Heterocycles with Nitrogen (N)

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Stability Hygroscopic Applications 5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic Acid Hydrochloride is used as a reagent in the synthesis of N-(2-acylaminobenzyl or 2-acylaminoheterocyclylmethyl)thiophene-2-carboxamide derivatives as antithrombotics. It is also used as a reagent in the synthesis of diamide derivatives as FXa inhibitors. 5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic Acid Hydrochloride is an intermediate for Edoxaban (E555520). References Mochizuki, A., et al.: Jpn. Kokai Tokkyo Koho. JP 2010120852 A 20100603. Jun 3, 2010; Mochizuki, A., et al.: PCT Int. Appl. WO 2008123017 A1 20081016. Oct 16, 2008

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5-Pyrimidineboronic acid is a molecule that is involved in the synthesis of nucleotides, amino acids and sugars. It has been shown to cause cancer in animals and humans. 5-Pyrimidineboronic acid also inhibits the activity of an enzyme called ns3 protease, which plays a key role in tumor growth. The acidic nature of this compound makes it suitable for use as a chemotherapeutic agent against hypoxic tumors.

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Temsavir is an antiretroviral drug that belongs to the class of piperazine. It is a prodrug that is converted by liver enzymes into its active form, 1-Boc-3,5-dimethyl-piperazine (1-BDMP). Temsavir has shown long-term clinical benefits in HIV patients and it has been approved for use in combination with other antiretroviral drugs. Temsavir inhibits the activity of reverse transcriptase, which is an enzyme needed for HIV replication. Temsavir also inhibits the activity of human liver microsomes. Studies have shown that temsavir can be effective against different chemotypes of HIV such as MDR or XDR strains.

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2-Chloro-4-iodopyridine is an antibacterial agent that inhibits bacterial growth by interfering with the synthesis of folic acid. It has been shown to be effective against Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa. 2-Chloro-4-iodopyridine is a ligand that binds to metal ions such as copper and silver. The transfer of electrons from the metal ion to the ligand facilitates the cross-coupling reaction in organic synthesis. Cross-coupling reactions are also used in devices such as solar cells and hydrogen fuel cells. 2-Chloro-4-iodopyridine can also be used for photophysical experiments with single crystal x-ray diffraction studies.

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Please enquire for more information about N'-(5-Aminopentyl)-N-(4-methoxybenzyl)-N'-methyl-N-2-pyridinyl-1,2-ethanediamine, dimaleate salt including the price, delivery time and more detailed product information at the technical inquiry form on this page

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Applications 2,5-Diacetamido-2,3-dihydrothiazolo[4,5-d]pyrimidine-7-(6H)-one (cas# 22365-29-3) is a compound useful in organic synthesis.

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Applications 3-(Chloromethyl)pyridine Hydrochloride has been used as a reactant for the synthesis of (E)-3-((1H-Indazol-6-yl)methylene)indolin-2-one derivatives as Polo-like kinase 4 (PLK4) inhibitors. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Laufer, R., et. al.: J. Med. Chem., 56, 6069 (2013)

4-Fluoroindole is a compound that belongs to the class of 5-methoxyindoles, which are used as drugs in plant physiology. The analog of 4-fluoroindole is important for cell culture and transcriptomic analysis. It has been shown to reduce the growth of cryptococcus neoformans by inhibiting its ability to produce acid. 4-Fluoroindole also inhibits the growth of other opportunistic fungi, such as Aspergillus niger. This drug is addictive and can be toxic if it enters the environment. 4-Fluoroindole also inhibits the growth of plants when applied as a pesticide.

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Applications The (R)-enantiomer intermediate in the preparation of Oxiracetam (O846905). References Kondepudi, D., et al.: Science, 250 975 (1990), Di Silvestro, G., et al.: J. Pharm. Sci., 82, 758 (1993),

(R)-3-Phenylpiperidine is a synthetic compound that belongs to the group of pyrazoles. It is an analog of pyridoxine and has been shown to inhibit HMG-CoA reductase, which is a key enzyme in the synthesis of cholesterol. (R)-3-Phenylpiperidine has been shown to have anti-inflammatory properties and is hepatoselective, meaning it has selective toxicity for liver cells over other cells. This may be due to its ability to induce efflux in Caco-2 cells.

