Heterocycles with Oxygen (O)

Please enquire for more information about {2-[5-(Tetrahydrofuran-2-yl)-1,2,4-oxadiazol-3-yl]ethyl}amine hydrochloride including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about 2-[3-Cyano-4-methyl-5-phenyl-5-(trifluoromethyl)-2(5H)-furanylidene]-propanedinitrile including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about 6-Chloro-9-(2-O-acetyl-5-O-(p-toluoyl)-3-azido-3-deoxy-beta-D-ribofuranosyl)-9H-purine including the price, delivery time and more detailed product information at the technical inquiry form on this page

Tetrahydro-3-furanmethanol is a polyol that can be used as an intermediate for the synthesis of medicines. It is synthesized from ethyl bromoacetate and sodium borohydride in an acidic medium. The reduction of tetrahydrofuran to tetrahydro-3-furanmethanol is facilitated by sodium borohydride and oxygenated with ozone. This reaction occurs in an organic solvent, such as benzene or chloroform, at room temperature. Tetrahydro-3-furanmethanol can also be synthesized by reduction of furfural with sodium borohydride in the presence of a catalytic amount of acid or alkali metals such as lithium, potassium, or sodium. Tetrahydrofuran is reduced to tetrahydro-3-furanmethanol via the use of sodium borohydride in aqueous solution at room temperature.

Methyl benzofuran-6-carboxylate is a synthetic retinoid that is a conformationally constrained analogue of retinoic acid, which is one of the most powerful biological molecules. Methyl benzofuran-6-carboxylate has been shown to be an effective anti-inflammatory agent and may be useful in the treatment of inflammatory skin diseases. It also inhibits the production of proinflammatory cytokines and chemokines, such as TNF-α, IL-1β, IL-8, CCL2, CXCL1, and CXCL2. Methyl benzofuran-6-carboxylate binds to specific receptors on cell surfaces to inhibit the production of inflammatory mediators. The drug also has been shown to have antiangiogenic activity. This property may be due to its ability to inhibit the production of vascular endothelial growth factor (VEGF) and other angiogenic factors.

Disulfide is a heterocyclic organic compound that contains two adjacent sulfur atoms. Disulfides are found in many naturally occurring substances, such as vitamins, minerals, and proteins. Disulfides are also produced by some industrial processes and can be released into the environment as pollutants. Disulfides can be found in small amounts in foods, but they are usually not detectable because they are masked by stronger flavors or scents. The flavor of disulfide has been described as "mildly buttery."

3-Aminobenzofuran-2-carboxamide is a synthetic compound with a radical scavenging activity. It has been shown to function as an antioxidant and as a co-substrate for the hydroxylation of phenols. This chemical also has anticancer potential in vitro and in vivo, which may be due to its ability to inhibit G1 phase progression of cancer cells. 3-Aminobenzofuran-2-carboxamide is structurally similar to quinazolinones, which are bioactive chemicals that act as inhibitors of protein kinases.

Please enquire for more information about 6-[(4-Methylphenyl)thio]-2-oxo-9-(2',3',5'-tri-O-acetyl-b-D-ribofuranosyl)-2,3-dihydropurine including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about (2Z)-6-Hydroxy-2-[(3-methyl-2-thienyl)methylene]-1-benzofuran-3(2H)-one including the price, delivery time and more detailed product information at the technical inquiry form on this page

RITA is a novel compound that has been shown to have anticancer activity in vivo in a rat model. RITA is a small molecule with high potency and low toxicity. It binds selectively to the α subunit of the enzyme topoisomerase II, which is involved in DNA replication and repair. RITA has been shown to induce apoptosis in cancer cells by pro-apoptotic proteins such as Bax and Bak. These proteins are known for their ability to induce apoptosis by increasing mitochondrial membrane permeability, inhibiting mitochondrial functions, or destabilizing the mitochondrial membrane potential. The compound class of RITA is not yet known, but it has been shown to be chemically stable at physiological pH levels and does not require metabolic activation for its cytotoxicity. The pharmacokinetics of this drug have also been studied in human liver cells and humans, indicating that this drug may be able to cross the blood-brain barrier.

