Cytoskeletal Signaling
Cytoskeletal signaling inhibitors are compounds that disrupt the signaling pathways regulating the cytoskeleton, which is crucial for cell shape, motility, division, and intracellular transport. These inhibitors are used to study the dynamics of cytoskeletal proteins, such as actin and tubulin, and their role in processes like cell migration, adhesion, and cancer metastasis. Cytoskeletal signaling inhibitors are valuable in research on cell biology, cancer, and neurobiology. At CymitQuimica, we offer a comprehensive range of high-quality cytoskeletal signaling inhibitors to support your research in these areas.
Products of "Cytoskeletal Signaling"
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Tubulin inhibitor 6
CAS:Tubulin inhibitor 6 (iHAP1) is an inhibitor of tubulin and a potent inhibitor of multiple cancer cell lines.Formula:C20H14ClNO2SPurity:99.05%Color and Shape:SolidMolecular weight:367.85Ref: TM-T13224
5mg50.00€10mg80.00€25mg117.00€50mg170.00€100mg259.00€200mg369.00€1mL*10mM (DMSO)51.00€PKC-θ inhibitor 1
CAS:PKC-theta inhibitor 1 is an inhibitor of PKCθ (Ki of 6 nM)Formula:C17H15F3N4OPurity:98%Color and Shape:SolidMolecular weight:348.32FGFRs-IN-1
FGFRs-IN-1 (Compound A16) is an orally active inhibitor targeting FGFR1/2/3/4, with IC50 values of 2.3, 7, 11, and 163 nM respectively. It also inhibits VEGFR1/2/3, Abl, and Flt3, with IC50 values of 61, 176, 112, 26, and 353 nM. The compound shows weak inhibition of CYP enzymes. FGFRs-IN-1 reduces the expression of α-SMA and collagen I, and it inhibits epithelial-mesenchymal transition (EMT) in A549 cells stimulated by TGF-β1. Additionally, FGFRs-IN-1 demonstrates anti-inflammatory activity in mouse models of lung fibrosis induced by Bleomycin and liver fibrosis induced by CCl4.Formula:C28H26Cl2N4O3Color and Shape:SolidMolecular weight:537.44HSP90-IN-27
CAS:HSP90-IN-27, also known as compound 19, is an inhibitor of HSP90 [1].Formula:C18H21N3O2SPurity:98%Color and Shape:SolidMolecular weight:343.44PF-431396
CAS:PF-431396 is a dual PYK2/FAK inhibitor (IC50: 11/2 nM).Formula:C22H21F3N6O3SPurity:98.83% - 99.82%Color and Shape:SolidMolecular weight:506.5Dynole 34-2
CAS:Dynole 34-2 is a non-competitive inhibitor of dynamin1 and dynamin2 GTPases that inhibits receptor-mediated endocytosis and synaptic vesicle endocytosis.Formula:C25H36N4OPurity:99.61%Color and Shape:SolidMolecular weight:408.58Tonabersat
CAS:Tonabersat (SB-220453) is a novel and orally available gap-junction modulator and CSD (Cortical spreading depression) inhibitor that,migraine and epilepsy.Formula:C20H19ClFNO4Purity:99.49%Color and Shape:SolidMolecular weight:391.82Uprosertib
CAS:Uprosertib (GSK2141795) is a potent, selective Akt broad-spectrum inhibitor for Akt1/Akt2/Akt3.Cost-effective and quality-assured.Formula:C18H16Cl2F2N4O2Purity:95.62% - 99.54%Color and Shape:SolidMolecular weight:429.25Ref: TM-T6849
1mg47.00€2mg59.00€5mg85.00€10mg124.00€25mg202.00€50mg324.00€100mg535.00€200mg752.00€1mL*10mM (DMSO)108.00€Xentuzumab
CAS:Xentuzumab (BI836845) is a recombinant monoclonal antibody to humanised IGF ligand that inhibits AKT activation and can be used to study solid tumours.Purity:95% - > 95%Color and Shape:LiquidMolecular weight:143.7 kDaEV206
