Heterocycles with Nitrogen (N)

The drug, 10-[2-(1-methyl-2-piperidinyl)ethyl]-2-(methylthio)-10H-phenothiazine hydrochloride (CGP 46660), is a competitive antagonist at the human histamine H3 receptor. It has been shown to bind to the histamine H3 receptor in the range of 0.001 to 1 μM and is selective for this receptor over other receptors. CGP 46660 is an optical sensor that can be used in titration calorimetry experiments to measure changes in heat production when it binds to histamine H3 receptors. The drug also has been shown to inhibit guanine nucleotide-binding protein (G protein) signaling pathways and brain functions such as memory formation, learning, and attention span. These effects were demonstrated in humans by measuring EEG activity. The optimum concentration of CGP 46660 for these effects was found to be between 0.01 and 10 μM.

Please enquire for more information about 2-Methyl-3-oxo-3,5,6,7-tetrahydro-2H-cyclopenta[c]pyridine-4-carbonitrile including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about 3-Chloro-5-ethynylpyridine including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about 1-Methyl-2-pyridin-4-yl-ethylamine including the price, delivery time and more detailed product information at the technical inquiry form on this page

Applications Intermediate for heterocyclic compounds as tyrosine kinase inhibitors and anticancer agents. References McLean, A., et al.: J. Chem. Phys., 72, 5639 (1980), Watts, J., et al.: J. Biol. Chem., 276, 43197 (2001),

Please enquire for more information about 2-Chloro-3,5-difluoropyridine including the price, delivery time and more detailed product information at the technical inquiry form on this page

4-Chloro-1H-imidazo[4,5-c]pyridine (4CI) is a nucleoside analog that inhibits the replication of RNA and DNA. It has significant inhibitory activity against herpes simplex virus type 1 and human immunodeficiency virus type 1 (HIV-1). 4CI inhibits the synthesis of adenosine, an important component in the synthesis of RNA and DNA. This drug also has antiviral properties against influenza A and B viruses. 4CI's effect on plasma cholesterol levels is thought to be due to inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase.

Applications 4-(6-hydrazinylpyrimidin-4-yl)morpholine (cas# 5767-36-2) is a useful research chemical.

2-Chloro-3-hydroxypyridine is a reactive chemical that can be synthesized from hydrochloric acid and ammonia. It has a high melting point, which is an indication of its strength. 2-Chloro-3-hydroxypyridine has been used in the kinetic and population growth studies for bacteria. The reaction of 2-chloro-3-hydroxypyridine with sodium hydrogen is exothermic and has a red shift, which indicates that the activation energy for this reaction is low. Activation energies are important because they indicate the stability of molecules.

Please enquire for more information about 1-{2-(4-Chlorophenyl)-7-[(E)-2-(dimethylamino)vinyl][1,2,4]triazolo[1,5-a]pyrimidin-6-yl}ethanone including the price, delivery time and more detailed product information at the technical inquiry form on this page