Miscellaneous Organic Molecules with Isotopical Substitutions

Applications 2-(Chloromethyl)-8-(1,1-dimethylethyl)-1,4-dioxaspiro[4.5]decane-d4 is an intermediate used in the synthesis of Spiroxamine-d4 (S683502), which is the labeled analogue of Spiroxamine (S683500), which is a spiroketalamine fungicide for use on cereal crops. Spiroxamine inhibits ergosterol synthesis. Spiroxamine is used as agricultural fungicide. References Wang, J., et al.: J. Agric. Food Chem., 53, 1857 (2005), Abrahim, A., et al.: J. Pharm. Biomed. Anal., 51, 131 (2010), Wang, J., et al.: Anal. Bioanal. Chem., 396, 1513 (2010),

Applications Bedaquiline-d6 is the labelled analog of Bedaquiline, a diarylquinoline derivative that acts as a mycobacterial inhibitor. Bedaquiline shows promise as potential drug in the treatment of tuberculosis. References de Jonge M.R. et al.: Proteins, 67, 971 (2007); Diacon A.H. et al.: N. Eng. J. Med., 360, 2397 (2009);

Applications Labelled Medroxyprogesterone, an orally active progestogen used in hormone replacement therepy (HRT), in the past has been used as a component of oral contraceptives. References Pan, Q., et al.: Mol. Hum. Reprod., 13, 797 (2007), Matsson, P., et al.: J. Pharmacol. Exp. Ther., 323, 19 (2007), Jukosky, J.A., et al.: Bull. Environ. Contam. Toxicol., 81, 230 (2008), Cherkasov, A., et al.: J. Med. Chem., 51, 2047 (2008),

Applications Semisynthetic labelled Erythromycin derivative. Antibacterial. References Jones, R.N., et al.: Antimicrob. Agents Chemother., 24, 209 (1983), Barry, A.L., et al.: Eur. J. Clin. Microbiol., 5, 536 (1986), Grassi, C., et al.: Chemioterapia, 6, 41 (1987),

Applications Isotope labelled L-Serine, used in the synthesis of purines and pyrimidines as antibacterial/antifungal agents, as well as acting as a proteinogenic compound. References Olivella, M. et al.: Bioorg. Med. Chem., 20, 6109 (2012);

Applications Labelled analogue of Diisobutyl Phthalate, a dialkyl phthalate ester phthalate plasticizer which can be used as a substitute of dibutyl phthalate. Diisobutyl Phthalate as well as other phthalates have genotoxic effects and studies shown an increase in its monoester metabolite in human urine over the years. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Kleinsasser, N.H. et al.: Tetragen. Carconogen. Mutagen., 21, 189 (2001); Silva, M.J. et al.: Environ. Health Perspect., 112, 331 (2004); Wittassek, M. et al.: Int. J. Androl., 31, 131 (2008);

Stability Hygroscopic Applications Alternariol Monomethyl Ether-d3 is labelled methyl este analog fo Alternariol. An alternaria mycotoxin and genotoxin, found in common edible crops. It inhibits the activity of various DNA-topoisomerases, increasing the rate of DNA strand breaks. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Asam, S., et al.: J. Agric. Food Chem., 57, 5152 (2009); Fehr, M., et al.: Mol. Nut. Food Res., 53, 441 (2009); Tiemann, U., et al.: Toxicol. Lett., 186, 139 (2009);

Applications 2-Methylpyrazine-d6 (CAS# 1219804-84-8) is a useful isotopically labeled research compound.

Applications Isotope labelled Coumatetralyl is used as an anticoagulant rodenticide. Coumatetralyl is widely used to control rodent populations. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Jones, A., et al.: Bull Environ. Contain Toxicol., 56, 8 (1996), Brakes, C., et al.: J. Appl. Ecol., 42, 118 (2005), Giraudoux, P., et al.: Environ. Res., 102, 291 (2006),

Applications Antipsychotic. References Flanagan, T.L., et al.: J. Pharm. Sci., 51, 996 (1962), Post., A., et al.: Anal. Profiles Drug Subs., 9, 543 (1980)

Applications Exemestane-13C,D3 is the labeled analogue of Exemestane (E957000), an antineoplastic (hormonal). References Giudici, D., et al.: J. Steroid Biochem., 30, 391 (1988), Evans, T.R.J., et al.: Cancer Res., 52, 5933 (1992), Zilembo, N., et al.: Brit. J. Cancer, 72, 1007 (1995)

Applications Labelled Glycidyl Palmitate (G615950). Used for preparation of lysophosphatidic acids which inhibit apoptosis. References Mills, G.B., et al.: Nat. Rev. Cancer., 3, 582 (2003), Zhang, C., et al.: J. Exp. Med., 199, 763 (2004), Lee, C.W., J. Biol. Chem., 281 (2006),

