Miscellaneous Organic Molecules with Isotopical Substitutions

Stability Hygroscopic Applications A labelled metabolite of Cefpodoxime Proxetil (C243860). An antibacterial. References Fujimoto, K., et al.: J. Antibiot., 40, 370 (1987), Utsui, Y., et al.: Antimicrob. Agents Chemother., 31, 1085 (1987),

Applications Isotope labelled Nicotelline is a Nicotine (N412420) related metabolite with potential as an inhibitor of human cytochrome P-450 2A6. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Denton, T. et al.: Biochem. Pharm., 67, 751 (2004); Gorrod, J. et al.: Anal. Det. Nic. Rel. Comp. Metab., 69, (1999);

Applications Oxindole-3-acetic Acid-13C6 is labelled derivative of Indoleacetic Acid (I577342) which has the potential to be used in anti-cancer therapy in conjunction with horseradish peroxidase. References Kawano, T. et al.: Gen. Hypo. 60, 664 (2003)

Applications Labelled Choleretic produced by, and isolated from liver cells. References Nomoto, M., et al.: Biol. Pharm. Bull., 32, 172 (2009), Simonsen, H., et al.: J. Agric. Food Chem., 57, 2056 (2009), Miyata, M., et al.: Drug Metab. Disposition, 37, 338 (2009),

Stability Hygroscopic Applications A labelled metabolite of Dantrolene (D185000) that has shown to have muscle relaxant effects. References Ellis, K.O., et al.: J. Med. Chem., 21, 127 (1977), Jayyosi, Z., et al.: Drug Metab. Dispos., 21, 939 (1993),

Applications A labelled metabolite of Lumefantrine (L474000). References Lefevre, G., et al.: Br. J. Clin. Pharmacol., 54, 485 (2002), Schepers, U., et al.: J. Pharm. Biomed. Anal., 310 (2005),

Applications 2,6-Di-tert-butyl-4-methyl-d3-phenol (CAS# 86819-59-2) is a useful isotopically labeled research compound. This compound has been shown to significantly have lower toxic potency in mice compared to butylated hydroxytolune (BHT). References Mizutani, T., et.al., Toxicol. Appl. Pharmacol. 69,283-290,(1983);

Applications Tris(2-butyloxyethyl)phosphate-d27 is the isotope analog of Tris(2-butyloxyethyl)phosphate. Tris(2-butyloxyethyl)phosphate,is an organophosphate, that can be used in the preparation of flame retardant, such as viscose fiber. References Wang, Y., et al.: Fangzhi Xuebao, 33, 16 (2012); Xiaoshan, L. et al.: Aquatic Toxicology, 114, 173 (2012);

Applications Preparation from Naringen, a flavanone glycoside occurring naturally in grapefruit. It is used as sweetening agent, especially in chewing gum and dentifrices. References Inglett, et al.: J. Food Sci., 34, 101 (1969), Fisher, J.F., J. Agric. Food Chem., 25, 682 (1977), Pratter, P.J., Perfum. Flavor., 5, 12 (1981), Lina, B.A.R., et al.: Food Chem. Toxicol., 28, 507 (1990),

Applications A labelled metabolite of Topotecan. References Herben, V., et al.: Anti-Cancer Drugs, 9, 411 (1998), Hsiang, Y., et al.: Cancer Res., 48, 1722 (1988), Hertzberg, R., et al.: J. Med. Chem., 32, 715 (1989), Beijnen, J., et al.: J. Pharm. Biomed. Anal., 8, 789 (1990),

Applications (±)-Bupivacaine-d9 (butyl-d9) (CAS# 474668-57-0) is a useful isotopically labeled research compound.

