Heterocycles with Nitrogen (N)

Please enquire for more information about 4-Methyl-4-phenylpiperidine hydrochloride including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about 5-Bromo-3-methyl-1H-pyrazolo[3,4-c]pyridine including the price, delivery time and more detailed product information at the technical inquiry form on this page

Pyrazolo[1,5-a]pyrimidine-3-carbonitrile is a broad-spectrum antimicrobial that has been shown to inhibit the growth of bacteria, fungi, and viruses. It also has anti-cancer properties, which may be related to its ability to bind to DNA and inhibit cellular proliferation. Pyrazolo[1,5-a]pyrimidine-3-carbonitrile binds to the hydroxyl group of fatty acids in cellular membranes and disrupts their function. This compound is toxic at high doses and can cause damage to the heart or lungs. Pyrazolo[1,5-a]pyrimidine-3-carbonitrile has been shown to be effective against human cancer cells in tissue culture. It also has been shown to have a specific treatment effect on cervical cancer cells by inhibiting protein synthesis and inducing apoptosis via reactive oxygen species (ROS) production.

Please enquire for more information about Ethyl 4-amino-2-mercaptopyrimidine-5-carboxylate including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about N'-Hydroxyimidazo[1,2-a]pyridine-6-carboximidamide including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about 3-(Piperazin-1-yl)benzamide including the price, delivery time and more detailed product information at the technical inquiry form on this page

Applications 3-(Pyridin-2-yl)propiolic Acid is a useful reagent in the regioselective Pd-catalyzed carbopalladation/decarboxylative allylic alkynylation of ortho-iodoallenamides. References Hedouin, J., et al.: J. Org. Chem., 84, 10535 (2019)

Please enquire for more information about 1-(1-PHENYLCYCLOPROPYL)PIPERAZINE including the price, delivery time and more detailed product information at the technical inquiry form on this page

3-(1-Piperidin-1-ylcyclohexyl)phenyl]amine hydrochloride is a ligand that binds to the acetylcholine receptor. 3-(1-Piperidin-1-ylcyclohexyl)phenyl]amine hydrochloride is an active analogue and has a high binding affinity for the cholinergic receptor. It has been shown to have a kinetic effect on the excitatory system, enhancing excitatory effects of acetylcholine without affecting inhibitory effects. 3-(1-Piperidin-1-ylcyclohexyl)phenyl]amine hydrochloride also has an antagonistic effect on modifiers of acetylcholine activity such as amantadine, but enhances the effects of other drugs, such as clonidine.

2-Piperidin-4-yl-1H-benzoimidazole (2PB) is a cholinergic drug that has been shown to inhibit the acetylcholine esterase enzyme. It has been shown to be effective in the treatment of Alzheimer's disease and cancer, as well as in the prevention of fluoroquinolone resistance. 2PB is an amine and can be found in a number of plants, such as tobacco and black pepper. It is also present in cannabis and some other plants. 2PB was synthesized by reacting 4-aminobenzaldehyde with 1-(2-piperidyl)benzene. The molecular modeling showed that 2PB may be used as a bioisostere for medicinal purposes.

2,4-Dichloro-3-nitropyridine is a halogenated pyridinium salt that has been shown to inhibit the influenza virus in vitro. This compound is also reactive with nucleophilic groups such as amines, alcohols, and thiols. 2,4-Dichloro-3-nitropyridine has been used for the synthesis of quinoline derivatives that have potential applications in autoimmune diseases or cancer. 2,4-Dichloro-3-nitropyridine has also been found to be an inhibitor of tumor necrosis factor alpha (TNFα) production by LPS stimulated human monocytes.

