Miscellaneous Organic Molecules with Isotopical Substitutions

Applications Naloxone-d5 3-β-D-Glucuronide is a labelled metabolite of Naloxone ((N285000). Narcotic antagonist. References Scheurer, U., et al.: J. Pharmacol. Exp. Ther., 252, 1324 (1990), Yuan, C., et al.: Clin. Pharmacol. Ther., 59, 469 (1996), Ulens, C., et al.: Biochem. Pharmacol., 62, 1273 (2001), Comert, M., et al.: Eur. J. Pharmacol., 511, 183 (2005),

Applications Bifenazate-d5 is the labelled analogue of Bifenazate (B383021), which is a selective miticide for the control of a variety of mite pests on crops. Used in Pesticide detection. Useful in cannabis testing kits as a component of pesticide mixes (P698240). References Sipes, N.S., et al.: Chem. Res. Toxicol., 26, 878 (2013); Sbartai, I., et al.: Adv. Environ. Biol., 6, 2249 (2012);

Applications Glyphosate-13C is an isotopic analog of Glyphosate (G765000) which is used as a herbicide. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Davis, V., et al.: Weed Sci., 57, 494 (2009), Bellaloui, N., et al.: J. Agric. Food Chem., 57, 9050 (2009),

Applications Labelled analogue of Neomycin, an aminoglycoside antibiotic found in many topical medications. Neomycin has been used as a preventive measure for hepatic encephalopathy and hypercholesterolemia.

Applications Labelled Metopimazine (MPZ) is used to prevent emesis during chemotherapies. Antiemetic. References Catz, P., et al.: Int. J. Pharm., 58, 93 (1990), Sato, K., et al.: J. Pharm. Sci., 80, 104 (1991), Herrstedt, J., et al.: Cancer Chemother. Pharmacol., 33, 53 (1996), Sigsgaard, T., et al.: J. Clin. Onc., 19, 2091 (2001),

Applications Methyl Indole-2,4,5,6,7-d5-3-acetate is an isotopic analog of Methyl Indole-3-acetate (M313475), an important phytohormone. References Quittenden, L., et al.: Plant Physiol., 151, 1130 (2009), Jiraskova, D., et al.: J. Phycol., 45, 108 (2009),

Applications A labelled dipeptide ester about 160 times sweeter than sucrose in aqueous solution. A non-nutritive sweetener. References Cloninger, B., et al.: Science, 170, 81 (1970), Oppermann, et al.: J. Nutr., 103, 1454 (1973),

Applications A labelled derivative of Flumethasone. An antiallergic; anti-asthmatic; anti-inflammatory. References Meltzer, E.O., et al.: J. Allergy Clin. Immunol., 86, 221 (1990), Mitchison, H.C., et al.: Gut, 32, 260 (1991), Phillipps, G.H., et al.: J. Med. Chem., 37, 3717 (1994)

Applications Raloxifene-d10 Hydrochloride, is the labeled analogue of Raloxifene (R100000), a nonsteroidal, selective estrogen receptor modulator (SERM). Antiosteoporotic. References Jone, C.D., et al.: J. Med. Chem., 27, 1057 (1984), Buelke-Sam, J., et al.: Reprod. Toxicol., 12, 217 (1998),

Applications A deuterated version of Meprobamate, an anxiolytic.This is a controlled substance. Liscence required. References Summerfield, S., et al.: J. Pharmacol. Exp. Ther., 322, 205 (2007), Ma, C., et al.: J. Pharm. Biomed. Anal., 47, 677 (2008), Cone, E., et al.: J. Anal. Toxicol., 33, 1 (2009),

Applications Phenoxy-d5-acetic Acid (cas# 154492-74-7) is a compound useful in organic synthesis.

Applications A labelled phenethylamine derivative; 2C-B designer drugs. References Quirino, J., et al.: Science, 282, 465 (1998), de Boer, D., et al.: Pharm. World Sci., 26, 110 (2004), Carmo, H., et al.: Toxicology, 206, 75 (2005), Kanamori, T., et al.: Forensic Sci. Int., 148, 131 (2005),

Applications Hexamethyl-d18-disiloxane (CAS# 19108-55-5) is a useful isotopically labeled research compound.

