Antibiotics

Kanamycin sulfate (Kanamycin monosulfate) is an aminoglycoside antibiotic. Kanamycin sulfate exhibits antimicrobial effect. Cost-effective and quality-assured.

7-Aminodeacetoxycephalosporanic acid (Cefalexine EP IMpurity B) is used as an antibiotic.

3-Methyl-chuangxinmycin, an antibiotic, inhibits the enzyme responsible for synthesizing tryptophan tRNA (TrpRS), thereby affecting the translation process in both bacteria and mammalian cells. Additionally, it downregulates genes associated with interferon, TNF, and inflammatory responses in RDEB_L1 cells.

Amorolfine hydrochloride (Amorolfine HCl) is an antifungal reagent.

L-Lactic acid: organic, chiral, prevalent in organisms, vital in biochemistry, forms in muscles during exertion.

CORM-401 is an oxidant-sensitive CO-releasing molecule. It can be used in oxidative stress-mediated pathologies and the research of inflammatory.

Broxyquinoline (5,7-Dibromo-8-hydroxyquinoline) is an antiprotozoal agent, and it can release oxygen free radicals from the water in mucous membranes.

Inhibitor of cell-wall synthesis; carbapenem class

Walrycin B is a new-type antibacterial compound targeting the WalR response regulator.

Cefmenoxime hydrochloride is a third-generation cephalosporin antibiotic with action on bacterial cell wall synthesis and is used for treating gynecological and obstetric infections.

D-Cycloserine (RO-1-9213) is an antibiotic for drug-resistant TB, used with other TB drugs.

Zanamivir (GG167) is a guanido-neuraminic acid that is used to inhibit NEURAMINIDASE.

Applications Harman alkaloid like harmane, harmine, harmalol, harmaline obtained from Banisteriopsis caapi L. showed cytotoxicity, antimicrobial activity against Staphylococcus aureus, Escherichia coli, Proteus vulgaris and Candida albicans. References Sigg, E.B., et al.: Arch. Int. Pharmacodyn., 149, 164 (1964), Saano, V., et al.: Acta Pharmacol. Toxicol., 51, 300 (1982), Tse, S., et al.: Biochem. Pharmacol., 42, 459 (1991), Rommelspacher, H., et al.: Eur. J. Pharmacol., 252, 51 (1994), Louis, E., et al.: Neurology, 59, 1940 (2002),

Aminosidine is a nucleoside analogue that inhibits the HIV-1 reverse transcriptase and the integrase, which are enzymes involved in viral DNA synthesis. Aminosidine is active against Leishmania spp., but not against bacteria. Aminosidine has been shown to be effective in experimental models of human bowel disease and in patients with inflammatory bowel disease. It was also found to be active against wild-type strains of human immunodeficiency virus type 1, but not resistant mutants. The mechanism of action is the inhibition of cellular mitochondrial membrane potential.

Applications Cefotiam Dihydrochloride-13C, 15N2 is labelled Cefotiam Dihydrochloride (C243005), which is an antibiotic product used in injections to treat bacterial infections. Cefotiam Dihydrochloride can also reduce allergic reactions and mixed with pharmaceutical carriers for medical formulations. References Jiang, C., et al.: Faming Zhuanli Shenqing, CN 105646539 A, 20160608 (2016); Liu, X.: Faming Zhuanli Shenqing, CN 105193819 A, 20151230, (2015); Weng, Y., et al.: Faming Zhuanli Shenqing, CN 103601737 A. 20140226 (2014)

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Cefoperazone (Medocef) inactivates PBPs, disrupting bacterial cell wall synthesis and division; inhibits rMrp2 [3H]E217βG uptake (IC50: 199 μM).

Stability Temperature sensitive Applications A semi-synthetic antibiotic related to Tetracycline (T291400). Antibacterial. References Andrews, C., et al.: Pharm. Res., 17, 639 (2000), Votano, J., et al.: J. Med. Chem., 49, 7169 (2006), Davis, A., et al.: Curr. Opin. Chem. Biol., 8, 378 (2004),

Kanamycin monosulfate, is used as an aminoglycoside antibiotic. Kanamycin can be used as a selection agent in several types of isolation media.Kanamycin sulfate from Streptomyces kanamyceticus has been used in tissue culture media. Kanamycin sulfate can also be used as a selection agent for cells transformed with kanamycin B resistance gene. It is recommended for use in cell culture applications at 100mg/mL. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Cefotaxime sodium - Sterile grade is a cephalosporin antibiotic, which is derived from the beta-lactam class of antibacterial agents. It effectively disrupts bacterial cell wall synthesis by binding to and inhibiting penicillin-binding proteins, leading to cell lysis and death. This mechanism of action is potent against a variety of Gram-positive and Gram-negative bacteria, making it a valuable tool in clinical settings. Cefotaxime sodium is extensively used in the treatment of severe bacterial infections, including respiratory tract infections, urinary tract infections, skin and soft tissue infections, and septicemia. Its sterile formulation ensures suitability for intravenous administration, providing rapid therapeutic effects in critical situations. This antibiotic is a cornerstone in antimicrobial therapy, often employed when patients present with life-threatening infections or when other treatments have failed. Its broad-spectrum activity and reliable efficacy underscore its significance in combating resistant bacterial strains, making it indispensable in both hospital and clinical environments.