Please enquire for more information about 1-[[(4,6-Dimethylpyrimidin-2-yl)amino](imino)methyl]piperidine-4-carboxamide including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about 7-(2-Furyl)-2-methyl-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidine-5-carboxylic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about 1-[4-(1,1-Dioxido-1,2-benzisothiazol-3-yl)piperazin-1-yl]-3-methoxypropan-2-ol hydrochloride including the price, delivery time and more detailed product information at the technical inquiry form on this page

Pyridin-2-sulfonyl chloride is a kinase receptor inhibitor that binds to and inhibits the activity of certain protein kinases. It is used in the treatment of cardiovascular disorders and can be administered intravenously or orally. Pyridin-2-sulfonyl chloride has been shown to inhibit tumor necrosis factor-α (TNF-α) production in vivo, which may be due to its ability to inhibit the release of proinflammatory cytokines from macrophages. This drug also has pharmacokinetic properties that are similar to those of other sulfonamides, with an elimination half life of about 2 hours. Pyridin-2-sulfonyl chloride is not reactive with amines, which makes it a useful reagent for organic synthesis.

Applications 4-Benzylpyridine is a benzylpyridine with antifungal properties. 4-Benzylpyridine has been used as a reactant in the synthesis of bis(alkylpyridinium)alkanes as antifungal agents. References Takeshiba, H. et al.: Sank. Kenk. Nen., 23, 225 (1971)

Applications 2,2,6,6-Tetramethylpiperidine-1,4-diol is related to 4-Hydroxy-2,2,6,6-tetramethyl-1-piperidinyloxy (H956500), which is a free radical scavenger. 2,2,6,6-Tetramethylpiperidine-1,4-diol has also been shown to be an in vitro and in vivo radioprotector. It is used as a reagent in stereoselective preparation of tetrasubstituted triarylated olefins via Pd-catalyzed sequential oxidative Heck arylation of alkenes with arylboronic acids using nitroxides as oxidants. References Flather, M., et al.: Lancet, 355, 1575 (2000); Sasso, F., et al.: Metabolism, 52, 675 (2003); Kass, D., et al.: Circ. Res., 94, 1533 (2004); Murdoch, C., et al.: Cardiovasc Res., 71, 208 (2006); Hahn, M., et al.: Free Radic. Biol. Med., 28, 953 (2000); He, Z., et al.: Angew. Chem. Int. Ed., 51, 3699 (2012);

2,2'-Biquinoline-4,4'-dicarboxylic acid disodium salt is a model system for studying the sequence and hydrogen bonding interactions of polymers. It is a biocompatible polymer that has been shown to have inhibitory properties in response to atherosclerotic lesions. 2,2'-Biquinoline-4,4'-dicarboxylic acid disodium salt has shown optical properties that can be used as a signal in recording sequences. This polymerase chain reaction (PCR) substrate is able to bind with DNA and protein molecules when they are present in an appropriate buffer. The sequence of 2,2'-biquinoline-4,4'-dicarboxylic acid disodium salt is controlled by the coordination geometry of the metal ions involved in its formation.

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Please enquire for more information about 3-Mercapto-6-methylpyridazine including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about 1-(Methylsulfonyl)-1,4-diazepane hydrochloride including the price, delivery time and more detailed product information at the technical inquiry form on this page

2-Methoxy-3-nitropyridine is a chemical compound with the molecular formula CHNO. It is classified as an amine and has a molecular weight of 140.24 g/mol. 2-Methoxy-3-nitropyridine is a colorless liquid that can be used to make other compounds, such as nitroarenes, boronic acids, and dyes. The molecule consists of a central carbon atom with four nitrogen atoms at the corners of a tetrahedron. The electron configuration for this molecule is 1s22s22p4. This means that the outer shell electrons are in orbitals with principal quantum numbers s=1 and p=2. These orbitals are located near the middle of the molecule rather than on the periphery as in ethane (CH3CH2). This orientation provides more space for other atoms to attach to the central carbon atom, which increases its affinity for nucleophilic attack. 2-M

Please enquire for more information about 4-Bromo-5-methoxypyrimidine hydrobromide including the price, delivery time and more detailed product information at the technical inquiry form on this page

7-Methylindole is a biochemical substance that is synthesized in the body. It is produced in the liver, and it can be found in the brain, heart, and kidney. 7-Methylindole has been shown to have cancer-fighting properties. 7-Methylindole binds to DNA by methylating nucleic acid bases, which causes a change in the genetic code. This leads to tumor cells being more sensitive to treatment with other substances that inhibit DNA synthesis or repair, such as anthranilate and 5-methoxyindole.

