Heterocycles with Oxygen (O)

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Applications Tetrahydro-2-furanpropanol is used in organic reactions the synthesis of oxocanes. References Sakamoto, Y. et al.: Org. Lett., 4, 675 (2002); Paquette, L. et al.: J. Am. Chem. Soc., 94, 6760 (1972);

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5-Chloro-2-(3H)-benzofuranone (CBT) is a decarboxylated product of 5-hydroxytryptophan. It is an analog of serotonin and has been shown to be an inhibitor of the reuptake of serotonin, dopamine, and norepinephrine in rat brain synaptosomes. The synthesis of CBT can be achieved through a number of steps that include formylation, molecule formation, and thiazolo ring closure. This compound has been shown to have strong affinity for 5-HT1D receptors and may be useful as a formylation inhibitor or a reuptake inhibitor.

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1,3-Dihydro-5-nitro-isobenzofuran is a chemical compound that is used as a probe for metal cations in biological samples. 1,3-Dihydro-5-nitro-isobenzofuran has been shown to be activated by hydroxide and p-hydroxybenzoic acid, which generate the corresponding nitrite anion and the corresponding hydroxybenzoate anion. This reaction is catalyzed by aerobacter aerogenes. The nitrite anion can be detected with probes labeled with colorants such as phenol red or 2,4-dinitrophenylhydrazine. In this way, 1,3-dihydro-5-nitroisobenzofuran can be used to detect the presence of iron ions in biological samples such as blood or urine.

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2-Methoxyfuran is a furanic compound and an intermediate in the preparation of trifluoroacetic acid. It has been used in the production of dyes, such as 2-methoxy-5-methylbenzaldehyde. The Friedel-Crafts reaction is one of the most widely used methods for converting alkyl halides to alkenes. In this reaction, 2-methoxyfuran is converted to ethyl diazoacetate by reacting with hydrogen over an aluminum chloride catalyst. The ethyl diazoacetate can then be reacted with a variety of electrophiles, including alcohols and phenols, to produce different products. The reaction proceeds via nucleophilic attack on the carbonyl group by the oxygen atom on carbon 2. This stereoselective reaction produces only one enantiomer (the S configuration). 2-Methoxyfuran is also used in asymmetric synthesis via transfer reactions

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Perfluoro(2-butyltetrahydrofuran) is a fluorinated, non-polar organic solvent with a high boiling point. It can be used for thermal expansion measurements of dextran sulfate solutions and in the preparation of cell culture samples prior to histological analysis. The phase transition temperature of perfluoro(2-butyltetrahydrofuran) is 4.6°C, which means that it is liquid at room temperature and can be used as a vehicle to deliver magnetic particles to lung tissue. Perfluoro(2-butyltetrahydrofuran) also has an experimental model for studying the effects of laser ablation on lung cells.

Please enquire for more information about [2-(Dibenzo[b,d]furan-2-yloxy)ethyl]amine hydrobromide including the price, delivery time and more detailed product information at the technical inquiry form on this page

Applications (3aR,7aS)-rel-Hexahydro-1,3-isobenzofurandione is a reagent used in the synthesis of Pregabalin (P704800), a GABA analogue used as an anticonvulsant. Also used to prepare P2X7 receptor antagonists. References Taylor, C.P., at al.: Epilepsy Res., 14, 11 (1993), Field, M.J., et al.: Pain, 80, 391 (1999); Eur. J. Org. Chem., 2013, 4495 (2013); Yang, H. et al.: Chinese. Chem. Lett., 24, 553 (2013);

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Please enquire for more information about 2-[(1E)-2-Nitroprop-1-en-1-yl]dibenzo[b,d]furan including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about Methyl 5-(((4-methylphenyl)sulfonyl)methyl)furan-2-carboxylate including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about 1-(3,5-Di-O-benzoyl-2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-5-iodo-2,4(1H,3H)-pyrimidinedione including the price, delivery time and more detailed product information at the technical inquiry form on this page

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Trans-4-Methylene-2-octyl-5-oxotetrahydrofuran-3-carboxylic acid is a modulator that interacts with focusing and modifying enzymes. It is a synthetic analogue of the natural molecule, 5-hydroxytetrahydrofolate, which has been shown to be an enzymatic inhibitor and anti-cancer drug. Trans-4-Methylene-2-octyl-5-oxotetrahydrofuran-3-carboxylic acid has been shown to inhibit the growth of cancer cells by inhibiting the production of proteins vital for cell division. Trans 4 methylene 2 octyl 5 oxotetrahydrofuran 3 carboxylic acid is being investigated as a possible treatment for cancer globally.