Applications Labelled Boldenone, an anabolic steroid. Controlled substance. References Watanabe, K., et al.: J. Appl. Bacteriol., 62, 151 (1987), Liu, W., et al.: J. Ind. Microbiol., 13, 167 (1994), Barthakur, S., et al.: J. Basic Microbiol., 36, 383 (1996), Grinenko, G., et al.: Pharmaceut. Chem. J., 36, 510 (2002), de Brabander, H., et al.: Food Addit. Contam., 21, 515 (2004),

Applications Labelled Coumarin (C755380). Pharmaceutic aid (flavor). Found in tonka beans, levender oil, woodruff, sweet clover. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Hazleton, L., et al.: J. Pharmacol. Exp. Ther., 118, 348 (1956), Lake, B., et al.: Food Chem. Toxicol., 37, 423 (1999), Frerot, E., et al.: Flavour Fragrance J., 17, 218 (2002), Yang, Z., et al.: Food Chem., 114, 289 (2009),

Applications Labelled analogue of 2-Bromopropane, a short chain alkyl halide used in organic synthesis primarily as an alkylating agent for introducing the isopropyl functional groups. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Mayants, A.G. et al.: Zhur. Org. Khim., 25, 419 (1989); Miller, B. et al.: J. Org Chem., 30, 3895 (1965);

Applications 4'-Aminoacetanilide-2',3',5',6'-d4 (CAS# 1219802-76-2) is a useful isotopically labeled research compound.

Stability Hygroscopic Applications Antipsychotic. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Anderson, E.L., et al.: Arzneim.-Forsch., 12, 937 (1962), Dreyfuss, J., et al.: J. Pharm. Sci., 60, 826 (1971), Florey, K., et al.: Anal. Profiles Drug Subs., 2, 245 (1973).

Applications A labelled nitrosoamino acid with oncogenic activity. References Nagasawa, H.T., et al.: J. Med. Chem., 16, 583 (1973)

Applications Aminopyrine (N,N-Dimethyl-13c2, 99%) Microbiological/Pyrogen Tested (cas# 60433-90-1) is a useful research chemical.

Applications Labelled Tributyl O-Acetylcitrate (T772950). Topical pharmaceutical formulation anesthetic surfactant ester. References Cherian., et al.: Br. J. Anaesthesia, 87, 502 (2001),

Applications γ-Cyclodextrin Deuterated is a labelled version is γ-Cyclodextrin, which is used as nanomolecular encapsulation for drug delivery and pharmaceuticals. Used in the synthesis of unilamellar vesicles. References Ikeda, A. et al.: Chem. Comm., 50, 1288 (2014); Gudmundsdottir, B. et al.: J. Ocular Pharm. Ther., 30, 35 (2014);

Applications Labelled Metalaxyl (M258740). Agricultural fungicide. Phenylamide fungicide or use in food crops, shrubs and turf. References Boughalleb, N., et al.: Int. J. Agric. Res., 5, 1057 (2010), Lian, Y., et al.: J. Agric. Food Chem., 58, 9428 (2010),

Applications p-Benzoquinone-d4 is the labelled analogue of p-Benzoquinone (B206580) which is used as a catalyst in the preperation of allyl silyl ethers. p-Benzoquinone is a superoxide scavenger that has been used in the characterization of carnation-like SnS2 nanostructure photocatalysts for photodegredation. p-Benzoquinone is a toxic metabolite found in human blood. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Kinoshita, H., et. al.: Org. Lett., 15, 5538 (2013); Liu, H., et. al.: J. Mol. Catal. A-Chem., 288, 19221 (2013); Du, H., et. al.: Environ Sci. Technol., 47, 2823 (2013)

Applications Labelled Benzyl Butyl Phthalate (B233555). A phthalate metabolite with genotoxic effect. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Reyes, F., et al.: J. Clin. Endocrinol. Metab., 37, 74 (1973), Engel, S., et al.: Neurotoxicology, 30, 522 (2009),

Applications Isobutyric-d6 Acid is the isotope labelled analogue of Isobutyric Acid, a carboxylic acid found in vanilla. Isobutryic Acid was used as an intermediate in the synthesis of novel inhibitors of signal transducer and activators of transcription 3 signaling pathway. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Zhang, M.M., et al.: Euro. J. Med. Chem., 62, 301 (2013);

