Miscellaneous Organic Molecules with Isotopical Substitutions

Applications L-2-Aminobutyric Acid-d6 is the isotope labelled analog of L-2-Aminobutyric Acid (A602930); a receptor antagonist. References Porter, D.J.T., et al.: Biochem. Pharmacol., 50, 1475 (1995)

Applications Fipronil-detrifluoromethylsulfinyl-3C2 15N2, is the unlabeled analogue of Fipronil-detrifluoromethylsulfinyl, that can be used in the synthesis of Fipronil (F342200), which is a GABA receptor antagonists and insecticides. References Ling, S., et al.: App. Entomol. Zool., 44, 543 (2009), Li, X., et al.: Environ. Toxicol. Chem., 29, 127 (2010), Savant, R., et al.: J. Agric. Food Chem., 58, 1447 (2010),

Applications 2,4-Diaminotoluene-13C6 is a isotope labelled analog of 2,4-Diaminotoluene (D416780). 2,4-Diaminotoluene is an aromatic amines likely to have high carcinogenic potency. QSARs of aromatic amines. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Franke, R., et al.: Carcinogenesis, 22, 1561 (2001), Benigni, R., et al.: Chem. Rev., 105, 1767 (2005), Benigni, R., et al.: Environ. Mol. Mutagen., 50, 152 (2009),

Applications A reagent used to synthesize various dyes used in the textile industry. This is the labeled analog. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Rosenkranz, H.S. et al.: Mutagen., 5, 137 (1990);

Applications A labelled chemical additive to control bacterial contamination in ethanol fermentation. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Vaisanen, O., et al.: J. Ind. Microbio., 4, 419 (1989), Costerton, J., et al.: J. Bacteriol., 176, 2137 (1994), Pirttijarvi, T., et al.: J. Appl. Bacteriol., 81, 445 (1996),

Applications A labelled metabolite of Desipramine. References De Jongh, G.D., et al.: Drug Metab. Dispos., 2, 48 (1981), Suckow, R.F., et al.: J. Pharm. Sci., 73, 1745 (1984), Fraser, A.D., et al.: J. Anal. Toxicol., 11,168 (1987),

Stability Hygroscopic Applications Labelled analogue of Triethylenetetramine, a crosslinking agent.It is the labeled form of Triethylenetetramine Tetrahydrochoride (CAS#: 4961-40-4) used in preparation of Motuporamine derivatives, Cyclopentadecyl Polyamines and Cholic Acid derivatives as membrane-active antibiotic enhancers active against Gram-neg. multidrug-resistant species. References Phanstiel, O., et al.: U.S. Pat. Appl. Publ., (2017);

Applications Labelled D-Glucose is a simple sugar that is present in plants. A monosaccharide that may exist in open chain or cyclic conformation if in solution. It plays a vital role in photosynthesis and fuels the energy required for cellular respiration. D-Glucose is used in various metabolic processes including enzymic synthesis of cyclohexyl-α and β-D-glucosides. Can also be used as a diagnostic tool in detection of type 2 diabetes mellitus and potentially Huntington's disease through analysis of blood-glucose in type 1 diabetes mellitus. References Wang, R., et al.: J. Mol. Catal. B. Enz., 56, 131 (2009); Springhorn, C. et al.: J. Clin. Endocrinol. Metab., 97, 4640 (2012); Hashimoto, K. et al.: J. Clin. Endocrinol. Metab., 97, 3016 (2012); Avelange, M. et al.: Plant. Phys., 94, 1157 (1990); Cramer, C. et al.: J. Chem. Soc., 115, 5745 (1993);

Applications Labelled Methotrexate (M260675) analog. DAMPA is an antitumor agent. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Martinelli, J.E., et al.: J. Med. Chem., 22, 869 (1979);

Applications Difethialone-d4 is the isotope labelled analog of Difethialone, which is an anticoagulant rodenticide widely used to control rodent infestations. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Eason, C., et al.: Ecotoxicology, 11, 35 (2002), Hegdal, P., et al.: Environ. Toxicol. Chem., 7, 245 (1988), Stone, W., et al.: Environ. Contam. Tox., 70, 34 (2003),

Applications An intermediate for the synthesis of Labelled Ketoprofen. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Derewenda, Z., et al.: J. Mol. Biol., 227, 818 (1992), Grochulski, P., et al.: J. Biol. Chem., 268, 12843 (1993).

Applications Labelled Florfenicol (F405750). Florfenicol is a fluorinated derivative of thiamphenicol. Florfenicol inhibits bacterial protein synthesis by binding to ribosome 50S and 70S subunits. Florfenicol is used as an antibacterial. References Kim, E and Aoki, T.: Microbiol. Immunol., 40, 665, (1996), Keyes, K.: Antimicrob. Agents Chemother., 44, 421 (2000)

Applications Isotope labelled 17β-Estradiol (E888000), which is the major estrogen (1) secreted by the premenopausal ovary (2).Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants. References 1. Salole, E. et al.: Anal. Profiles Drug Subs. 1986 15, 23 283-3182. Lievertz, R. et al.: Am. J. Obstet. Gynecol. 1987 May;156(5):1289-93.

Applications Labelled Sulthiame, a benzenesulfonamide derivative. Sulthiame acts as an inhibitor of the enzyme carbonic anhydrase. Sulthiame is used as an anticonvulsant in the treatment of benign and symptomatic focal epilepsy. References Green, J. et al.: Antiepilep. Drugs, 744 (1972); Inui, M.: Seish. Shin. Zas., 71, 114 (1969); Leniger, T. et al.: Epilepsia, 43, 469 (2002);

Applications Labelled analog of a Cardioselective β1-adrenergic blocker. Antihypertensive, antianginal. References Mazzo, D.J., et al.: Anal. Profiles Drug Subs., 20, 237 (1991), Meininger, C., et al.: Biochem. J., 349, 353 (2000), Ruan, H., et al.: Diabetes, 51, 1319 (2002), Liao, Y., et al.: Circulation, 110, 692 (2004),

Stability Hygroscopic, Moisture Sensitive, Temperature Sensitive Applications Labelled Myosmine (M835000). Myosmine is an alkaloid found in tobacco. Myosmine has been suspected to be a tobacco-independent carcinogenic source.

