Cytoskeletal Signaling
Cytoskeletal signaling inhibitors are compounds that disrupt the signaling pathways regulating the cytoskeleton, which is crucial for cell shape, motility, division, and intracellular transport. These inhibitors are used to study the dynamics of cytoskeletal proteins, such as actin and tubulin, and their role in processes like cell migration, adhesion, and cancer metastasis. Cytoskeletal signaling inhibitors are valuable in research on cell biology, cancer, and neurobiology. At CymitQuimica, we offer a comprehensive range of high-quality cytoskeletal signaling inhibitors to support your research in these areas.
Products of "Cytoskeletal Signaling"
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Plinabulin
CAS:Plinabulin (NPI-2358) (NPI-2358) is a vascular disrupting agent (VDA) against tubulin-depolymerizing tumor cells ( IC50: 9.8-18 nM).Formula:C19H20N4O2Purity:100% - 98.69%Color and Shape:SolidMolecular weight:336.39Staurosporine
CAS:Staurosporine (AM-2282) is a protein kinase inhibitor with ATP-competitive and non-selective inhibitory activity (IC50=6/15/2/3/3000 nM) against PKC, PKA, c-FgrFormula:C28H26N4O3Purity:99.24% - 99.98%Color and Shape:Off-White PowderMolecular weight:466.53Ref: TM-T6680
1mg62.00€2mg87.00€5mg97.00€10mg145.00€25mg246.00€50mg401.00€100mg597.00€500mg1,283.00€1mL*10mM (DMSO)109.00€Carbenoxolone disodium
CAS:Carbenoxolone disodium treats stomach ulcers; derived from licorice, often has antidiuretic effects, low toxicity.Formula:C34H48Na2O7Purity:98.01%Color and Shape:SolidMolecular weight:614.72Tubulin inhibitor 1
CAS:Tubulin inhibitor 1 blocks tubulin polymerization, with strong anti-tumor effects, induces apoptosis and G2/M mitotic arrest.Formula:C21H24N2O4Purity:98%Color and Shape:SolidMolecular weight:368.43Eribulin
CAS:Eribulin binds microtubules, halts cancer cell growth, treating metastatic breast cancer.Formula:C40H59NO11Purity:99.96%Color and Shape:SolidMolecular weight:729.90Hypocrellin A
CAS:Hypocrellin A is a natural PKC inhibitor with light-induced antitumor, antifungal and antiviral activities.Cost-effective and quality-assured.Formula:C30H26O10Purity:98% - 99.81%Color and Shape:SolidMolecular weight:546.52Conteltinib
CAS:Conteltinib (CT-707) is an enzyme inhibitor with antitumor activity targeting FAK, ALK and Pyk2. It can be used to study lymphoma.Formula:C32H45N9O3SPurity:98.12% - 99.54%Color and Shape:SolidMolecular weight:635.82Ref: TM-T14997
1mg77.00€5mg167.00€10mg240.00€25mg409.00€50mg572.00€100mg800.00€1mL*10mM (DMSO)227.00€Hsp110-STAT3 interaction-IN-2
Hsp110-STAT3 interaction-IN-2 (compound 10b) is an inhibitor of the Hsp110-STAT3 interaction. It is utilized in research related to pulmonary arterial hypertension (PAH).Formula:C24H18F3N5O3Color and Shape:SolidMolecular weight:481.43AKT-IN-25
CAS:AKT-IN-25 (Compound 14a) is an inhibitor of Akt that prevents the phosphorylation of Akt, thereby hindering the PI3K/Akt/mTOR signaling pathway. It arrests the cell cycle at the G1 phase, inhibits the migration of PANC-1 cells, and suppresses the proliferation of cancer cells PANC-1, PATU-T, and SUIT-2, with IC50 values of 3.05, 1.32, and 3.85 μM, respectively.Formula:C14H16N4OColor and Shape:SolidMolecular weight:256.3Tasidotin hydrochloride
CAS:Tasidotin hydrochloride, a dolastatin 15 analog, inhibits microtubule assembly and dynamics.Formula:C32H59ClN6O5Purity:98%Color and Shape:SolidMolecular weight:643.30CLT-28643
