Miscellaneous Organic Molecules with Isotopical Substitutions

Stability Light Sensitive Applications A labelled metabolite of Rifampicin. References Blumenfeld,O.O., et al.: J. Biol. Chem., 236, 2472 (1961), Cowxan, R.A., et al.: Biochem. Biophys. Res. Commun, 23, 799 (1966)

Stability Hygroscopic Applications Naturally occurring amino acid; precursor of tetrapyrroles in the biosynthesis of chlorophyll and heme. Antineoplastic (photosensitizer). References Sisler, E.C., et al.: Physiol. Plant., 16, 315 (1963), Herdeis, C., et al.: Arch. Pharm., 317, 304 (1984), Peng, Q., et al.: Cancer, 79, 2282(1997),

Applications Vitamin K antagonist; structurally similar to Warfarin (W498500). Anticoagulant. References Leroux, M., et al.: Therapie, 11, 85 (1956), Wheeler, C.R., et al.: J. Med. Chem., 22, 1122 (1979),

Applications Labelled Capsaicin analogue (C175680). It is used as a tool in neurobiological research. Prototype vanilloid receptor agonist. Topical analgesic. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Artursson., et al.: J. Pharma. Sci., 73, 1507 (1984), Fu., et al.: Pharma. Res., 17, 100 (2000),

Applications Labelled Phenyl Acetate (P319150). Phenyl Acetate is a metabolite of Phenylbutyrate (PB), useful in the treatment of neuroblastoma and lung cancer. An odorant found in strawberries, passion fruit and black tea. References Ubeda, C. et al.; J. Agr. Food Chem. 60, 6095 (2012); Burzynski, S.R. & Nagy-Kubove, E.; J. Cancer Ther. 2, 518 (2011); Brat, P. et al.; J. Agr. Food Chem., 48, 6210 (2000); Mick, W. & Schreier, P.; J. Agr. Food Chem., 32, 924 (1984)

Stability Hygroscopic Applications A deoxyribonucleoside as Eg5 kinesin modulator with antiproliferative and apoptosis-inducing activity. References Hecht, S., et al.: Chem. Res. Toxicol., 17, 588 (2004), Choi, J., et al.: J. Biol. Chem., 281, 38244 (2006), Lao, Y., et al.: Chem. Res. Toxicol., 20, 246 (2007),

Applications Labelled Ibuprofen, a selective cyclooxygenase inhibitor (IC50=14.9uM). Inhibits PGH synthase-1 and PGH synthase-2 with comparable potency. References Busson, M., et al.: J. Int. Med Res., 14, 53 (1986), Meade, E.A., et al.: J. Biol. Chem., 268, 6610 (1993), Davies, N.M., et al.: Clin. Pharmacokinet., 34, 101 (1998),

Applications Antagonist of dibutyryl cyclic AMP in the regulation of narcosis. Norepinephrine modulates human dendritic cell activation by altering cytokine release. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Piguet, P., et al.: J. Exp. Med., 173, 673 (1991), Hosoi, J., et al.: Nature, 363, 159 (1993), Elenkov, I., et al.: Pharmacol. Rev., 52, 595 (2000), Kaplan, D., et al.: Immunity, 23, 611 (2005),

Applications rac-2-Palmitoyl-1-oleoyl-3-chloropropanediol-d5 is the labeled analogue of rac-2-Palmitoyl-1-oleoyl-3-chloropropanediol (P160515), which is used to detect 3-chloro-1,2-propanediol fatty acid esters in edible oils. References Yamazaki, K., et. al.: Food Addit. Comtam. A., 30, 52 (2013)

Applications 4-Guanidinobenzoic acid-D4 hydrochloride salt is a labelled analogue of 4-Guanidinobenzoic acid hydrochloride salt.

Applications Labelled analogue of Diphenyl Phosphate, an organophosphate diester and metabolite of the flame retardant Triphenyl phosphate (T808990) and also a metabolite of 2-Ethylhexyl diphenyl phosphate. References Cooper, E.M. et al.: Anal. Bioanal. Chem., 401, 2123 (2011); Nishimaki-Mogami, T. et al.: Arch. Toxicol., 61, 259 (1988);

Applications Thiouracil-13C,15N2 is the labelled version of 2-Thiouracil (T375400), which is a reagent used in the preparation of Antithyroid agents. References Toropov, A., et al.: Eur. J. Med. Chem., 45, 3581 (2010), Daniels, C., et al.: J. Bacteriol., 192, 2169 (2010), Castillo-Garit, J., et al.: Eur. J. Pharm. Sci., 39, 30 (2010),

Applications An important marker for renal failure, in kidney transplantation, and for the renal metabolic activity. References Banker, R., et al.: J. Phycol., 33, 613 (1977), Hawkins, P.R., et al.: Toxicon, 35, 341 (1997),

Stability Air Sensitive Applications A labelled Folic acid (F680300) derivative (or folate) found in daily dietary intake that is often used in cancer risk correlation studies. References Keszei, A.P. et al.: Cancer Epidimiol. Biomarker Prev., 18, 1785 (2009); Koning, E.J. et al.: Cancer, 95, 1421 (2002);

