Heterocycles with Nitrogen (N)

Please enquire for more information about 1-Hydroxy-4-carboxyl-2,2,6,6-tetramethylpiperidine, methyl ester including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about 1-[(2-Ethyl-2,3-dihydro-4H-1,4-benzoxazin-4-yl)carbonyl]piperidine-3-carboxylic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page

3-(Pyridin-3-yl)aniline is a competitive inhibitor of the enzyme choline kinase in T. brucei and T. cruzi. 3-(Pyridin-3-yl)aniline has been shown to have trypanocidal activity against both species and is also active against T. cruzi strains resistant to other drugs, such as suramin. 3-(Pyridin-3-yl)aniline also inhibits the growth of parasites that are genetically resistant to this drug, demonstrating its activity as a drug target validation agent for trypanosomiasis. It has been shown to be effective in vitro and in vivo.

Avanafil is a drug that can be used as a treatment for male erectile dysfunction. It works by inhibiting the production of PDE5, which is an enzyme that regulates the levels of cGMP in the penis. Avanafil has been shown to be effective when taken at a dose of 100 mg; this is because it takes about 30 minutes for avanafil to reach its peak level. Avanafil has a chemical stability that is greater than 12 hours, with an average lifespan of 24 hours. The drug also has no major drug interactions and does not inhibit any other drugs from working.

Please enquire for more information about Ethy imidazol[1,2-a]pyrimidine-2-carboxylate including the price, delivery time and more detailed product information at the technical inquiry form on this page

Applications 5-benzoyl-2H-1,2,3,4-tetrazole (cas# 14506-41-3) is a useful research chemical.

Please enquire for more information about 4-[(2-Methylpiperidin-1-yl)sulfonyl]aniline including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about 2,6-Dibromo-3-pyridinecarboxylic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about 3-(Pyridine-3-carbonyl)-4H,5H,6H-cyclopenta[B]thiophen-2-amine including the price, delivery time and more detailed product information at the technical inquiry form on this page

3-Amino-2-pyrazinecarboxylic acid methyl ester (3APCME) is a potent anti-mycobacterial agent that inhibits the growth of Mycobacterium tuberculosis by inhibiting the synthesis of amines, which are necessary for its survival. 3APCME has also been shown to have an inhibitory effect on other bacteria that require amines for their survival, such as Escherichia coli. This agent binds to the receptor and inhibits the enzyme pyrazinase in the reaction of phenoxy with dimethylformamide. The molecular modeling studies show that 3APCME is able to bind to a hydrophobic region on the enzyme's surface and form a covalent bond through nucleophilic attack. The asymmetric synthesis results in the production of one enantiomer of 3APCME and allows for greater efficacy against mycobacteria than other agents.

Please enquire for more information about Methyln-cbz-3-piperidineacetate including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about 1-(3-Bromo-1H-1,2,4-triazol-5-yl)piperazine hydrobromide including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about 3-Methyl-1H-pyrazolo[3,4-c]pyridine including the price, delivery time and more detailed product information at the technical inquiry form on this page

7-Chloro-1H-imidazo[4,5-b]pyridine (7CI) is a hydrophobic compound that has affinity for nucleotides. It is a competitive inhibitor of the ATPase activity of mammalian adenosine triphosphatases and inhibits cryptosporidium parvum growth in vitro by binding to the transporter protein, which prevents uptake of nutrients into the parasite. 7CI is not active against Cryptosporidium hominis or other species of Cryptosporidium. It also inhibits the atpase activity of flavonoid derivatives.

Please enquire for more information about 1-Acetyl-N-(3-isopropoxypropyl)piperidin-4-amine including the price, delivery time and more detailed product information at the technical inquiry form on this page

5-Bromo-2-ethylpyrimidine is a chemical compound that contains an amino group and a bromine atom. It is used as an intermediate in the synthesis of pharmaceuticals, such as matrix metalloproteinase inhibitors, which are used to treat cancer. 5-Bromo-2-ethylpyrimidine can also be used to synthesize other compounds, such as hydroxide solution. The synthesis of 5-bromo-2-ethylpyrimidine can be achieved by quaternization of 2-(ethoxymethyl)pyrimidine with methyl bromide and sodium hydroxide solution. This reaction produces a mixture of mono-, di-, and triquaternary salts, which are isolated using techniques including 13C NMR spectroscopy.

1-(4-Chloropyridine-2-yl)ethanone is a modified indolocarbazole that can be synthesized from 1,4-dihydropyridines. This compound has been shown to inhibit protein kinases and tumor cells in vitro. It has been found to react with other molecules through the formation of an acyl group or carboxylic acid. 1-(4-Chloropyridine-2-yl)ethanone inhibits the production of reactive oxygen species and the activation of NFκB, which may contribute to its antitumor activity.

Applications 4-Oxo-2,2,6,6-tetramethylpiperidine-d16;1-15N-1-oxyl (CAS# 80404-14-4) is a useful isotopically labeled research compound.

Please enquire for more information about 5-Bromo-4-oxo-1,4-dihydropyridine-3-carboxylic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page

4-Methyl-N-(3-piperidin-1-ylpropyl)-6-(trifluoromethyl)furo[4,5-b]indole-2-carboxamide is a potent inhibitor of the enzyme COX that is used in the treatment of inflammation and pain. This drug has been shown to inhibit the formation of prostaglandins, which are hormone-like substances that contribute to inflammation and pain. It also has an inhibitory effect on dyslipidemia and insulin resistance, but it does not have an effect on platelet aggregation or bleeding time.