CAS:CLT-28643 is a specific α5β1-Integrin inhibitor that prevents fibrosis in GFS, inhibits tumor growth and angiogenesis, suppresses fibrosis and inflammation.Formula:C19H17N3O4Purity:99.98%Color and Shape:SolidMolecular weight:351.36Dasatinib
CAS:Dasatinib (BMS-354825) is a tyrosine kinase inhibitor that inhibits Src and Bcr-Abl (Ki=16/30 pM) and is orally active and ATP-competitive.Formula:C22H26ClN7O2SPurity:99.59% - 99.86%Color and Shape:Pale-Yellow SolidMolecular weight:488.01DM1-SMe
CAS:DM1-SMe (DM1-SSMe) potently inhibits microtubules, 3-10x stronger than Maytansine with IC50s of 0.003-0.01 nM in human cancer cells.Formula:C36H50ClN3O10S2Purity:97.19%Color and Shape:SolidMolecular weight:784.38JB062
CAS:JB062 is a chemical compound acting as a nonmuscle myosin inhibitor, exhibiting IC50 values of 1.6, 5.4, and >100 μM against skeletal muscle myosin, cardiacFormula:C19H17NO4Purity:99.49%Color and Shape:SolidMolecular weight:323.34Ref: TM-T67952
1mg185.00€5mg465.00€10mg680.00€25mg1,035.00€50mg1,406.00€100mg1,882.00€500mg3,771.00€1mL*10mM (DMSO)457.00€Gap19
CAS:Gap19 is a peptide that corresponds to a sequence on the cytoplasmic loop (CL) of Cx43.Formula:C55H96N14O13Purity:97.67%Color and Shape:SolidMolecular weight:1161.44Verubulin hydrochloride
CAS:Verubulin hydrochloride (MPC-6827 hydrochloride) is an agent of blood brain barrier permeable microtubule-disrupting, with potent and broad-spectrum cytotoxicFormula:C17H18ClN3OPurity:98.29% - 99.77%Color and Shape:SolidMolecular weight:315.8Ref: TM-T13298
5mg50.00€10mg78.00€25mg145.00€50mg210.00€100mg300.00€200mg434.00€1mL*10mM (DMSO)56.00€SAMβA TFA
SAMβA TFA, a selective antagonist of Mfn1-βIIPKC association conjugated to the cell permeable peptide TAT47-57, is a rationally designed inhibitor that improvesFormula:C50H73N17O16·xC2HF3O2Purity:98%Color and Shape:SolidMolecular weight:1168.22 (free acid)Calyxin H
CAS:Calyxin H at 1uM can increase the expression of heat shock factor 1 (HSF1), it has a possible application as a heat shock protein (HSP) inducer.Formula:C35H34O7Purity:98%Color and Shape:SolidMolecular weight:566.64K-252c
CAS:K-252c is a staurosporine analog isolated from Nocardiopsis sp.Formula:C20H13N3OPurity:98%Color and Shape:SolidMolecular weight:311.34Drp1 peptide inhibitor P110
CAS:Compound P110 (Drp1 peptide inhibitor P110) is a selective Drp1 peptide inhibitor with neuroprotective effects. It inhibits the activation of Drp1, prevents Drp1 mitochondrial translocation induced by MPTP, and alleviates dopamine neuron loss, dopaminergic terminal damage, and behavioral deficits caused by MPTP. This compound is useful for Alzheimer's disease research. Additionally, Compound P110 reduces mitochondrial and organ damage in animal models of Huntington's disease, cerebral ischemia, and myocardial infarction.Formula:C100H179N45O25Color and Shape:SolidMolecular weight:2411.78Albendazole sulfoxide
CAS:Albendazole sulfoxide (Ricobendazole) is a metabolite of Albendazole, an anthelmintic.Formula:C12H15N3O3SPurity:98.04%Color and Shape:White To Off-White PowderMolecular weight:281.33CCT251455
CAS:CCT251455, the mitotic kinase monopolar spindle 1 (MPS1/TTK) inhibitor, is a potent (IC50=3 nM) and specific chemical tool.Formula:C26H26ClN7O2Purity:99.1% - 99.1%Color and Shape:SolidMolecular weight:503.98NSC668394
