
2mg34.00€5mg50.00€10mg84.00€25mg145.00€50mg229.00€100mg340.00€200mg472.00€1mL*10mM (DMSO)70.00€Ifebemtinib
CAS:Ifebemtinib (BI-853520) is an adhesion plaque kinase inhibitor with anti-tumour activity for the study of breast cancer.Formula:C28H28F4N6O4Purity:98.07% - 99.82%Color and Shape:SolidMolecular weight:588.55Ionomycin calcium
CAS:Ionomycin calcium (SQ23377 calcium) is an effective and selective calcium ionophore, exhibiting high specificity for calcium ions. Cost-effective and quality-assured.Formula:C41H70CaO9Purity:98% - 98.11%Color and Shape:SolidMolecular weight:747.07NAMI-A
CAS:NAMI-A is a ruthenium-based compound with selective activity against tumor metastasis.NAMI-A inhibits cancer cell adhesion and migration.Formula:C8H15Cl4N4ORuSPurity:98%Color and Shape:SolidMolecular weight:458.18Ipfencarbazone
CAS:Ipfencarbazone herbicide agent, is a substance being developed for the control of weeds such as watergrass in rice.Formula:C18H14Cl2F2N4O2Color and Shape:SolidMolecular weight:427.23Dynapyrazole A
CAS:Dynapyrazole A inhibits dynein 1 and 2 (IC50s: 2.3, 2.6 μM) and Hedgehog signaling (IC50: 1.9 μM).Formula:C20H12ClIN4OPurity:98.01%Color and Shape:SolidMolecular weight:486.69RWJ 50271
CAS:RWJ 50271 inhibits LFA-1/ICAM-1 interaction with IC50 5.0 μM in HL60 cells.Formula:C18H17F3N4O2SPurity:99.09%Color and Shape:SolidMolecular weight:410.41Ref: TM-T12783
1mg127.00€5mg311.00€10mg472.00€25mg747.00€50mg1,017.00€100mg1,311.00€200mg1,786.00€1mL*10mM (DMSO)344.00€AMP-945
CAS:AMP-945 is a proprietary focal adhesion kinase (FAK) inhibitor.Formula:C28H32F3N5O2Purity:99.60%Color and Shape:SolidMolecular weight:527.58Ref: TM-T9576
1mg97.00€5mg188.00€10mg311.00€25mg533.00€50mg755.00€100mg1,035.00€1mL*10mM (DMSO)254.00€Etrolizumab
CAS:MEDI-578 is a CHO-expressed humanized monoclonal antibody targeting NGF/bNGF for the study of neurological and immune system disorders.Purity:95% - 95%Color and Shape:LiquidAdhesamine diTFA
CAS:Adhesamine diTFA, a dumbbell-shaped molecule, activates the MAPK/FAK pathway. It promotes adhesion and growth in mammalian cells and accelerates differentiation and enhances the survival rate of primary cultured mouse hippocampal neurons.Formula:C28H32Cl2F6N8O6S2Color and Shape:SolidMolecular weight:825.63BX-2819
CAS:BX-2819 is an Hsp90 inhibitor that exhibits potent antiproliferative activity with an IC50 of 41 nM .Formula:C21H24N4O4SPurity:98%Color and Shape:SolidMolecular weight:428.51αvβ1 integrin-IN-1 TFA (1689540-62-2 free base)
αvβ1 integrin-IN-1 TFA is an effective and selective αvβ1 integrin inhibitor (IC50: 0.63 nM).Formula:C28H35F3N6O8SPurity:98%Color and Shape:SolidMolecular weight:672.67Hydroxy-Dynasore
CAS:Hydroxy-Dynasore (Dyngo-4a) , a effective dynamin inhibitor, inhibits withDynI (brain), DynI (rec), and DynII (rec) of IC50 of 0.38 μM, 1.1 μM, and 2.3 μM,Formula:C18H14N2O5Purity:100% - 97.60%Color and Shape:SolidMolecular weight:338.31Ref: TM-T6822
5mg50.00€10mg84.00€25mg137.00€50mg221.00€100mg329.00€200mg490.00€500mg783.00€1mL*10mM (DMSO)55.00€αvβ6-IN-1
αvβ6-IN-1 (compound 28) is an effective orally active inhibitor of αvβ6 integrin (αvβ6integrin), with a pIC50 value of 8.1. This compound shows potential for research in idiopathic pulmonary fibrosis.Formula:C25H32F2N4O3Color and Shape:SolidMolecular weight:474.5416-38-Thymosin β4 (cattle) (TFA)
Thymosin β4 (cattle) TFA is a high-affinity activator of MLCK that operates independently of Ca2+ [1].Formula:C120H205F3N32O43Purity:98%Color and Shape:SolidMolecular weight:2841.1K858 (Racemic)
