Miscellaneous Organic Molecules with Isotopical Substitutions

Applications Apalutamide-d3 is a labelled analog of Apalutamide (A726120) and has been explored for its pharmacological activities. References Pang, X., et al.: Bioorg. Med. Chem. Lett., 27, 2803 (2017)

Applications Cresyl Diphenyl Phosphate-d7 Isomer 1 is the deuterated form of Cresyl Diphenyl Phosphate (C783015), which is a phosphorus flame retardant additive. References van der Veen., et al.: Chemosphere, 88, 1119 (2012);

Applications Orally active progestogen; formerly used in combinations as oral contraceptive. References Chang, K., et al.: Steroids 12, 689 (1968),

Applications A labelled antihypertensive. An angiotensin converting enzyme (ACE) inhibitor, converted to active, diacid metabolite. References Teetz, V., et al.: Arzneim.-Forsch., 34, 1399 (1984), Ruggenenti, P., et al.: Lancet, 352, (1998), Bosch, J., et al.: Br. Med. J., 324, 1 (2002),

Applications A major metabolite of Sulfadiazine. References Woolley, J., et al.: Drug Metab. Dispos., 7, 94 (1979), Nielsen, P., et al.: Biochem. Pharmacol., 35, 2509 (1986), Anari, M., et al.: Anal. Chem., 76, 823 (2004), Edlund, P., et al.: J. Pharm. Biomed. Anal., 34, 1079 (2004),

Stability Hygroscopic Applications Robenidine-d8 HCl [bis(phenyl-d4)] (CAS# 1173097-77-2) is a useful isotopically labeled research compound.

Applications Labelled Derivative of Artemisinin (A777500). Antimalarial, used to treat strains of malaria which are multi-drug resistant. References Hombhanje, F., et al.: Pharma., 3, 3581 (2010), Michael, O., et al.: Malaria J., 9, 335 (2010), Cesar, I., et al.: J. Pharm. Biomed. Anal., 54, 114 (2011),

Applications Labelled 4-Dimethylaminoantipyrine(D460890). Antipyretic; analgesic. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Takahashi, T., et al.: Chem. Pharm. Bull., 6, 98 (1958), Lockwood, G.F., et al.: J. Pharm. Pharmacol., 31, 787 (1979),

Applications D-Serine-2,3,3-d3 is derived from 2-Chlorobenzyl Chloride (C364225), which is a reagent in the synthesis of piperidine derivatives which are used as human heat shock protein 70 inhibitors for treatment of drug-resistant tumors. 2-Chlorobenzyl Chloride is also used as a reagent in the synthesis of benzothiazole derivatives bearing indole-based moiety which can exhibit anticancer activity. References Zeng, Y., et al.: Eur. J. Med. Chem., 97, 19 (2015); Ma, J., et al.: Eur. J. Med. Chem., 96, 173 (2015)

Applications Labelled analogue of Tefluthrin, a pyrethroid based insecticide. Tefluthrin is used in the control of a broad range of soil pests, including members of the Coleoptera, Lepidoptera, and Diptera. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References McDonald, E. et al.: Bright. Crop Prot. Conf. Pest Dis., 3, 1143 (1986); Jutsum, A.R. et al.: Bright. Crop Prot. Conf. Pest. Dis. Proc., 1, 199 (1986);

Applications 4-Phenanthrol-d9 has been used as a reactant for the preparation of stable isotope-labeled internal standards of PAH metabolites from urine of smokers and nonsmokers. References Jacob, P. III, et. al.: Anal. Chem., 79, 587 (2007)

Applications A labelled metabolite of the drug Oxybutynin (D289475). Used in the treatment of incontinence. References Hughes, K., et al.: Xenobiotica, 22, 859 (1992), Oki, T., et al.: Biol. Pharm. Bull., 24, 491 (2001), Fetscher, C., et al.: Br. J. Pharmacol., 136, 64 (2002), Zobrist, R., et al.: Pharm. Res., 20, 103 (2003)

Applications Acetyl-d3 L-Carnitine Hydrochloride is labelled Acetyl L-Carnitine Hydrochloride (A171990) which is used for transmembrane action potential studies. Acetylcarnitine has antinociceptive activity that may be mediated by enhanced activity of muscarinic cholinergic receptors or mGlu2 glutamate receptors. References Matsui, K., et al.: Japanese J. Pharmcol., 39, 263 (1985); Chlechio, S., et al.: J. Endocrinol. Invest., 27, 171 (2004): Walker, R., et al.: Comparative General Pharmacol., 4, 65 (1973)

Applications An amino ketone metabolite of nicotine, and precursor to NNK. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Stephen S. Hect, Sharon E. Murphy, et. al. , Proc. Natl. Acad. Sci. USA, Oct. 24, 2000.