CAS:NSC668394 is an ezrin phosphorylation inhibitor.NSC668394 has antitumor activity and increases ezrin cleavage.NSC668394 can be used to study tumor metastasis.Formula:C17H12Br2N2O3Purity:99.29% - 99.29%Color and Shape:SolidMolecular weight:452.1SNX0723
CAS:SNX0723 is a potent Hsp90 Inhibitor with anti-Plasmodium activity.Formula:C22H26FN3O3Purity:99.86%Color and Shape:SolidMolecular weight:399.46Ref: TM-T28824
1mg89.00€5mg188.00€10mg316.00€25mg512.00€50mg702.00€100mg940.00€500mgTo inquire1mL*10mM (DMSO)207.00€Vedolizumab
CAS:Vedolizumab is a humanized monoclonal antibody that targets the α4β7 integrin for the treatment of Crohn's disease and ulcerative colitis.Purity:SDS-PAGE:98.4%;SEC-HPLC:99.1%Color and Shape:LiquidMolecular weight:146.80 kDa7-Aminocephalosporanic acid
CAS:7-Aminocephalosporanic acid (7-ACA) is used for synthesis of cephalosporin antibiotics and intermediates.Formula:C10H12N2O5SPurity:91.05% - 98.22%Color and Shape:White Solid PowderMolecular weight:272.282-Chlorophenoxazine
CAS:2-Chlorophenoxazine is an Akt inhibitor that demonstrates an in vitro inhibitory concentration (IC50) of 2-5 μM and has the capacity to induce apoptosis.Formula:C12H8ClNOPurity:98%Color and Shape:SolidMolecular weight:217.65PD173955
CAS:PD173955 is src family-selective tyrosine kinase inhibitor with IC50 of ~22 nM for Src, Yes and Abl kinase; less potent for FGFRα and no activity on InsR andFormula:C21H16Cl2N4OSPurity:98.52% - 99.28%Color and Shape:SolidMolecular weight:443.35Olverembatinib
CAS:Olverembatinib (GZD 824) is an orally bioavailable Bcr-Abl inhibitor for Bcr-Abl(WT, IC50: 0.34 nM) and Bcr-Abl(T315I, IC50: 0.68 nM).Formula:C29H27F3N6OPurity:100% - 99.29%Color and Shape:SolidMolecular weight:532.56Ref: TM-T3071
1mg35.00€2mg48.00€5mg70.00€10mg96.00€25mg210.00€50mg338.00€100mg535.00€1mL*10mM (DMSO)82.00€Thiocolchicine
CAS:Thiocolchicine inhibits tubulin polymerization (IC50: 2.5 µM, Ki: 0.7 µM), induces apoptosis, and serves as an ADC cytotoxin.Formula:C22H25NO5SPurity:98.19%Color and Shape:SolidMolecular weight:415.5Kanosamine hydrochloride
CAS:Kanosamine hydrochloride is an antibiotic which inhibits the growth of plant-pathogenic oomycetes, certain fungi and a few bacterial species.Formula:C6H14ClNO5Purity:98%Color and Shape:SolidMolecular weight:215.63Imatinib Mesylate
CAS:Imatinib Mesylate (STI-571) is a tyrosine kinase receptor inhibitor with antineoplastic activity (IC50s: 0.6 μM, 0.1 μM and 0.1 μM for v-Abl, c-Kit and PDGFR,Formula:C29H31N7O·CH4SO3Purity:100% - 99.97%Color and Shape:White Crystalline PowderMolecular weight:589.71KG-548
CAS:KG-548 is a dual inhibitor of ARNT/TACC3 and HIF-1α, inhibiting lactate production, and can be used in cancer research.Formula:C9H4F6N4Purity:99.62%Color and Shape:SolidMolecular weight:282.15Y15
CAS:Y15 (1,2,4,5-Benzenetetramine tetrahydrochlor) is a potent and specificsmall-molecule FAK scaffolding inhibitor that inhibits its autophosphorylation activity,Formula:C6H14Cl4N4Purity:98% - 98%Color and Shape:Dark Brown CrystalsMolecular weight:284.01Ref: TM-T7119
10mg50.00€25mg69.00€50mg82.00€100mg137.00€200mg188.00€500mg331.00€1mL*10mM (DMSO)48.00€Tubulin polymerization-IN-55
CAS:Tubulin polymerisation-IN-55 is a Tubulin Polymerization inhibitor that displays antiproliferative effects on A549, K562, HepG2, MDA-MB-231 and HFL-1.Formula:C22H24N2O4Purity:98.68%Color and Shape:SoildMolecular weight:380.44T807
CAS:T807 (AV-1451) is a novel tracer of tau positron emission tomography (PET).Formula:C16H10FN3Purity:99.72%Color and Shape:SolidMolecular weight:263.27Ref: TM-T19573
