Heterocycles with Oxygen (O)

5-(3-Trifluoromethyl-Phenyl)-Furan-2-Carbaldehyde is an antioxidant that inhibits the formation of reactive oxygen species. It is synthesized by condensing acetophenone with methylene in the presence of an azide and a propenoic acid. This compound has been shown to have antioxidant activity, as seen in its ability to inhibit the oxidation of malononitrile. 5-(3-Trifluoromethyl-Phenyl)-Furan-2-Carbaldehyde is used as a light stabilizer in plastics and rubbers, and has also been used for the synthesis of pharmaceuticals, including acetaminophen.

Applications 5-Formylfuran-2-boronic Acid Neopentyl Glycol Ester is a useful reagent in lapatinib synthesis. References Radl, S., et al.: PCT Int. Appl. (2014), WO 2014059956 A1

7-Bromo-5-methylbenzofuran is a carbene that can be used as a starting material for the synthesis of other chemicals. It is an intermediate in the transition metal catalyzed, mechanistic study of the pyrolysis and cyclization of esters. 7-Bromo-5-methylbenzofuran undergoes a six-membered ring formation to form two different products, depending on which reaction conditions are present. The mechanism for this process has been studied using computational methods.

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3-Acetyl-3-chlorodihydrofuranone is a synthetic chemical with the molecular formula C8H4ClO2. It is a chlorinating agent that reacts with styrene to form an epoxide. 3-Acetyl-3-chlorodihydrofuranone can be used as medicine or as a stabilizer in the production of other medicines. The use of 3-acetyl-3-chlorodihydrofuranone in the synthesis of prothioconazole has been well documented.

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Dronedarone is a cardioselective antiarrhythmic agent that has been used as a treatment for atrial fibrillation and atrial flutter. It is insoluble in water and most organic solvents. Dronedarone crystallizes from petroleum ether, chloroform, or benzene as needles of mp 188°C.

2,3-Dihydrobenzofuran-5-sulfonyl chloride is a chemical compound that has been shown to inhibit the enzymatic activity of hydrolase. It has been shown to be effective in catalytic and medicinal analyses. 2,3-Dihydrobenzofuran-5-sulfonyl chloride has also been shown to have pharmacological properties and is capable of inhibiting the production of cytokines by creating reactive oxygen species. This product can be used as a model for mutational profiling, which is an important technique in chemical biology.

(E)-2-(1,6,7,8-Tetrahydro-2H-indeno[5,4-b]furan-8-ylidene)ethylamine is an inhibitor that is optically active. It is a crystalline solid with a high purity and yield that can be industrially produced by catalytic asymmetric synthesis. The reaction temperature for the reaction is usually between 60°C and 120°C. The product of this process is an optically active crystal that can be used as a catalyst in industrial processes. No byproducts are formed during the reaction.