Applications Major metabolite of labelled Bromazepam (B678502) References Musshoff, F., et al.: Clin. Chem. Lab. Med., 36, 803 (1998), El-Haj, B., et al.: J. Anal. Toxicol., 25, 316 (2001), Darzy, K., et al.: Clin. Endocrinol., 70, 287 (2009),

Applications A labelled metabolite of Arecoline, a cholinergic agonist. References Boyland, E., et al.: Biochem. J., 113, 123 (1969), Wenke, G., et al.: J. Cancer Res. Clin. Oncol., 108, 110 (1984), Winstock, A., et al.: Addict. Biol., 7, 133 (2002), Kulanthaivel, P., et al.: Drug Metab. Dispos., 32, 966 (2004), Hukkanen, J., et al.: Pharmacol. Rev., 57, 79(2005),

Applications An isotopically labelled antimitotic agent that disrupts microtubles by binding to tubulin and preventing its polymerization. Stimulates the intrinsic GTPase activity of tubulin. Induces apoptosis in several normal and tumor cell lines and activates the JNK/SAPK signaling pathway. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Lunduena, R.F., et al.: Curr. Opin. Cell Biol., 4, 53 (1992), Ceccatelli, S., et al.: Neuroreport, 8, 3779 (1997), Want, T.H., et al.: J. Biol. Chem., 273, 4928 (1998), Andreu, J.M., et al.: Biochemistry, 37, 8356 (1998), Jordan, A., et al.: Med. Res. Rev., 18, 259 (1998),

Applications A labelled metabolite of Tolperisone (T535475). References Shiozawa, A., et al.: Eur. J. Med. Chem. Chim. Ther., 30, 85 (1995),

Stability Hygroscopic Applications Arotinolol-D5 Hydrochloride, is a labelled analogue of Arotinolol (A771500).

Stability Volatile Applications Trichloroethylene-d (CAS# 13291-68-4) was useful in an isotope exchange column study to understand the slow desorption of organic compounds in soils and sediments. References Werth, C. J., et al.: ACS Division Environ. Chem., 37, 174 (1997)

Applications 4,6-Di(methyl-d3)benzen-2,3,5-d3-amine is a useful isotopically labeled research compound.

Applications Labelled L-Citrulline. An amino acid, first isolated from the juice of watermelon, Citrullus vulgaris Schrad., Cucurbitaceae. Used in the treatment of asthenia. References Kurtz, et al.: J. Biol. Chem., 122, 477 (1938), Rajantie, J., et al.: J. Pediatr., 97, 927 (1980), Carpenter, T.O., et al.: N. Engl. J. Med., 312, 290 (1985),

Applications p-Bromofluorobenzene-d4 is the isotope labelled analog of p-Bromofluorobenzene (B684545); a dihalogenated benzene used in the preparation of pharmaceutical compounds such as atypical antipsychotic agents. References Sunil K.I.V. et al.: Beil. J. Org. Chem., 7, 29 (2011); Li, W. et al.: Adv. Mat. Res., 236, 2594 (2011)

Stability Light Sensitive Applications A labelled metabolite of Rifampicin. References Blumenfeld,O.O., et al.: J. Biol. Chem., 236, 2472 (1961), Cowxan, R.A., et al.: Biochem. Biophys. Res. Commun, 23, 799 (1966)

Stability Hygroscopic Applications Naturally occurring amino acid; precursor of tetrapyrroles in the biosynthesis of chlorophyll and heme. Antineoplastic (photosensitizer). References Sisler, E.C., et al.: Physiol. Plant., 16, 315 (1963), Herdeis, C., et al.: Arch. Pharm., 317, 304 (1984), Peng, Q., et al.: Cancer, 79, 2282(1997),