CAS:EV206 is an effective inhibitor of Hsp70, exhibiting antiproliferative properties. This compound induces cell apoptosis (apoptosis) and enhances the protein expression of cleaved PARP and caspase-3. Additionally, EV206 demonstrates antitumor activity.Formula:C21H19N3OColor and Shape:SolidMolecular weight:329.40ILK-IN-3
CAS:ILK-IN-3 is an inhibitor of integrin linked kinase, and with antitumor activity.Formula:C10H12N6OPurity:99.69%Color and Shape:SolidMolecular weight:232.24(±)-1,2-Diolein
CAS:(±)-1,2-Diolein (1,2-Dioleoyl-rac-glycerol) (1,2-Dioleoyl-rac-glycerol) is a PKC activator. (±)-1,2-Diolein could increases myotubes Ca 2+ influx.Formula:C39H72O5Color and Shape:SolidMolecular weight:620.99Alvespimycin
CAS:Alvespimycin (17-DMAG) is a potent Hsp90 inhibitor with potential anticancer activity, which acts by binding to Hsp90.Formula:C32H48N4O8Purity:100%Color and Shape:SolidMolecular weight:616.75IIQLPEIVVV TFA
IIQLPEIVVV TFA serves as a specific inhibitor targeting the Drp1-Mff interaction. This compound discriminates between physiological and pathological fission, hindering physiological fission which leads to mitochondrial dysfunction. IIQLPEIVVV TFA is also utilized in research related to Huntington's disease.Formula:C54H95N11O14·xC2HF3O2Color and Shape:SolidMolecular weight:1122.40 (free base)Tyrosine kinase-IN-9
CAS:Tyrosine kinase-IN-9 (Compound B) is an inhibitor of c-Abl. It is useful for studying neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease.Formula:C20H14ClN3O3Color and Shape:SolidMolecular weight:379.796PF-03814735
CAS:PF-03814735 is a novel, potent and reversible inhibitor of Aurora A/B with IC50of 0.8 nM/5 nM, is less potent to Flt3, FAK, TrkA, and minimally active to Met and FGFR1. Phase 1.Formula:C23H25F3N6O2Purity:98%Color and Shape:SolidMolecular weight:474.48Tirofiban
CAS:Tirofiban (L700462) (MK-383) is a selective palate GPIIb/IIIa antagonist which inhibits platelet aggregation with IC50 of 9 nM.Formula:C22H36N2O5SPurity:99.87%Color and Shape:SolidMolecular weight:440.63-Hydroxyxanthone
CAS:3-Hydroxyxanthone (3-Hydroxy-xanthen-9-one), a xanthone derivative, exhibits inhibitory effects on NADPH-catalyzed lipid peroxidation in human umbilical veinFormula:C13H8O3Purity:98%Color and Shape:SolidMolecular weight:212.2NPX800
CAS:NPX800 is an inhibitor of heat shock factor 1 (HSF1) and can be used in studies about the treatment of cancer.Formula:C32H32FN5O4Purity:99.26%Color and Shape:SolidMolecular weight:569.63Ref: TM-T9804
1mg96.00€5mg240.00€10mg375.00€25mg627.00€50mg893.00€100mg1,216.00€1mL*10mM (DMSO)300.00€AKT-IN-6
CAS:AKT-IN-6 (INCB-047775) inhibits Akt, a key signaling protein linked to type 2 diabetes and cancer.Formula:C22H20FN5OPurity:98.83%Color and Shape:SolidMolecular weight:389.43Ref: TM-T36310
1mg35.00€5mg74.00€10mg111.00€25mg216.00€50mg354.00€100mg567.00€200mg805.00€1mL*10mM (DMSO)84.00€Radicicol
CAS:Radicicol is an antifungal antibiotic, a inhibitor of Hsp90 & FTO, Anti-malarial , inhibits iNOS gene expression by blocking the p38 kinase and NF-κB/Rel.Formula:C18H17ClO6Purity:98%Color and Shape:White/Yellow PowderMolecular weight:364.78Phorbol 12-myristate 13-acetate
CAS:Phorbol 12-myristate 13-acetate (PMA) belongs to the phorbol ester group of natural products and is an activator of PKC, SphK, and NF-κB.Formula:C36H56O8Purity:100% - 99.5%Color and Shape:White To Off-White SolidMolecular weight:616.83Eg5 Inhibitor V, trans-24