Applications 4-Acetaminophen-d3 Sulfate Potassium Salt is a deuterium labeled metabolite of Acetaminophen (A161220) (1,2,3). References (1) Lloyd, A., et al.: Biochim. Biophys. Acta., 52, 413 (1961)(2) Purohit, A., et al.: J. Steroid Biochem. Mol. Biol., 86, 423 (2003) (3) Winum, J., et al.: J. Med. Chem., 46, 2197 (2003)

Stability Volatile Applications N-Hexane (D14, 98%) (cas# 21666-38-6) is a useful research chemical.

Applications 4-Aminobiphenyl-d9 (CAS# 344298-96-0) is a useful isotopically labeled research compound.

Stability Very Hygroscopic Applications A labelled metabolite of Temozolomide. References Jaeken, J., et al.: Lancet, 2, 1058 (1984), Baggott, J., et al.: Biochem. J., 236, 193 (1986), Baggott, J., et al.: Arch. Dermatol., 135, 813 (1999),

Stability Very Hygroscopic Applications A potent inhibitor of NO synthase of adrenal glands, brain, and vascular endothelial cells. References Vallence, P., et al.: Lancet, 339, 572 (1992),

Applications rac Galaxolidone-d6 is the isotope labelled analog of rac Galaxolidone (G189005); a metabolite of Galaxolide (G189000/ G189001) which is a polycyclic musk (PCM) used as a fragrance ingredient in perfumes, soaps, cosmetics, body lotions, deodorants, and detergents. References Mori, T. et al.: J. Health Sci., 52, 276 (2006); Chen Y. et al.: Flav. Frag. J., 21, 822 (2006); Martin, C., et al.: Environ. Sci. Technol., 41, 5395 (2007); Reiner, J., et al.: Chemosphere, 62, 867 (2006)

Applications Riboflavin Phosphate Sodium Salt-d3 is the labelled analogue of Riboflavin Phosphate Sodium Salt (R415000), one of the bioactive forms of Riboflavin. Nutritional factor found in milk, eggs, malted barley, liver, kidney, heart, leafy vegetables. Richest natural source is yeast. Minute amounts present in all plant and animal cells. Vitamin (enzyme cofactor). References Unna, K., et al.: J. Pharmacol. Exp. Ther., 76, 75 (1942), Rivlin, et al.: N. Engl. J. Med., 283, 463 (1970), Al-Shammary, F.J., et al.: Anal. Profiles Drug Subs., 19, 429 (1990),

Applications Sodium Acetate (2-13c, 99%) (cas# 13291-89-9) is a useful research chemical.

Applications Labelled N-Vanillylnonanamide, a synthetic analogue of Capsaicin (175680) with similar bioactivity. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Turgut, C. et al.: Environ. Sci. Pollut. Res., 11, 7 (2003); Xu, Q. et al.: Environ. Toxicol., 20, 467 (2005);

Applications The acidic inactive labelled metabolite of Metoprolol. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Erhardt, et al.: J. Med. Chem., 25, 1408 (1982), Bodor, N., et al.: Pharmaceutical Res., 3, 120 (1984),

Applications Labelled D-Ribose (R417500). D-Ribose is produced by microorganism fermentation of glucose in a fermentation culture medium without adding calcium carbonate. References Ostrowski, S., et al.: Science, 305, 71 (2004), Vavilin, D., et al.: Biochim. Biophys. Acta, 1708, 91 (2005), Fletcher, J., et al.: Anal. Chem., 79, 2199 (2007), Weissleder, R., et al.: Nature, 452, 580 (2008),

Stability Hygroscopic Applications Antineoplastic. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Ross, W.C.J., et al.: Biochem. Pharmacol., 13, 969 (1964); Donelli, M.G., et al.: J. Pharm. Pharmacol., 18, 760 (1966), Furner, R.L., et al.: Cancer Treat. Rep., 64, 559 (1980),

Stability Hygroscopic Applications A labelled metabolite of Epinephrine (E588585). A naturally occurring derivative of Epinephrine, found together with Metanephrine in urine and in certain tissues. References Eisenhofer, G., et al.: J. Clin. Endocrinol. Metab., 82, 3864 (1997), Akiyama, T., et al.: Cardiovasc. Res., 49, 78 (2001), Burke, W., et al.: Brain Res., 891, 218 (2001),

Applications rac-Clopidogrel-d3 Hydrogen Sulfate is the labeled analogue of rac-Clopidogrel Hydrogen Sulfate (C587248), which is used in the synthesis of Clopidogrel derivatives as platelet aggregation inhibitors. References Chen, J., et. al.: Hecheng Huaxue, 18, 586 (2010)

Applications 17beta-Estradiol-16,16,17-d3 3-Benzoate (CAS# 1192354-74-7) is a useful isotopically labeled research compound.