CAS:K858 Racemic (K858) is a selective mitotic kinesin Eg5 inhibitor which acts in an ATP-noncompetitive manner.Formula:C13H15N3O2SPurity:100%Color and Shape:SolidMolecular weight:277.34AZ13705339
CAS:AZ13705339 is an effective inhibitor of PAK1 with an IC50 of 0.33 nM and a Kd of 0.28 nM.Formula:C33H36FN7O3SPurity:98.57%Color and Shape:SolidMolecular weight:629.75FAK-IN-7
CAS:FAK-IN-7 has potential antiproliferative activity and is a FAK inhibitor.Formula:C16H13N3OSPurity:98.2%Color and Shape:SolidMolecular weight:295.36AJH-836
CAS:AJH-836 is a compound that activates Munc13-1 and PKC ε/α, demonstrating a dissociation constant (Kd) of 4.5 nM for PKCα, and facilitates the translocation ofFormula:C22H38O5Purity:98%Color and Shape:SolidMolecular weight:382.5310-Deacetyltaxol
CAS:10-Deacetyltaxol (10-DAT) is extracted from Taxus brevifolia barks.Formula:C45H49NO13Purity:94.63% - 99.93%Color and Shape:SolidMolecular weight:811.87Tadocizumab
CAS:Tadocizumab (C4G1) is a humanized monoclonal antibody targeting integrin αIIbβ3 with antiplatelet and antithrombotic effects.Color and Shape:LiquidKNK437
CAS:KNK437 (Heat Shock Protein Inhibitor I), a pan-HSP inhibitor, suppresses the synthesis of inducible HSPs(HSP105, HSP72, and HSP40).Formula:C13H11NO4Purity:98.90%Color and Shape:SolidMolecular weight:245.23PKC-IN-1
CAS:PKC-IN-1 is an ATP-competitive and reversible conventional PKC enzymes inhibitor (PKCα, PKCβI, PKCβII, PKCθ, PKCγ, PKC mu and PKCε with IC50s of 2.3, 8.1, 7.6,Formula:C25H37FN8O2Purity:98% - 98.79%Color and Shape:SolidMolecular weight:500.61Gamitrinib TPP
CAS:Gamitrinib TPP targets mitochondrial HSP90, inhibiting cancer, and blocks mitochondrial matrix.Formula:C52H65N3O8PPurity:98%Color and Shape:SolidMolecular weight:891.078API-1
CAS:API-1 (NSC-177223) is a potent inhibitor of Akt. It induces GSK3-dependent, β-TrCP- and FBXW7-mediated Mcl-1 degradation, resulting in induction of apoptosis .Formula:C13H15N5O6Purity:99.07%Color and Shape:SolidMolecular weight:337.29Ref: TM-T8969
1mg59.00€5mg125.00€10mg207.00€25mg376.00€50mg562.00€100mg787.00€200mg1,035.00€1mL*10mM (DMSO)133.00€AKT-IN-1
CAS:AKT-IN-1 (AZD-26) is an allosteric AKT inhibitor (IC50: 1.04 μM).Formula:C22H21N3OPurity:98.63%Color and Shape:SolidMolecular weight:343.42Ref: TM-T4489
1mg113.00€2mg158.00€5mg235.00€10mg400.00€25mg652.00€50mg909.00€100mg1,225.00€1mL*10mM (DMSO)188.00€HSP70/SIRT2-IN-2
CAS:HSP70/SIRT2-IN-2 (Compounds 1a), a dual inhibitor of SIRT2 and HSP70, exhibits an IC50 of 45.1±5.0 μM against SIRT2 and demonstrates antitumor activity [1].Formula:C17H13N3S3Purity:98%Color and Shape:SolidMolecular weight:355.5LXH254
CAS:LXH254 is a B/C RAF inhibitor with IC50 values of 0.2 nM and 0.07 nM for inhibiting BRAF and CRAF.Cost-effective and quality-assured.Formula:C25H25F3N4O4Purity:98.3% - 99.92%Color and Shape:SolidMolecular weight:502.49Ref: TM-T11898
1mg52.00€5mg122.00€10mg185.00€25mg363.00€50mg567.00€100mg690.00€200mg948.00€500mg1,444.00€1mL*10mM (DMSO)135.00€Debio 0932
CAS:Debio 0932 (CUDC-305) is a Hsp9 inhibitor, apoptosis, and has the advantage of being orally available and cross the BBB for cancers NSCLC and neuroblastoma.Formula:C22H30N6O2SPurity:98.98%Color and Shape:SolidMolecular weight:442.58AT9283
CAS:AT9283 (J-504568) is an effective multi-targeted inhibitor of JAK2(IC50=1.2 nM) and JAK3(IC50=1.1 nM), Aurora A, Aurora B and Abl(T315I).Formula:C19H23N7O2Purity:99.83% - 99.98%Color and Shape:SolidMolecular weight:381.43Ref: TM-T3068
