Heterocycles with Oxygen (O)

Applications (R)-2-(Benzyloxy)-5-((5-oxotetrahydrofuran-2-yl)methyl)phenyl Neopentyl Sulfate is an intermediate in the synthesis of metabolite of (-)-Epicatechin (E582260).

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Applications 5-Fluorobenzofuran-3-one

2-Methyl-3-(methylthio)furan is an antiproliferative compound. It has been shown to inhibit the growth of cancer cells in vitro at optimal conditions. The antiproliferative effect was determined by a number of techniques, including reaction system and food chemistry. 2-Methyl-3-(methylthio)furan reacts with carbon source such as maltol to form volatile compounds, which are detected using gas chromatography-mass spectrometry (GC-MS). The volatile compounds were identified using GC-MS analysis and headspace analysis. The temperature range for the reaction was between 40°C and 60°C, while the reaction time was around 20 minutes at 50°C.

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Hexahydro-1H-4,6-ethenocyclopropa[4,5]benzo[1,2-c]furan-1,3(3aH)-dione is a cyclohexane anhydride that has been used as a precursor to other organic compounds. It is formed by the condensation of hexahydrobenzene with ethylene oxide. Hexahydro-1H-4,6-ethenocyclopropa[4,5]benzo[1,2-c]furan-1,3(3aH)-dione can be crystallized in several different forms depending on the conditions and solvent used for its synthesis. Hexahydro-1H-4,6-ethenocyclopropa[4,5]benzo[1,2-c]furan-1,3(3aH)-dione has been

2-Methyl-2,5-dimethoxy-2,5-dihydrofuran is a furan compound that can be synthesized from methanol. The hydrolytic reaction of 2-methyl-2,5-dimethoxyfuran with hydrochloric acid provides 2,5-dimethoxyphenethylamine and 2,5-dimethoxybenzaldehyde. The synthesis of racemates starts by reacting the corresponding racemic acid with an alcohol in the presence of an acid catalyst to produce the enantiomers. This process can be carried out using either hydrolysis or electrolysis as a means of separating the stereoisomers. Hydrolysis is accomplished by adding water to a mixture containing the racemic acid and alcohol in an organic solvent such as benzene or chloroform. In this reaction, one half of the ester group reacts with water to form a carboxylic acid and an alcohol. The

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Applications 2-(4-Hydroxybutoxy)tetrahydrofuran is an impurity of Poly(butylene terephthalate) and a by-product of 1,4-Butanediol. References Rafler, G., et al.: Acta Polymerica, 39, 661 (1988);

2,3-Dihydrobenzofuran-5-carboxaldehyde (DBF) is an aldehyde that has been synthesised with high resistance to the mitochondria. DBF inhibits the mitochondrial membrane potential and induces necrotic cell death in staphylococcus. Mitochondrial membrane potential is essential for the production of ATP by oxidative phosphorylation and is crucial for bacterial growth. DBF has inhibitory effects on P. aeruginosa and chalcones have also shown antimycobacterial activity.

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2,5-Dibromofuran is a synthetic chemical that is synthesized from acetonitrile and palladium-catalyzed cross-coupling reaction. It can be obtained by the reaction of sodium in anhydrous form with bromine and subsequent evaporation to dryness. 2,5-Dibromofuran has been shown to reversibly react with chloride at room temperature for one hour, which can be attributed to its electron withdrawing properties. The FTIR spectra of 2,5-dibromofuran show bands corresponding to carbonyl and hydroxyl groups. This chemical has been used in synthesis methods involving surfactants and anhydrous sodium chloride as well as uv irradiation.

5-Methoxybenzofuran-2-carboxylic acid is a formylation reagent that is used to synthesize amides. It can be prepared through the reaction of furan with formic acid and methanol. 5-Methoxybenzofuran-2-carboxylic acid can also undergo a solvolysis using tetrahydrofuran as a solvent. This compound has been shown to react with serine protease at temperatures below 100°C and form an amide. It is soluble in organic solvents such as tetrahydrofuran, benzene, and dioxane.

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Applications Methyl 4-Bromofuran-2-carboxylate is used to prepare pyrimidinamines and pyridinamines as adenosine receptor modulators for treatment of CNS disorders. References Borroni, E., et al.; PCT Int. Appl., WO 2001062233 A2 20010830 (2001)

5-(3-Trifluoromethyl-Phenyl)-Furan-2-Carbaldehyde is an antioxidant that inhibits the formation of reactive oxygen species. It is synthesized by condensing acetophenone with methylene in the presence of an azide and a propenoic acid. This compound has been shown to have antioxidant activity, as seen in its ability to inhibit the oxidation of malononitrile. 5-(3-Trifluoromethyl-Phenyl)-Furan-2-Carbaldehyde is used as a light stabilizer in plastics and rubbers, and has also been used for the synthesis of pharmaceuticals, including acetaminophen.

