Deuterated Compounds

Applications Pyruvic Acid-13C2 is an intermediate in synthesizing L-Lactic Acid-d3 Sodium Salt (L113503), a labelled sodium salt of L-Lactic Acid (L113500). L-Lactic Acid occurs in small quantities in the blood and muscle fluid of man and animals. The lactic acid concentration increases in muscle and blood after vigorous activity. L-(+)-Lactic acid is also present in liver, kidney, thymus gland, human amniotic fluid, and other organs and body fluids. References Wenzel, A., et al.: J. Neurosci., 21, 53 (2001); Martinez., et al.: Development, 6, 851 (2002); Nakayama, K., et al.: J. Biochem., 146, 757 (2009); Tanaka, T., et al.: J. Pharmacol. Sci., 109, 24 (2009)

Applications N-Boc-piperazine-d8 is a useful synthetic intermediate for the preparation of labelled compounds.

Applications 1-Bromo-3-chloro-5-fluorobenzene-d3 (CAS# 1219805-00-1) is a useful isotopically labeled research compound.

Applications Propane-1,3-diylbis((3-acetamidopropyl)carbamic Acid) di-tert-Butyl Ester-d6 is an isotope labelled intermediate in the synthesis of derivatives of Spermine (S680510) which is a biogenic polyamine formed from Spermidine (S680400) that occurs in almost all tissues. References Theoharides, T.C., et al.: Life Sci., 27, 703 (1980); Horn, Y., et al.: Cancer Res., 42, 3248 (1982)

Applications Indole-3-Acetic-d2 Acid (cas# 24420-86-8) is a useful research chemical.

Applications tert-Butyl-d9 Methyl Ether (CAS# 1219795-06-8) is a useful isotopically labeled research compound.

Applications A bactericide detected in rivers and lakes. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Lindstrom, A., et al.: Environ. Sci. Technol., 36, 2322 (2002)

Applications Butoxy-d9-acetic Acid (CAS# 669720-55-2) is a useful isotopically labeled research compound.

Applications O,O-Di(Ethyl-d5)phosphate Sodium Salt is labelled Diethyl Phosphate Sodium Salt (D444720) which is used in a cosmetic composition for treating keratin materials, for example, keratin fibers such as the hair.

Applications Labeled D-Mannitol is widespread in plants and plant exudates; obtained from manna and seaweeds. D-Mannitol is used in the food industry as anticaking and free-flow agent, flavoring agent, lubricant and release agent, stabilizer and thickener and nutritive sweetener. References Pigman, W., et al.: The Carbohydrates, 249 (1957), Makkee, M., et al.: Chem. Commun., 930 (1980),

Applications 1,3,5-Tris(3-chloro-2-hydroxypropyl)-1,3,5-triazine-2,4,6(1H,3H,5H)-trione-d15 is an intermediate for the synthesis of Triglycidyl Isocyanurate-d15 (T793817). Isotope labelled Triglycidyl isocyanurate is a reagent used in the synthesis of N-Benzyl Metaxalone (B285000), which is a muscle relaxant used to relax muscles and relieve pain. References Toth, P.E., et al.: Clin. Ther., 26, 1355 (2004)

Applications N-Ethylaniline-d5 is labelled N-Ethylaniline (E899362) which is a versatile organic building block used for the synthesis of various pharmaceutical and biologically active compounds. It can be used for the synthesis of benzenesulfonamides as inhibitors of microsomal prostaglandin E2 synthase 1 (mPGES-1) in mice and in humans as potential anti-inflammatory agents. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Hanke, Th., et al.: Biorg. Med. Chem., 21 (24), 7874 (2013)

Applications 3-Nitro-1-pyrenol is an nitroarene which may contribute to genotoxicity associated with air pollution. This is the labeled analog. References Kameda, T., et al.: J. Health. Sci., 57, 372 (2011); Van, B., et al.: Chem. Biol. interact., 117, 15 (1999);

Applications Synaptamide-d4 is labelled Synaptamide (S910000) which is an endocannabinoid-like derivative of docosahexaenoic acid with cannabinoid-independent function. It has potent synaptogenic activity and structural similarity to anandamide. Synaptamide (S910000) is subjected to hydrolysis by fatty acid amide hydrolase, and can be oxygenated to bioactive metabolites. References Kim, H., et al.: Prostaglandins Leukot Essent Fatty Acids, 88, 121 (2013); Burstein, S., et al.: Bioorg. Med. Chem., 16, 9644 (2008); Fu, J., et al.: J. Biol. Chem., 282, 1518 (2007)

