Heterocycles with Nitrogen (N)

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1-(3-Fluorobenzyl)piperazine is a potent inhibitor of annexin A1. It has been shown to inhibit the proliferation of pancreatic cancer cells and induce apoptosis in these cells by inhibiting cholinesterase activity. 1-(3-Fluorobenzyl)piperazine also inhibits tumor growth in vivo and induces apoptosis, which may be due to its ability to inhibit the mitochondrial membrane potential. The compound has also been shown to have antitumor effects in other types of cancer cells. This drug is an amine that emits acidic compounds as a result of hydrolysis.

Please enquire for more information about 5-Bromo-1-(2,6-Difluorobenzyl)-6-Methyl-2,4(1H,3H)-Pyrimidinedione including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about (4-[1,3]Oxazolo[4,5-b]pyridin-2-ylmorpholin-2-yl)methylamine dihydrochloride including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about 1-Methyl-2-pyridin-2-yl-ethylamine including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about N,N-Dimethyl-N'-(1-pyridin-4-ylethyl)ethane-1,2-diamine including the price, delivery time and more detailed product information at the technical inquiry form on this page

5-Chloropyrazine-2-carboxylic acid is a phenoxy heterocyclic amine that has been shown to have antibacterial and antimycobacterial activities. It inhibits the growth of Mycobacterium avium and Mycobacterium tuberculosis, with MIC values of 8 and 16 μg/mL respectively. This compound also shows bioisosteric properties, which means it can be used as an alternative for other compounds with similar chemical structures. 5-Chloropyrazine-2-carboxylic acid is a neutral compound that can be dissolved in water at any pH level. It is also soluble in organic solvents, such as hydrochloric acid, acetone, and ethanol.

Please enquire for more information about 3-Chloro-2-methoxypyridine-4-boronic acid, pinacol ester including the price, delivery time and more detailed product information at the technical inquiry form on this page

1-(6-Pyridazinyl)piperazine is a chemical compound that is structurally related to gabapentin. It has been shown to be an effective treatment for chronic cough, which may be due to its ability to inhibit the activity of c1-6 alkyl cation channels in airway smooth muscle cells. 1-(6-Pyridazinyl)piperazine has been shown to have a non-selective cation channel blocking effect on the human respiratory tract, leading to inhibition of cough reflexes and reduced sensitivity of the cough receptors. This drug also inhibits citric acid cycle enzymes and hydrogen ion secretion by parietal cells, which may contribute to its anti-inflammatory effects.

Please enquire for more information about 3-Chloro-6,7-dihydro-[1,4]dioxino[2,3-c]pyridazine including the price, delivery time and more detailed product information at the technical inquiry form on this page

3-Methylpiperidine is a synthetic chemical that belongs to the group of heterocyclic compounds. 3-Methylpiperidine has a low energy and is not reactive with chloride or amines. It can be synthesized from piperidine, which is obtained from coal tar or petroleum, by reacting it with methanol and hydrochloric acid. 3-Methylpiperidine has the potential to be an efficient hydrogen bond donor in proteins and may have applications in molecular modeling. 3-Methylpiperidine has been shown to bind to model proteins, such as Bovine Serum Albumin (BSA) in order to study protein structure and function. Magnetic resonance spectroscopy data analysis showed that 3-methylpiperidine binds to the amide carbonyl of BSA at high concentrations and modifies its vibrational properties. This interaction was found to be reversible, which means that 3-methylpiperidine can dissociate from

2-Fluoro-5-(trifluoromethyl)pyridine is a dichromatic, reactive chemical that can be used as a sealant. It is typically synthesized by reacting hydrogen fluoride with citric acid, and it exhibits fluorescence properties. The molecule is polar, which means that it has an electric charge that allows it to interact with other polar molecules. This chemical has been shown to react with ornithine and malic acid in the presence of polyvinyl alcohol. 2-Fluoro-5-(trifluoromethyl)pyridine is also soluble in water and liquid ammonia.

1H-Imidazo[4,5-d]pyridazine-4,7-diol is an unsaturated heterocyclic compound. It reacts with phosphorus oxychloride to form the phosphorus oxychloride adduct. The alkylating properties of this compound are due to the presence of an unsaturated C=C bond in the molecule. The binding of 1H-imidazo[4,5-d]pyridazine-4,7-diol to DNA is thought to be due to its ability to intercalate between base pairs and cause crosslinking of DNA strands. This causes a decrease in DNA synthesis and cell division. Additionally, 1H-imidazo[4,5-d]pyridazine-4,7-diol can react with hydrazine or halogen in a hypotensor fashion to form an alkylating agent that inhibits protein synthesis by interfering with ribonucleotide

Applications N-Boc-4-(aminomethyl)piperidine is a protected 4-substituted piperidinecarboxylate used in the preparation of orally active platelet-activating factor antagonists as well as other biologically active compounds. References Carceller, E. et al.: J. Med. Chem., 39, 487 (1996);

Please enquire for more information about 2-[(2-Pyridin-4-ylethyl)thio]ethanol including the price, delivery time and more detailed product information at the technical inquiry form on this page

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2-Cyano-5-nitropyridine is a high-potency sweetener that has been found to be an efficient catalyst for the uncatalysed conversion of hexacarbonyl compounds to their corresponding hydroxylamines. The catalytic activity is dependent on the presence of a hydroxy group and an aminopipecolic acid moiety. 2-Cyano-5-nitropyridine is also a high potency sweetener, which means that it is not required in very large amounts to provide a sweet taste. It has been used as a nitrosylating agent for the preparation of trifluoroacetylated amines. This compound has also been shown to be reproducible and can be prepared from readily available starting materials in good yield.

