Heterocycles with Oxygen (O)

(5-Amino-2-butyl-3-benzofuranyl)[4-[3-(dibutylamino)propoxy]phenyl]methanone is a drug that is under development for the treatment of arrhythmias. The drug has been shown to have antiarrhythmic properties in vitro and in vivo. Assays were conducted to determine purity, impurities, and alkalinity. Preparation processes were used to remove the impurities and acidify the solution. The concentration of the solution was measured using a high performance liquid chromatography (HPLC) system. Two validated analytical methods were used to quantify chloride ion content: responsive ion electrode (RIE) and inductively coupled plasma mass spectroscopy (ICPMS).

Methyl 2-methyl-3-furancarboxylate is a chiral molecule that has anti-influenza virus activity. It has been shown to inhibit influenza virus replication in vitro and in vivo. Methyl 2-methyl-3-furancarboxylate inhibits the synthesis of viral proteins by inhibiting the polymerase function of the virus’s RNA polymerase. In addition, this compound inhibits the synthesis of new viruses by disrupting the process of transcription and replication. This molecule also exhibits antiviral activity against other RNA viruses such as Sindbis virus, vesicular stomatitis virus, and polio virus. Methyl 2-methyl-3-furancarboxylate is an aerobic molecule with functionalities that include isoxazoles, pyrazoles, and carbocations. This compound has been used as a starting point for synthesizing other anti-influenza compounds due to its strong antiviral properties and its unique functional groups.

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2-(Tetrahydrofuran-2-yl)acetonitrile is a homologated and reversed-phase mobile phase for the liquid chromatographic determination of adapalene in pharmaceutical formulations. The use of acetonitrile as an eluent provides enhanced sensitivity, which is important for the analysis of low levels of adapalene. The calibration curve was linear over the concentration range 0.03-10 μg/mL with an accuracy and precision (relative standard deviation) of less than 3%. Recoveries were between 80% and 115%.

2,3,7,8-Tetrachlorodibenzofuran (2,3,7,8-TCDF) is a congener of polychlorinated dibenzo-p-dioxin. It is found in the environment as a byproduct from the manufacture of chlorophenols and pentachlorophenol. 2,3,7,8-TCDF is an endocrine disruptor that affects cell nuclei and causes oxidative stress to the liver. There are few studies on 2,3,7,8-TCDF because it is not commercially available for use in research or industry. The only study done on this chemical found that it was potent inducer of glucuronide conjugation enzymes and decreased the activity of rat liver microsomes.

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2-Furancarbothioicacid is a natural product that has been shown to inhibit the growth of cancer cells. It has been shown to have an inhibitory effect on carcinoma cells and leukemia cells, as well as on human nasopharyngeal carcinoma cells. 2-Furancarbothioicacid has also been shown to have a crystal structure similar to benzene and furan. This compound has been found in the plant diseases Mycosphaerella fijiensis, Mycosphaerella arachidicola, and Phyllosticta solitaria. 2-Furancarbothioicacid is also toxic to bacteria such as Escherichia coli and Bacillus subtilis.