Applications A labelled analog of a metabolite of Cetirizine and Hydroxyzine.

Applications A labelled Dextrorphan. Orally active synthetic morphine analog. Analgesic (narcotic). The labelled d-form of Levorphanol. References Tallarida, R., et al.: Life Sci., 45, 947 (1989), Netzer, R., et al.: Eur. J. Pharmacol., 238, 209 (1993), Mao, J., et al.: Pain, 67, 361 (1996), Chow, L., et al.: J. Biomed. Sci., 11, 717 (2004),

Applications Isotope labelled Coumachlor (C745000) an internal standard in the analysis of the rodenticide Warfarin. References Dikshith, T., et al.: J. Exp. Biol., 29, 149 (1991),

Applications Labelled Ephedrine derivative for controlling respiratory tract goblet cell hyperplasia in respiratory diseases including infection and bronchitis. References Tan, Z., et al.: J. Therm. Anal., 45, 59 (1995), van Berkel, G., et al.: Anal. Chem., 76, 479 (2004), Di, Y., et al.: Chin. Phy., 17, 3276 (2008),

Applications Glucocorticoid. Used in chronic asthma and allergic rhinitis. Antiallergic, antiasthmatic (inhalant). Anti-inflammatory (topical). References Malfitan, V.A., et al.: Clin. Ther., 4, 472 (1982), Rao, M., et al.: J. Asthma, 19, 21 (1982), Small, P., et al.: Ann. Allergy, 49, 127 (1982), Brogden, R.N., et al.: Drugs, 28, 99 (1984),

Applications Labeled D-Mannitol is widespread in plants and plant exudates; obtained from manna and seaweeds. D-Mannitol is used in the food industry as anticaking and free-flow agent, flavoring agent, lubricant and release agent, stabilizer and thickener and nutritive sweetener. References Pigman, W., et al.: The Carbohydrates, 249 (1957); Makkee, M., et al.: Chem. Commun., 930 (1980);

Applications A lactone of meconinic acid, extracted from opium. Meconin is a marker for illicit opiate use. References Pavlic, M., et al.: Anal. Bioanal. Chem., 386, 69 (2006), Morley, S., et al.: J. Anal. Toxicol., 31, 105 (2007), Ashour, A., et al.: Drug Test. Anal., 1, 327 (2009),

Applications A labelled novel NO-donor of the N-nitrosoamines series. It is suitable for the preparation of N-nitrosoamines and their analogs.

Applications IQ is highly mutagenic in the Ames test. Investigations have shown that this compound may be present in broiled fish, fried beef, commercial beef extracts and protein pyrolysates. References Ohgaki, H., et al.: Carcinogenesis, 5, 921 (1984), Stavric, B., et al.: Fd. Chem. Toxic., 31, 12, 981 (1993), Sugimura, T., et al.: Mutation Research, 290, 43 (1993), Eisenbrand & Tang: Toxicology, 84, 1 (1993), Josephy, P.D., et al.: Carcinogenesis, 16, 9, 2037 (1995),

Applications Labelled analog (RS)-N’-Nitrosonornicotine-13C6 is a tobacco alkaloid and a risk factor of human cancer. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Stepanov, I., et al.: Cancer Res., 69, 8236 (2009), Maertens, R., et al.: Chem. Res. Toxicol., 22, 1406 (2009), Gaworski, C., et al.: Toxicol., 269, 54 (2010),

Applications Camostat mesylate-D4 is a labelled analogue of Camostat mesylate (C150300).

Applications Genfatinib-d3 (Imatinib-d3) is the labeled analogue of Genfatinib, a treatment of chronic myeloid leukemia (CML). It is a COVID19-related research product. References Helmann, R., et. al.: J. Clin. Oncol., 32, 415 (2014)

Applications Isotope labelled 1,2-Phenylenediamine, an amino substituted benzene used in the manufacture of dyes. Potential use in sensitive immunosensor for cancer biomarker. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Wu, Y. et al.: Anal. Bioanal. Chem., 400, 2141 (2011); Du, D. et al.: Anal. Chem., 82, 2989 (2010);

Stability Hygroscopic Applications Sodium salt of Tauro-α-muricholic Acid is a labeled bile acid released by the liver and is typically used in cholestasis studies. References Yang, L. et al.: Chem. Res. Toxicol., 21, 2280 (2008); Holm, R. et al.: Phys. Chem. Chem. Phys., 11, 5070 (2009);

Applications A labelled metabolite of Budesonide (B689490), a non-halogenated glucocorticoid related to triamcinolone hexacetonide. Used as an antiinflammatory agent. References Ryrfeldt., A., et a.: J. Steroid Biochem., 10, 317 (1979), Roth, G., et al.: J. Pharm. Sci., 69, 766 (1980), Edsbaecker, S., et al.: Drug Metab. Dispos., 15, 412 (1987),

Applications Rosuvastatin-d3 Sodium Salt is the labeled analogue of Rosuvastatin (R700500), a selective, competitive HMG-CoA reductase inhibitor. Antilipemic. References Watanabe, M., et al.: Bioorg. Med. Chem., 5, 437 (1997); Lee, E., et al.: Clin. Pharmacol. Ther., 78, 330 (2005); Ferdinand, K.C., et al.: Am. J. Cardiol., 97, 229 (2006)