Deuterated Compounds

Applications Talaporfin-13C4-15N is labelled Talaporfin which is a photosensitizer used in photodynamic therapy. References Yoshinori, N., et al.: Photochem. Photobio., 85, 714 (2009); Gomer, C., et al.: Cancer Res., 56, 2355 (1996)

Applications (±)-Tetrahydro-2-furoic-d7 Acid (CAS# 1219798-42-1) is a useful isotopically labeled research compound.

Applications Dihydro-3-(3-pyridoyl)-2-(3H)-furanone-d4 is an intermediate in the synthesis of 1-(3-Pyridyl-d4)-1,4-butanediol (P992504). 1-(3-Pyridyl-d4)-1,4-butanediol is the labeled analogue of 1-(3-Pyridyl)-1,4-butanediol (P992500), a metabloite of NNK (M325750), a carcinogen that readily produces cancer in rats and hamsters. References Koenigs, L., et al.: Drug Metab. Dispos., 25, 1407 (1997); Gu, J., et al.: Toxicol. Appl. Pharmacol., 165, 158 (2000); Jalas, J., et al.: Chem. Res. Toxicol., 18, 95(2005); Zhu, L., et al.: Drug Metab. Dispos., 34, 1672(2006)

Applications (±)-(1-Bromoethyl-2,2,2-d3)benzene (CAS# 23088-42-8) is a useful isotopically labeled research compound.

Applications Phenylboronic Acid-13C6 is the isotope labelled 13C6 analog of Phenylboronic Acid (P319590); a compound used in the organic synthesis of various pharmaceutical goods. References Ainley, A.D., et al.: J. Chem. Soc., 2171 (1930)

Applications Isotope labelled Quinoline (Q700380), which is a starting material that may be transformed by bacteria and fungi to produce intermediates useful for the synthesis of drugs. Used in the synthesis of tertiary alcohol modulators of RORγ (1) which appears to have various biological functions. Also derivatives of quinoline have been seen to promote anticancer, antibacterial and antiviral activity, however quinoline itself is often seen as an environmental contaminant (2,3).Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants. References 1. Kummer, D. et al.: Bioorg. Med. Chem. Lett. 2017 Feb 21.2. Ramirez-Prada, J. et al.: Eur J Med Chem. 2017 Mar 16;131:237-254.3. Mestankova, H. et al.: Water Res. 2016 Apr 15;93:110-20

p-Cresol-2,3,5,6-d4 is a metabolite of p-cresol. It is produced by the intestinal microflora of humans and animals. This compound has been detected in urine samples of patients with liver disease and in the feces of healthy human volunteers. p-Cresol-2,3,5,6-d4 is an aromatic amino acid that can be synthesized from toluene or by hydroxyation of an aromatic amino acid by escherichia coli. The enzyme responsible for this reaction is called phenylalanine hydroxylase.

Applications Decanoic-2,2-d2 Acid (CAS# 62716-49-8) is a useful isotopically labeled research compound.

Phenol-d6 is a chemical compound that can be used for wastewater treatment. It is a high molecular weight compound that is soluble in water and does not dissolve in organic solvents. Phenol-d6 is used to remove chloride from wastewater, which results from the reaction of chlorine with organic compounds. The functional groups on phenol-d6 react with the chloride ions, forming insoluble hydrochloric acid, which precipitates from the solution. Phenol-d6 has been shown to bind to muscle proteins and has been used as a model for studying muscle reactions. Phenol-d6 also reacts with activated intermediates, such as nitrite and nitrate, in order to form stable products that are easier to analyze. Phenol-d6 also has vibrational properties and can be ionized by electron capture or mass spectroscopy.

Applications Isotope labelled Isopropyl DL-Mandelate is used in nonporous silica/alumina amorphous material. Pregabalin (P704800) impurity. References Wang, Z. et al.:; ACS Catal., 3, 1573 (2013);

Stability Hygroscopic, Light Sensitive, Temperature Sensitive Applications 3-Deoxyglucosone-13C6, is the labeled anologue of 3-Deoxyglucosone (D239150), an intermediate in the Maillard reaction of proteins with glucose, which is metabolised to 3-Deoxyfructose. An intermediate in the formation of pyrraline, which might contribute to a pathological effect, such as carcinogenesis. References Kato, H. et al.: Agric. Biol. Chem., 51, 683 (1987), Hayase, F. et al.: J. Biol. Chem., 264, 3758 (1989), Kato, H. et al.: Biochimica et Biophysica Acta, 1035, 71 (1990)

