Heterocycles with Sulphur (S)

2,5-Dibromo-3-methylthiophene is a small molecule that has been shown to have anti-bacterial properties. It reacts with the bacterial cell membrane, disrupting the bacteria's ability to function and causing it to die. 2,5-Dibromo-3-methylthiophene can be used as an antibacterial agent in medicine or cosmetics. The chemical structure of 2,5-dibromo-3-methylthiophene is similar to that of oxadiazole and 5H-[1]benzothiazol[5,4,-d][1,2]oxazole and it has been shown that these compounds can also be used for antibacterial purposes. The anti-bacterial activity of 2,5-dibromo-3-methylthiophene is due to its functional groups which are reactive with metal ions such as Cu(II) and Fe(III).

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3-Methylthiophene-2-boronic acid pinacolester is a crystalline compound that is soluble in organic solvents, such as benzene, toluene and chloroform. The mesogenic properties of this material allow it to be used in the fabrication of liquid crystals. 3-Methylthiophene-2-boronic acid pinacolester has a transition temperature of about 135°C, which makes it useful for optical microscopy and as an additive in thermophysical applications. 3-Methylthiophene-2-boronic acid pinacolester also has semiconducting properties and can be used in advances in electronics. It has a high solubility parameter (log σ = -10), which makes it an excellent solvent for organic compounds with low solubility parameters (log σ > 10).

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Dibenzo[b,d]thiophene-4-carbaldehyde is an immunosorbent that binds to hydrocarbons and other aromatic compounds. It is used as a functional derivative in enzyme-linked immunosorbent assay (ELISA), which is used to measure the amount of antibodies or antigens in a sample. Dibenzo[b,d]thiophene-4-carbaldehyde has been shown to be sensitive and efficient for the detection of hydrocarbons. This compound also inhibits the activity of enzymes by binding to their active site, leading to inhibition assays that are used in industrial processes.

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4-Azido-2,3,5,6-Tetrafluorophenyl)-[6-hydroxy-2-(4-hydroxyphenyl)-1-benzothiophen-3-yl]methanone is an unlabeled compound that binds to the estrogen receptor with high affinity and has been shown to inhibit breast cancer cell growth. It is a novel small molecule that can be used for the treatment of hormone receptor positive cancers. The structure of this drug is based on the known antiestrogen clomiphene citrate. The 4AHTFPPM has been radiolabeled with aziridine to form a radiopharmaceutical that can be used for imaging in vivo. This drug can also be labeled with other compounds such as azides or silylating agents for use in affinity labeling experiments.

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2-Propylthiophene is a sulfur-containing organic compound that is used as a desulfurization agent. It has been shown to have interactive effects with fatty acids and can be used in the industrial process of making polymers. 2-Propylthiophene has been shown to deplete glutathione, which may lead to toxicity and inflammatory diseases. The molecule also inhibits autophagy and increases the severity of kidney cell and congestive heart disease. The activation energy for 2-propylthiophene is low, making it easier to study than other molecules with higher activation energies.

3-Methylthiophene-2-carboxylic acid is a chemical compound with the molecular formula C5H8O3. It has been used in the synthesis of pharmaceuticals, agrochemicals, and dyestuffs. 3-Methylthiophene-2-carboxylic acid can be used as an intermediate in organic synthesis. This compound can be injected into mice to study its effects on melanoma cells. The chlorine atom in this molecule is acidic and elutes first when chromatography is performed on it. This compound has three functional groups: a carboxylate group, a methyl group, and a thiophene ring. The carboxylate group is neutral at pH 7 and forms intermolecular hydrogen bonds with other molecules in solution. 3-Methylthiophene-2-carboxylic acid has a molecular weight of 154 grams per mole and a structural formula that consists of six carbon atoms, eight oxygen atoms

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2,5-Dimethylthiophene is a metastable form of 2,5-dimethylthiophenesulfonic acid (DTPS) that can be prepared by hydrolysis or chlorination of 2,5-dimethylthiophene. DTPS is used as an analytical reagent in the detection of fatty acids and chloride ions with high sensitivity. The activation energies for the reaction between DTPS and chloride ions are 25-30 kcal/mol. The reaction mechanism for this process includes nucleophilic attack on the sulfur atom followed by a rearrangement to form a sulfonyl chloride. Reaction products include amines and thiosulfate.