Applications A labelled antibacterial agent. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Piipari, R., et al.: Clin. Exp. Allergy, 28, 358 (1998), Kanerva, L., et al.: Contact Dermatitis, 44, 193 (2001), Frauen, M., et al.: J. Pharm. Biomed. Anal., 25, 965 (2001),

Stability Hygroscopic Applications N-Desethyl Amodiaquine-d5 Dihydrochloride is a labeled metabolite of Amodiaquine (A634200), an antimalarial. References Bayliss, M., et al.: Xenobiotica, 29, 253 (1999); Projean, D., et al.: Drug Metab. Dispos., 31, 748 (2003); Bray, P., et al.: Mol. Microbiol., 56, 323 (2005); Xiang, H., et al.: J. Pharm. Sci., 95, 2657 (2006); Natarajan, L., et al.: Arzneim.-Forsch., 22, 1230 (1972); Kracmer, J., et al.: Pharmazie, 29, 773 (1974); Ahmad, I., et al.: Anal. Profiles Drug Subs., 21, 43 (1992)

Applications Hexanoyl Glycine-13C2,15N is a labelled analogue of Hexanoyl Glycine (H281200).

Stability Hygroscopic Applications Lauroyl-L-carnitine-d3 Hydrochloride is labelled Lauroyl-L-carnitine (L178680) which is a long-chain fatty ester of carnitine which is accumulated and released into the circulation, in fatty-acid oxidation defects. Pattern of Lauroyl-L-carnitine can be diagnostic for a number of ß-oxidation defects. References Ventura, F., et al.: Clinica Chimica Acta, 281, 1 (1999); Pourfarzam, M., et al.: Clinical Chem,, 40, 2267 (1994); Schaefer, J., et al.: Pediatric Res., 37, 354 (1995)

Stability Light Sensitive Applications Trans-p-Coumaric-d6 Acid is deuterium labelled trans-p-Coumaric Acid (C755390). Trans-p-Coumaric Acid is the E-isomer of p-Coumaric Acid (C755365), a hydroxy derivative of Cinnamic Acid with antioxidant properties. p-Coumaric Acid is a major component of lignocellulose. Studies suggest that p-Coumaric Acid may reduce the risk of cancer by reducing the formation of carcinogenic nitrosamines. References Kikugawa, K. et al.: J. Agric. Food Chem., 1, 780 (1983); Ferguson, L.R. et al.: Mol. Nutrit. Food Res., 585 (2005); Chung, F.L. et al.: IARC Sci. Pub., 57, 797 (1984);

Applications DL-Cytarabine-13C3 is labelled Cytarabine, a compound used as an antineoplastic and antiviral. Cytarabine is a selective inhibitro of DNA synthesis. Does not inhibit RNA synthesis. References Donehower, R.C., et al.: Cancer Treat. Rep., 70, 1059 (1986)

Applications rac 1-Palmitoyl-2-stearoyl-3-chloropropanediol-d5 is labelled 1-Palmitoyl-2-stearoyl-3-chloropropanediol (P163500) which is a fatty acid ester with glycerol chlorohydrins found in a variety of vegetable oils. References Hamlet, C., et al.: Food Addit. Contam., 19, 619 (2002); Zelinkova, Z., et al.: Eur. Food Res. Technol., 228, 571 (2009)

Applications N-Acetyl-L-alanine-2,3,3,3-d4 is an isotope labelled compound of N-Acetyl-L-alanine (A168065),which is used as a biomaker for prostrate cancer. References Jansen, R., et al.: Clin. Biochem., 38, 362 (2005)

Applications n-Triacontane-d62 is the labeled compound of Triacontane (CAS #: 638-68-6). Triacontane releases selective material in thermally degradable capsule. It also, increases charge carrier mobility and molecular packing of a solution sheared Diketopyrrolopyrrole-based donor-acceptor copolymer by Alkyl side chain modification. References Shkolnikov, V., et al.; PCT Int. Appl., (2018); Hambsch, M., et al.: Journal of Materials Chemistry C: Materials for Optical and Electronic Devices, 7, 3665-3674, (2019);

Applications Tadalafil-13C2,d3 is labelled Tadalafil (T004500) which is used for the treatment of erectile dysfunction. It is a phosphodiesterase 5 inhibitor. References Carrier, S., et al.: Can. J. Urol., 10(1), 12 (2003), Doggrell, S.A., et al.: Expert Opin. Pharmacother., 6, 75 (2005), Forgue, S.T., et al.: Br. J. Clin. Pharmacol., 61, 280 (2005)

Applications Labelled Tinidazole. Antiprotozoal (Trichomonas, Giardia); antiamebic; antibacterial. References Miller, M.W., et al.: J. Med. Chem., 13, 849 (1970), Oderdea, G., et al.: Gut, 33, 1328 (1992),

Stability Hygroscopic Applications Isotope labelled Aztreonam (A965200), the first totally synthetic monocyclic β-lactam antibiotic. References Sykes, R.B., et al.: Antimicrob. Agents Chemother., 21, 85 (1982), Florey, K., et al.: Anal. Profiles Drug Subs., 17, 1 (1988),

Applications Clomipramine-d3 HCl (N-methyl-d3) (CAS# 1398065-86-5) is a useful isotopically labeled research compound.