Applications 1,2,3,5-Tetra-O-acetyl β-D-Ribofuranose-13C5 is an intermediate used in the synthesis of Ribavirin-13C5 (R414477), which is a labeled Rivavirin. Purine nucleoside analog; inhibits inosine monophosphate dehydrogenase (IMPDH). Used as an antiviral agent.This compound is suitable for pyruvate dehydrogenase (PDH) related research. References Fernandez, H., et al.: Eur. J. Epidemiol., 2, 1 (1986), Liao, H.J. and Stollar, V.: Antiviral Res., 22, 285 (1993), Honda, Y., et al.: Antimicrob. Agents Chemother., 38, 653 (1994), Reichard, O., et al.: Lancet, 351, 83 (1998)

Applications A labelled Wittig reagent for Horner-Wadsworth-Emmons olefination References Sugiura, M., et al.: Chem. Pharm. Bull., 37, 1039 (1989), Grimes, K., et al.: ChemMedChem, 3, 1936 (2008),

Applications 1-Hydroxyadamantane-d15 (CAS# 33830-11-4) is a useful isotopically labeled research compound. This compound can be used to treat viral diseases. References Atkinson, J., et.al., Can., 16, (1971);

Applications 2,6-Dichlorobenzamide-3,4,5-d3 (CAS# 1219804-28-0) is a useful isotopically labeled research compound.

Applications Phenelzine-d5 Sulfate (phenyl-d5) (CAS# 1219798-40-9) is a useful isotopically labeled research compound.

Applications A labelled metabolite of a mixed disulfide S-(N,N-diethyldithiocarbamoyl)-N-acetyl-L-cysteine (AC-DDTC), an antimutagenic mixed disulfide from disulfiram. References Madan, A., et al.: Drug Metab. Dispos., 23, 1153 (1995), Lambert, D., et al.: J. Med. Chem., 48, 5059 (2005), Tsuboi, K., et al.: J. Biol. Chem., 280, 11082 (2005),

Applications Indoramin-d5 (phenyl-d5) (CAS# 57165-41-0) is a useful isotopically labeled research compound. This compound can be used for detecting drugs and their metabolites in biological specimens using gas chromatography-mass spectrometry. References Draffan, G., et.al., Adv. Mass Spec., 6,245-250,(1974);

Applications Sodium Acetate-d3, is the labeled analogue of Sodium Acetate, the sodium salt of acetic acid, with a wide range of uses. Sodium Acetate is used in the textile industry to neutralize sulfuric acid waste streams, and as a photoresist while using aniline dyes. Sodium Acetate may be added to foods as a seasoning. References Clayden, j., et al.: Org. Chem., 1st ed. (2001);

Applications 1-Dodecan-d25-ol, is the labeleld isptope of Dodecanol, that can be used to make surfactants, lubricating oils,and pharmaceuticals, such as Brij L23-d25 (P688277). References Richard Stephenson and James Stuart, "Mutual Binary Solubilities: Water-Alcohols and Water-Esters", J. Chem. Eng. Data, 1986, 31, 56-70

Applications Tetramethyl-d12-ammonium Bromide (CAS# 284474-82-4) is a useful isotopically labeled research compound.

Applications 2,5-Furandicarboxylic Acid-13C6 is isotopically labelled analogue of 2,5-Furandicarboxylic Acid (F863750), which is Furan (F863650) derivative that can be produced from biomass derived sugars using catalytic processes. References Tong, X., et al.: Appl. Catal., A, 385, 1 (2010);

Applications Diphenyl-d20-borinic Anhydride is the labeled analogue of Diphenylborinic Anhydride (D487370), which is used as a photopolymerization co-initiator. References Santos, W.G., et. al.: 89, 1362 (2013)

Applications 2-Bromopropane-1,1,1,2-d4 (CAS# 1219799-22-0) is a useful isotopically labeled research compound.

Applications 4-Chlorophenyl-1,2-epoxybutane-d5 (cas# 1189717-28-9) is a compound useful in organic synthesis.

Applications 1-Iodopentane-5,5,5-d3 (CAS# 920502-31-4) is a useful isotopically labeled research compound.

Applications Sodium n-Decyl-d21 Sulfate (CAS# 933826-83-6) is a useful isotopically labeled research compound.

Applications N-Methylaminophthalimide-d3 is the labeled analogue of N-Methylaminophthalimide (M287295), which is used in the preparation of 2:1-[α/aza]-oligomer precursors. References Abbas, C., et. al.: Tetrahedron Lett., 50, 4158 (2009)

Stability Volatile Applications Isotope labelled Acetonitrile is used as a polar aprotic solvent in organic synthesis. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Hu, H.H., et al.: Phy. Chem. Phys., 15, 7666 (2013); Kim, J.Y., et al.: J. Mater. Chem. A., et al.: 1, 5982 (2013);