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Dimethyl thiophene-2,5-dicarboxylate is a monomer that is used in the production of polyethylene terephthalate (PET) plastics. It reacts with ethylene to form a cyclohexene ring and two methyl groups. The compound is expressed from the bacterium Acetobacter xylinum and can be prepared by chlorination and butyllithium reduction of dimethyl acetylenedicarboxylate. Dimethyl thiophene-2,5-dicarboxylate has been shown to react with aminophenols to form fluorescent products. This reaction occurs when the aminophenol molecule acts as an acid catalyst, which facilitates the elimination of hydrogen chloride and formation of an ester bond between the aminophenol and dimethyl thiophene-2,5-dicarboxylate. Dimethyl thiophene-2,5-dicarboxylate can

2-Thiophene ethanol is a synthetic compound that reacts with HCl and BF3 to produce 2-thiophene acetic acid. The reaction is carried out in the presence of an acid catalyst. The yield of the reaction depends on the concentration of HCl and BF3, as well as the amount of time allowed for the reaction to occur. The carbonyl group found at C2 in 2-thiophene ethanol can be used as a starting point for introducing other functional groups onto it, such as a chloride group by using ammonolysis. This synthetic route is used in the synthesis of clopidogrel, which is a drug for preventing blood clots.

1-Benzothiophene-3-carbohydrazide (1BZC) is a small molecule that inhibits the growth of cancer cells. It acts by inhibiting the protein kinase pim-1, which is necessary for many cellular processes, including cell proliferation and cell adhesion. 1BZC has been shown to inhibit tumor growth in vivo, as well as in vitro in cancer cell lines and mouse xenografts. The drug has also been shown to disrupt tumor vascularization by targeting the protein vegfr-2. 1BZC has also been shown to be effective against two different human cancers: MDA-MB231 breast cancer cells and MKN45 gastric cancer cells. The drug has anti-proliferative activity against both cell lines and inhibits the growth of MDA-MB231 cells more than MKN45 cells.

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2-Mercaptothiophene is a potent inhibitor of epidermal growth factor (EGF). It has been shown to inhibit the growth of cancer cells in vitro and in vivo. 2-Mercaptothiophene also has potent inhibitory activity against EGF-induced chloride ion currents and membrane depolarization. 2-Mercaptothiophene binds with fatty acids, glutamate, and amines to form tautomers that are inactive in inhibiting EGF. This drug also inhibits the production of prostaglandins, which may play a role in its anti-inflammatory properties.

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5-Chloro-3-methylbenzo[b]thiophene is a chemical compound that is used as an intermediate in the production of other chemicals. It has been shown to be catalytic in oxidation reactions, with a reaction rate of 10,000 times faster than the uncatalyzed reaction. 5-Chloro-3-methylbenzo[b]thiophene also selectively oxidizes one electron at a time, which leads to high selectivity in an oxidation process. The active substance is activated by light or heat and catalyses the transformation of aromatic compounds into benzoic acid derivatives. 5-Chloro-3-methylbenzo[b]thiophene is an enzyme catalyst that accelerates the conversion of phenols to benzoic acid derivatives, such as salicylic acid, which are used in pharmaceuticals and industrial products.

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Ethyl 3-thiophenacetate is a molecule that has been shown to have phase equilibrium assays, combination effect and specific interaction with other molecules. It has been reported that the ethyl 3-thiophenacetate molecule interacts with other molecules by enthalpic interactions. The efficiencies of this molecule in vitro were tested on mammalian cells and it was found to be biodegradable and non-toxic. This molecule also undergoes a reaction called exciton formation, which causes it to emit light when excited.

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Applications 2,4,7-Trimethyldibenzothiophene is found in crude oil and can be used to determine the maturity of the oil. References Hegazi, A.H., et. al.: Polycycl. Aromat. Comp., 24, 123 (2004)

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3-Bromothiophene-4-boronic acid is an organic compound that is used in chemical synthesis. It reacts with a variety of organic and inorganic compounds to form boronate esters. 3-Bromothiophene-4-boronic acid can be used as the catalyst for many different reactions, including the conversion of aryl chlorides to boronic acids. This compound is also reversibly deprotonated by a nonpolar solvent, such as hexane or chloroform. 3-Bromothiophene-4-boronic acid has been shown to be catalytically active when using an iodide or chloride as an oxidant, which may be due to its high electron density on the heteroatom (i.e., boron).

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Octithiophene is a compound that is used in the synthesis of organometallic compounds. It can be used in the fabrication of semiconductor devices, such as solar cells and light-emitting diodes. Octithiophene has been shown to have a photocurrent response to a crystal system that can be oriented in an electric field. The photocurrent response is dependent on the concentration of octithiophene and the orientation of the crystal system. This compound also has a high affinity for cardiac tissue, which may be due to its transport properties. In addition, octithiophene has been shown to reduce acetaldehyde levels in heart tissue and increase the activity of dehydrogenase enzymes.

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3-Decylthiophene is a colorless, crystalline solid with a molecular weight of 160. In the solid state it has a molecular geometry of planar and in the gas phase it has an extended conformation. The compound is soluble in alcohols and ethers and insoluble in water. 3-Decylthiophene has been shown to be a low energy material that exhibits gravimetric analysis due to its presence as monomers and polymers. This polymerization process can be followed by ultraviolet spectroscopy, photoelectron spectroscopy, or analytical chemistry methods such as constant spacing or gel permeation chromatography.

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