Heterocycles with Nitrogen (N)

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Please enquire for more information about Tert-Butyl 3-((P-Tolylsulfonyloxy)Methyl)Piperidine-1-Carboxylate including the price, delivery time and more detailed product information at the technical inquiry form on this page

1-Aminopiperidine is a hydrochloric acid derivative that is used to treat tuberculosis. It inhibits the enzyme catalysis of phospholipase A2 (PLA2) and blocks the release of arachidonic acid from cell membranes. 1-Aminopiperidine has been shown to have tuberculostatic activity in vivo by inhibiting PLA2 and blocking the release of arachidonic acid. This agent also exhibits antitumor properties, which may be due to its ability to inhibit the production of prostaglandin E2 (PGE2), an inflammatory mediator that can stimulate tumor growth. 1-Aminopiperidine binds to cannabinoid receptors, but does not bind to opioid or benzodiazepine receptors. This drug also exhibits antagonist activity against rimonabant, a type of receptor blocker for cannabinoid receptors.

Applications 3-((2S,4S)-4-Mercaptopyrrolidine-2-carboxamido)benzoic Acid Hydrochloride is used as a reactant in the synthesis of a carbapenem antibiotic; Ertapenem Sodium. References Williams, J. Michael, et al.: J. of Org. Chem., 70(19), 7479-7487 (2005)

Applications N-Succinimidyl 3-Methoxy-4-nitrobenzoate (cas# 2006277-78-5) is a useful research chemical.

Please enquire for more information about N-[Amino(imino)methyl]piperidine-1-carboximidamide including the price, delivery time and more detailed product information at the technical inquiry form on this page

Applications 6-(Dibutylamino)-1,3,5-triazine-2,4-dithiol (cas# 29529-99-5) is a useful research chemical.

Please enquire for more information about Methyl 7-(4-chlorophenyl)-5-methyl-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidine-6-carboxylate including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about 3-nitro-6-(trifluoromethyl)pyridin-2-amine including the price, delivery time and more detailed product information at the technical inquiry form on this page

Applications 4-Aminopiperidine is a useful reactant in organic synthesis. References Park, Sun Jun, et al.: Bioorg. & Med. Chem. Let., 27(18), 4399-4404 (2017);Le Manach, Claire, et al.: J. of Med. Chem., 59(21), 9890-9905 (2016)

Please enquire for more information about 6-Chloro-2-ethoxypyrimidin-4-amine including the price, delivery time and more detailed product information at the technical inquiry form on this page

6-Bromo-N2-ethylpyrazine-2,3-diamine is an electron donor that can be used as a bronchodilator. It is a cyclic heterocycle that is substituted with electron donating groups and can inhibit the enzyme cyclic nucleotide phosphodiesterase (PDE). The enzyme PDE breaks down cAMP, which leads to the relaxation of muscle. 6-Bromo-N2-ethylpyrazine-2,3-diamine has been shown to have relaxant and bronchodilatory effects in animal studies.

Applications 3-Chloro-6-ethynylpyridazine is an pyridazine triflate intermediate used for the preparation of (alkynyl)pyridazine. References Toussaint, D., et al.: Acta. Chimica, Slovenica., 41, 253 (1994);

3-Pyridinecarboxylic acid magnesium salt is a polymer film absorber that is used in the radiation process of reducing or eliminating harmful substances that are present in the air. This product is made by combining magnesium oxide with lanthanum and 3-pyridinecarboxylic acid, which has been shown to be effective in preventing heart disease. The absorption process of this product is based on solid dispersions, and it can be applied to various surfaces due to its high stability. It also has a high selectivity for water molecules, which makes it suitable for use in humid environments. Thermodynamic data shows that 3-pyridinecarboxylic acid magnesium salt can absorb up to 17% of its weight in water vapor without any change in temperature or pressure.

Please enquire for more information about 2-Chloro-N-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)acetamide including the price, delivery time and more detailed product information at the technical inquiry form on this page

Applications A labelled imidazole, a versatile heterocycle used in the preparation of various biologically active compounds such as the amino acid histidine and is present in many antifungal medication. It is also used extensively as a corrosion inhibitor on transition metals such as copper. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Arispe, N. et al.: Biophys. J., 95, 4879 (2008); Troesken, E.R. et al.: Endo. Res., 30, 387 (2004); Otmacic Curkovic, H. et al.: Corr. Sci., 51, 2342 (2009);

Please enquire for more information about 1-(Cyclohexylcarbonyl)piperidine-2-carboxylic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page

8-Methyl-2,3,3a,4,5,6-hexahydro-1H-pyrazino[3,2,1-jk]carbazole hydrochloride (MCPZ) is a voltage-dependent calcium channel blocker. It inhibits the voltage dependent calcium channels in the intestine. This prevents the release of neurotransmitters and blocks the transmission of stimuli to the central nervous system. MCPZ has been shown to have locomotor activity in vitro assays and has been shown to increase energy metabolism in cells. MCPZ is toxic to granule neurons that are involved in regulating secretion of cortisol from the adrenal gland. MCPZ also blocks pirlindole binding and inhibits its inhibitory properties on experimental models. MCPZ is a reactive compound that can be prepared by hplc with preparative scale resolution for further use.

