Miscellaneous Organic Molecules with Isotopical Substitutions

Applications N-Acetyl-S-(3,4-dimethylbenzene)-L-cysteine-d3 (cas# 1331892-61-5) is a compound useful in organic synthesis. References Gonzalez-Reche, L., et al.: Arch. Toxicol., 77, 80 (2003),

Applications Isotope labelled Flocoumafen is a second generation anticoagulant rodenticide. Flocoumafen is extremely effective against strains of pest rodents resistant to conventional anticoagulants. Flocoumafen is highly toxic and is used strictly in sewers and indoors in some places such as UK. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Bowler, D.J. et al.: Br. Crop Prot. Conf. Pests Dis. Proc., 2, 397 (1984); Rowe, F.P. et al.: J. Hygiene, 95, 623 (1985); Vandenbroucke, V. et al.: J. Vet. Pharmacol. Therap., 31, 437 (2008);

Applications Flupyradifurone (F598615), the unlabelled version of Flupyradifurone-d5, can be used as an insecticide. References Anon, IP.com J., 12, 19 (2011)

Stability Hygroscopic Applications a β2-adrenergic agonist, used as a bronchodilator/antiasthmatic Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Murali, S., et al.; Eur. J. Med. Chem., 42, 966 (2007), Nielen, M., et al.: Anal. Bioanal. Chem. 391, 199 (2008), Shao, B., et al.: Food Chem., 114, 1115 (2009),

Applications Labelled analogue of Fenbutatin Oxide, an organotin pesticide. Fenbutatin Oxide is widely used as an aracacide in the control of mites, in particular spider mites. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Ishaaya, I. et al.: Pest. Biochem. Physiol., 6, 270 (1976); Inglesfield, C.: Bull. Environ. Contam. Toxicol., 38, 813 (1987); Riedl, H. et al.: Exp. Appl. Acarol., 11, 149 (1991);

Applications Benzaldehyde-(carbonyl-13C) is the (carbonyl-13C) labelled analogue of Benzaldehyde (B119740) which is mainly used as a precursor to other organic compounds, such as pharmaceuticals, and plastic additives. It is also the primary component of bitter almond oil and can be extracted from a number of other natural sources, and thus can be used for the almond flavor. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Pino, J.A, et al.: Food Chemistry, 141, 795 (2013); Peng, T. et al.: Tianran Chanwu Yanjiu Yu Kaifa, 24, 342 (2012);

Applications Labelled Dydrogesterone. A synthetic progestin largely used in hormone therapy, on the central nervous system by studying two markers of the neuroendocrine function: the neurosteroid allopregnanolone and the opioid .beta.-endorphin. Progestogen. References Bernardi, F., et al.: Eur. J. Endocrinol., 138, 316 (1998), Rupprecht, R., et al.: Steroids, 64, 83 (1999), Uzunova, V., et al.: Brain Res., 976, 1 (2003), Pluchino, N., et al.: J. Steroid Biochem. Mol. Biol., 102, 205 (2006),

Applications N-Acetyl-S-benzyl-d5-L-cysteine is deuterium labelled N-Acetyl-S-benzyl-L-cysteine, which is a metabolite of toluene. References Gargas, M., et al.: Toxicol. Appl. Pharmacol., 98, 87 (1989), Commandeur, J., et al.: Pharmacol. Rev., 47(2), 271 (1995), Campo, P., et al.: Neurotoxicol. Teratol., 21, 427 (1999), Lohse, C., et al.: J. Agr. Food Chem., 48, 5913 (2000),

Applications Glyphosate-13C,15N is an isotopic analog of Glyphosate (G765000) which is used as a herbicide. References Davis, V., et al.: Weed Sci., 57, 494 (2009), Bellaloui, N., et al.: J. Agric. Food Chem., 57, 9050 (2009),

