Heterocycles with Nitrogen (N)

1-(2-Methoxybenzyl)piperazine (1-MBP) is a multitarget drug that has been shown to have medicinal properties. It inhibits the cholinergic system, which is involved in memory and cognition, as well as pathways such as the inflammatory response and amyloid production. 1-MBP has been shown to inhibit acetylcholinesterase, an enzyme that breaks down acetylcholine, thus increasing the amount of acetylcholine available for signaling. 1-MBP also inhibits cholinesterase, which increases the amount of acetylcholine in the brain. This drug may have synergistic effects with other drugs for Alzheimer's disease, such as donepezil and tacrine. 1-MBP has been used in optimization studies to find new potential treatments for Alzheimer's disease by targeting different aspects of its pathogenesis.

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7-Methyl-2-(trifluoromethyl)[1,2,4]triazolo[1,5-a]pyrimidine-6-carboxylic acid is a versatile building block that is useful in the synthesis of complex compounds. It is also a reagent for research and as a speciality chemical. It has been used in the synthesis of many important drugs such as methotrexate and trimethoprim. 7-Methyl-2-(trifluoromethyl)[1,2,4]triazolo[1,5-a]pyrimidine-6-carboxylic acid can also be used as an intermediate for the synthesis of other compounds and scaffolds.

Applications 5-Bromo-6-chloropyridine-3-sulfonyl Chloride (cas# 216394-05-7) is a compound useful in organic synthesis.

2,4-Dimethoxypyrimidine is a pyrimidine compound with two asymmetric carbon atoms. It is a white crystalline solid that is soluble in organic solvents and is insoluble in water. 2,4-Dimethoxypyrimidine can be synthesized by the palladium-catalyzed coupling of an aromatic hydrocarbon with a sugar residue. The reaction solution will contain chloride ions, which are removed by adding an organic solution containing hydrogen chloride or nitro groups. Removal of chloride ions produces the desired product. 2,4-Dimethoxypyrimidine has been shown to have properties that make it suitable for use as a growth regulator and has been used in experiments on plant chlorophyll content and protein synthesis. 2,4-Dimethoxypyrimidine exhibits optical activity due to its chiral nature, which can be observed using nmr spectra.

3-Amino-5-fluoropyridine is a chiral amino acid that can be synthesized from butyronitrile and fluorine in the presence of an organocatalyst. The synthesis can be carried out with either a biodegradable or non-biodegradable catalyst. 3-Amino-5-fluoropyridine can be used as a precursor to prepare medicines such as fluoroquinolones, which are antibiotics that inhibit bacterial growth by binding to DNA-dependent RNA polymerase and preventing transcription and replication. Fluoroquinolones are also potent anti-inflammatory agents and have been shown to reduce inflammation in animal models of asthma, arthritis, and colitis. 3-Amino-5-fluoropyridine can be synthesized from nitro compounds with aluminium mediated reactions. Nitro compounds are toxic substances that have been used in explosives or as herbicides.

2-Chloro-6-ethoxypyridine is an amination reaction intermediate that is used as a penetrant. It reacts with hydrochloric acid to form 2-chloro-6-(ethylthio)pyridine, which then reacts with nucleophilic reagents such as piperazine to produce the desired end product. The terminal half-life of 2-chloro-6-ethoxypyridine is about 1 hour in humans. This compound can be analyzed using analytical methods such as gas chromatography and mass spectrometry. 2-Chloro-6-ethoxypyridine is also a reaction product of pyrimidine derivatives and anions, which can be synthesized by reacting aniline with ketones or amides.

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4-Aminoimidazole-5-carboxamide is used as Catalytic agent, Petrochemical additive. It is metabolite of temozolomide. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

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4-(4-Fluorophenyl)-1,2,3,6-tetrahydro-1-methylpyridine hydrochloride (1:1) is a neuroleptic drug that has analgesic and antihistaminic effects. It is an alkylthio compound that inhibits serotonin release from the pre-synaptic neuron. 4-(4-Fluorophenyl)-1,2,3,6-tetrahydro-1-methylpyridine hydrochloride (1:1) also blocks the uptake of dopamine by nerve cells in the brain and prevents its conversion to norepinephrine. This medicine acts as an antagonist for both alpha and beta receptors because it binds to the benzene ring of these neurotransmitters. The alpha receptor antagonist properties of this drug are due to its ability to prevent norepinephrine from binding with alpha receptors on muscle cells. The beta receptor antagonist properties are due to its ability

Pyrazine-2-carboxamidine is a synthesized, water-soluble nucleotide analog that has been shown to inhibit the synthesis of procollagen and solvates. Pyrazine-2-carboxamidine also has anti-viral properties and inhibits the replication of viruses such as HIV, HSV, and HPV in vitro. This compound is able to inhibit the activity of serine proteases that are involved in viral replication by binding to their active site. The inhibitory effect on these enzymes is reversible. Pyrazine-2-carboxamidine has not been observed to have any adverse effects on human cells because it does not affect cell proliferation or viability.

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Pyridin-4-ylmethanamine is a chemical compound that contains a pyridine ring and an amine (-NH2) group. It is usually used as a building block for the synthesis of other compounds. Pyridin-4-ylmethanamine can be synthesized from picolinic acid, which is obtained through a reaction with sodium hydrochloride in an alkaline solution. This reaction proceeds via two steps: first, the formation of a pyridinecarboxylic acid ester and then the addition of ammonia to form pyridin-4-ylmethanamine. The transfer reactions that occur during this process are highly dependent on temperature and pH. The frequency shift effect can be observed when pyridin-4-ylmethanamine interacts with amines, which changes its absorption spectrum.