Applications 1,1-Dimethylethyl 4-(2-Hydroxyethyl)piperazine-1-carboxylate-d4 is an isotope labelled intermediate in the synthesis of labelled Flupentixol. References Panteleev, J., et al.: Synlett., 26, 953 (2015); Liang, Y.K., et al.: Euro. J. Med. Chem., 84, 505 (2014);

Applications N'-[(2-Chloro-5-thiazolyl)methyl]-N-nitro-carbamimidothioic Acid Methyl Ester-13C is an intermediate used in the synthesis of Clothianidin-d3,13C1(C588502), which is the isotope labelled analog of Clothianidin. Clothianidin is a neonicotinoid insecticide for use in food crops. References Kamel, A., et al.: J. Agric. Food Chem., 58, 5926 (2010), Lynd, L., et al.: Energy Environ. Sci., 3, 1150 (2010), Cresswell, J., et al.: Ecotoxicology, 20, 149 (2011),

Applications Intermediate in the preparation of labelled α-Carboline derivatives

Applications N-Methyl Lacosamide-d3 is the labeled analogue of N-Methyl Lacosamide (M315210), a methly analogue of Lacosamide (L098500), a medication used for the adjunctive treatment of partial-onset seizures and diabetic neuropathic pain. Lacosamide is a potent anticonvulsant. References Lees, G., et al.: Brain Res., 612, 190 (1993), Kuo, C., et al.: Mol. Pharmacol., 51, 1077 (1997); Barton, M., et al.: Epilepsy Res., 47, 217 (2001); Beyreuther, B., et al.: Eur. J. Pharmacol., 539, 64 (2006); Beyreuther, B., et al.: CNS Drug Rev., 13, 21 (2007)

Applications 1,3-Propane-d6-diamine, Dihydrochloride is used in the study of trimethylsilylated di and polyamine and their isotopically labelled analogs. References Smith, R. G., et al.: J. Org. Chem., 43, 2178 (1978)

Applications Cyanamide-13C (cas# 21420-35-9) is a compound useful in organic synthesis. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications 2-(1-Oxo-2(1H)-naphthalenylidene)-hydrazinecarboxamide-d4 is labelled 2-(1-Oxo-2(1H)-naphthalenylidene)-hydrazinecarboxamide (N359270) which is a novel anti-anflammatory agent as well as an anti-proliferative agent due to its 1,2-napthoquinone substructure. References Marrero-Ponce, Y. et al.: Eur. J. Med. Chem., 46, 5736 (2011);

Applications Isotope labelled Isonipecotic Acid Methyl Ester is a an ester derivative of 4-piperidinecarboxylic acid used as a reagent in the organic synthesis of neurochemicals, antibacterials and other biologically active compounds. References Kim, E.-K. et al.: Yak. Hoechi, 48, 182 (2004); Tanitame, A. et al.: Bioorg. Med. Chem. Lett., 14, 2857 (2004);

Applications L-Alanine-d7 (CAS# 74280-71-0) is a useful isotopically labeled research compound.

Applications Nandrolone Octanoate-d15 is the isotope analog of Nandrolone Octanoate. Nandrolone Octanoate is a metabolite of nandrolone (N315000), which is an anabolic steroid. References Gradeen, C., et al.: J. Anal. Toxicol., 14, 120 (1990), Teale, P., et al.: Biol. Mass Spectrom., 20, 109 (1991), Yamada, M., et al.: J. Pharm. Biomed. Anal., 45, 125 (2007), Yamada, M., et al.: J. Anal. Toxicol., 32, 387 (2008),

Applications 3,5-Dimethylphenol-2,4,6-d3,OD (CAS# 1219803-59-4) is a useful isotopically labeled research compound.

Applications Used as an insecticide. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications 2-Bromoethyl-4-nitrophenyl Ether-d4 (cas# 1190017-10-7) is a compound useful in organic synthesis.