CAS:Eg5 Inhibitor V, trans-24 is a specific and potent Eg5 inhibitor that can be used in cancer research with an IC50 value of 0.65 uM.Formula:C26H21N3O3Purity:97.45%Color and Shape:SolidMolecular weight:423.46Ref: TM-T11155
1mg92.00€5mg205.00€10mg305.00€25mg495.00€50mg677.00€100mg905.00€200mg1,216.00€1mL*10mM (DMSO)227.00€A-286982
CAS:A 286982 blocks the LFA-1 and ICAM-1 integrin-ligand interaction.Formula:C24H27N3O4SPurity:97.81%Color and Shape:SolidMolecular weight:453.55Ref: TM-T21781
1mg35.00€2mg50.00€5mg74.00€10mg107.00€25mg210.00€50mg350.00€100mg522.00€1mL*10mM (DMSO)81.00€BX517
CAS:BX517 (PDK1 inhibitor 2) is a potent and selective inhibitor of PDK1.Formula:C15H14N4O2Purity:99.07%Color and Shape:SolidMolecular weight:282.3DTHIB
CAS:DTHIB robustly inhibits the HSF1 cancer gene signature and prostate cancer cell proliferation.Formula:C13H9ClFN3O3Purity:98.86% - 99.29%Color and Shape:SolidMolecular weight:309.68Ref: TM-T8858
1mg35.00€5mg70.00€10mg104.00€25mg210.00€50mg338.00€100mg540.00€500mg1,130.00€1mL*10mM (DMSO)78.00€AN-019
CAS:AN-019 (NRC-019) is a Bcr-Abl kinase inhibitor with antitumor activity for the study of chronic myelogenous leukemia (CML) and breast cancer.Formula:C25H17F6N5OPurity:98.01%Color and Shape:SolidMolecular weight:517.43ZIP acetate(863987-12-6 free base)
ZIP acetate inhibits PKMζ (protein kinase Mζ), affecting LTP maintenance and spatial memory, with an IC50 of 1-2.5 μM.Formula:C92H158N30O19Purity:94.68%Color and Shape:SolidMolecular weight:1988.43Tilavonemab
CAS:Tilavonemab (ABBV-8E12), a humanized anti-tau antibody, halts tau uptake in neurons and may help with Alzheimer's research.Purity:95% - 95%Color and Shape:LiquidSuprafenacine
CAS:Suprafenacine (N'-[(E)-(4-methylphenyl)methylidene]-4,5,6,7-tetrahydro-1H-indazole-3-carbohydrazide) is a cell-permeable microtubule destabilizer that inducesFormula:C16H18N4OPurity:99.72%Color and Shape:SolidMolecular weight:282.34GRGDSP acetate(91037-75-1 free base)
GRGDSP acetate(91037-75-1 free base) is a synthetic linear RGD peptide and is an integrin inhibitor.Formula:C24H41N9O12Purity:99.77%Color and Shape:SolidMolecular weight:647.64Auristatin E
CAS:Auristatin E, MMAE analog, blocks tubulin polymerisation, has cytotoxic and potent antitumor effects, used in ADCs.Formula:C40H69N5O7Purity:98.81%Color and Shape:SolidMolecular weight:732.01SB-216
CAS:SB-216, a potent anti-cancer compound, inhibits tubulin polymerization and curbs growth in various cancer cells.Formula:C17H18N4O2Purity:100%Color and Shape:SolidMolecular weight:310.35Ref: TM-T60757
1mg54.00€5mg116.00€10mg188.00€25mg331.00€50mg475.00€100mg655.00€1mL*10mM (DMSO)133.00€Dynamin inhibitory peptide, myristoylated acetate
Myristoylated acetate peptide inhibits DynaMin, blocking amphiphysin binding; myristoylated TFA variant hinders endocytosis.Formula:C63H111N19O16Purity:99.42%Color and Shape:SolidMolecular weight:1390.67SC-10
CAS:SC-10 is a direct activator of PKC with potential antiproliferative activity, useful in leukemia research.Formula:C17H22ClNO2SPurity:99.24% - 99.58%Color and Shape:SolidMolecular weight:339.88GRP78-IN-3
CAS:GRP78-IN-3: Potent Hsp70 blocker, selective Grp78 (HSPA5) inhib., IC50 0.59 μM, 7x more vs HspA9, 20x vs HspA2.Formula:C17H18N4O2SPurity:99.11%Color and Shape:SoildMolecular weight:342.42ALK inhibitor 1
