Miscellaneous Organic Molecules with Isotopical Substitutions

Applications Di-n-decyl Phthalate-3,4,5,6-d4 (CAS# 1276197-18-2) is a useful isotopically labeled research compound.

Applications Useful for diagnostic determination of Melamine and related compounds in kidney tissue. References Mast, R., et al.: Food Chem. Toxicol., 21, 807 (1983), Yokley, R., et al.: J. Agric. Food Chem., 48, 3352 (2000), Ehling, S., et al.: Food Addit. Contam., 24, 1319 (2007), Vail, T., et al.: J. Anal. Toxicol., 31, 304 (2007),

Applications Dabigatran-d7, is the labeled analogue of Dabigatran (D100090), Nonpeptide, direct thrombin inhibitor. Antithrombotic. References Hauel, N., et al.: J. Med. Chem., 45, 1757 (2002), Mungall, D., et al.: Curr. Opin. Invest. Drugs, 3, 095 (2002), Stangier, J., et al.: J. Clin. Pharmacol., 45, 555 (2005),

Applications Chlordimeform-d6 is the isotope labelled analog of Chlordimeform (C327060); an unique insecticide and acaricide that displays synergistic effects and was detected in Spanish commercial beeswax. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Ahmed, M.A.I., et al.: J. Med. Entomol., 49, 1405 (2012); Serra-Bonvehi, J., et al.: Pest Manag. Sci., 66, 1230 (2010)

Applications Isotope labelled Diethyl Oxalate is used in the synthesis of novel indole β-diketo acid derivatives as HIV-1 integrase inhibitors. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Sechi, M., et al.: J. Med. Chem., 47, 5298 (2004);

Applications Labelled Mebendazole (M200500). Anthelmintic (Nematodes). References Al-Badr, A.A., et al.: Anal. Profiles Drug Subs., 16, 291 (1987)

Applications Labelled Dihydroisoferulic Acid 3-O-β-D-Glucuronide, the glucuronide conjugate of Dihydroisoferulic Acid (H946365). Dihydroisoferulic Acid 3-O-β-D-Glucuronide is a minor circulating metabolite in human plasma after ingestion of coffee and can be used as a biomarker of coffee consumption. References Fumeaux, R. et al.: Org. Biomol. Chem., 8, 5199 (2010); Stalmach, A. et al.: Drug Metab. Disp., 37, 1749 (2009);

Applications Coumarin anticoagulant. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Hagan, E.C., et al.: J. Am. Pharm. Assoc. Sci. Ed., 42, 379 (1953), Bell, R.G., et al.: Biochemistry, 11, 1959 (1972), Valente, J.E., et al.: J. Med. Chem., 20, 1489 (1977), Back, N., et al.: Pharmacol. Res. Commun., 10, 445, (1978), Babhair, S.A., et al.: Anal. Profiles Drug Subs., 14, 423 (1985), Takahashi, H., et al.: Echizen, Clin. Pharmacokinet., 40, 587 (2001),

Applications Bisphenol E-d12 is an isotope labelled analog of Bisphenol E-13C6. Bisphenol E is a derivative of Bisphenol A (B519495) which is a monomer used for policarbonate and epoxy resins. References Krishnan, A.V., et al.: Endocrinology, 132, 2279 (1993); Steinmetz, R., et al.: Trends Endocrinol. Metab., 9, 124 (1998); Petersen, H., et al.: Eur. Food Res. Technol., 216, 355 (2003)

Applications Macitentan-d4 is an isotopic form of Macitentan (M105005). Macitentan, is an orally active endothelin receptor antagonist used for pulmonary arterial hypertension. References Emoto, N. Ensho to Men'eki, 20, 487 (2012);

Applications Cyclizine-d3 (N-methyl-d3) (CAS# 1170155-67-5) is a useful isotopically labeled research compound. This compound can be used to treat cancer using heat-shock protein inhibitors (HSP90) in combination with antineoplastic compounds and immunotherapeutic agents. References Haggerty, T., et.al., PCT Int. Appl., 172,(2012);

Applications Labelled Zephirol. Quaternary ammonium composition to treat herpes, pseudomonas, staph, hepatitis and other infectious diseases. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Berr, S., et al.: J. Phys. Chem., 91, 4760 (1987), Jones, M., et al.: Eur. J. Pharm. Biopharm., 48, 101 (1999), Okano, L., et al.: Langmuir, 16, 3119 (2000),

Applications Glucocorticoid; antipsoriatic. References Pearlman, R., et al.: Int. J. Pharm., 18, 53 (1984), Neufeld, E., et al.: J. Chromatogr., 718, 273 (1998),

Stability Hygroscopic Applications A labelled metabolite of Valproic acid. References Rudy, A., et al.: J. Pharmacol. Exp. Ther., 259, 1133 (1991), Nagai, K., et al.: J. Antimicrob. Chemother., 39, 295 (1997), Yamamura, N., et al.: Drug Metab. Dispos., 27, 724 (1999)

Applications A labelled metabolite of Ciclopirox. References Kellner, H.M., et al.: Arzneim.-Forch., 31, 1337 (1981),

Applications Mandelic Acid-13C8 is C13 labelled Mandelic Acid which is used as an antiseptic (urinary). It is also used as a short-term exposure biomarker in urine from styrene exposed workers. References Pessela, B., et al.: Enzyme Microb. Technol., 40, 310 (2007); Carrasco-Lopez, C., et al.: J. Biol. Chem., 284, 4365 (2009); Fustinoni, S., et al.: Toxicol. Lett., 192, 40 (2010)

Applications 12-Hydroxylauric-d20 Acid is the labeled analogue of 12-Hydroxylauric Acid (H943775), which is used in the structural and functional characterization of S-nitrosoglutathione reductase from Solanum lycopersicum. References Kubienova, L., et. al.: Biochimie, 95, 889 (2013)