2mg47.00€5mg70.00€10mg107.00€25mg187.00€50mg323.00€100mg550.00€200mg758.00€500mg1,159.00€BCR-ABL-IN-1
CAS:BCR-ABL-IN-1 is a BCR-ABL tyrosine kinase inhibitor (pIC50: 6.46) and may be used in the research of chronic myelogenous leukemia.Formula:C23H21F4N5OPurity:98%Color and Shape:SolidMolecular weight:459.44MK-2206 free base
CAS:MK-2206 free base is an allosteric Akt inhibitor that is both potent and selective, administered orally, exhibiting IC50 values of 8, 12, and 65 nM for Akt1,Formula:C25H21N5OPurity:98%Color and Shape:SolidMolecular weight:407.47ARQ 621
CAS:ARQ 621 is an allosteric, and selective Eg5 mitotic motor protein inhibitor. Phase 1.Formula:C28H24Cl2FN5O2Purity:98.38%Color and Shape:SolidMolecular weight:552.43PKC-θ inhibitor hcl
CAS:PKC-theta inhibitor hcl is a selective PKC-θinhibitor(IC50:12 nM).Formula:C20H26ClF3N6O3Purity:98.93%Color and Shape:SolidMolecular weight:490.91Ref: TM-T5817
1mg93.00€2mg120.00€5mg233.00€10mg376.00€25mg628.00€50mg895.00€100mg1,216.00€500mg2,432.00€KT D606
CAS:KT D606 is a PAK kinase family inhibitor with an IC50 of 4 μM. It selectively inhibits the proliferation of cancer cells transformed by oncogenic RAS mutants, making it useful for studying RAS/PAK1-induced cancers.Formula:C59H50N6O10Color and Shape:SolidMolecular weight:1003.06Cyclo(RGDyK)
CAS:Cyclo(RGDyK) is a potent and selective αVβ3 integrin inhibitor with IC50 of 20 nM.Formula:C27H41N9O8Purity:98%Color and Shape:SolidMolecular weight:619.68Cyclo(-RGDfK) TFA
CAS:Cyclo(-RGDfK) is a selective αvβ3 integrin inhibitor(IC50 : 0.94 nM).Formula:C29H42F3N9O9Purity:98.99% - 99.54%Color and Shape:SolidMolecular weight:717.69HSP90-IN-23
HSP90-IN-23 (Comp 12-1), a heat shock protein 90 (HSP90) inhibitor, exhibits potent activity with an IC50 of 9nM.Formula:C22H24N2O6SPurity:98%Color and Shape:SolidMolecular weight:444.5FAK activator 1
CAS:ZINC40099027 is a FAK activator that induces gastric mucosal repair in persistent aspirin-associated gastric injury.Formula:C23H26F3N3O3Purity:98.85%Color and Shape:SoildMolecular weight:449.47Ref: TM-T77665
1mg99.00€5mg229.00€10mg383.00€25mg627.00€50mg1,005.00€100mg1,589.00€200mg2,078.00€1mL*10mM (DMSO)296.00€DN401
CAS:DN401 is a potent TRAP1 and Hsp90 Inhibitor( IC50 = 79 nM for TRAP1, IC50 = 698 nM for Hsp90) with potent anticancer activity.Formula:C13H9BrClN5O2Purity:100%Color and Shape:SolidMolecular weight:382.6Ref: TM-T27193
1mg185.00€5mg409.00€10mg605.00€25mg938.00€50mg1,293.00€100mg1,738.00€500mg3,496.00€1mL*10mM (DMSO)406.00€TRAP1-IN-2
CAS:TRAP1-IN-2, also known as compound 36, is a selective degrader of the TRAP1 client protein that does not affect Hsp90-cytosolic clients.Formula:C46H42F6N2O5P2Purity:98%Color and Shape:SolidMolecular weight:878.77Ethoxyquin
CAS:Ethoxyquin (Santoflex) is an antioxidant used in animal feeds.Formula:C14H19NOPurity:95.94%Color and Shape:Yellow Liquid Mercaptan-Like Odor (Ntp 1992)Molecular weight:217.31CWHM-12
CAS:CWHM-12 is a potent inhibitor of αV integrins (IC50s of 0.2/0.8/1.5/1.8 nM for αvβ8/αvβ3/αvβ6/αvβ1).Formula:C26H32BrN5O6Purity:98.05% - 98.5%Color and Shape:SolidMolecular weight:590.47Ref: TM-TQ0250
1mg40.00€2mg52.00€5mg88.00€10mg126.00€25mg221.00€50mg369.00€100mg550.00€1mL*10mM (DMSO)96.00€Protein Kinase C 19-31 acetate
PKC 19-31 acetate, a serine-altered PKCa-derived PKC inhibitor, tests PKC activity.Formula:C69H122N26O18Purity:100%Color and Shape:SolidMolecular weight:1603.9