Applications Labelled Sulfamonomethoxine. Protein binding. Inhibitor of enzyme. Sulfamonomethoxine and Trimethoprim are used for treating porcine unknown hyperpyrexia. References Bridges, et al.: Biochem. J., et al.: 96, 829 (1965), Hong, Y.-L., et al.: Antimicrob. Agents Chemother., 39, 1756 (1995)

Applications D-Mannose is a carbohydrate that is important in the glycosylation of molecules in a variety of cellular processes. It is involved in N and O glycosylation of bovine why protein products, used in infant formulas. It is also responsible for the O-glycosylation of the T helper cell-derived cytokine interlukin-17A, an important cell-signaling molecule. This is the labeled analog. References Van Leeuwen, S. et al.: J. Agri. Food Chem., 60, 12553 (2012); Geoghegan, K. et al.: Prot. Express. Purif., 87, 27 (2013);

Applications A labelled imidazole, a versatile heterocycle used in the preparation of various biologically active compounds such as the amino acid histidine and is present in many antifungal medication. It is also used extensively as a corrosion inhibitor on transition metals such as copper. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Arispe, N. et al.: Biophys. J., 95, 4879 (2008); Troesken, E.R. et al.: Endo. Res., 30, 387 (2004); Otmacic Curkovic, H. et al.: Corr. Sci., 51, 2342 (2009);

Applications D-Cellobiose-13C12 is the isotope labelled analogue of D-Cellobiose (C255000), a disaccharide consisting of two glucose in a beta 1-4 linkage. References Yang, S.Q.. et al.: Carbo. Poly., 92, 784 (2013);

Applications Iodoethane-1-d1 (CAS# 3652-81-1) is a useful isotopically labeled research compound.

Stability Hygroscopic Applications Tiglylcarnitine-d3 is labelled Tiglylcarnitine (T793780), a long-chain fatty ester of carnitine which is accumulated and released into the circulation, in fatty-acid oxidation defects. Pattern of Tiglylcarnitine can be diagnostic for a number of ß-oxidation defects. References Adams, S., et al.: J. Nutrition, 139, 1073 (2009); Ventura, F., et al.: Clinica Chimica Acta, 281, 1 (1999); Pourfarzam, M., et al.: Clinical Chem,, 40, 2267 (1994); Schaefer, J., et al.: Pediatric Res., 37, 354 (1995)

Applications An anticonvulsant, hypnotic. A labelled metabolite of Mephentoin.A representative lot was 85% d5; 15% d4 1% d3 with no detectable d0. References Karlaganis, G., et al.: Drug Metab. Dispos., 8, 173 (1980), Knabe, J., et al.: Arch. Phar., 313, 538 (1980),

Applications 2,4-Dihydroxybenzophenone-d5 is deuterium labelled of 2,4-Dihydroxybenzophenone (D451780), which is a metabolite of Benzophenone (B204980). Benzophenone can be used to synthesize antihistamines, hypnotics and insecticides. References Li, M.H., et al.: Toxicol. Environ. Chem., 94, 566 (2012); Leon, Z.. et al.: Anal. Bioanal. Chem., 398, 831 (2010); Bechard, K., et al.: Aquat. Toxicol., 90, 310 (2008)

Applications Anthracene-d10 is an isotope labelled analogue of Anthracene (A678400), an polycyclic aromatic hydrocarbon found readily as an component in coal tar. Anthracene is also used in the preparation of various dyes. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications n-Hexyl 4-Methyl-2-pentyl Phthalate, is the labeled analogue of n-Hexyl 4-Methyl-2-pentyl Phthalate (H297165), a phthalic acid ester (PAEs), widely used in many consumable products with potential carcinogenic properties. References Wang, Zh., et al.: Guocheng Gongcheng Xuebao, 5 (6), 670 (2005);

Applications Labelled Aldicarb (A514650). Aldicar is used as an insecticide. Used in Pesticide detection. References Ashby, J., et al.: Environ. Mutagen., 7, 919 (1985), Ashby, J., et al.: Mutat. Res., 257, 229 (1991), Kazius, J., et al.: J. Med. Chem., 48, 312 (2005), Benigni, R., et al.: Mutagenesis, 25, 335 (2010),

Applications 2-(2-Aminoethoxy)anisole-d3 (cas# 1189881-28-4) is a compound useful in organic synthesis.

Stability Very Hygroscopic Applications Labelled Sodium Trifluoroacetate, a compound used as an intermediate for various pharmaceutical, agricultural and chemical applications.

Applications 4'-Chloroacetophenone-2',3',5',6'-d4 (CAS# 284474-50-6) is a useful isotopically labeled research compound.