Heterocycles with Nitrogen (N)

Applications 6,7-Dimethoxy-2-(4-(tetrahydrofuran-2-carbonyl)piperazin-1-yl)quinazolin-4(1H)-one is an analogue of Terazosin (T105000), an α-1-adrenergicblocker related to prazosin (P702325). References Patterson, S.E., et al.: J. Chromatog., 311, 206 (1984), Fort, F.L., et al.: Drug Chem. Toxicol., 7, 435 (1984), Lepor, H., et al.: J. Urol., 148, 1467 (1992),

3-Amino-6-bromopyridine is a viscosity modifier that is used in the formulation of polymeric matrix tablets and as an additive in cosmetic products. It has been shown to be effective against cancer and may have other therapeutic uses. 3-Amino-6-bromopyridine is reactive and can easily react with amines, such as dopamine, to form a covalent bond. This chemical can also react with hydrogen chloride to form a ring opening product. The chloride ion can also react with 3-amino-6-bromopyridine to form a polymeric matrix. 3-Amino-6-bromopyridine has been shown to be active against cancer cells in model studies, but it has not been tested on humans or animals yet.

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Butenafine is a topical antifungal agent which inhibits the growth of fungi that cause superficial skin infections. It is effective against tinea cruris and tinea pedis. Butenafine has been shown to be more effective than terbinafine hydrochloride in clinical trials with a higher rate of symptom relief. The mechanism of action for butenafine is not completely understood, but it may inhibit the synthesis of ergosterol, which is an important component for fungal cell membranes. Butenafine also inhibits the production of prostaglandin E2 (PGE2), which leads to skin inflammation and itching.

Applications Methyl 3-(Imidazol-4-yl) Propionate (cas# 31434-93-2) is a compound useful in organic synthesis.

5-(4,6-Dimorpholino-1,3,5-triazin-2-yl)-4-(trifluoromethyl)pyridin-2-amine is an experimental drug that inhibits the growth of cells by inhibiting protein synthesis. It has been shown to be effective in vitro against t-cell lymphomas and monoclonal antibody resistant B cell lymphomas. This molecule also inhibits the production of a number of growth factors, including those for T cells and B cells, which may explain its ability to inhibit the growth of these types of cancer cells. 5-(4,6-Dimorpholino-1,3,5-triazin-2-)yl)-4-(trifluoromethyl)pyridin-2-amine has also been shown to have anti microbial activity against a variety of microbes that cause infections in humans.

4-Chloro-8-methoxy-2-methylquinoline is a compound that has been found in nature. It is a diversity of nonreciprocal nucleic acid sequences and has been shown to be polymorphic. This nucleotide can cause stenosis in the coronary heart, which may lead to heart disease. 4-Chloro-8-methoxy-2-methylquinoline also inhibits the growth of Plasmodium falciparum and Plasmodium vivax. The drug's mechanism of action is not yet known, but it may have evolved from other compounds with a similar molecular structure.

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Trifluridine is an anti-inflammatory drug that inhibits the production of tumour necrosis factor-α (TNF-α) and serum enzymes, such as dismutase activity, in mice with lung cancer. It has been used clinically to treat patients with various diseases including chronic inflammatory conditions, asthma, and rheumatoid arthritis. Trifluridine has been shown to inhibit the production of TNF-α in human fetal bovine cells in vitro. It also has a toxic effect on respiratory system cells, which may be due to its ability to induce apoptosis. Trifluridine is a potent inhibitor of TNF-α and other cytokines by binding to TNF receptor 1 (TNFR1). This binding prevents the formation of an enzyme complex with the TNFR1 that is required for cell division.

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Applications Methyl 4-hydroxy-1H-pyrrole-2-carboxylate is a useful reagent for organic synthesis.

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Applications A stable and versatile reagent for the efficient and chemically specific guanylation of sterically unhindered primary and secondary aliphatic amines under mild conditions. Useful reagent in peptide synthesis. References Baslow, M., et al.: J. Inherit. Metab. Dis., 23, 684 (2000), Lee, Y., et al.: Bioorg. Med. Chem. Lett., 10, 2771 (2000), Baslow, M., et al.: Neurochem. Res., 27, 403 (2002),

Applications 2-(pyrrolidin-1-yl)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidine dihydrochloride (cas# 1864058-89-8) is a useful research chemical.

