Nicotine and Nicotine Derivatives

AZD-8529 mesylate is a highly selective, and orally bioavailable positive allosteric modulator of mGluR2 (EC50: 285 nM).

Applications (R)-Anabasine is a minor tobacco alkaloid from Nicotiana tabacum that is known to have nicotinic receptor agonist activity. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Lee, S.T., et al.: Neurotoxicol. Teratol., 28, 220 (2006); Ayers, J.T., et al.: AAPS J., 4, E752 (2005)

Applications (S)-Anabasine is a nicotinic receptor agonist. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Keeler, R., et al.: Clin. Toxicol., 12, 49 (1978); Aceto, M., et al.: J. Med. Chem., 22, 17 (1979); Brand, J., et al.: J. Chem. Ecol., 19, 1315 (1993)

Stability Hygroscopic Applications Labelled (R,S)-Anatabine is a metabolite of Nicotine (N412420). Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Quan, P.M., et al.: J. Org. Chem., 30, 2769 (1965), Maciuk, A., et al.: J. Pharm. Biomed. Anal., 48, 238 (2008),

Applications Sorbicillin analog. A bioactive secondary metabolites from terrestrial Streptomyces species TN262. References Ma, L. et al. : J. Anitibiot. 64, 645 (2011); Elleuch, L. et al.: Appl. Biochem. Biotech. 162, 579 (2010)

Stability Light Sensitive Applications Labelled (RS)-Nornicotine (N757000). (RS)-Nornicotine is a tobacco alkaloid and the major Nicotine (N412420) metabolite in brain. Nornicotine appears to activate different nAChR subtypes, has a better pharmacokinetic profile, and produces less toxicity than Nicotine. Nornicotine shows a significant analgesic activity. References Hecht, S., et al.: Carcinogenesis, 9, 875 (1988), Rivenson, A., et al.: Cancer Res., 48, 6912 (1988), Hoffmann, D., et al.: Chem. Res. Toxicol., 14, 767 (2001), Kool, J., et al.: J. Med. Chem., 49, 3287 (2006), Kool, J., et al.: Drug Metab. Dispos., 35, 640 (2007),