Applications Deethylterbutryne-d9 is the deuterium labelled form of Deethylterbutryne (D228585), which is a pollutant and degradation product of herbicide Irgarol (I764100). References Konstantinou, I., et al.: Environ. Sci. Technol., 35, 398 (2001); Thomas, K., et al.: Sci. Total Environ., 293, 117 (2002); Hollender, J., et al.: Environ. Sci. Technol., 43, 7862 (2009);

Stability Hygroscopic Applications A labelled α-androgenic blocker with selective venoconstrictor properties. Also binds to serotonin 5HT1-receptors. Antimigraine. References de Marees, et al.: Eur. J. Clin. Pharmacol., 30, 685 (1986), McCarthy, B.G., et al.: Headache, 29, 420 (1989), Ziegler, D., et al.: Neurology, 44, 447 (1994),

Applications Labelled Bilastine. It is a novel, nonsedating H1-antihistamine developed for symptomatic treatment of allergic rhinitis and chronic idiopathic urticaria. References Van Cauwenberge, P., et al.: Clin. Exp. Allergy, 30, 891 (2000), Bauchau, V., et al.: Eur. Respir. J., 24, 758 (2004), Lehman, J., et al.: Drugs, 66, 2309 (2006),

Applications A labelled version of Losartan, a nonpeptide angiotensin II AT1-receptor antagonist. Antihypertensive. References Chiu, T.A., et al.: J. Pharmacol. Exp. Ther., 252, 711 (1990), McIntyre, M., et al.: Pharmacol. Ther., 74, 181 (1997), Pitt, B., et al.: Lancet, 355, 1582 (2000)

Stability Hygroscopic Applications Formoterol-d6 Fumarate is the labeled analogue of Formoterol Fumarate (F693401), an impurity of Formoterol fumarate dihydrate (F693400), a selective β2-adrenergic receptor agonist. Formoterol is used as an antiasthmatic. References Yoshida, T., et al.: Pharmacometrics, 26, 811 (1983); Bartow, R.A., et al.: Drugs, 55, 303 (1998)

Applications Labelled Uridine, a nucleoside; widely distributed in nature. Uridine is one of the four basic components of ribonucleic acid (RNA). References Lorine, P., et al.: J. Biol. Chem., 178, 439 (1949), Grakoui, A., et al.: J. Virol., 63, 5216 (1989),; Strauss, J., et al.: Microbiol. Rev., 58, 491 (1994), Lin, Y., et al.: Virology, 292, 78 (2002);

Applications Isotope labelled Triclosan is used as bactericide and preservative for cosmetic and detergent compositions (1). Broadly used as an antiseptic and disinfectant (2). This compound is a contaminant of emerging concern (CECs). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA). Environmental contaminants; Food contaminants. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References 1. Lindström, A. et al.: Environ. Sci. Technol. 2002 Jun 1;36(11):2322-9. 2. Ruszkiewicz, J. et al.: J. Toxicol. Environ. Health B. Crit. Rev. 2017;20(2):104-117.

Applications Uridine Diphosphate-α-D-[UL-13C6]galactose Disodium Salt is a labelled synthetic glycan that is used in drug innovation and discovery. References Matsushita, T. et al.: J. Am. Chem. Soc., 132, 16651 (2010);

Applications Anti-inflammatory. References Carson, et al.: J. Med. Chem., 14, 646 (1971), Wong, S., et al.: J. Pharmacol. Exp. Ther., 185, 127 (1973), Brogden, R.N., et al.: Drugs, 15, 429 (1978).

Applications Labelled Isonicotinamide is an isomeric analogue of nicotinamide and a metabolite of isonicotinic thioamide. Isonicotinamide strongly inducde apoptosis in human acute myelomonocytic leukemia cells, HL-60. References Taguchi, H.: Furi Rajik. Rin., 14, 23 (1999); Golovinski, E. et al.: Comp. Rend. Acad. Bulg. Sci., 21, 375 (1968);

Applications A labelled metabolite of Diethylstilbestrol. References Liehr, J.G., et al.: Steroids, 40, 713 (1982),

