Miscellaneous Organic Molecules with Isotopical Substitutions

Applications A labelled metabolite of Carnitine used in diagnostic screening of patients with inherited disorders of fatty acid oxidation. References Johnson, D.W. et al.: Chem. Phys. Lipids, 129, 161 (2004);

Applications Labelled Deshydroxyethoxy Ticagrelor analog of Ticagrelor (T437700) an antiplatelet agent, and preventative in the treatment of heart attacks, myocardial infarction, and other pulmonary diseases. References Zhang, H. et al.: Bioorg. Med. Chem. Lett., 22, 3598 (2012);

Applications Cytidine-1',2',3',4',5'-13C5 is the isotope labelled analogue of Cytidine (C998300), a constituent of nucleic acids. References Parrou, J., et al.: Anal. Biochem., 248, 186 (1997), Phipps, A., et al.: Xenobiotica, 28, 527 (1998), Mohler, R., et al.: Anal. Chem., 78, 2700 (2006),

Applications Labelled analogue of Tildipirosin, a novel 16-membered-ring macrolide used in veterinary medicine. Tildipirosin treat bacterial pathogens including Mannheimia haemolytica and Pasteurella multocida that cause respiratory tract infections in cattle and swine. References Rose, M. et al.: J. Vet. Pharmacol. Ther., (2012); Anderson, N.M. et al.: Antimicrob. Agents. Chemother., (2012);

Applications Isotope Labelled Formaldehyde (F691350), used in various organic synthesis and reactions. It is used in the textile industry in the area of crosslinking molecules to vary the properties of cotton fabrics (1). It can help improve the water resistance of biodegradable collagen films (2). In the food industry it is used to reinforce and improve packaging of meats and produce. Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References 1. Liang, T. et al.: Text Res. J. 1992 Sep:62(9) 547-5512. Sommer, I. et al.: J. Appl. Polym. Sci. 2012 Sept:125(S2) ppE27-41