Applications Perampanel-d5, is the labeled analogue of Perampanel (P285520), an antiepileptic drug. References Shih, J., et al.: Therap. Clinical Risk Management, 9, 285 (2013); Rogawski, M. A., et al.: Epilepsy Curr., 11, 56 (2011);

Applications Coronene-d12 is deuterium labelled Coronene, a polycyclic aromatic hydrocarbon found in smoked fish. It can also be utilized to develop fluorescent sensors that detect the presence of nerve agent mimic. References Dale, T. and Rebek, J.: J. Am. Chem. Soc. 128, 4500 (2006); Mihlca, G. L., et al.: J. Agroliment. Process. Technol., 17, 392 (2011); Zitka, O., et al.: Int. J. Electrochem. Sci., 7, 908 (2012); Rogge, W.F., et al.: Anal. Bioanal. Chem., 401, 3069 (2011);

Applications Serotonin 5-HT3 receptor antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV). Antiemetic. References Clark, R.D., et al.: J. Med. Chem., 36, 2645 (1993), Wong, E.H.F., et al.: Br. J. Pharmacol., 114, 851 (1995), Grunberg, S.M., et al.: Expert. Opin. Pharmacother., 4, 2297 (2003), Eisenberg, P., et al.: Ann. Oncol., 15, 330 (2004), Siddiqui, M.A.A., et al.: Drugs, 64, 1125 (2004),

Applications 2-(2-Iodophenyl-d4)-N,N-dimethylacetamide is an intermediate in the synthesis of Diclofenac-d4 (D436452); the labeled analogue of Diclofenac (D436450); a nonsteroidal anti-inflammatory compound an decycloxygenase (COX) inhibitor. References Kenny, J. R., et al.: J. Med. Chem., 47, 2816 (2004); Sasaki, A., et al.: J. Pharmacol. Sci., 108, 266 (2008); Dalvie, D., et al.: Chem. Res. Toxicol., 22, 357 (2009)

Applications A labelled metabolite of 5-Fluorouracil (F596000). References Bocci, G., et al.: Eur. J. Clin. Pharmacol., 58, 593 (2002), Longley, D.B., Nature Rev. Cancer, 3, 330 (2003), Fischel, J., et al.: Anti-Cancer Drugs, 15, 969 (2004)

Applications 3-(Methoxy-d3)-L-tyrosine Hydrochloride, is the labeled analogue of 3-(Methoxy)-L-tyrosine, which is a levodopa (D533751) metabolite, that can be used for the treatment of Parkinson's Disease. References Fennoy, L. V., et al.: J. Org. Chem., 26, 4696 (1961); Nyholm, D., et al.: AAPS Journal, 15, 316 (2013);

Applications Labelled analogue of Mono(5-carboxy-2-ethylpentyl) Phthalate, a metabolite of Bis(2-ethylhexyl) Phthalate (DEHP) (B433850). References Engel, S. et al.: NeuroToxicol., 30, 522 (2009); Hernandez-Diaz, S. et al.: Environ. Health Perspectives, 117, 185 (2009); Berman, T. et al.: Environ. Int., 35, 353 (2009);

Applications Lumefantrine-d9, is the labeled analogue of Lumefantrine (L474000), which Inhibits hemozoin formation, used as Antimalarial. References Kumar, N., et al.: Parasitol Res., 76, 214 (1990), Pradines, B., et al.: Antimicrob. Agents Chemother., 43, 418 (1999), Chotivanich, K., et al.: J. Infect. Dis., 182, 629 (2000), Mutabingwa, T., et al.: Lancet, 365, 1474 (2005),

Stability Hygroscopic Applications β-Nicotyrine-d3, is the labeled analogue of β-Nicotyrine (N445002), which is an alkaloid derived from the dehydrogenation of nicotine and its analog, nornicotine. An alkaloid occurring in cigaret smoke. References Swain, M.L., et al.: J. Am. Chem. Soc., 71, 1341 (1949);

Applications Bisphenol A-3,3',5,5'-d4 (CAS# 347841-41-2) is a useful isotopically labeled research compound.

Applications Hexaflumuron-D3 is an isotope labeled compound of Hexaflumuron (H293885). Hexaflumuron is an benzoylphenylurea based chitin synthesis inhibitor used against Ephestia figulilella. References Sun, C.X., et al.: Bull. Environ. Contamin. Toxicol., 89, 868 (2012); Khajepour, S., et al.: J. Insect. Sci., 12, 102 (2012);