2-sec-Butyl-3-methoxypyrazine is a natural compound that belongs to the class of capsicum annuum. It can be found in chilli peppers. 2-sec-Butyl-3-methoxypyrazine has been shown to have an antioxidant effect, as it inhibits lipid peroxide formation and scavenges free radicals. The lc-ms/ms method has been used for the identification and quantification of 2-sec-Butyl-3-methoxypyrazine in chilli peppers. In addition, the biosynthesis of 2-sec-Butyl-3-methoxypyrazine has been studied. 2 sec Butyl 3 methoxy pyrazine has also been shown to have a high degree of thermal stability, withstanding temperatures up to 200°C.

1,2-Dimethylpiperazine is a covalent inhibitor that binds to the active site of bacterial enzymes. It has been shown to be effective against cancer cells in vitro and in vivo. 1,2-Dimethylpiperazine also inhibits the growth of bacteria by inhibiting their cell division and protein synthesis. This drug has been shown to be successful as an anticancer agent when used with l-tartaric acid (an organic solvent) and hydrogen bond additives. It is currently being investigated for its use as a treatment for symptoms associated with psychotic disorders.

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2-Iodopyridine is an organic compound with the chemical formula C5H5N. It is a white crystalline solid that is soluble in water, alcohol, and ether. The molecule contains a methyl group and two iodine atoms. 2-Iodopyridine has several industrial uses. It acts as a precursor to various pharmaceuticals and agrochemicals. The compound also exhibits insulin resistance properties, which may be related to its ability to bind to the insulin receptor and inhibit insulin signaling. 2-Iodopyridine can also be used for treating cancer because it binds to the DNA of cancer cells, preventing replication and leading to cell death.

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Applications 2,3-Pyrazinedicarboxylic Acid has been found to exhibit antifungal and antibacterial acitivity. It has also been used as a reagent in the preparation of transition metal pyrazinedicarboxylate complexes. References Beaula, T.J., et al.: Spectrochim. Acta A, 138, 723 (2015); Premkumar, T., et al.: World J. Microb. Biot., 21, 479 (2005); Gunay, G., et al.: Inorg. Chim. Acta, 399, 19 (2013)

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Inhibitor of CD4+ - GP120 binding during HIV infection

N,N'-Bis(3-hydroxypropyl)homopiperazine is a synthetic compound that inhibits platelet aggregation by binding to the membrane of the platelet. It causes an increase in the concentration of calcium ions in the platelet membrane, which leads to platelet activation and aggregation. N,N'-Bis(3-hydroxypropyl)homopiperazine also dilates blood vessels and lowers blood pressure. This drug has a constant elimination rate of 24 hours.

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Imidazo[1,2-a]pyridin-2(3H)-one is a heterocyclic organic compound. It has a bathochromic shift between 490 and 540 nm. The functional groups present in this compound are an amine group, an imino group, and an imidazole ring. Imidazo[1,2-a]pyridin-2(3H)-one is soluble in solvents of various polarity. It emits light when excited by x-rays or UV radiation. It also shows fluorescence and magnetic properties. This compound can be used as ligand for coordination compounds with metal ions like nickel or copper.

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6-Amino-5-bromopyrimidine-2,4(1H,3H)-dione (6ABPD) is a purine derivative that functions as an inhibitor of phosphorylase kinase. It has been shown to inhibit tumor growth in vivo and in vitro and is used as a therapeutic agent for the treatment of cancer. 6ABPD inhibits the production of phosphorylase kinase by binding to the enzyme's active site with noncompetitive inhibition. Inhibition of phosphorylase kinase leads to a decrease in the levels of ATP and thus decreases the availability of substrates for tumor cell growth and proliferation. 6ABPD also binds to thymidine kinase and inhibits its activity, which may account for some of its antitumor effects.

2,4-Diphenylpyridine is a ligand that can be used in cross-coupling reactions. It is a x-ray crystal structure that has been determined by x-ray crystallography and functional theory calculations. The compound contains a pyridine ring with two phenyl groups attached to it. This ligand can be used in homogeneous catalysis as an ancillary ligand to bind to metal ions, which are then able to catalyze organic reactions. 2,4-Diphenylpyridine is soluble in solvents such as trifluoroacetic acid and has been shown to be an efficient catalyst for many reactions.

Applications 1-Pyridin-2-yl-propan-2-one is an antimicrobial bioactive compound extracted from Lactarius vellereus fermenting liquor. References Ji, H., et al.: Beijing Linye Daxue Xuebao, 30, 92 (2008); Song, R., et al.: From Faming Zhuanli Shenqing (2008), CN 101230368 A 20080730;