1-Phenylpiperazine is a piperazine derivative that can bind to the DNA of cervical cancer cells and inhibit their growth. It also has antihypertensive effects. 1-Phenylpiperazine is a white crystalline solid that is soluble in water, ethanol, ether, and chloroform. It binds to the hydrogen chloride ion (HCl) with high affinity and forms an equilibrium mixture with HCl gas. The binding constants of 1-phenylpiperazine to HCl are greater than those for piperazine. This compound has been shown to inhibit tumor cell growth in vitro through its ability to bind to DNA and prevent RNA synthesis. 1-Phenylpiperazine has been shown to have antihypertensive activity in rats by blocking alpha1-adrenergic receptors on vascular smooth muscle cells.br>br> In addition, this molecule has been shown to have binding properties for amines which may be due to the presence

Please enquire for more information about Ethyl 1-(2-cyano-4-nitrophenyl)piperidine-3-carboxylate including the price, delivery time and more detailed product information at the technical inquiry form on this page

4-Phenyl-5-pyridin-4-yl-4H-1,2,4-triazole-3-thiol is a piperazine derivative that has antibacterial properties. It binds to the triazole ring of bacterial DNA gyrase, which prevents the unwinding of DNA strands and thus inhibits DNA synthesis. This compound is soluble in acidic solvents and exhibits strong antibacterial activity against certain Gram positive bacteria. It can be used to inhibit the growth of mycobacteria such as Mycobacterium tuberculosis and Mycobacterium avium complex. 4-Phenylpyridinethiol has also been shown to have antiinflammatory effects by inhibiting prostaglandin synthesis.

5-Aminoindole is a hydrogen bond acid. It has been shown to have an optimum concentration of 0.1 mM in the presence of 0.2 mM potassium chloride and 2 mM magnesium chloride, which is similar to the pH range for biological systems. 5-Aminoindole also acts as a competitive inhibitor of quinoline derivatives, such as chloroquine and hydroxychloroquine, which are used in the treatment of malaria and rheumatoid arthritis. The compound has been shown to be active against primary cells grown in culture, including mouse erythrocytes and human hepatocytes. When used with agarose gel electrophoresis or electrochemical impedance spectroscopy, 5-aminoindole shows excellent selectivity for kinases over other enzymes. 5-Aminoindole is not reactive under physiological conditions because it does not have any redox potentials that can be measured by Langmuir adsorption isother

Please enquire for more information about 2-Amino-6-bromothiazolo[5,4-b]pyridine including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about 2-Methyl-5-[(4-methylpiperazin-1-yl)sulfonyl]benzoic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about 1-(4-Hydroxymethylphenyl)piperidin-4-ol including the price, delivery time and more detailed product information at the technical inquiry form on this page

Applications Benzotriazol-1-yl-oxytripyrrolidinphosphonium Hexafluorophosphate (cas# 128625-52-5) is a compound useful in organic synthesis.

3-Aminohomopiperidine is a synthetic compound that is an analog of the natural amino acid histidine. It is a potent inhibitor of histone deacetylase, which may be due to its ability to bind covalently with the active site and inhibit access of acetyl groups. 3-Aminohomopiperidine has been shown to inhibit the growth of cancer cells in vitro, and has been modeled using molecular dynamics simulations. This drug also binds to and inhibits cisplatin in vitro. The molecule can exist as two different enantiomers: cis and trans. The cis form is more potent than the trans form in inhibiting histone deacetylase, but both forms have similar binding affinities with cisplatin.

Please enquire for more information about 2-Chloro-N-(4-{[(4,6-dimethylpyrimidin-2-yl)amino]sulfonyl}phenyl)propanamide including the price, delivery time and more detailed product information at the technical inquiry form on this page

1,1'-Dimethyl-4,4'-bipyridinium dichloride hydrate is a bipyridine with a divalent chloride. It has been shown to have synergic effects in the presence of dextran sulfate and paraquat. This compound has good photochemical properties, which are used for wastewater treatment and surface methodology. 1,1'-Dimethyl-4,4'-bipyridinium dichloride hydrate also has toxicological studies that show it does not cause any cellular toxicity or mitochondrial membrane potential changes. It also reduces potassium dichromate toxicity in glomerular filtration rate studies. This compound can be used as an analytical method for other bipyridines.

Please enquire for more information about 2,5,6-Triamino-4-hydroxypyrimidine dihydrochloride including the price, delivery time and more detailed product information at the technical inquiry form on this page

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Please enquire for more information about 5-Hydrazinyl-2-methylpyridine hydrochloride including the price, delivery time and more detailed product information at the technical inquiry form on this page

Applications An intermediate in the preparation of CDK inhibitors References Jakobsen, P., et al.: Bioorg. Med. Chem., 8, 2803 (2000), Chu, X., et al.: J. Med. Chem., 49, 6549 (2006),

Please enquire for more information about 1-Isobutylpiperidin-4-amine including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about 2-Hydroxy-N-pyridin-2-ylbenzamide including the price, delivery time and more detailed product information at the technical inquiry form on this page

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Prasugrel is a pharmaceutical compound that belongs to the class of thienopyridines. It has been shown to inhibit platelet aggregation and is used for the prevention of blood clots in patients with coronary artery disease. Prasugrel binds to the P2Y12 receptor on the surface of platelets, which prevents ADP from binding, thereby inhibiting platelet aggregation. Prasugrel is a crystalline solid that is soluble in water.

4,4'-Bis(bromomethyl)-2,2'-bipyridine is a cyclic molecule that can be synthesized by the reaction of 4-bromo-2,2'-bipyridine with a brominating agent. It is used as a precursor to ruthenium catalysts in organic synthesis, and as an additive in dendrimers. The compound has been shown to have light absorption properties and can be used in photovoltaics and electropolymerization.