Miscellaneous Organic Molecules with Isotopical Substitutions

Applications A labelled substituted hippurate analog as substrate and inhibitor of peptidylglycine α-hydroxylating monooxygenase (PHM). References Erion, M., et al.: J. Med. Chem., 37, 4430 (1994), Feng, J., et al.: Biochem. J., 350, 521 (2000), Zhang, L., et al.: Cancer Res., 66, 5696 (2006),

Applications (S)-Pregabalin-13C3, is the labeled analogue of (S)-Pregabalin (P704790), a S-Enantiomer of Pregabalin. A GABA analogue used as an anticonvulsant. Anxiolytic analgesic used to treat peripheral neuropathic pain and fibromyalgia. References Taylor, C.P., at al.: Epilepsy Res., 14, 11 (1993), Field, M.J., et al.: Pain, 80, 391 (1999)

Applications A major active labelled metabolite related to the adverse effects of Sulfasalazine in human serum. References Stenson, W., et al.: J. Clin. Invest., 69, 494 (1982), Bissonnette, E., et al.: J. Immunol., 156, 218 (1996), Hirohata, S., et al.: J. Neurol. Sci., 67, 115 (1985), Pullar, T., et al.: Br. Med. J., 290, 1535 (1985), Ireland, A., et al.: Clin. Sci., 78, 119 (1990),

Applications Isotope labelled Terephthalic acid is a benzenepolycarboxylic acid with potential anti-hemorrhagic properties. References Veronese, E., et al.: Phytomedicine, 12, 123 (2005), Panfoli, I., et al.: Toxins, 2, 417 (2010), Aung, H., et al.: Bioorg. Med. Chem., 19, 2392 (2011),

Applications A labelled metabolite of Raltegravir. References Bosma, P., et al.: J. Biol. Chem., 269, 17960 (1994) , Richman, D., et al.: Nature, 410, 995 (2001), Williams, J., et al.: Drug Metab. Dispos., 32, 1201 (2004), Miners, J., et al.: Biochem. Pharmacol., 71, 1531 (2006),

Applications N-Isopropyl quaternary salt of Atropine. Nonselective muscarinic acetylcholine receptor antagonist; bronchodilator. References Groeben, H., et al.: Anesthesiology, 85, 867 (1996), Haddad, et al.: Br. J. Pharmacol., 127, 413 (1999), Barnes, P. J., et al.: Chest, 117, 63S (2000),

Applications A deuterated analog of Paliperidone, a combined serotonin (5-HT2) and dopamine (D2) receptor antagonist. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Tiberghien, F., et al.: Anticancer Drugs, 7, 568 (1996), Kansy, M., et al.: J. Med. Chem., 41, 1007 (1998), Kerns, E., et al.: J. Pharm. Sci., 90, 1838 (2001), Kerr, K., et al.: J. Biol. Chem., 276, 8657 (2001), Doran, A., et al.: Drug Metab. Dispos., 33, 165 (2005),

Applications Labelled Fludioxonil, nonsystemic phenylpyrrole fungicide structurally related to pyrrolnitrin. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Chang, C.-H., et al.: Biochemistry 30, 5352 (1991),

Applications 2,3,3',4,4',5-Hexachlorobiphenyl-2',6,6'-d3 (CAS# 1219798-44-3) is a useful isotopically labelled compound. It has been used for wearable monitoring devices to detect environment chemical exposure. References O’Connell, S., & Anderson, K.: U.S. Pat. Appl. Publ. (2016), US 20160209298 A1

Stability Very Hygroscopic Applications An arginine derivative; used in chronic kidney diseases.A potential endogenous nitric oxide inhibitor in dialysis. References Ogawa, T., et al.: J. Biol. Chem., 264, 10205 (1989), Boulanger, C., et al.: J. Clin. Invest., 85, 587 (1990), Alipui, C., et al.: J. Pharmacol. Methods, 26, 211 (1991), Azuma, H., et al.: Br. J. Pharmacol., 106, 665 (1992), Vallence, P., et al.: Lancet, 339, 572 (1992), Goto, M., et al.: J. Cardiovasc. Pharmacol., 41, 265 (2003),

Applications Labelled D-Glucose is a simple sugar that is present in plants. A monosaccharide that may exist in open chain or cyclic conformation if in solution. It plays a vital role in photosynthesis and fuels the energy required for cellular respiration. D-Glucose is used in various metabolic processes including enzymic synthesis of cyclohexyl-α and β-D-glucosides. Can also be used as a diagnostic tool in detection of type 2 diabetes mellitus and potentially Huntington's disease through analysis of blood-glucose in type 1 diabetes mellitus. References Wang, R., et al.: J. Mol. Catal. B. Enz., 56, 131 (2009); Springhorn, C. et al.: J. Clin. Endocrinol. Metab., 97, 4640 (2012); Hashimoto, K. et al.: J. Clin. Endocrinol. Metab., 97, 3016 (2012); Avelange, M. et al.: Plant. Phys., 94, 1157 (1990); Cramer, C. et al.: J. Chem. Soc., 115, 5745 (1993);

Applications Labelled Chloroxylenol. Chloroxylenol is an antiseptic and germicide. Chloroxylenol is used for mildew prevention. Chloroxylenol is also an antibacterial. References Heberer, T., et al.: Toxicol. Lett., 131, 5 (2002); Nikolaou, A., et al.: Anal. Bioanal. Chem., 387, 1225 (2007); Focazio, M., et al.: Sci. Total Environ., 402, 201 (2008); Miege, C., et al.: Environ. Pollut., 157, 1721 (2009);