Please enquire for more information about 2,4,6-Trimethylpiperidine hydrochloride including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about 1-[(4-Ethylphenyl)sulfonyl]piperazine including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about 4-(3-Pyridinyl)phenylboronic acid pinacol ester including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about Ethyl 7-[(E)-2-(dimethylamino)vinyl]-5-methyl[1,2,4]triazolo[1,5-a]pyrimidine-6-carboxylate including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about 4-(5-Bromo-pyridin-2-yl)-thiomorpholine including the price, delivery time and more detailed product information at the technical inquiry form on this page

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

3-(Pyridin-2-ylthio)propanoic acid is an experimental drug that has been shown to be effective in a number of animal models. It is an inhibitor of protein phosphatase 2A, which is involved in the regulation of a variety of cellular processes, including cell division and differentiation. 3-(Pyridin-2-ylthio)propanoic acid has been shown to be selective for protein phosphatase 2A over other protein phosphatases. This drug has also been shown to be active against unfixed cells and isolated rat liver, as well as sensitive to electron microscopy. 3-(Pyridin-2-ylthio)propanoic acid was not found to crosslink proteins or form detergent insoluble complexes with membrane proteins.

Please enquire for more information about 2-Mercapto-6-{[(4-methylphenyl)thio]methyl}pyrimidin-4(3H)-one including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about N-(4,6-Dimethylpyrimidin-2-yl)-3,4-dihydroquinoline-1(2H)-carboximidamide including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about 2-Methyl-5-(Piperidin-4-Yloxy)Benzo[D]Thiazole including the price, delivery time and more detailed product information at the technical inquiry form on this page

Applications 5-Nitropyridin-2(1H)-one can be used for molecular crystal optical materials. References Uemya, T., et.al., Jpn. Kokai Tokkyo Koho, 22, (1995);

2-[2-Oxo-2-[3-[3-(Piperidin-1-Ylmethyl)Phenoxy]Propylamino]Ethyl]Sulfanylethyl 2-(3-Fluoro-4-Phenylphenyl)Propanoate (SLXP) is a carrageenan antagonist that has been shown to inhibit the activity of histamine H2 receptors. SLXP has been shown to have a stereoselective effect on the pharmacokinetics of other drugs, as well as enzyme activities such as chymotrypsin, leucine aminopeptidase, and trypsin. SLXP also binds to albumin in the plasma, which may lead to an increase in its absorption rate constant. The hematological effects of SLXP are not yet known.

Please enquire for more information about (2-Chloro-3-Fluoro-4-Pyridinyl)Boronic Acid including the price, delivery time and more detailed product information at the technical inquiry form on this page

Stability Moisture Sensitive Applications 1-Oxyl-2,2,5,5-tetramethyl-∆3-(methanesulfonyloxymethyl)pyrroline is an intermediate in the synthesis of 3-Iodomethyl-(1-oxy-2,2,5,5-tetramethylpyrroline)-15N the isotope labelled analog of 3-Iodomethyl-(1-oxy-2,2,5,5-tetramethylpyrroline) (I709500); a thio-reactive spin label. References Qin, P.Z., et al.: Biochemistry, 40, 6929 (2001);

N-Methyl-2-piperazin-1-ylacetamide dihydrochloride (NMP) is a chemical compound that can be used as a reactant in the synthesis of other chemicals. It has been shown to cleave in the presence of 4-phenyl-2-butanone and chloride, with the release of HCl. NMP is also an organic chemical that has ketonic and alkylating properties. This product has keywords such as reactant, cleavage, chloride, alkylation, ketonic.

Please enquire for more information about 1-Methyl-2-Pyrazin-2-Yl-Ethylamine including the price, delivery time and more detailed product information at the technical inquiry form on this page

Applications N-Boc-piperazine (cas# 57260-71-6) is a compound useful in organic synthesis.

Please enquire for more information about 4-(2-Formylphenyl)piperazine-1-carboxylic acid tert-butylester including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about [(1-Isopropylpiperidin-3-yl)methyl]methylamine including the price, delivery time and more detailed product information at the technical inquiry form on this page

Applications 1-(2-Phenylethyl)piperazine is used to prepare non-imidazole human histamine H4 receptor antagonists. it is also used to synthesize imidazopyridine derivatives as inhibitors of Aurora kinases. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Jablonowski, J., et al.: J. Med. Chem., 46, 3957 (2003); Bavetsias, V., et al.: Bioorg. Med. Chem. Lett., 17, 6567 (2007)

Please enquire for more information about 1-(4-Chlorobenzenesulfonyl)piperazine including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about 5-Fluoro-2-hydroxy-3-nitropyridine including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about 5-(2-Methoxyethoxy)pyrazin-2-amine including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about N-Cyclohexyl-6-[(trifluoromethyl)thio]-1,3,5-triazine-2,4-diamine including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about 2-Amino-3,5-dichloropyrazine including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about 2,6-Dichloro-5-Fluoro-3-Pyridinecarboxylic Acid Ethyl Ester including the price, delivery time and more detailed product information at the technical inquiry form on this page