5,6-Dihydroxybenzofuran-3-one is a chemical compound that has been found in propolis. It has been studied for its in vitro activity against filamentous fungi and dermatophytes. 5,6-Dihydroxybenzofuran-3-one has shown minimal inhibitory concentrations of 0.25 mg/mL against dermatophytes and itraconazole (1 mg/L) against dermatophytes and mentagrophytes. The dilution method was used to determine the minimal inhibitory concentrations of 5,6-dihydroxybenzofuran-3-one against dermatophytes and mentagrophytes. This compound is not active against yeasts or molds.

Please enquire for more information about 2-Tetrahydrofuranyloxy carbonyl5-norbornene including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about 5-(Furan-2-yl)-1,3,4-oxadiazole-2-amine including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about (+/-)-trans-3-Bromotetrahydro-2-(2-propynyloxy)-furan including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about 2,3-Dihydro-5-(2-hydroxyethyl)benzo[b]furan including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about (3S,3aR,6aS)-Hexahydrofuro[2,3-b]furan-3-yl acetate including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about Benzofuran-2-boronic acid, pinacol ester including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about 1-(2-O-Acetyl-5-O-(p-toluoyl)-3-deoxy-3-fluoro-beta-D-ribofuranosyl)-5-nitropyridine-2(1H)-one including the price, delivery time and more detailed product information at the technical inquiry form on this page

4-Bromo-2,3-dihydrobenzofuran is a chemical compound and an agonist of the melatonin receptor. It has been shown to be active against bacteria, fungi and viruses. The drug is synthesized by reacting 4-bromobenzofuran with hydrogen in the presence of sodium hydroxide. This reaction produces 4-bromo-2,3-dihydrobenzofuran, which can be further converted into a variety of other chemicals by coupling with other reagents. 4-Bromo-2,3-dihydrobenzofuran is used as a starting material for the synthesis of other chemicals including antibiotics (e.g., erythromycin) and antihistamines (e.g., diphenhydramine).

Applications 2,5-Diacetoxy-2,5-dihydrofuran is used as a reagent to synthesize Mexicanin H, a biologically active sesquiterpene lactone that exhibits antiparasitic activity against Trypanosoma cruzi (a parasite that causes Chagas disease) References Jimenez-Ortiz, V., et al.: Parasitology, 91, 170 (2005); Romo, J., et al.: Tetrahedron Lett., No vol. given, 1029 (1966)

Please enquire for more information about Hexahydro-furo[3,2-b]furan-3,6-diamine including the price, delivery time and more detailed product information at the technical inquiry form on this page

Methyl 4-bromofuran-2-carboxylate is a benzene derivative that has been optimised for furan production. Furan is an aromatic compound that is found in coal tar and can be converted to other compounds, such as pyridine, using the method of Dimethylformamide (DMF). DMF reacts with butyllithium in the presence of methyl 4-bromofuran-2-carboxylate to produce pyridine. DMF is also used to synthesise other organic compounds, such as chloroacetic acid and chloral hydrate. The chloride ion is used as a catalyst during this process. Methyl 4-bromofuran-2-carboxylate has shown cytotoxicity against carcinoma cells through the inhibition of cellular respiration and synthetic methods.

Please enquire for more information about 5-(METHOXYCARBONYL)FURAN-2-BORONICACID including the price, delivery time and more detailed product information at the technical inquiry form on this page

Applications Intermediate used to produce a variety of pharmaceutical agents, such as analgesic compounds and retinoic acid receptor (RAR) antagonists. References Caldwell, J.; et al.: Bioorg. Med. Chem. Lett., 17, 2281 (2007), Tashiro, T., et al.: Biosci., Biotechnol., Biochem., 72, 2398 (2008),

Please enquire for more information about 4-Amino-7-(2-deoxy-beta-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidin-5-carboxylic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page