1mg47.00€2mg60.00€5mg95.00€10mg170.00€25mg299.00€50mg499.00€100mg723.00€1mL*10mM (DMSO)97.00€Bisindolylmaleimide III
CAS:Bisindolylmaleimide III is a potent and selective inhibitor of protein kinase C (PKC).Bisindolylmaleimide III selectively interacts with PKCα or ribosomal S6Formula:C23H20N4O2Purity:98.6%Color and Shape:SolidMolecular weight:384.43Pifithrin-μ
CAS:Pifithrin-μ (NSC-303580) is an inhibitor of p53 and HSP70, with neuroprotective and antitumor activity.Formula:C8H7NO2SPurity:99.33% - 99.79%Color and Shape:SolidMolecular weight:181.21KP-23172
CAS:KP-23172 is a inhibitor of PI3-K/Akt pathway.Formula:C10H4N6OPurity:98%Color and Shape:SolidMolecular weight:224.18ML346
CAS:ML346 is a novel activator of Hsp70.Formula:C14H12N2O4Purity:99.25% - 99.29%Color and Shape:SolidMolecular weight:272.26Ref: TM-T3594
1mg40.00€2mg52.00€5mg85.00€10mg115.00€25mg172.00€50mg274.00€100mg427.00€500mg938.00€1mL*10mM (DMSO)85.00€Degrasyn
CAS:Degrasyn (WP1130) inhibits DUBs (USP5, UCH-L1, USP9x, USP14, UCH37) and Bcr/Abl without affecting the 20S proteasome.Formula:C19H18BrN3OPurity:98.32% - 99.98%Color and Shape:SolidMolecular weight:384.27Ref: TM-T6300
2mg44.00€5mg64.00€10mg97.00€25mg198.00€50mg340.00€100mg532.00€200mg747.00€1mL*10mM (DMSO)69.00€Phorbol 12,13-dibutyrate
CAS:Phorbol 12,13-dibutyrate (Phorbol dibutyrate) is a PKC activator that induces contraction of isolated rabbit vascular smooth muscle.Formula:C28H40O8Purity:100% - 99.32%Color and Shape:SolidMolecular weight:504.61Ref: TM-T16526
1mg62.00€5mg169.00€10mg283.00€25mg557.00€50mg795.00€100mg1,074.00€1mL*10mM (DMSO)180.00€Akt3 degrader 1
CAS:Akt3 degrader 1 counters Osimertinib resistance in NSCLC, inhibits cell growth, and reduces mouse tumors.Formula:C53H72N8O4Purity:98.18% - 99.14%Color and Shape:SolidMolecular weight:885.19VTX-27
CAS:VTX-27 is a selective inhibitor of protein kinase C θ (PKC θ) (Kis: 0.08 nM and 16 nM for PKC θ and PKC δ).Formula:C20H24ClFN6OPurity:99.49%Color and Shape:SolidMolecular weight:418.9Ref: TM-T13314
1mg93.00€2mg125.00€5mg244.00€10mg364.00€25mg562.00€50mg780.00€100mg1,035.00€1mL*10mM (DMSO)225.00€Ruboxistaurin hydrochloride
CAS:Ruboxistaurin HCl (LY 333531) selectively inhibits PKCβI/II with IC50 of 4.7/5.9 nM; much less effective on other PKC types and ATP-kinases.Formula:C28H28N4O3·HClPurity:98.44% - 99.22%Color and Shape:SolidMolecular weight:505.01Ref: TM-T3689
1mg71.00€2mg93.00€5mg157.00€10mg256.00€25mg513.00€50mg740.00€100mg1,035.00€500mg2,072.00€1mL*10mM (DMSO)202.00€Imatinib
CAS:Imatinib (STI571) is a multi-targeted receptor tyrosine kinase inhibitor that selectively inhibits the kinase activities of BCR/ABL, v-Abl, PDGFR, and c-kitFormula:C29H31N7OPurity:100% - 99.94%Color and Shape:Off White PowderMolecular weight:493.6Tetradecyltrimethylammonium bromide
CAS:Tetradecyltrimethylammonium bromide (MitMAB) is a Dynamin GTPase activity inhibitor and a cationic surfactant with asymmetrical structure.Formula:C17H38BrNPurity:100%Color and Shape:SolidMolecular weight:336.39K-252b
CAS:K-252b, an indolocarbazole derived from the actinomycete Nocardiopsis, functions as a protein kinase C (PKC) inhibitor.Formula:C26H19N3O5Purity:98%Color and Shape:Ready-To-Use SolutionMolecular weight:453.45Larazotide acetate
CAS:Larazotide acetate is a synthetic peptide. It functions as a tight junction regulator and reverses leaky junctions to their normally closed state.Formula:C34H59N9O12Purity:95.53%Color and Shape:SolidMolecular weight:785.89
