Heterocycles with Oxygen (O)

Applications 5-Nitro-1-benzofuran is a chemical reagent used in the synthesis of internal alkynes. Also used in the preparation of anti-oxidants quinolines. References Lu, L. et al.: Eur. J. Org. Chem., 2013, 1644 (2013); Kuzmin, V. et al.: Russ. Chem. Bull., 57, 2405 (2008);

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1,2,3,4,6,7,8-Heptachlorodibenzofuran is a polychlorinated dibenzofuran (PCDF) that has been found to be an environmental pollutant. This compound is used in the production of plastics and pesticides. It is also used as a catalyst for the conversion of hydrocarbons into other chemicals. It can be found in wastewater as a result of these processes. 1,2,3,4,6,7,8-Heptachlorodibenzofuran has shown potential to act as a proliferation inhibitor on cells in culture and may have immunosuppressive effects.

Applications 5-[3-(Trifluoromethoxy)phenyl-2-Furancarboxylic Acid is the structural analogue of 5-[2-(Trifluoromethoxy)phenyl]-2-furancarboxylic Acid (T790925), a reactant used in the preparation of (phenyl)-N-[(mercapto)(pyrrolyl)triazolyl]furancarboxamide and (phenoxy)-N-[(mercapto)(pyrrolyl)triazolyl]acetamide derivatives as herbicides. References Xue, S., Lu, C.: Youji Huaxue, 28, 1083 (2008)

5-Ethoxy-2(5H)-furanone is an oxidation product of 5-ethoxy-2(5H)-furanone. It has an isomeric, stereospecific, regiospecifically, and a tautomeric relationship with furfural. 5-Ethoxy-2(5H)-furanone can be produced by the oxidation of furfural with boron trifluoride etherate in the presence of iodosobenzene. The reaction mechanism involves the addition of hydrogen peroxide to the boron trifluoride etherate to form hydroperoxydiborane. This compound then reacts with iodosobenzene to produce 5-ethoxy-2(5H)-furanone and 2,5-dihydroxybenzaldehyde. The reaction produces a mixture of diastereomers that contain different numbers of carbon atoms due to the regiospecific

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Applications 2-((Tetrahydrofuran-2-yl)methoxy)phenoxy)tetrahydro-2H-pyran is an intermediate used in the synthesis of Bufetolol (B689435), a β-adrenergic blocking agent and it inhibits the activation of adenyl cyclase. References Ikegami, K., and Imamura, H.: Yakugaku Zasshi 96, 614 (1976); Yamaji, A., et al.: Yakugaku Zasshi 105, 1179 (1985)

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Applications 1,3-Dihydro-1,3-dioxo-5-isobenzofurancarboxylic Acid is an analog of Trioctyl Trimellitate (T804400) which is a plasticizer that was evaluated for endocrine disrupting activities through estrogen receptor alpha binding assay.

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Xylyldibutylbenzofuranone is a stabilizer that is added to plastics to prevent the polymer from splitting into its constituent monomers. It has been shown to be an effective antioxidant, inhibiting the oxidation of polyvinyl chloride and polyethylene terephthalate plastics. Xylyldibutylbenzofuranone can be used in combination with phosphites, which form stable compounds with the stabilizer. These compounds are not allergenic or damaging to health, but may cause allergic reactions in sensitive individuals. The analytical method for determining the content of xylyldibutylbenzofuranone in a plastic material is based on its carboxylate group and functional groups. Xylyldibutylbenzofuranone does not damage the environment and has been shown to have antioxidant effects against ozone-induced oxidation of polystyrene.

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4,5,6-Trimethoxy-2-benzofuran-1(3H)-one is a metabolite of dehydrocholic acid. It has been shown to have pharmacological activity in pharmacological tests and the demethylation of syringic acid. The pharmacological activities of 4,5,6-Trimethoxy-2-benzofuran-1(3H)-one are similar to those of syringic acid and formaldehyde. This metabolite is produced by the demethylation of syringic acid, which may be due to the presence of formaldehyde or other unidentified compounds.

Furancarboxaldehyde is a molecule with a heterocyclic ring. The molecule has an isomeric form, in which the two rings are not identical. Furancarboxaldehyde can be made by reacting acetoacetate and chlorides in the presence of nitrosyl chloride to yield the desired product. It can also be made by reacting furfural and acid chlorides in the presence of nitrogen gas to yield the desired product. Furancarboxaldehyde is an isomer of 5-(4-chlorophenyl)-2-furancarboxaldehyde, which differs from it only in that its conformation has been changed so that a proton on one of its carbons is replaced with a tetrahydropyrimidinone group.

3-Acetyl-3-methyldihydrofuran-2(3H)-one (AMF) is a monofunctional, acidic initiator that is used in polymerization reactions. It is a fast and efficient catalyst for polymerization reactions, which can be initiated with peroxides or hydroperoxides. AMF has been used in crosslinking reactions to produce polymers with desirable properties such as high heat resistance and flame retardancy.

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Stability Moisture Sensitive Applications 4,7-dimethyl-1,3-dihydro-2-benzofuran-1,3-dione (cas# 5463-50-3) is a useful research chemical.

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7-Hydroxybenzofuran is an organic solvent that is used as a reagent in the synthesis of carbofuran, a pesticide. 7-Hydroxydihydrobenzofuran is also used as a precursor to other organic compounds such as diazonium salts, hydrogen bonds, and acid catalysts. It has low energy with a chloride ion, which forms a hydrogen bond with the functional groups on the organic molecule. The acid catalyst then converts it into an acidic solution. This process can be carried out at room temperature or heated to higher temperatures. When heated, thermally activated reactions take place and isobutyraldehyde becomes dehydrated to form magnesium oxide and aluminium oxide.

3-Iodotetrahydrofuran is a stereoselective synthesis of 3-iodo-2,2,3,3-tetrafluoropropane. The reaction involves the use of anhydrous acetonitrile as a solvent and intermolecular hydrogen bonding to yield the desired product. 3-Iodotetrahydrofuran has been shown to inhibit the protease activity of human immunodeficiency virus (HIV) and may be useful in treating hepatic steatosis. It also has been shown to inhibit insulin resistance due to its ability to inhibit the chemokine receptor CXCR4. 3-Iodotetrahydrofuran is not currently approved for use in humans or animals.

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(R,R)-3,4-Dihydroxytetrahydrofuran is a carbon compound with the chemical formula C4H8O2. It is a tetritol and is formed by the elimination of two water molecules from two molecules of glycerol. The (R,R)-form has an asymmetric carbon atom that can be analyzed through an argon gas-based technique called high-temperature gas chromatography. The analytical results will show the reaction products of this elimination process and the temperatures at which they are formed. This compound has been shown to react with alditol under dehydration conditions to form alpha-hydroxylated ketones, which are often used in chemical structures for intramolecular reactions.

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