Heterocycles with Nitrogen (N)

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2,3,5,6-Tetrafluoro-4-hydrazinopyridine is a hydroxide ion analog of pentafluoropyridine. It has been shown to undergo a coupling reaction to yield the corresponding organometallic compound with methoxide in dimethylformamide. The yields for this reaction are high and range from 76% to 98%. This technique has been shown to be applicable for the synthesis of other organometallic compounds.

2-Chloro-5-fluoro-3-nitropyridine (2C5NP) is an imidazopyridine that has been used as a medicine. It is a nucleophile and hydrolyzes to form 2,5-dichloroimidazolium chloride and 5-fluoronicotinic acid. 2C5NP hydrolyzes in water to release the two products, which are also reactive. The hydrolysis of 2C5NP releases toxic gases such as HCl and HF, and therefore must be handled carefully. Hydrolysis of this compound by acid or base leads to the formation of chlorinated compounds.

Applications L-Dihydroorotic acid is used as a reactant in the preparation of long acting Gonadotrophin-releasing hormone (GnRH) antagonist containing p-ureido-phenylalanine. References Jiang, G., et al.: J. Med. Chem., 44, 453 (2001);

4-Isocyanatopyridine is a copper complex that exhibits supramolecular and metal ion properties. It binds to halide ions, forming bidentate ligands, which allow it to be used as an antibacterial agent. 4-Isocyanatopyridine has been shown to have potent antibacterial activity against Gram-positive bacteria, in particular Staphylococcus aureus and Streptococcus pneumoniae. This compound can also bind sulfoxides and linkers, which are linear molecules that contain anions that are negatively charged. The nature of these linkers will determine the architecture of the molecule.

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3-(Pyridin-4-yl)benzoic acid (3PBA) is a carboxylic acid with the chemical formula CHCOOH. It is a white crystalline solid that can be obtained by reacting pyridine-3-carboxylic acid with malonic acid. 3PBA has a melting point of 122 degrees Celsius and can be used in organic synthesis as ligands for metal ions such as copper(II). 3-(Pyridin-4-yl)benzoic acid can also be used to synthesize luminescent molecules, such as 2,2’-bipyridine.

Methanesulfonic Acid, 2-Phenoxy-N-[2-[4-[3-(Trifluoromethyl)Phenyl]Piperazin-1-Yl]Ethyl]Acetamide (MSAA) is a potent inhibitor of the enzyme creatine kinase. It has been shown to be just as potent as the commonly used drug, phenytoin, in inhibiting this enzyme. MSAA also has an excitatory effect on laboratory mice and animals. It is hypothesized that this may be due to its ability to potentiate glutamate receptors. The effects of MSAA are not limited to laboratory animals; it has also been shown to have neuropharmacological effects in psychiatric patients.

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2-(Hydroxymethyl)pyridin-4-ol is a versatile building block that can be used in the synthesis of complex compounds and research chemicals. This fine chemical is a reagent, speciality chemical, and useful scaffold in organic synthesis. 2-(Hydroxymethyl)pyridin-4-ol is also an intermediate for the production of useful building blocks. It has high purity and can be used as a reaction component or a useful scaffold in organic synthesis.

Tert-butyl piperidin-3-ylmethylcarbamate is an antithrombotic drug that belongs to the class of carboxamides. It is a racemic mixture of two enantiomers, one with a right-handed chiral center and the other with a left-handed chiral center. Tert-butyl piperidin-3-ylmethylcarbamate inhibits platelet activation by reducing the formation of thromboxane A2 (TXA2) from arachidonic acid. This agent also reduces collagen synthesis in blood vessel walls, which may reduce the risk for atherosclerosis and thromboembolism.

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1H-Pyrazolo[4,3-b]pyridin-3(2H)-one is an antiviral compound that inhibits viral replication by acting as a competitive inhibitor of the viral RNA-dependent RNA polymerase. It has been shown to be active against human and animal viruses, including HIV and Ebola virus. 1H-Pyrazolo[4,3-b]pyridin-3(2H)-one also inhibits coagulation by inhibiting the synthesis of fibrinogen. 1H-Pyrazolo[4,3-b]pyridin-3(2H)-one is orally active and can be used in combination with other drugs for the prevention or treatment of viral infections.

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Applications 1,3-Dimethyl-1H-pyrazole-4-carboxylic acid

Applications 1H-1,2,4-triazol-5-ol (cas# 930-33-6) is a useful research chemical.

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Applications Succinimidyl Nervonate (cas# 191354-88-8) is a compound useful in organic synthesis.

2,6-Dimethoxy-3-nitropyridine is a heteroaromatic compound that can be synthesized by reacting benzene with nitric acid. It is a conjugate acid of pyridine. 2,6-Dimethoxy-3-nitropyridine has been shown to react with electrophiles via nitration and also undergoes homolytic cleavage. This compound reacts with nitronium ion to form a heteroaromatic compound.