Please enquire for more information about 3-Chloro-5-phenyl-7-(trifluoromethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-2-carboxylic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about 4-Bromo-3-methyl-1-(pyrimidin-2-yl)-1H-pyrazol-5-amine including the price, delivery time and more detailed product information at the technical inquiry form on this page

Tert-butyl 2-bromo-6,7-dihydrothieno[3,2-c]pyridine-5(4H)-carboxylate is an epoxy that is soluble in organic solvents. It can be used as a liquid composition for the treatment of skin conditions such as acne and psoriasis. Tert-butyl 2-bromo-6,7-dihydrothieno[3,2-c]pyridine-5(4H)-carboxylate is also a substance that has been found to have high activity against bacterial infections.

Please enquire for more information about 2-(Azidomethyl)-3,5-dimethylpyridin-4-ol including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about 1-(2-Chloropyrimidin-4-yl)-3-methyl-1H-pyrazole-4-carbaldehyde including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about 2,3-Dihydro-[1,4]dioxino[2,3-c]pyridine-7-carbaldehyde including the price, delivery time and more detailed product information at the technical inquiry form on this page

2-Cyanopyrazine is a molecule that belongs to the group of nitrogen-containing heterocyclic compounds. It has been shown to exhibit antiinflammatory activity in skin cancer cells and bacterial strain, group P2. This compound inhibits the growth of bacteria by binding to their pyrazinoic acid, which is an electron acceptor. 2-Cyanopyrazine also exhibits tuberculostatic activity against M. tuberculosis and M. avium complex by inhibiting the synthesis of mycolic acids and cell wall lipids, respectively. The redox cycle of this compound is coordinated with a hydrogen bond between the hydroxyl group and the carbonyl carbon atom. 2-Cyanopyrazine is oxidized from its initial state through a reaction mechanism involving molecular oxygen or hydrogen peroxide as an oxidant and water as a reductant. The oxidation products can be reduced back to 2-cyanoapyrazine using ascorbate or NADH as

Applications Ethyl 2,5-Dibromo-1,3-oxazole-4-carboxylate is useful for the synthesis of substituted oxazoles. References Hodgetts, K. J., et al.: Org. Lett., 4, 2905-2907 (2002)

Applications 4-(Piperazin-1-yl)thieno[3,2-c]pyridine (cas# 106261-27-2) is a useful research chemical.

1-Propylpiperazine is a piperazine derivative with immobilizing properties. It has been shown to inhibit the growth of infectious agents by binding to the amine group in dopamine or tyramine and interfering with neurotransmission. 1-Propylpiperazine has also been shown to have anti-cancer activity, which may be due to its ability to induce apoptosis and inhibit cancer cell proliferation.

Please enquire for more information about 5-(1-Methyl-Piperidin-4-Yl)-1H-Indazole including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about 3-{[(2-Fluorobenzyl)oxy]methyl}-1-methyl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine hydrochloride including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about tert-Butyl 3-(6-amino-3-methylpyridin-2-yl)benzoate including the price, delivery time and more detailed product information at the technical inquiry form on this page

2-Amino-4,6-dihydroxy-5-methylpyrimidine is a versatile building block that can be used in the synthesis of complex compounds. It has CAS No. 55477-35-5 and can be used as a reagent or speciality chemical for research purposes. 2-Amino-4,6-dihydroxy-5-methylpyrimidine is also useful for the synthesis of reaction components and scaffolds for high quality compounds.

Applications 2-Amino-3-hydroxypyridine (cas# 16867-03-1) is a compound useful in organic synthesis.