Miscellaneous Organic Molecules with Isotopical Substitutions

Applications Labelled Dihydroisoferulic Acid 3-O-β-D-Glucuronide, the glucuronide conjugate of Dihydroisoferulic Acid (H946365). Dihydroisoferulic Acid 3-O-β-D-Glucuronide is a minor circulating metabolite in human plasma after ingestion of coffee and can be used as a biomarker of coffee consumption. References Fumeaux, R. et al.: Org. Biomol. Chem., 8, 5199 (2010); Stalmach, A. et al.: Drug Metab. Disp., 37, 1749 (2009);

Applications Coumarin anticoagulant. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Hagan, E.C., et al.: J. Am. Pharm. Assoc. Sci. Ed., 42, 379 (1953), Bell, R.G., et al.: Biochemistry, 11, 1959 (1972), Valente, J.E., et al.: J. Med. Chem., 20, 1489 (1977), Back, N., et al.: Pharmacol. Res. Commun., 10, 445, (1978), Babhair, S.A., et al.: Anal. Profiles Drug Subs., 14, 423 (1985), Takahashi, H., et al.: Echizen, Clin. Pharmacokinet., 40, 587 (2001),

Applications Bisphenol E-d12 is an isotope labelled analog of Bisphenol E-13C6. Bisphenol E is a derivative of Bisphenol A (B519495) which is a monomer used for policarbonate and epoxy resins. References Krishnan, A.V., et al.: Endocrinology, 132, 2279 (1993); Steinmetz, R., et al.: Trends Endocrinol. Metab., 9, 124 (1998); Petersen, H., et al.: Eur. Food Res. Technol., 216, 355 (2003)

Applications Macitentan-d4 is an isotopic form of Macitentan (M105005). Macitentan, is an orally active endothelin receptor antagonist used for pulmonary arterial hypertension. References Emoto, N. Ensho to Men'eki, 20, 487 (2012);

Applications Cyclizine-d3 (N-methyl-d3) (CAS# 1170155-67-5) is a useful isotopically labeled research compound. This compound can be used to treat cancer using heat-shock protein inhibitors (HSP90) in combination with antineoplastic compounds and immunotherapeutic agents. References Haggerty, T., et.al., PCT Int. Appl., 172,(2012);

Applications Labelled Zephirol. Quaternary ammonium composition to treat herpes, pseudomonas, staph, hepatitis and other infectious diseases. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Berr, S., et al.: J. Phys. Chem., 91, 4760 (1987), Jones, M., et al.: Eur. J. Pharm. Biopharm., 48, 101 (1999), Okano, L., et al.: Langmuir, 16, 3119 (2000),

Applications Glucocorticoid; antipsoriatic. References Pearlman, R., et al.: Int. J. Pharm., 18, 53 (1984), Neufeld, E., et al.: J. Chromatogr., 718, 273 (1998),