Please enquire for more information about 2-Bromo-6-chloro-3-iodo-5-methylpyridine including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about 2-(Bromomethyl)-6-oxo-1,4,5,6-tetrahydropyridine-3-carboxylic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about 4-(2-Chlorothieno[2,3-d]pyrimidin-4-yl)morpholine including the price, delivery time and more detailed product information at the technical inquiry form on this page

1-n-Butyl-3-methylimidazolium tetrafluoroborate is an ionic liquid used for various reactions such as hydrogenations, asymmetric hydrogenations proceed in higher enantioselectivity than in homogeneous phase. It is also used in Suzuki cross-coupling. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Please enquire for more information about 2,5-Dichloropyridine-4-boronic acid, pinacol ester including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about 2,5-Dimethyl[1,2,4]triazolo[1,5-a]pyrimidin-7(4H)-one including the price, delivery time and more detailed product information at the technical inquiry form on this page

Diethyl 2-(pyrimidin-2-yl)malonate is an antibacterial agent that is used for the treatment of infections caused by bacteria. It is a sulfoxide with a malonate group, which has been shown to have antioxidant properties. Diethyl 2-(pyrimidin-2-yl)malonate inhibits bacterial growth in vitro assays and in vitro tests by binding to the terminal C4 atom of the carrageenan molecule. This binding prevents the formation of a hydrogen bond between the sulfoxide and chloride ions, which disrupts the ionic interactions between carrageenan, chloride, and folic acid. The malonate group has been found to bind to formamide and inhibit bacterial growth through its ability to inhibit protein synthesis.

Please enquire for more information about 3-Chloro-N-{4-[(pyrimidin-2-ylamino)sulfonyl]phenyl}propanamide including the price, delivery time and more detailed product information at the technical inquiry form on this page

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6-Chloro-3,4-pyridinediamine (6CPD) is a dual inhibitor of protein kinases and is one of the most efficient inhibitors in its class. 6CPD is an analog of staurosporine and has been shown to be an inhibitor of protein kinase C (PKC) and tyrosine kinase receptors. It also inhibits the activity of glycogen synthase kinase 3 (GSK-3), which plays a role in cell cycle progression and apoptosis. 6CPD has been found to be effective against family members that share a similar structure to PKCs, such as PKA, PKG, PKD, and PLK. 6CPD also binds to ATP binding sites on the target enzyme with high affinity.

Please enquire for more information about 4-Methyl-6-(Trifluoromethyl)-1H-Pyrazolo[3,4-b]Pyridin-3-Ylamine including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about 3-(1,3-Dioxo-1,3-dihydro-2H-pyrrolo[3,4-c]pyridin-2-yl)-N-mesitylpropanamide including the price, delivery time and more detailed product information at the technical inquiry form on this page

(S)-(-)-2-(a-Methylbenzylamino)-5-nitropyridine is a heterocyclic amine which contains an imidazole ring fused to a pyridine ring. It is an optical isomer of the compound 2-(a-methylbenzylamino)-5-nitropyridine, which has been shown to have potential as a chemotherapeutic drug. The crystal structure of (S)-(-)-2-(a-methylbenzylamino)-5-nitropyridine was determined using X-ray crystallography.

Please enquire for more information about 3-Amino-2-chloropyridine-5-boronic acid pinacol ester including the price, delivery time and more detailed product information at the technical inquiry form on this page

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Please enquire for more information about [4-(1'-AMino-4'-Methylpiperazine-1-carbonyl)phenyl]boronic acid pinacol ester including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about 1-Pyrazin-2-ylacetone including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about 1H-Pyrrolo[2,3-b]pyridine, 3-methyl-,7-oxide including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about {4-[4-(4-Amino-2-chlorophenyl)piperazin-1-yl]-3-chlorophenyl}amine including the price, delivery time and more detailed product information at the technical inquiry form on this page

Applications ((4S,5S)-4-Isopropyl-2,2,5-trimethyl-1,3-dioxolan-4-yl)methanone 1H-Imidazol-1-yl is an intermediate in the synthesis of (+)-amabiline, an unsaturated pyrrolizidine alkaloid from Cynoglossum amabile. References Senter, T. J., et al.: Org. Lett., 14, 1869 (2012);

Please enquire for more information about N2-Methylpyridine-2,4-diamine hydrochloride including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about tert-Butyl 3-(hydroxymethyl)piperazine-1-carboxylate including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about Methyl 3-iodopyridine-2-carboxylate including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about 5-Chloro-2-fluoropyridine-3-boronic acid pinacol ester including the price, delivery time and more detailed product information at the technical inquiry form on this page

4-Anilino-1-benzylpiperidine is a synthetic opioid analgesic that is a prodrug of the active metabolite pethidine. It is an agonist at µ-opioid receptors and is used as an analgesic medication. 4-Anilino-1-benzylpiperidine has been shown to have a high affinity for the δ subtype of opioid receptor and also inhibits the reuptake of naloxone, which may be related to its antinociceptive effects. 4-Anilino-1-benzylpiperidine has been shown to be effective in humans when given in doses around 100mg. The drug binds to functional groups on proteins, such as serine hydroxyls and cysteine sulfhydryl groups, which may account for its efficacy in humans.

Please enquire for more information about 2-(1H-1,2,3,4-Tetrazol-5-yl)propan-2-amine including the price, delivery time and more detailed product information at the technical inquiry form on this page