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Stability Hygroscopic Applications Pirlimycin Hydrochloride (Mixture of Diastereomers) is a semi-synthetic lincosaminide antibiotic; structural analog of Clindamycin. Antibacterial. References Ahonkhai, V.I., et al.: Antimicrob. Agents Chemother., 21, 902 (1982); Qadri, S.M.H., et al.: J. Antibiot., 36, 42 (1983); Birkenmeyer, R.D., et al.: J. Med. Chem., 27, 216 (1984);

An alpha-glucosidase inhibitor. Interferes with normal processing of N-linked glycoproteins.(+)-1-Deoxynojirimycin acts as an inhibitor of alfa-glucosidase I and II and maltase-glucoamylase. It also inhibits mammalian glucosidase, intestinal and lysosmal, beta-glucosidase from sweet almonds, pancreatic alfa-amylase and amyloglucosidase. Further, it serves as a enzyme enhancer for the treatment of Fabry and Pompe disease. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Climbazole (BAY-e 6975) is a broad-spectrum imidazole antifungal agent with anti-dandruff benefits.

N-Demethylvancomycin is a glycopeptide antibiotic that can be extracted from Nocardia orientalis and exhibits activity against various strains of Staphylococcus aureus and Staphylococcus epidermidis. It is utilized in research related to infections.

Grepafloxacin is a synthetic fluoroquinolone antibiotic, which is derived from the chemical modification of natural quinolones. It acts by inhibiting bacterial DNA gyrase and topoisomerase IV. This inhibition disrupts DNA replication and transcription in bacteria, leading to cell death. The high affinity of grepafloxacin for these bacterial enzymes over human analogs makes it an effective antibacterial agent, specifically targeting the bacterial replication machinery. Grepafloxacin was primarily used in the treatment of a variety of bacterial infections, including respiratory tract infections, skin infections, and sexually transmitted diseases. Its broad spectrum of activity covers both Gram-negative and Gram-positive bacteria. However, due to concerns regarding its cardiac side effects, including QT interval prolongation, grepafloxacin was withdrawn from the market. Despite this, studying its mechanism of action provides valuable insights into the development and optimization of newer quinolone antibiotics, aimed at balancing efficacy with safety.

It is used as an antibacterial agent. This compound has been shown to be effective in vitro against Staphylococcus intermedius and sensitive mycoplasma organisms. Although a lot of antibiotics tend to suppress the immune system, macrolide antibiotics have been reported to enhance the immune system when used in chicken models. Studies suggest that chronic exposure to this compound may have a negative effect on the respiratory system. For turkeys - for treatment of infectious synovitis and sinusitis. It is effective also for treatment of ileitis, dysentery and necrotic enteritis in swine. It is successfully applied as a preventive measure in stress conditions as vaccinations, transportation and others. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Ketolide; binds bacterial ribosomes and inhibits translation

Sulfadiazine is a sulfonamide antibiotic with action on bacterial folate synthesis inhibition and is used for treating toxoplasmosis and urinary tract infections.

Gentamicin C1a pentaacetate is an aminoglycoside antibiotic derivative, which is synthesized through the acetylation of the hydroxyl groups in gentamicin C1a. This compound is derived from the fermentation products of Micromonospora species, a genus of actinobacteria. Its mode of action is similar to that of standard aminoglycosides, primarily involving the binding to bacterial 30S ribosomal subunits. This binding interferes with protein synthesis by causing misreading of mRNA, ultimately leading to the inhibition of protein production and bacterial cell death. In scientific research, Gentamicin C1a pentaacetate is utilized in studies focusing on antibiotic resistance mechanisms, structure-activity relationships, and the development of new derivative antibiotics. Its modified structure offers opportunities to explore variations in bacterial susceptibility and efflux mechanisms. Understanding such interactions is vital for the design of potent antibiotic candidates and combating resistant bacterial strains. Given the growing concern over antibiotic resistance, studies involving Gentamicin C1a pentaacetate contribute to a broader comprehension of aminoglycoside modifications and their potential applications in clinical and laboratory settings.

Impurity Cefalotin EP Impurity D Applications Deacetylcephalothin Lactone (Cefalotin EP Impurity D) is an impurity in the synthesis of Cefalonium (C236800), a first-generation cephalosporin antibiotic used as a long-acting intramammary cerate for infusion of dairy cows. References Endo, T.: Kach. Kokin. Kenk., 12, 8 (1991); Berry, E.A. et al.: J. Dairy Sci., 90, 760 (2007); Bradley, A.J. et al.: J. Dairy Sci., 93, 1566 (2010); Shibata, K., et al.: J. Antibiot., 50, 135 (1997);

SQ109 (NSC-722041) is an effective inhibitor of the trypomastigote form of the parasite (IC50 = 50 nM). SQ109 is an antitubercular agent and targets MmpL3.

Piromidic acid, an antibacterial, targets gram-negative bacteria and staphylococci; used for urinary and intestinal infections.

Sarubicin B, an active quinone antibiotic isolated from the culture filtrate of the Streptomyces strain (Streptomyces strain) JA 2861, effectively inhibits Gram-positive bacteria while showing ineffectiveness against Gram-negative organisms.