Applications is the labeled analogue of Cyprodinil (C989060), which is a a broad-spectrum fungicide of the class of pyrimidinamines. It is commonly used for protection of cereal crops and fruits against fungal infections. References Heye, U.J. et al.: Bright. Crop Prot. Conf., Pests Dis., 2, 501 (1994); Boric, B. et al.: Pesticidi, 12, 277 (1997); Knauf-Beiter, G. et al.: Plant Dis., 79, 1098 (1995);

Applications A deuterated alcohol used in the study of lignite liquefaction. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Kuznetov, P.N. et al.: Fuel, 70, 559 (1991);

Applications The labelled analogue of Diphenhydramine; a H1-histamine receptor antagonist. Diphenhydramine is categorized as an antihistaminic; sedative, hypnotic. References Gruhzit, O.M., et al.: J. Pharmacol. Exp. Ther., 89, 227 (1947), Holcomb, I.J., et al.: Anal. Profiles Drug Subs., 3, 173 (1974), Scavone, J.M., et al.: J. Clin. Pharmacol., 38, 603 (1998),

Stability Hygroscopic Applications Labelled rac FTY720 (F805010). rac FTY720 is a sphingosine 1-phosphate receptor modular, ameliorates experimental autoimmune encephalomyelitis by inhibition of T cell infiltration. References Igarashi, J., et al.: J. Biol. Chem., 275, 32363 (2000), Bandhuvula, P., et al.: J. Biol. Chem., 280, 33697 (2005),

Applications Labelled Menthol. Used for oral gel patch or film containing herb extracts or Chinese medicine, fruit extract, spearmint, and menthol for smoking cessation. References Ikaheimo, I., et al.: J. Antimicrob. Chemother., 46, 287 (2000), Gillet, Y., et al.: Lancet, 359, 753 (2002), Turos, E., et al.: Bioorg. Med. Chem. Lett., 2002, 12, 2229 (2002),

Applications Citric Acid-13C6 is an isotope labelled compound of citric acid (C521000). Citric acid is mainly used as an acidifier, flavoring agent and chelating agent. Citric acid is also a metabolite of Dimethyl Fumarate (D464965), a compound used as a treatment for the relapsing forms of multiple sclerosis and psoriasis. References Dawson, R.M., et al.: Data for Biochem. Rsch., (1959); Gruber, C. M., et al.: J. Pharmacol. Exp. Ther., 94, 65 (1948); Lofty, W.A., et al.: Bioresource. Tech., 98, 3470 (2007); Schimrigk, S., et al.: Eur. J. Neurol., 13, 604 (2006)

Stability Hygroscopic Applications Isotope labelled analogue of Phenethicillin is a semisynthetic penicillin based β-lactam antibiotic and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive bacteria. References Lucien, C., et al.: Can. med. Assoc. J., 84, 535 (1961); Timmers, G.J., et al.: Clin. Microbiol. Infect., 13, 497 (2007);

Applications Labelled Chenodiol (Chenodeoxycholic acid). A major bile acid in many vertebrates, occurring as the N-glycine and/or N-taurine conjugate. With other bile acids, forms mixed micelles with lecithin in bile which solubilize cholesterol and thus facilitates its excretion. Fcilitates fat absorption in the small intestine by micellar solubilization of fatty acids and monoglycerides. Anticholelithogenic. Epimeric with Ursodiol. References Danzinger, et al.: N. Engl. J. Med., 286, 1 (1972), Iser, J.H., et al.: Drugs, 21, 90 (1981), Tint, G.S., et al.: Gastroenterology, 91, 1007 (1986),

Applications (4S)-Brivaracetam-d7, is the labeled analogue of (4S)-Brivaracetam (B677650), which is an isomer of Brivaracetam (B677645), a 4-n-propyl analog of levetiracetam (L331500), and a racetam derivative with anticonvulsant properties. References Rosenstiel, P., et al.:Neurotherapeutics, 4 (1), 84 (2007); Malawska, B., et al.:, Curr. Opin. Investig. Drugs, 6(7), 740 (2005);

Applications 1-Naphthol-D7 β-D-Glucuronide Sodium Salt is the isotope labelled analog of 1-Naphthol β-D-Glucuronide Sodium Salt (N368000); a metabolite of 1-Naphthol. References Redegeld, F., et al.: J. Pharmacol. Exp. Ther., 244, 263 (1988); Lohr, J., et al.: Pharmacol. Rev., 50, 107 (1998); Yokota, H., et al.: Biochem. J., 340, 405 (1999); Daidoji, T., et al.: Drug Metab. Dispos., 31, 993 (2003)

Stability Light Sensitive Applications Acrylamide (1-13c, 99%) (cas# 287399-24-0) is a useful research chemical.