Applications 5-Formylfuran-2-boronic Acid Neopentyl Glycol Ester is a useful reagent in lapatinib synthesis. References Radl, S., et al.: PCT Int. Appl. (2014), WO 2014059956 A1

7-Bromo-5-methylbenzofuran is a carbene that can be used as a starting material for the synthesis of other chemicals. It is an intermediate in the transition metal catalyzed, mechanistic study of the pyrolysis and cyclization of esters. 7-Bromo-5-methylbenzofuran undergoes a six-membered ring formation to form two different products, depending on which reaction conditions are present. The mechanism for this process has been studied using computational methods.

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3-Acetyl-3-chlorodihydrofuranone is a synthetic chemical with the molecular formula C8H4ClO2. It is a chlorinating agent that reacts with styrene to form an epoxide. 3-Acetyl-3-chlorodihydrofuranone can be used as medicine or as a stabilizer in the production of other medicines. The use of 3-acetyl-3-chlorodihydrofuranone in the synthesis of prothioconazole has been well documented.

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Dronedarone is a cardioselective antiarrhythmic agent that has been used as a treatment for atrial fibrillation and atrial flutter. It is insoluble in water and most organic solvents. Dronedarone crystallizes from petroleum ether, chloroform, or benzene as needles of mp 188°C.

2,3-Dihydrobenzofuran-5-sulfonyl chloride is a chemical compound that has been shown to inhibit the enzymatic activity of hydrolase. It has been shown to be effective in catalytic and medicinal analyses. 2,3-Dihydrobenzofuran-5-sulfonyl chloride has also been shown to have pharmacological properties and is capable of inhibiting the production of cytokines by creating reactive oxygen species. This product can be used as a model for mutational profiling, which is an important technique in chemical biology.

(E)-2-(1,6,7,8-Tetrahydro-2H-indeno[5,4-b]furan-8-ylidene)ethylamine is an inhibitor that is optically active. It is a crystalline solid with a high purity and yield that can be industrially produced by catalytic asymmetric synthesis. The reaction temperature for the reaction is usually between 60°C and 120°C. The product of this process is an optically active crystal that can be used as a catalyst in industrial processes. No byproducts are formed during the reaction.

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3-Amino-2-methoxy-dibenzofuran (3AMD) is a cytotoxic agent that is used in the treatment of bladder carcinoma. 3AMD inhibits DNA synthesis, leading to cell death by inhibiting the production of proteins vital for cell division. 3AMD has been shown to be a potent inhibitor of cyclen-dependent kinases and to induce DNA damage in human cells. 3AMD also has significant cytotoxicity against malignant cells and has been shown to inhibit the growth of tumours in mice. 3AMD may have carcinogenic potential due to its structural similarity with other carcinogens such as aniline and aminobiphenyl.

2-Ethyl-3-methylbenzofuran is an aromatic compound that is a derivative of benzofuran. It is prepared by reacting benzaldehyde with ethyl acetate and iodomethane. The cyclization reaction proceeds by the intramolecular addition of the ester to the carbonyl followed by acid-catalyzed hydrolysis. This reaction also yields chlorides, which are used in the preparation of 2-ethyl-3-methylbenzofuran. 2-Ethyl-3-methylbenzofuran can be acylated with various acids to produce different derivatives, such as acid chlorides and esters. A zinc powder or titanium tetrachloride will catalyze this reaction. The reactant ketoester undergoes refluxing with trichloride to produce 2-ethyl-3-methylbenzofuran.

Furan-2-acrolein is a reaction product of furfuryl alcohol and acrolein. Furan-2-acrolein has been synthesized as an intermediate for the production of 2,5-furandione, which is used in the manufacture of dyes and pharmaceuticals. The optimal conditions for this reaction are a temperature range from 130 to 140°C and a pH range from 7 to 9. Furan-2-acrolein is bacteriostatic due to its steric interactions with bacterial enzymes and its ability to inhibit proton transfer reactions that are essential for bacterial growth. This compound also has functional groups that can be modified by chemical reactions, such as amination reactions. Furan-2-acrolein may also have potential applications in magnetic resonance spectroscopy.br>br> Furan-2-acrolein is produced by reacting furfuryl alcohol with acrolein. The optimal conditions for this reaction

6-Fluoro-9-beta-D-Ribofuranosyl-9H-Purine (6FdRP) is a metabolite of cisplatin, an anticancer agent. Cisplatin is used in the treatment of various types of cancer. 6FdRP inhibits DNA synthesis by competitively binding to the active site of thymidylate synthase, which is responsible for the production of thymidine from deoxyuridine monophosphate. This drug also inhibits cellular protein synthesis and can produce teratogenic effects in infants if administered during pregnancy. 6FdRP has been shown to inhibit cardiac cells at frequencies below those that cause malformation.

Applications 4-carbamoylfuran-2-carboxylic acid (cas# 1315367-95-3) is a useful research chemical.

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2,5-Dimethylfuran is a furan derivative that has been used as an alternative biofuel. It has a high kinetic stability and can be produced from biomass such as wheat straw or corn stover. 2,5-Dimethylfuran could be used in the production of biofuels to replace gasoline and other fossil fuels. It is also an efficient thermal insulator with low thermal expansion and excellent heat resistance. 2,5-Dimethylfuran has been shown to have toxicological effects on rats, but it does not appear to be carcinogenic. The metabolic pathway for 2,5-dimethylfuran involves conversion of the hydroxyl group into formaldehyde through oxidation by molecular oxygen or hydrogen peroxide. This reaction produces 5-hydroxymethylfurfural (HMF), which is then converted into 5-hydroxymethylbenzoic acid (HMBA) and ultimately carbon dioxide and water.