CAS:ALK inhibitor 1 is a selective ALK kinase inhibitor.Formula:C23H28BrN7O3SPurity:98.27%Color and Shape:SolidMolecular weight:562.48Ref: TM-T10285
1mg52.00€5mg116.00€10mg170.00€25mg340.00€50mg472.00€100mg645.00€1mL*10mM (DMSO)143.00€KIF18A-IN-3
CAS:KIF18A-IN-3 is a KIF18A inhibitor (IC50=61 nM) that causes significant mitotic arrest and increases the number of mitotic cells in tumor tissues.Formula:C28H38N4O5S2Purity:98.45%Color and Shape:SolidMolecular weight:574.76Combretastatin A-1
CAS:Combretastatin A-1 is a microtubule inhibitor with anti-tumour and can be used to study liver cancer.Formula:C18H20O6Purity:97.49% - 97.49%Color and Shape:SolidMolecular weight:332.35Lifitegrast
CAS:Lifitegrast (SAR 1118) is a lymphocyte, function-associated antigen-1 antagonist.Formula:C29H24Cl2N2O7SPurity:99.39% - 99.66%Color and Shape:SolidMolecular weight:615.48CGP 53353
CAS:CGP 53353 (DAPH-7) is a PKC inhibitor with inhibitory effects on PKCβII and PKCβI and can be used to study atherosclerosis.Formula:C20H13F2N3O2Purity:98.11%Color and Shape:SolidMolecular weight:365.33PKC-θ inhibitor
CAS:PKC-theta inhibitor is PKC-θinhibitor, with an IC50 of 12 nM.Formula:C20H25F3N6O3Purity:98%Color and Shape:SolidMolecular weight:454.45Ref: TM-T5423
1mg106.00€5mg250.00€10mg329.00€25mg467.00€50mg612.00€100mg944.00€200mg1,264.00€1mL*10mM (DMSO)274.00€Borussertib
CAS:Borussertib is a covalent-allosteric and first-in-class inhibitor of protein kinase Akt(IC50 of 0.8 nM and a Ki of 2.2 nM for Aktwt)Formula:C36H32N6O3Purity:99.00%Color and Shape:SolidMolecular weight:596.68Ref: TM-T8427
1mg133.00€5mg274.00€10mg432.00€25mg715.00€50mg1,008.00€100mg1,359.00€1mL*10mM (DMSO)360.00€FAK-IN-11
FAK-IN-11 (Compound 4l), a FAK inhibitor, specifically targets the ATP binding pocket of FAK to prevent its phosphorylation.Formula:C25H41NO3Purity:98%Color and Shape:SolidMolecular weight:403.6Tirbanibulin Mesylate
CAS:Tirbanibulin Mesylate (KX01 Mesylate) is an inhibitor of Src that targets the peptide substrate site of Src (GI50: 9-60 nM in cancer cell lines).Formula:C27H33N3O6SPurity:99.42%Color and Shape:SolidMolecular weight:527.63Ref: TM-T15675
2mg38.00€5mg56.00€10mg70.00€25mg126.00€50mg243.00€100mg416.00€200mg562.00€1mL*10mM (DMSO)65.00€IPI-493
CAS:IPI-493 is a bioactive chemical.Formula:C28H39N3O8Purity:100%Color and Shape:SolidMolecular weight:545.62WAY-118959-A
CAS:WAY-118959-A is a potential microtubule acetylation inhibitor.Formula:C16H14N4OS2Purity:99.86%Color and Shape:SolidMolecular weight:342.44Ref: TM-T60065
1mg115.00€5mg255.00€10mg375.00€25mg562.00€50mg787.00€100mg1,074.00€200mg1,454.00€1mL*10mM (DMSO)261.00€Sangivamycin
CAS:Sangivamycin (NSC-65346) inhibits PKC (Ki=10μM) and hinders growth in various human cancers.Formula:C12H15N5O5Purity:98.11%Color and Shape:SolidMolecular weight:309.28Ref: TM-T9605
1mg126.00€5mg274.00€10mg416.00€25mg677.00€50mg944.00€100mg1,264.00€1mL*10mM (DMSO)360.00€AKT-IN-2
CAS:AKT-IN-2 is a selective, and orally bioavailable AKT inhibitor (IC50: 5 nM for AKT1).Formula:C25H34F3N7OPurity:98%Color and Shape:SolidMolecular weight:505.583CAI
CAS:3CAI inhibits AKT1/2, reduces mTOR/GSK3β, and triggers apoptosis in colon cancer cells.Formula:C10H8ClNOPurity:98.13%Color and Shape:SolidMolecular weight:193.63Ref: TM-T14034
5mg55.00€10mg77.00€25mg125.00€50mg220.00€100mg330.00€200mg485.00€500mg787.00€1mL*10mM (DMSO)64.00€