Applications N,N-Dimethylformamide-13-C is the isotope labelled analog of N,N-Dimethylformamide. N,N-Dimethylformamide-d7 is used as a cofactor for enzymic oxidation of brassinin, which allows the transformation of dithiocarbamate group into an aldehyde equivalent. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Pedras, M., et al.: Bioorg. Med. Chem., 19, 1390 (2011);

Stability Hygroscopic Applications Labelled (2-Chloroethyl)phosphonic acid. (2-Chloroethyl)phosphonic acid (Ethephon) is the most widely used plant growth regulator. Ethephon is often used on wheat, coffee, tobacco, cotton, and rice in order to help the plant's fruit reach maturity more quickly. The toxicity of Ethephon is actually very low, and any Ethephon used on the plant is converted very quickly to ethylene. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Brantley, B., et al.: J. Plant Physiol., 1428, 741 (1960), Ntui, V., et al.: J. Food Agricult. Environ., 5, 211 (2007), Vwioko, E., et al.: Biosci. Res. Communic., 21, 263 (2009),

Applications Labelled analogue of L-Phenylalanine, an essential amino acid. L-Phenylalanine is biologically converted into L-tyrosine, another one of the DNA-encoded amino acids, which in turn is converted to L-DOPA and further converted into dopamine, norepinephrine, and epinephrine. L-Phenylalanine is produced for medical, feed, and nutritional applications such as in the preparation of Aspartame. References Hollunger, G. et al.: Acta Pharmacol. Toxicol., 34, 391 (1974); Bagchi, S.P. et al.: Biochem. Pharmacol., 26, 900 (1977);

Applications N-Acetyl-L-serine-2,3,3-d3 (CAS# 2230887-17-7) is a useful isotopically labeled research compound.

Applications A labelled metabolite of Rosiglitazone (R693500). References Balton, G.C., et al.: Xenobiotica, 26, 6, 627 (1996),

Applications A vitamin needed to synthesize DNA, conduct DNA repair and methylate DNA, it also acts as a cofactor in biological reactions involving folate. References Xu, L., et al.: Mol. Pharm., 7, 1311 (2010), Everette, J., et al.: J. Agric. Food Chem., 58, 8139 (2010), Alshatwi, A., et al.: Food, Chem., Toxicol., 48, 1881 (2010), McKay, D., et al.: Nut. J., 9 (2010),

Applications An immunosuppressive. Inhibits T and B cell proliferation. Activity is attributed mainly to its metabolite, a malononitrile derivative, which is beleived to inhibit dihydroorotate dehydrogenase as well as several protein tyrosine kinases.This compound is suitable for dihydroorotate dehydrogenase (DHODH) related research. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Vrenken, T., et al.: J. Hepatol., 49, 799 (2008), Mazzucco, G., et al.: Clin. Nephrol., 70, 163 (2008), Davies, M., et al.: J. Med. Chem., 52, 2683 (2009),

Stability Hygroscopic Applications Labelled Milnacipran. Antidepressant. A selective norepinephrine and serotonin reuptake inhibitor approved for the management of fibromyalgia. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Moret, C., et al.: Neuropharmacology, 24, 1211 (1985), Palmier, C., et al.: Eur. J. Clin. Pharmacol., 37, 235 (1989), Spencer, C.M., et al.: Drugs, 56, 405 (1998),

Applications Labelled Firocoxib (F356002). A selective cyclooxygenase-2-(COX-2) inhibitor. Anti-inflammatory; analgesic. References McCann, M.E., et al.: Am. J. Vet. Res., 65, 503 (2004),

Applications Pyrimethanil-d5 (phenyl-d5) (CAS# 2118244-83-8) is a useful isotopically labeled research compound.

Applications Labelled 5-Hydroxy Thiabendazole (H961200). 5-Hydroxy Thiabendazole is the major metabolite of Thiabendazole (T344150). Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Fujitani, T., et al.: Food Chem. Toxicol., 29, 265 (1991), Mizutani, T., et al.: Chem. Res. Toxicol., 6, 174 (1993), Dalvie, D., et al.: J. Agric. Food Chem., 42, 2964 (2006),

Applications Alternariol-d2 is labelled version of Alternariol (A575760), an alternaria mycotoxin and genotoxin found in common edible crops. It inhibits the activity of various DNA-topoisomerases, increasing the rate of DNA strand breaks. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Asam, S., et al.: J. Agric. Food Chem., 57, 5152 (2009); Fehr, M., et al.: Mol. Nut. Food Res., 53, 441 (2009); Tiemann, U., et al.: Toxicol. Lett., 186, 139 (2009)

Stability Very Hygroscopic Applications L-(+)-Lactic Acid-13C3 Sodium Salt is the isotope labelled analog of L-(+)-Lactic Acid Sodium Salt. Sodium Salt of Lactic Acid (L113500). L-Lactic Acid occurs in small quantities in the blood and muscle fluid of man and animals. The lactic acid concentration increases in muscle and blood after vigorous activity. L-(+)-Lactic acid is also present in liver, kidney, thymus gland, human amniotic fluid, and other organs and body fluids. References Borsook, et al.: J. Biol. Chem., 102, 449 (1933); Brin, M., et al.: Ann. N.Y. Acad. Sci., 119, 851 (1965);

Applications A labelled metabolite of the drug Bupropion (B689625). References Hsyu, P-H., et al.: J. Clin. Pharmacol., 37, 737 (1997)