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6-Bromo-2-methyl-3H-imidazo[4,5-b]pyridine is a crystalline solid that has been shown to be an effective inhibitor of corrosion. It is an acidic substance that can react with metal surfaces to form a protective layer of bromides. This compound is used as a corrosion inhibitor in industrial and laboratory settings and has been shown to inhibit the efficiency of adsorption on Langmuir and Freundlich isotherms. 6-Bromo-2-methyl-3H-imidazo[4,5-b]pyridine has also been found to be an efficient inhibitor of acid rain by adsorption onto acidic soil particles.

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Applications 2-AMINO-4,6-DICHLOROPYRIMIDINE (cas# 56-05-3) is a useful research chemical.

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Ethyl 4-pyrimidinecarboxylate is a synthetic molecule that has been shown to be an effective ligand for bleomycin, and exhibits high activity in the oxidation of thiols. The FTIR spectrum of ethyl 4-pyrimidinecarboxylate shows intense bands at 1627 cm-1 (C=O stretching) and 1288 cm-1 (N=N stretching). This compound has also been shown to react with pyrazoles, nitrogen nucleophiles, and other parameters. Ethyl 4-pyrimidinecarboxylate is used as a molecular electrostatic potential for molecular modeling studies.

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Applications 2,4-Dichloro-5-bromopyrimidine (cas# 36082-50-5) is a compound useful in organic synthesis.

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Applications 2,2,6,6-Tetramethylpiperidine is used in the syntheses of HMP-Y1, Hibarimicinone and HMP-P1, tyrosine kinase inhibitors. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Liau, B. et al.: J. Am. Chem. Soc., 134, 16765 (2012); Tatsuta, K. et al.: Tetrahedron Lett., 53, 422 (2012);

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N-Nitroso-3-azabicyclo[3.3.0]octane is a nitrosating agent that can be used for the determination of gliclazide in pharmaceuticals and other applications. It is synthesized by reacting 3-azabicyclo[3.3.0]octane with sodium nitrite in an alkaline environment, followed by hydrolysis with hydrochloric acid. Nitrosation reactions are usually slow, but N-nitroso-3-azabicyclo[3.3.0]octane has been shown to have a fast reaction kinetics, which makes it useful for the determination of gliclazide in pharmaceuticals and other applications. The product is analyzed using chromatographic techniques such as high performance liquid chromatography (HPLC) or gas chromatography/mass spectrometry (GC/MS). The product was found to be linear over the range of 0-

Applications 5-Chlorobenzotriazole is a good inhibitor; it decreases anodic and cathodic reaction rates, and the highest inhibition efficiency was 91.2%. The inhibitory effect of 5-chlorobenzotriazole is explained by the formation of the layer on the copper surface. References Simonovic, Ana T., et al.: ACS Omeg., 5, 12832-12841 (2020);

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3-Bromo-6-mercaptopyridine is an inorganic compound that has a six-membered ring with a sulfide group and a pyridine ring. It is not soluble in water, but can be dissolved in organic solvents. 3-Bromo-6-mercaptopyridine can be used as a copper catalyst to produce hydroiodic acid from acetonitrile. This reaction produces copper ions that are coordinated to the nitrogen atoms of the ligand. The condition of this coordination changes when an organic ligand binds to the metal ion.

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N-Propyl-2,4,6-triphenylpyridinium tetrafluoroborate (NPPBF) is a versatile building block with a wide range of applications in the synthesis of complex compounds. It is a fine chemical that has been used as a reagent, speciality chemical, and useful scaffold for research chemicals. NPPBF has been shown to be an intermediate in the synthesis of various pharmaceuticals and agrochemicals. It can also be used as a reaction component in organic synthesis. The compound is soluble in polar solvents such as DMF, DMSO, THF, and acetonitrile.

2-(Trifluoromethyl)piperidine is a 6-membered ring compound with a trifluoromethyl group. It is a solvent and can react with amines to form solvents. 2-(Trifluoromethyl)piperidine reacts with pipecolic acid to form yields of lactams, and also reacts with pyridine to form diffraction crystals. This compound has been used in the synthesis of monocyclic compounds such as pyridinones and pyrimidinones.

10-Fluoro-7-thiophen-2-yl-1,2,3,4,4a,5-hexahydropyrazino[1,2-a][1,4]benzodiazepine (10FT) is a metabolite of the anti-seizure drug levetiracetam. 10FT has been shown to be a substrate for neural metabolism and an inhibitor of neuronal acetylcholine release. 10FT is also a potent competitive antagonist at the benzodiazepine binding site on the gamma subunit of the GABAA receptor in rat brain membranes. 10FT is devoid of any detectable anticonvulsant activity and does not bind to benzodiazepine receptors in mice.

5-Bromo-2-cyano-3-fluoropyridine is an antiviral agent that inhibits the HIV virus. It is a bicyclic molecule that has been shown to have broad-spectrum activity against a variety of viruses, including influenza, herpes simplex virus, and human cytomegalovirus. 5-Bromo-2-cyano-3-fluoropyridine binds to the ATP binding site on the enzyme cyclin kinase, which prevents the formation of ATP and leads to cell death. This compound also has low nanomolar and micromolar ranges of antiviral activity with affinity in the micromolar range.

2,6-Diamino-3,5-difluoropyridine is a synthetic drug that inhibits bacterial growth by reacting with nucleophilic sites on the cell. This antimicrobial drug is stable in crystal form and has a high yield of up to 98%. It is yellow in color and also reacts with fluorine to produce other compounds. 2,6-Diamino-3,5-difluoropyridine is used as an antimicrobial agent and has antibacterial properties. The reactivity of this compound makes it useful for treating infections caused by bacteria such as tetrafluoropyridine.