Applications Labelled Clonazepam (C587080). Antiepileptic agent with anxiolytic and antimanic properties. Anticonvulsant.This is a controlled substance (depressant). References Blum, et al.: Arzneim.-Forsch., 23, 377 (1973), Winslow, W.C., et al.: Anal. Profiles Drug Subs., 6, 61 (1977)

Applications Isotope labelled Trimellic Acid is a reagent used in the preparation of coordination polymers containing various luminescent properties. References Zhang, Z. et al.: Crys. Grow. Des., 13, 4338 (2013); Qin, L. et al.: Trans. Met. Chem., 38, 627 (2013);

Stability Hygroscopic Applications A labelled metabolite of Melatonin (S689050). References Huether, G., et al.: Life Sci., 51, 945 (1992), Holmes, M., et al.: J. Clin. Oncol., 18, 3668 (2000), Roth, G., et al.: J. Clin. Endocrinol. Metab., 86, 3292 (2001),

Stability Hygroscopic Applications Labelled Cytarabine, a compound used as an antineoplastic and antiviral. A selective inhibitor of DNA synthesis. Does not inhibit RNA synthesis. References Donehower, R.C., et al.: Cancer Treat. Rep., 70, 1059 (1986)

Applications p-Benzoquinone-d4 is the labelled analogue of p-Benzoquinone (B206580) which is used as a catalyst in the preperation of allyl silyl ethers. p-Benzoquinone is a superoxide scavenger that has been used in the characterization of carnation-like SnS2 nanostructure photocatalysts for photodegredation. p-Benzoquinone is a toxic metabolite found in human blood. References Kinoshita, H., et. al.: Org. Lett., 15, 5538 (2013); Liu, H., et. al.: J. Mol. Catal. A-Chem., 288, 19221 (2013); Du, H., et. al.: Environ Sci. Technol., 47, 2823 (2013)

Applications Labelled analog of Nilotinib (AMN1O7), which might be useful in treatment of chronic myelogenous leukemia. It is a COVID19-related research product. References Corbin, A., et al.: J. Biol. Chem., 277, 32214(2002), Golemovic, M., et al.: Clin. Cancer Res., 11, 4941 (2005), Gleixner, K., et al.: Blood, 107, 752 (2006), Nicolini, F., et al.: Leukemia, 20, 1061 (2006),

Applications Labelled Prilocaine (P725000). Prilocaine is a local anesthetic of the amino amide type. Prilocaine is often used in dentistry. Prilocaine is also often combined with lidocaine as a preparation for dermal anesthesia (lidocaine/prilocaine or EMLA), for treatment of conditions like paresthesia. References Caliaro, G., et al.: J. Pharm. Biomed. Anal., 26, 427 (2001), Ulmeanu, S., et al.: Pharm. Res., 20, 1317 (2003),

Applications Tralomethrin-d5, is the labeled analogue of Tralomethrin (T712400), which is a pyrethroid insecticide. It is effective against most members of class Arachnida as well as insects. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Laskowski, D.A., et al.: Review Env. Conatmin. Toxic., 174, 49 (2002); Tanaka, Y., et al.: Shokuhin Eiseigaku Zasshi, 41, 335 (200);

Applications L-Cysteine-13C3 is the isotope labelled analog of L-Cysteine (C995000); a non-essential amino acid that can be synthesized by the human body under normal physiological conditions if a sufficient quantity of methionine is available. L-Cysteine is commonly used as a precursor in the food and pharmaceutical industries. L-Cysteine is used as a processing aid for baking, as an additive in cigarettes, as well as in the preparation of meat flavours. References Pecivova, P. et al.: J. Sci. Food Agric., 90, 1681 (2010); Hui, N. et al.: Meat Sci. Appl., 74 (2001); Kiviharju, K. et al.: J. Biotechnol., 117, 299 (2005)

Applications Isotope labelled Sodium β-Hydroxyethoxyacetate is used in the synthesis of polymer microspheres that are magnetized and are used for enzyme catalysis or bioaffinity separations. References Horak, D. et al.: Macromol. Biosci., 12, 647 (2012); Pestov, A. et al.: Russ. J. Coord. Chem., 38, 738 (2012);

Applications Fexofenadine-d10 Hydrochloride is the labeled analogue of Fexofenadine Hydrochloride (F322490), the active metabolite of Terfenadine (T114500), a H1-histamine receptor antagonist. References Pratt, E., et al.: Diabet Med., 18, 515 (2001); Mizutani, N., et al.: J. Pharmacol. Sci., 93, 437 (2003); Scadding, G., et al.: Clin. Drug Invest., 25, 153 (2005); Asai, M., et al.: N. Engl. J. Med., 354, 307 (2006)