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5-Bromo-2,4-diamino-6-hydroxypyrimidine (5BDAP) is a ribonucleotide and aminoimidazole analog that has been shown to be a potent inhibitor of the enzyme dihydrofolate reductase. 5BDAP is structurally similar to the natural substrate for this enzyme, thymine, and like other analogues, it competes with the natural substrate for binding to the enzyme's active site. 5BDAP binds to the enzyme and blocks its activity, preventing it from reducing dihydrofolic acid into tetrahydrofolic acid. This prevents the production of thymidylate synthase and thymidylate, which are key enzymes in DNA synthesis.

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2-Amino-4,6-dichloro-s-triazine is a chemical compound that is used as an antimicrobial agent in wastewater treatment. It inhibits the growth of bacteria by binding to cell walls and disrupting the formation of crosslinks between peptidoglycan strands, thereby inhibiting the synthesis of proteins necessary for bacterial growth and reproduction. 2-Amino-4,6-dichloro-s-triazine has been shown to be effective against group p2 bacteria in cell culture experiments. This drug also displays antiinflammatory properties and has been shown to inhibit HIV infection in vitro.

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3-(1H-Pyrazol-3-yl)pyridine (PPY) is a potent and selective inhibitor of cyclooxygenase-2 (COX-2). PPY has been shown to inhibit COX-2 activity with an IC50 value of 0.4 μM. PPY does not inhibit COX-1, which is responsible for the production of prostaglandins that maintain the normal function of the stomach and intestine. PPY also has a low safety profile, with no significant effects on the heart or kidneys in animal studies. The compound is being developed as a potential treatment for inflammatory diseases such as rheumatoid arthritis. The drug was originally discovered by screening chemical libraries for compounds that could inhibit COX-2 activity. Molecular docking studies have shown that PPY binds to the active site of COX-2, preventing access to substrates and thereby inhibiting catalytic activity.

2,4-Dichloro-5-formyl-2-(methylthio)pyrimidine is a cyclocondensation compound that contains a chlorine atom. It is produced by the reaction of 2,4-dichloropyrimidine and formaldehyde. This product is hydrolyzed to produce methylthiopyrimidine.

Metabolite of etravirine

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2,2',6,6'-Tetramethoxy-4,4'-bis(diphenylphosphino)-3,3'-bipyridine (Pd-tmtpp) is a palladium catalyst that can be used for the asymmetric synthesis of β-unsaturated ketones. The reaction mechanism for this catalyst is similar to that of other palladium catalysts with a high degree of stereoselectivity. The reaction rate depends on the reaction temperature and the type of solvent. This compound is highly reactive and can react with an aryl halide to form an organopalladium complex in which the carbon atom is bound to two phosphine ligands and one palladium atom. Pd-tmtpp can also be used in allylation reactions with quinoline derivatives and prenylation reactions with functionalized substrates such as allenes.

2-Amino-3-nitropyridine is a synthetic molecule that has the chemical formula C6H7N5O2. It can exist in four different forms, three of which are isomers. These three isomers have different properties, such as melting point and solubility. The synthesis of 2-amino-3-nitropyridine can be achieved through a solid phase synthesis using sodium periodate as the acid catalyst. The reaction mechanism involves nitration of 2-amino pyridine with hydrogen peroxide to produce 3-nitro pyridine followed by hydrolysis to form 2-amino-3 nitropyridine. This reaction produces two dihedral angles in the molecule, one between the nitrogen and oxygen atoms and another between the nitrogen atom and carbon atom bonded to it. The functional groups present on this molecule are an amino group, a nitro group, and an amide group.

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