Deuterated Compounds

Vitamin D2-D6 is a dietary supplement that comes in the form of an oil. It is an ionizable vitamin and is structurally similar to Vitamin D3. The most common form of this vitamin is cholecalciferol, which is found in fish oils and dairy products. Vitamin D2-D6 has been shown to be efficacious at increasing mineralization in skin cells, as well as preventing symptoms of rickets. This nutrient also assists with calcium metabolism and the absorption of dietary calcium. It can be taken by infants or adults who may have low levels of Vitamin D due to a lack of exposure to sunlight or ingestion of a poor diet.

Stability Hygroscopic Applications Isotope labelled analogue of Guanosine (G837900), a constituent of nucleic acids. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Miles, et al.: Science, 142, 1458 (1963), Bugg, et al.: Biochem. Biophys. Res. Commun., 3, 436 (1968),

Applications 2,4-Dichlorobenzoic-d3 Acid (CAS# 1398065-99-0) is a useful isotopically labeled research compound.

Applications Ethynyl-2-13C-benzene, is the labeled analogue of Ethynylbenzene (E932150), which is an aromatic hydrocarbon, is important in the petrochemical industry as an intermediate in the production of styrene, which in turn is used for making polystyrene, a common plastic material. References Xiang, J., et al.: Tetrahedron Lett, 37, 5269 (1996);

Applications Nitroethane-d5 (CAS# 57817-88-6) is a useful isotopically labeled research compound.

Applications 5-Hydroxy-7-methoxy-2,2-dimethyl-4H-benzo[d][1,3]dioxin-4-one-d3 is an intermediate for the synthesis of Alternariol Monomethyl Ether-d3 (A575771), labelled methyl este analog fo Alternariol. An alternaria mycotoxin and genotoxin, found in common edible crops. It inhibits the activity of various DNA-topoisomerases, increasing the rate of DNA strand breaks. References Asam, S., et al.: J. Agric. Food Chem., 57, 5152 (2009); Fehr, M., et al.: Mol. Nut. Food Res., 53, 441 (2009); Tiemann, U., et al.: Toxicol. Lett., 186, 139 (2009)

Applications The microwace spectra of Dichloroacetic Acid-d1 consists of many weak absorption lines. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Van Zoeren, E., et al.: J. Mol. Struct., 97, 315-322 (1983);

Applications 6-Methyl-5-hepten-2-one-1,1,1,3,3-d5 is an intermediate used in the synthesis of Geraniol-D5 (G367003), which is a deuterium labelled analog of Geraniol, which is used in the synthesis of insect repellant. It is also used in the synthesis of Angelicoin A and Herecinone J, which inhibit collagen-induced platelet aggregation. References Barnard, D. et al.: J. Med. Entomol., 41, 726 (2004); Mori K. et al.: Phytomedicine, 17, 1082 (2010);

Applications Triphenylamine-d15 (CAS# 880462-20-4) is a useful isotopically labeled research compound.

Applications Nonanoic-6,6,7,7-d4 Acid (CAS# 1219795-27-3) is the labelled version of n-Nonanoic Acid (N649385(P)), which is commonly used in conjunction with glyphosate, a non-selective herbicide, for a quick burn-down effect in the control of weeds in turfgrass. It is also used in the preparation of plasticizers and lacquers. References Pline, W., et al.: Weed Technol., 14, 667 (2000); Frade, J., et al.: Anal. Bioanal. Chem., 395, 2167 (2009);

Applications p-Tolyl-d7 Isocyanate (CAS# 1219798-59-0) is a useful isotopically labeled research compound.

Applications A labelled antibacterial agent. References Kind, T., et al.: Anal. Biochem., 363, 185 (2007), Spratlin, J., et al.: Clin. Cancer Res., 15, 431 (2009),

Please enquire for more information about 2-(Methyl-13C)-5-nitro(imidazole-2-13C-1,3-15N2)-1-ethanol including the price, delivery time and more detailed product information at the technical inquiry form on this page

Applications Dihydro-3-(3-pyridoyl)-2-(3H)-furanone-d4 is an intermediate in the synthesis of 1-(3-Pyridyl-d4)-1,4-butanediol (P992504). 1-(3-Pyridyl-d4)-1,4-butanediol is the labeled analogue of 1-(3-Pyridyl)-1,4-butanediol (P992500), a metabloite of NNK (M325750), a carcinogen that readily produces cancer in rats and hamsters. References Koenigs, L., et al.: Drug Metab. Dispos., 25, 1407 (1997); Gu, J., et al.: Toxicol. Appl. Pharmacol., 165, 158 (2000); Jalas, J., et al.: Chem. Res. Toxicol., 18, 95(2005); Zhu, L., et al.: Drug Metab. Dispos., 34, 1672(2006)

Applications (±)-Tetrahydro-2-furoic-d7 Acid (CAS# 1219798-42-1) is a useful isotopically labeled research compound.

Applications (±)-(1-Bromoethyl-2,2,2-d3)benzene (CAS# 23088-42-8) is a useful isotopically labeled research compound.