(2R,3R,4S,5R)-2-(6-((2-Hydroxyethyl)amino)-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol (also known as 6-(2-(2'-hydroxyethoxy)ethylamino)-9H-purin-9-ol or Adoxostat), is an organic compound that belongs to the family of purine analogues. It is a potent antioxidant and has anti-inflammatory properties. The compound inhibits the production of reactive oxygen species (ROS) by scavenging free radicals and by inhibiting the activity of enzymes involved in ROS production. The compound also stimulates the production of growth factors and prevents apoptosis. Adoxostat has been shown to be effective in both biochemical and animal studies.

2-Propylfuran is a derivative of furan. It has been observed using a spectrometer that the compound reacts with alginic acid and β-unsaturated aldehydes to form disaccharides. 2-Propylfuran undergoes thermolysis to produce furfural, which is used in the production of certain foods. Furfural also has various health effects, including acting as an antioxidant, mutagen, and carcinogen. 2-Propylfuran may react with water molecules to produce hydrogen peroxide and hydroxyl radicals. It also reacts with aliphatic hydrocarbons to produce β-unsaturated ketones. 2-Propylfuran can react with halogens or other compounds to form a variety of products including alkyl halides, alcohols, amines, haloalkenes, amides, esters, nitriles, nitrosamines, and carboxylic acids.

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3,4-Epoxytetrahydrofuran is an organic compound with the chemical formula C8H8O2. It is a cyclic ether that can be synthesized by the reaction of epichlorohydrin and propylene oxide. The compound has two stereoisomers (R and S) due to the chiral nature of the propylene oxide starting material. 3,4-Epoxytetrahydrofuran is used in the production of acrylonitrile, which is used in the production of plastics. 3,4-Epoxytetrahydrofuran has been shown to have strong inhibitory effects on fungus Penicillium rubrum. This compound also inhibits germination rates in some plants.

6-Hydroxybenzofuran is a prenylated aromatic compound that has been shown to inhibit the activity of dopamine-beta-hydroxylase, an enzyme involved in the synthesis of norepinephrine and epinephrine. The chemical structure of 6-hydroxybenzofuran includes an amino group, a benzene ring and a hydroxyl group. Binding studies have shown that 6-hydroxybenzofuran has an affinity for amino transferases. It also inhibits the enzyme PTP1B, which is involved in the regulation of insulin secretion. In addition, 6-hydroxydbenzofuran has been found to cause neuroprotection by inhibiting the uptake of dopamine into brain cells and reducing oxidative stress.

(2-Butyl-5-nitro-3-benzofuranyl)[4-[3-(dibutylamino)propoxy]phenyl]methanone is a versatile compound that has multiple applications in various fields. It can act as a fluorescent probe for dopamine and other neurotransmitters, making it useful for neurochemical research. Additionally, it has been shown to inhibit the production of tumor necrosis factor-alpha (TNF-α), which is involved in inflammatory processes. This compound is commonly used as a research chemical due to its unique properties. It exhibits esterase activity, making it valuable for studying enzyme kinetics and drug metabolism. Furthermore, it has been used in studies involving trastuzumab, a monoclonal antibody used in cancer treatment, to investigate its pharmacokinetics and plasma levels. The heterocyclic structure of this compound makes it suitable for applications involving electrode materials. It can be incorporated into silicon oxide films or ceramic compositions to enhance their electrical

6-Methoxybenzofuran is a scalable, environmentally friendly and optimized process for the production of 2-hydroxy-4-methoxybenzaldehyde anhydride. The reaction is carried out using chloroacetic acid and chloroacetic anhydride to produce 6-methoxybenzofuran. This compound can be demethylated with sodium methoxide to produce 2-methoxybenzaldehyde, which can be used in the synthesis of other compounds.