Stability Moisture Sensitive Applications (s)-(-)-5-hydroxymethyl-2(5h)-furanone (cas# 78508-96-0) is a useful research chemical.

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(5-Amino-2-butyl-3-benzofuranyl)[4-[3-(dibutylamino)propoxy]phenyl]methanone is a drug that is under development for the treatment of arrhythmias. The drug has been shown to have antiarrhythmic properties in vitro and in vivo. Assays were conducted to determine purity, impurities, and alkalinity. Preparation processes were used to remove the impurities and acidify the solution. The concentration of the solution was measured using a high performance liquid chromatography (HPLC) system. Two validated analytical methods were used to quantify chloride ion content: responsive ion electrode (RIE) and inductively coupled plasma mass spectroscopy (ICPMS).

Methyl 2-methyl-3-furancarboxylate is a chiral molecule that has anti-influenza virus activity. It has been shown to inhibit influenza virus replication in vitro and in vivo. Methyl 2-methyl-3-furancarboxylate inhibits the synthesis of viral proteins by inhibiting the polymerase function of the virus’s RNA polymerase. In addition, this compound inhibits the synthesis of new viruses by disrupting the process of transcription and replication. This molecule also exhibits antiviral activity against other RNA viruses such as Sindbis virus, vesicular stomatitis virus, and polio virus. Methyl 2-methyl-3-furancarboxylate is an aerobic molecule with functionalities that include isoxazoles, pyrazoles, and carbocations. This compound has been used as a starting point for synthesizing other anti-influenza compounds due to its strong antiviral properties and its unique functional groups.

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2-(Tetrahydrofuran-2-yl)acetonitrile is a homologated and reversed-phase mobile phase for the liquid chromatographic determination of adapalene in pharmaceutical formulations. The use of acetonitrile as an eluent provides enhanced sensitivity, which is important for the analysis of low levels of adapalene. The calibration curve was linear over the concentration range 0.03-10 μg/mL with an accuracy and precision (relative standard deviation) of less than 3%. Recoveries were between 80% and 115%.

2,3,7,8-Tetrachlorodibenzofuran (2,3,7,8-TCDF) is a congener of polychlorinated dibenzo-p-dioxin. It is found in the environment as a byproduct from the manufacture of chlorophenols and pentachlorophenol. 2,3,7,8-TCDF is an endocrine disruptor that affects cell nuclei and causes oxidative stress to the liver. There are few studies on 2,3,7,8-TCDF because it is not commercially available for use in research or industry. The only study done on this chemical found that it was potent inducer of glucuronide conjugation enzymes and decreased the activity of rat liver microsomes.

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2-Furancarbothioicacid is a natural product that has been shown to inhibit the growth of cancer cells. It has been shown to have an inhibitory effect on carcinoma cells and leukemia cells, as well as on human nasopharyngeal carcinoma cells. 2-Furancarbothioicacid has also been shown to have a crystal structure similar to benzene and furan. This compound has been found in the plant diseases Mycosphaerella fijiensis, Mycosphaerella arachidicola, and Phyllosticta solitaria. 2-Furancarbothioicacid is also toxic to bacteria such as Escherichia coli and Bacillus subtilis.

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2,3-Dimethylfuran is a pharmaceutical preparation that is used as an intermediate in the synthesis of other drugs. It is normally prepared by reacting 2,3-dimethylbenzaldehyde with ammonia and sulfuric acid. The reaction mechanism is not well understood, but it is thought that the carbonyl group of this compound reacts with water vapor to produce 5-hydroxymethylfurfural. This reaction proceeds under acidic conditions and requires a solid catalyst. The dehydration of 5-hydroxymethylfurfural produces 2,3-dimethylfuran.

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2,6,7,8-Tetrahydro-1H-indeno[5,4-b]furan-8-ylethylamine is an important intermediate in the production of polyurethanes. This product has been produced industrially by hydrogenation of 2,6,7,8-tetrahydroindeno[5,4-b]furan with borohydride and an organic solvent. The process can be controlled easily by adjusting the reaction temperature and pressure. Hydrogenation is a reversible reaction that produces a hydrogenation product as well as byproducts.

Methyl 7-methoxy-1-benzofuran-2-carboxylate (MBC) is a cytotoxic compound that is used in the treatment of cancer. MBC has been shown to inhibit the growth of human cancer cell lines and induce apoptosis in these cells. The cytotoxicity of MBC was found to be related to its ability to inhibit protein synthesis, leading to cell death. MBC forms an ester with the carboxylic acid group on the cancer cell surface, which may lead to its accumulation within the cell and inhibition of protein synthesis. The structure of MBC has been determined by X-ray crystallography analysis, revealing significant similarities between this drug and other known anticancer agents.