Stability Light Sensitive, Temperature Sensitive Applications 9-cis-Retinol-d5, is the labeled analogue of 9-cis-Retinol (R252095), a metabolite of Vitamin A. References McCormick, A., et al.: J. Biol. Chem., 257(4), 1730 (1982), Buck, J., et al.: Science, 254, 1654 (1991), Napoli, J., et al.: Chem. Immunol. Immunopathol., 80, S52 (1996),

Applications DL-Glutamic Acid-d5 is the isotope labelled analog of DL-Glutamic Acid. Glutamic Acid is non-essential amino acid. Its salt form (glutamate) is an important neurotransmitter that plays a key role in long-term potentiation and is important for learning and memory. Glutamic Acid is also a key molecule in cellular metabolism. References McEntee, W. et al.: Psychopharmacology, 111, 391 (1993); Manev, H. et al.: Mol. Pharmacol., 36, 106 (1989);

Applications Labelled Lactose Monohydrate (L114000), which is used in the synthesis of casing for various methods of oral drug delivery, including dissolving pellets, and long-lasting pellets. References Kamble, M. et al.: Int. J. Pharm. Chem. Biol. Sci., 3, 55 (2013); Hiorth, M. et al.: Int. J. Pharm., 441, 544 (2013);

Applications A labelled metabolite of Estradiol. References Fishman, H.G, et al.: Biochemistry, 8, 4304 (1969), Ryan, Sugar, J., et al.: J. Clin. Endocrinol. Metab., 50, 137 (1980), Numazawa, M., et al.: Steroids, 38, 149 (1981), Travis, R., et al.: Breast Cancer Res., 5, 239 (2003),

Applications Clobetasol 17-Propionate-d5 is labelled Clobetasol 17-Propionate (C583500) which is a topical corticosteroid. Clobetasol 17-Propionate (C583500) is anti-inflammatory. References Olsen, E.A., et al.: J. Am. Acad. Dermatol., 15, 246 (1986),

Applications N,N-Dimethylformamide-d7 is the isotope labelled analog of N,N-Dimethylformamide. N,N-Dimethylformamide-d7 is used as a cofactor for enzymic oxidation of brassinin, which allows the transformation of dithiocarbamate group into an aldehyde equivalent. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Pedras, M., et al.: Bioorg. Med. Chem., 19, 1390 (2011);

Applications Celecoxib-d7 is the labeled analogue of Celecoxib (C251000), a selective cyclooxygenase-2 (COX-2) inhibitor. Anti-inflammatory. Used in treatment of familial adenomatous polyposis. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Simon, L.S., et al.: Arthritis Rheum., 41, 1591 (1998); Silverstein, F.E., et al.: J. Am. Med. Assoc., 284, 1247 (2000); Steinbach, G., et al.: N. Engl. J. Med., 342, 1946 (2000)

Applications Phenylglyoxylic Acid-13C8 is an intermediate used in the synthesis of Mandelic Acid-13C8 (M162523), which is the C13 labelled Mandelic Acid which is used as an antiseptic (urinary). It is also used as a short-term exposure biomarker in urine from styrene exposed workers. References Pessela, B., et al.: Enzyme Microb. Technol., 40, 310 (2007); Carrasco-Lopez, C., et al.: J. Biol. Chem., 284, 4365 (2009); Fustinoni, S., et al.: Toxicol. Lett., 192, 40 (2010)

Applications Tauro 6-Ethlchenodeoxycholic Acid-d5 Sodium Salt is the labelled version of Tauro 6-Ethlchenodeoxycholic Acid Sodium Salt (T009025) which can be otained from 6-Ethylchenodeoxycholic Acid (E899810), a derivative of the bile acid Chenodeoxycholic Acid (C291900). 6-Ethylchenodeoxycholic Acid (E899810) is a potent activator of the farnesoid X nuclear receptor which reduces liver fat and fibrosis in animal models of fatty liver disease. References Neuschwander-Tetri, B.A., et al.: Lancet., 385, 956 (2015)