Applications N'-[(2-Chloro-5-thiazolyl)methyl]-N-nitro-carbamimidothioic Acid Methyl Ester-13C is an intermediate used in the synthesis of Clothianidin-d3,13C1(C588502), which is the isotope labelled analog of Clothianidin. Clothianidin is a neonicotinoid insecticide for use in food crops. References Kamel, A., et al.: J. Agric. Food Chem., 58, 5926 (2010), Lynd, L., et al.: Energy Environ. Sci., 3, 1150 (2010), Cresswell, J., et al.: Ecotoxicology, 20, 149 (2011),

Applications Isotope labelled Quinoline (Q700380), which is a starting material that may be transformed by bacteria and fungi to produce intermediates useful for the synthesis of drugs. Used in the synthesis of tertiary alcohol modulators of RORγ (1) which appears to have various biological functions. Also derivatives of quinoline have been seen to promote anticancer, antibacterial and antiviral activity, however quinoline itself is often seen as an environmental contaminant (2,3).Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants. References 1. Kummer, D. et al.: Bioorg. Med. Chem. Lett. 2017 Feb 21.2. Ramirez-Prada, J. et al.: Eur J Med Chem. 2017 Mar 16;131:237-254.3. Mestankova, H. et al.: Water Res. 2016 Apr 15;93:110-20

p-Cresol-2,3,5,6-d4 is a metabolite of p-cresol. It is produced by the intestinal microflora of humans and animals. This compound has been detected in urine samples of patients with liver disease and in the feces of healthy human volunteers. p-Cresol-2,3,5,6-d4 is an aromatic amino acid that can be synthesized from toluene or by hydroxyation of an aromatic amino acid by escherichia coli. The enzyme responsible for this reaction is called phenylalanine hydroxylase.

Stability Hygroscopic, Light Sensitive, Temperature Sensitive Applications 3-Deoxyglucosone-13C6, is the labeled anologue of 3-Deoxyglucosone (D239150), an intermediate in the Maillard reaction of proteins with glucose, which is metabolised to 3-Deoxyfructose. An intermediate in the formation of pyrraline, which might contribute to a pathological effect, such as carcinogenesis. References Kato, H. et al.: Agric. Biol. Chem., 51, 683 (1987), Hayase, F. et al.: J. Biol. Chem., 264, 3758 (1989), Kato, H. et al.: Biochimica et Biophysica Acta, 1035, 71 (1990)

Applications Intermediate in the preparation of labelled α-Carboline derivatives

Applications 1,3-Propane-d6-diamine, Dihydrochloride is used in the study of trimethylsilylated di and polyamine and their isotopically labelled analogs. References Smith, R. G., et al.: J. Org. Chem., 43, 2178 (1978)

Applications 2-(1-Oxo-2(1H)-naphthalenylidene)-hydrazinecarboxamide-d4 is labelled 2-(1-Oxo-2(1H)-naphthalenylidene)-hydrazinecarboxamide (N359270) which is a novel anti-anflammatory agent as well as an anti-proliferative agent due to its 1,2-napthoquinone substructure. References Marrero-Ponce, Y. et al.: Eur. J. Med. Chem., 46, 5736 (2011);

Applications L-Alanine-d7 (CAS# 74280-71-0) is a useful isotopically labeled research compound.

Applications 2-Bromoethyl-4-nitrophenyl Ether-d4 (cas# 1190017-10-7) is a compound useful in organic synthesis.

Applications D-Mannose is a carbohydrate that is important in the glycosylation of molecules in a variety of cellular processes. It is involved in N and O glycosylation of bovine why protein products, used in infant formulas. It is also responsible for the O-glycosylation of the T helper cell-derived cytokine interlukin-17A, an important cell-signaling molecule. This is the labeled analog. References Van Leeuwen, S. et al.: J. Agri. Food Chem., 60, 12553 (2012); Geoghegan, K. et al.: Prot. Express. Purif., 87, 27 (2013);

Applications A labelled imidazole, a versatile heterocycle used in the preparation of various biologically active compounds such as the amino acid histidine and is present in many antifungal medication. It is also used extensively as a corrosion inhibitor on transition metals such as copper. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Arispe, N. et al.: Biophys. J., 95, 4879 (2008); Troesken, E.R. et al.: Endo. Res., 30, 387 (2004); Otmacic Curkovic, H. et al.: Corr. Sci., 51, 2342 (2009);

Applications An anticonvulsant, hypnotic. A labelled metabolite of Mephentoin.A representative lot was 85% d5; 15% d4 1% d3 with no detectable d0. References Karlaganis, G., et al.: Drug Metab. Dispos., 8, 173 (1980), Knabe, J., et al.: Arch. Phar., 313, 538 (1980),

Applications Iodoethane-1-d1 (CAS# 3652-81-1) is a useful isotopically labeled research compound.

Applications 2-(2-Aminoethoxy)anisole-d3 (cas# 1189881-28-4) is a compound useful in organic synthesis.

Applications n-Hexyl 4-Methyl-2-pentyl Phthalate, is the labeled analogue of n-Hexyl 4-Methyl-2-pentyl Phthalate (H297165), a phthalic acid ester (PAEs), widely used in many consumable products with potential carcinogenic properties. References Wang, Zh., et al.: Guocheng Gongcheng Xuebao, 5 (6), 670 (2005);