1-(1-Naphthylmethyl)piperazine (1-NMPP) is an antimicrobial agent that inhibits bacterial efflux pumps. It was shown to be active against Gram-positive bacteria, such as Erythromycin and tetracycline resistant mutants. 1-NMPP has been shown to inhibit the expression of efflux pump proteins in Gram-negative bacteria. One study showed that 1-NMPP can reverse the resistance of colistin and sulfa drugs in a multidrug resistant strain of Staphylococcus aureus. The mechanism of action for this drug is not yet known, but it may be due to its ability to prevent the synthesis of new efflux pump proteins by inhibiting translation or by decreasing mRNA stability.

Applications 2-(1H-imidazol-2-yl)benzoic acid (cas# 67792-82-9) is a useful research chemical.

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2,6-Difluoropyridine is a heterocyclic compound that can be used in organic synthesis. It can be synthesized by the palladium-catalyzed cross-coupling reaction between 2,6-dichloropyridine and phenylboronic acid. The addition of fluorine to the 2,6-difluoropyridine ring has been shown to increase its nucleophilic reactivity and ability to undergo irreversible oxidation. 2,6-Difluoropyridine is structurally similar to pyridinium compounds such as covidin which are found in some antihelminthics. Covidin has been shown to have antiviral properties against the 2009 pandemic H1N1 influenza virus.

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2-Amino-5-methoxypyridine (2AM5MP) is a synthetic compound that is used to study the nicotinic acetylcholine receptor. It has been shown that 2AM5MP can be used as an agonist for the nicotinic acetylcholine receptor, which may be due to its ability to act as a substrate for amine oxidase. This compound has been shown to have anti-cancer properties and fluoresce when exposed to positron emission tomography (PET) scans. The anti-cancer effects of 2AM5MP are thought to be due to its ability to inhibit cancer cell proliferation and induce cancer cell apoptosis.

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2,4-Diamino-6-methoxy-1,3,5-triazine is a formaldehyde releasing agent that has synergistic effects when used with phenol. It can be used in the manufacture of polymeric composites and intumescent fire retardant coatings. 2,4-Diamino-6-methoxy-1,3,5-triazine also has a high index of thermal stability and a low residue content. The phosphorous content is less than 0.01%. The copolymerization effect can be detected using thermogravimetric analysis and spectrometry techniques.

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2-Chloropyridine-3-sulfonyl chloride (2CPS) is a nucleophilic reagent that attacks the target enzyme. It is used in the preparation of 2-chloropyridines, which are used as antimalarial drugs. The chlorides of 2-chloropyridine-3-sulfonyl chloride are also used in the synthesis of other biologically active molecules. These compounds have shown inhibitory activity against malaria parasites and they can be administered orally or by injection. They may also be useful as antimalarial prophylactics and for treating drug resistant strains of malaria.

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4,4'-Bis(hydroxymethyl)-2,2-bipyridine is a replication inhibitor that has been used in the treatment of cancer. It has also been shown to be effective in the treatment of metabolic disorders and chronic bronchitis. 4,4'-Bis(hydroxymethyl)-2,2-bipyridine binds to the active site of human HMG-CoA reductase, which is an enzyme involved in cholesterol synthesis. This binding prevents the formation of HMG-CoA, preventing the conversion of acetyl coenzyme A into cholesterol. The drug also binds to microbial metabolism enzymes such as fatty acid synthase and alkanoic acid oxidoreductases and has significant cytotoxicity.

Pyridine-4-carboxylic acid-N-oxide is a white solid with a melting point of 130°C. It is soluble in water and ethanol. Pyridine-4-carboxylic acid-N-oxide has been found to be supramolecular, which means that it forms structures in which molecules are linked together without the use of covalent bonds. The compound can also be crystallized and studied using infrared spectroscopy and X-ray crystallography. Pyridine-4-carboxylic acid N-(2,6-dichloro)pyridinium salt (PDCP) is a derivative of this compound and has been shown to have anticancer properties by inhibiting the growth of cancer cells. PDCP inhibits the production of DNA and RNA by binding to amino groups on nucleic acids, preventing transcription and translation. PDCP also possesses antiinflammatory activities, which may be due to its ability to inhibit prostagland

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Applications 4-Hydroxypiperidine-3,3,4,5,5-d5 (CAS# 1219799-35-5) is a useful isotopically labeled research compound.

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Applications 1-(2-Pyridinyl)benzotriazole-15N3 (cas# 1189465-04-0) is a compound useful in organic synthesis.

5-Benzylthio-1H-tetrazole is a monomer with high specificity, which can be immobilized on solid supports. It has been used in the synthesis of antiviral agents and bifunctional molecules. 5-Benzylthio-1H-tetrazole is a coreceptor antagonist that competes with HIV gp120 for binding to CD4, preventing the virus from entering CD4 cells. The molecule also inhibits the interaction between gp120 and cytidine deaminase, an enzyme that converts cytidine to uridine. This stepwise process inhibits the synthesis of viral DNA, leading to cell death by apoptosis.

1-(4-Bromophenyl)piperazine hydrochloride is a linker that binds to serotonin receptors. It has been shown to inhibit the reuptake of serotonin, which may lead to an increase in the neurotransmitter's level in the synaptic cleft. The compound also inhibits the production of 5-hydroxytryptamine and other monoamine neurotransmitters, which can lead to anaphylactic reactions in humans.

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