Miscellaneous Organic Molecules with Isotopical Substitutions

Applications Labelled Perphenazine. D2 dopamine receptor antagonist; α-adrenergic receptor antagonist and σ-receptor agonist; phenothiazine antipsychotic. Inhibits glutamate dehydrogenase in vitro. Antipsychotic. References Gaertner, H.J., et al.: Drug Metab. Dispos., 3, 437 (1975), O Brien, S., et al.: J. Med. Chem., 48, 1287 (2005), Briggs, K., et al.: Toxicology, 231, 113 (2007), Toga, T., et al.: J. Pharmacol. Sci., 105, 207 (2007),

Applications Labelled Chlorpromazine (C424750). Used as an antiemetic; antipsychotic. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Anden, N.-E., et al.: Eur. J. Pharmacol., 11, 303 (1970), Curzon, G., et al.: Trends Pharmacol. Sci., 11, 61 (1990),

Stability Hygroscopic Applications (±)-Mevalonolactone-4,4,5,5-d4 (CAS# 349553-98-6) is a useful isotopically labeled research compound.

Applications Labelled analogue of Testosterone Cypionate, an anabolic steroid with androgenic properties. Testosterone Cypionate is used for testosterone therapy in males with hypogonadism. Controlled Substance. References Rabkin, J.G., et al.: J. Clin. Psychopharmacol., 19, 19 (1999); Hajjar, R., et al.: J. Clin. Endocrinol. Metab., 82, 3793 (1997); Rhoden, E., et al.: J. Sex Med., 7, 277 (2010);

Applications Mixed β-adrenergic blocker and serotonin 5HT1A-receptor antagonist. Antihypertensive; antianginal; antiarrhythmic; antiglaucoma. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Dreshfield, L.J., et al.: Neurochem. Res., 21, 557 (1996), Perez, V., et al.: Lancet, 349, 1594 (1997),

Applications Sethoxydim is a neuroplastin isoforms, a member of Ig superfamily. It is expressed and important in stereocilia of outer hair cells function. Also, it is derived from Crotonaldehyde (C818650), which is an αβ-unsaturated aldehyde and an alkylating agent that is commonly found in tobacco smoke and some foods. Crotonaldehyde is also a known mutagen and carcinogen. References Zeng, W., et al.: J. Neurosci., 36, 9201-9216 (2016); Scherer, G., et al.: Hum. Exp. Toxicol., 26, 37 (2007); Zhang, S., et al.: Chem. Res. Toxicol., 19, 1386 (2006)

Applications A labelled metabolite of Atomoxetine. References Creighton, C.J., et al.: Bioorg. Med. Chem. Lett., 14, 15, 4083 (2004)