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7-Methoxybenzofuran is a benzofuran derivative that has been shown to inhibit phosphodiesterase type 4 (PDE4) and PDE5, which are enzymes involved in the breakdown of cyclic nucleotides. 7-Methoxybenzofuran has potent inhibitor effects on these enzymes, especially at high concentrations. It is possible that this compound may be used as a treatment for asthma since it inhibits the production of inflammatory agents from cells. 7-Methoxybenzofuran has also been shown to have anti-inflammatory properties in animal models. This may be due to its ability to inhibit prostaglandin synthesis by inhibiting phosphodiesterase activity.

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Methyl-5-chloromethyl-2-furancarboxylate is an organic compound that belongs to the class of benzyl ethers. It is a colorless liquid with a strong, unpleasant odor. Methyl-5-chloromethyl-2-furancarboxylate has been shown to be an antiplatelet agent and to inhibit calcium ion influx into platelets, which leads to inhibition of platelet aggregation. It also has sulfhydryl properties and can be used as an antidote for sulfide poisoning. Methyl 5 chloromethyl 2 furancarboxylate is also used in the synthesis of other compounds such as methyl 5 chloromethyl 3 phenoxymethyl 2 furancarboxylate, methyl 5 chloromethyl 4 phenoxymethyl 2 furancarboxylate, and methyl 5 chloromethyl 3 methanethiol 1 furancarboxylate.

Please enquire for more information about Benzofuran-2,5-diboronic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page

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Please enquire for more information about {2-[(2,2-Dimethyl-2,3-dihydro-1-benzofuran-7-yl)oxy]ethyl}amine hydrochloride including the price, delivery time and more detailed product information at the technical inquiry form on this page

2-Methyl-3-furanthiol is a compound with antioxidative properties. It has been shown to inhibit the formation of butyric acid, which is a reactive byproduct of fatty acid synthesis. 2-Methyl-3-furanthiol also inhibits the formation of fatty acids, which are important for cell membrane integrity and signaling. The antioxidant activity of this compound has been demonstrated in model studies using n-hexane as an oxidative agent. 2-Methyl-3-furanthiol may have a synergistic effect with other antioxidants such as butylated hydroxytoluene (BHT). This chemical is not typically used as a food additive but it may be used as an antioxidant in other applications such as in polymers or rubber products.

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3,4-Difluoro-5,5-dimethyl-2(5H)-furanone is an organic compound with the molecular formula CF3SO2. It is a sulfide complex that contains a carbonyl group and a carbonyl. This compound reacts with copper ions to form copper complexes such as Grignard reagents and fluoride ion. 3,4-Difluoro-5,5-dimethyl-2(5H)-furanone has been used in the synthesis of spirocyclic sulfides, alkoxides, and hydroxy compounds.

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Dantrolene is an experimental model for malignant hyperthermia, a rare genetic condition that can cause muscle rigidity and death. Dantrolene has been shown to inhibit the activity of the dinucleotide phosphate (NADH) dehydrogenase enzyme in muscle cells. In addition, it inhibits calcium release from the sarcoplasmic reticulum and activates ryanodine receptors. Dantrolene also inhibits muscle contractions and prevents neuronal death by inhibiting the release of glutamate.

4-Methyl-3a,4,7,7a-tetrahydro-2-benzofuran-1,3-dione is a racemic benzofuran analogue

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Applications 6-Chloro-1-benzofuran-2-carboxylic Acid is used to prepare cis-diaminocyclohexane derivatives as factor Xa inhibitors. It is also used to synthesize tachykinin NK2 receptor antagonists. References Bioorg. Med. Chem., 17, 8206 (2009); Gensini, M., et al.: ChemMedChem, 5, 65 (2010)

Applications Benzofuran-3(2H)-one is a useful research chemical, an intermediate used in the catalytic asymmetric synthesis of chiral benzofuranones. References Li, Y., et al.: Adv. Synth. Catal., 356, 1172 (2014); Huang, Z., et al.: Org. Lett., 19, 3524 (2017)

Dibenzo[b,d]furan-4-carbaldehyde is a reactive molecule that belongs to the group of aldehydes. It is an intermediate in the reaction between methanol and sodium methoxide. Dibenzo[b,d]furan-4-carbaldehyde reacts with electron-deficient molecules such as phenols or alkenes to form new compounds. This compound has been shown to have a dihedral angle of about 90°.