Antibiotics

A broad-spectrum antibiotic of macrolide class, which targets 50S ribosomal subunit and inhibits protein synthesis. Erythromycin is widely used in molecular biology and biotechnology as a selection marker. Erythromycin is also an agonist of the motilin receptor, and it has prokinetic activity on the gut.

Stability Hygroscopic Applications Piperacilloic Acid-Piperacillin Dimer Disodium Salt is Piperacillin (P479950) impurity and can be obtained from it. Piperacillin (P479950) is broad spectrum semi-synthetic antibiotic related to Penicillin. Antibacterial. References Takai, A., et al.: Chemotherapy, 25, 816 (1977); Bodey, G.P., et al.: Antimicrob. Agents Chemother., 14, 78 (1978); Kuck, N.A., et al.: J. Antibiot., 31, 1175 (1978);

Cefpiramide acid (Cefpiramidum) is a third-generation cephalosporin antibiotic.

Tunicamycin, inhibits the expression of functional thrombin receptors on human T-lymphoblastoid cells. Also inhibits thrombin-induced Ca2+ mobilization in cells. Also available as a 25 mM solution in DMSO. Antibacterial and antifungal. Blocks the formation of protein N-glycosidic linkages This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Vulgamycin is a novel antibiotic, which is derived from a specific strain of soil bacteria belonging to the genus *Streptomyces*. This microorganism is known for its prolific secondary metabolite production, enabling the development of unique compounds with therapeutic potential. Vulgamycin operates by inhibiting bacterial cell wall synthesis, a mechanism of action that targets key enzymatic pathways, resulting in effective bactericidal activity against a wide range of Gram-positive bacteria. The compound's applications are primarily in the treatment of resistant bacterial infections. Due to its unique mode of action, Vulgamycin is effective in combating strains that have developed resistance to traditional antibiotics. Its use is particularly significant in clinical settings where antibiotic resistance poses a substantial challenge, particularly with pathogens like *Staphylococcus aureus* and *Enterococcus* species. Ongoing research is focused on understanding its full spectrum of activity, optimizing its pharmacokinetics, and evaluating its use in combination therapy to broaden its therapeutic potential.

C16G2 is a Specific Targeted Antimicrobial Peptide (STAMP) that selectively targets the cariogenic oral pathogen Streptococcus mutans. This compound operates by recognizing and disrupting the bacterial cell membrane, leading to small molecule leakage and the loss of membrane potential, which results in bacterial death. Unlike broad-spectrum antimicrobial peptides, C16G2 exhibits higher selectivity and efficacy against Streptococcus mutans.

Sitafloxacin Hydrate (DU-6859a) is a fluoroquinolone antibiotic that shows promise in the treatment of Buruli ulcer.

Applications N-Methylol Minocycline is a derivative of Minocycline Hydrochloride (M344800); a second generation tetracycline antibiotic. Antibacterial. References Zbinovsky, V., et al.: Anal. Profiles Drug Subs., 6, 323 (1977); Oringer, R.J., et al.: J. Periodontol., 73, 835 (2002); Chung, J.Y.L., et al.: Tetrahedron Lett., 49, 6095 (2008)

8-Hydroxyquinoline hemisulfate (Oxyquinoline sulfate) is an antiseptic with mild fungistatic, bacteriostatic, anthelmintic, and amebicidal action

BITC, found in cruciferous veggies, exhibits anticancer, antimicrobial, and immunomodulatory effects.

Actinomycin D is an antibiotic commonly used in chemotherapy for cancer treatment, such as sarcomas, and pediatric solid tumors, Wilm’s tumor, testicular cancer, and choriocarcinoma; it is generally not very useful in antibiotic therapy. It acts as a transcription inhibitor, binding to DNA duplexes at the transcription initiation complex and preventing RNA polymerase elongation.

Avermectin B1a is a macrocyclic lactone disaccharide anthelmintic agent .

Ticarcillin disodium salt is a beta-lactam antibiotic that has in vitro activity against Gram-positive and Gram-negative bacteria. Ticarcillin is active against penicillinase-producing strains of Staphylococcus aureus, Enterobacter aerogenes, Proteus mirabilis, Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae, Serratia marcescens, Streptococcus pyogenes, Streptococcus faecalis, and Streptococcus pneumoniae. Furthermore, it inhibits transpeptidase activity of the cell wall of bacteria which prevents peptidoglycan synthesis. It is bactericidal for many bacteria at low concentrations.

Acetylspiramycin (Spiramycin B) targets 50S ribosome to inhibit protein synthesis.

Inhibitor of DNA replication; aminoglycoside class

Quinocetone is an animal growth promoter and potential anti-tumor activity.

Inhibitor of translation on the 50S subunit at the peptidyltransferase step. (R,R)-Chloramphenicol is widely utilized as an antibiotic, which is used for the treatment of number of bacterial infections and also act as a bacteriostatic. It is often used for bacterial selection in molecular biology applications. It also finds an application in ophthalmic and veterinary purposes. It also protects the mitochondrial and chloroplast protein synthesis and ribosomal formation of (p)ppGpp, de-pressing rRNA transcription. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Stability Very Hygroscopic Applications Clindamycin-13C,D3 Hydrochloride is the labeled analog of Clindamycin (C580000, HCl salt), a semi-synthetic antibiotic prepared from Lincomycin. Antibacterial. References Birkenmeyer, R.D., et al.: J. Med. Chem., 13, 616 (1970); Oesterling, et al.: J. Pharm. Sci., 59, 63 (1970); Gray, J.E., et al.: Toxicol. Appl. Pharmacol., 21, 516 (1972); Brown, L.W., et al.: Anal. Profiles Drug Subs., 10, 75 (1981)

Nanaomycin A, a quinone antibiotic, reactivates cancer suppressor genes and inhibits DNMT3B (IC50=500nM).

Tildipirosin, a veterinary antibiotic, is a 16-membered macrolide that blocks bacterial protein synthesis and biofilm formation.

Impurity Cefalexin EP Impurity F Applications Δ2-Cephalexin (Cefalexin EP Impurity F) is an isomeric impurity of the semi-synthetic antibiotic Cephalexin (C256800). References Marincel, J. et al.: Acta Pharmacol Jugo., 38, 35 (1988); Hendrix, C. et al.: Arck. Pharm., 327, 215 (1994);

Applications A third generation cephalosporin antibiotic for used in veterinary medicine. It is resistant to antibiotic resistance enzyme beta-lactamase. References Donaldson, S.C. et al.: Appl. Environ. Microbiol., 72, 3940 (2006); Yancey, R.J. et al.: Am. J. Vet. Res., 48, 1050 (1987);

Tetracyclines and their derivatives; salts thereof

Roxithromycin is a macrolide antibiotic with action on bacterial protein synthesis by binding to the 50S ribosomal subunit and is used for treating respiratory, skin, and soft tissue infections.

2-Acetyl-2-decarboxamidotetracycline is a tetracycline-class antibiotic. It exhibits a UV absorption spectrum similar to that of tetracycline or 5-oxytetracycline at concentrations above 300 mμ, characteristic of the BCD ring system.