Heterocycles with Nitrogen (N)

Please enquire for more information about 5-Bromo-2-(trifluoromethyl)-4-pyridinecarboxylic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page

Applications 2,5-Dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-pyridine is used in the synthesis of morpholinothiazoles as alpha 7 position allosteric modulators. References MacDonald, G., et al.: PCT Int. Appl. (2011), WO 2011064288 A1 20110603

Please enquire for more information about Ethyl 4-methyl-2-(4-phenylpiperazin-1-yl)pyrimidine-5-carboxylate including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about 1-[4-(4,4,5,5-TetraMethyl-1,3,2-dioxaborolan-2-yl)phenyl]piperidine including the price, delivery time and more detailed product information at the technical inquiry form on this page

Monomethyl triazeno imidazole carboxamide (MTIC) is a drug that is used to treat cancer. It has been shown to inhibit the proliferation of tumor cells and induce apoptosis by inhibiting the expression of proteins, such as Bcl-2, which are involved in regulating mitochondrial membrane potential. MTIC has also been shown to inhibit protein synthesis and cell signaling pathways, such as the PI3K/Akt pathway. The use of MTIC for diagnosis purposes can be achieved using electrochemical impedance spectroscopy. A concentration-time curve can be obtained by incubating a biological sample with MTIC and measuring cell response using an impedance spectrophotometer. The clinical properties of MTIC include its ability to be administered orally or intravenously, have low toxicity, and inhibit the growth of tumor cells in vivo and in vitro.

Please enquire for more information about 1-Butyrylpiperidin-4-one including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about 6-Amino-4-methoxy-1-(2-deoxy-alpha-D-ribofuranosyl)-1H-pyrazolo[3,4-d]pyrimidine including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about 7,8-Dihydro-5H-pyrano[4,3-d]pyrimidin-2-amine including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about 4-Benzyl-piperazine-1-carbonylchloride including the price, delivery time and more detailed product information at the technical inquiry form on this page

Stability Moisture Sensitive Applications Pentathiodiphosphorus(V) Acid P,P′-Bis(pyridinium betaine) is an thionating agent used in synthetic chemistry. References Bergman, J., et al.: J. Org. Chem., 76, 1546 (2011);

2,2'-Dithio-bis(5-nitrophenyl) is a redox probe that can be used to study ATP-sensitive K+ channels. This probe has been shown to bind to the carboxy terminal of the channel and disulfide bond through its thiol group. The binding of 2,2'-dithio-bis(5-nitropyridine) to the activated liver cells causes an increase in the redox potential, which leads to an accumulation of electrons in these cells. These electrons are then transferred to pyridine nucleotides and phosphate ions, leading to an increase in ATP levels and activation of ATP-sensitive K+ channels.

1-Ethyl-3-methylpyridinium ethyl sulfate is a viscometric technique that can be used to measure the viscosity of liquids. This method is based on the principle that as the concentration of a liquid increases, its viscosity will also increase. This method is typically used for measurements in xylene, ternary phase, and sensor surface methodology. The viscosity of solids and liquids can be determined using this technique. Viscosity measurements are important in determining the flow properties of materials and their suitability for various industrial processes. 1-Ethyl-3-methylpyridinium ethyl sulfate has been shown to have an osmotic pressure effect on pyrrole, n-hexane, and oleic acid solutions. It has also been shown to have an aromatic hydrocarbon dispersive effect on benzene and other aliphatic hydrocarbons.

Please enquire for more information about CP-​601932 including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about 1-[3-(Benzyloxy)-4-methoxybenzyl]piperazine including the price, delivery time and more detailed product information at the technical inquiry form on this page

Applications 4-Benzoyl-1H-pyrrole-2-carboxylic Acid (cas# 15372-84-6) is a useful research chemical.

Please enquire for more information about 4-(Phenylamino)-1-benzyl-4-piperidinecarboxamide including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about 5-Fluoro-2,4(1H,3H)-(2-14C)pyrimidine including the price, delivery time and more detailed product information at the technical inquiry form on this page

Applications 4-BROMO-2-PYRIDINECARBOXAMIDE (cas# 62150-46-3) is a useful research chemical.

Please enquire for more information about 6-Bromo-5-methylpyridin-3-ol including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about tert-Butyl4-(1H-indol-3-yl)piperazine-1-carboxylate including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about 1-(3-Methylbenzyl)piperidine-4-carboxylic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about 5-Nitro-2-(4-pyridin-2-ylpiperazin-1-yl)benzonitrile including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about (2-Bromo-5-methoxypyridin-4-yl)boronic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about 3,5-Dimethylpyrazine-2-carboxylic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about 4-(3,5-Dimethoxyphenyl)-4,5,6,7-tetrahydro-3H-imidazo[4,5-c]pyridine including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about N-Cyclopropyl-4-(piperidin-4-ylmethoxy)benzamide hydrochloride including the price, delivery time and more detailed product information at the technical inquiry form on this page

Applications Methyl 1-[(2-Fluorophenyl)methyl]pyrazolo[3,4-b]pyridine-3-carboximidate is a useful reactant to study metabolites of orally active NO-independent pyrazolopyridine stimulators of soluble guanylate cyclase. References Straub, A., et al.: Bioorg. Med. Chem., 10, 1711 (2002);

5-Chloro-6-hydroxy-1H-pyrimidin-4-one is an oxychloride of malonate. It can be extracted from malonate by chlorination, which is a reaction of phosphorus oxychloride and diethyl malonate in the presence of an organic solvent. The synthesis method for this compound is a chlorination reaction with formamidine, phosphorus oxychloride, diethyl malonate and an organic alkali such as methanol in dropwise fashion. This process produces 5-chloro-6-hydroxy-1H-pyrimidin-4-one and formamide as products.

Please enquire for more information about 3,5-Difluoro-4-iodopyridine including the price, delivery time and more detailed product information at the technical inquiry form on this page

4-Piperidinopiperidine is a potential inhibitor of the enzyme, fatty acid synthase (FASN), which catalyzes the conversion of acetyl-CoA to malonyl-CoA. This reaction is important for the production of palmitic acid and other long chain fatty acids. 4-Piperidinopiperidine has been shown to inhibit FASN activity in a dose dependent manner with an IC50 value of 0.1 mM. The inhibition was not reversible and covalent adducts were formed with lysine residues on the protein surface. 4-Piperidinopiperidine has been shown to bind to DNA templates in an agarose gel electrophoresis assay, suggesting that this drug may be useful as a template molecule for therapeutic purposes.

Please enquire for more information about 5-Amino-2-(4-methylpiperazin-1-yl)benzonitrile including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about 6-Chloropyridine-2-boronic acid pinacol ester including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about 4-Chloro-2-piperazin-1-yl-pyrimidine including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about 8-Ethyl-2-pyridin-3-ylquinoline-4-carboxylic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about 2-chloro-3-nitro-5-(trifluoromethyl)pyridine including the price, delivery time and more detailed product information at the technical inquiry form on this page

2-(1-(2-(4-chlorophenyl)-5-methylpyrazolo[1,5-a]pyrimidin-7-yl)piperidin-2-yl)ethanol is a drug that belongs to the group of orthosteric agonists. It has significant effects on rat brain concentration response curves and a profile that is receptor mediated. This compound has been shown to bind to 5HT2 receptors and alkoxycarbonylamino groups in membranes from rat brain. It also has an effect on locomotor activity in rats. 2-(1-(2-(4-chlorophenyl)-5-methylpyrazolo[1,5-a]pyrimidin-7-yl)piperidin-2-yl)ethanol is used clinically for the treatment of depression, anxiety disorders, and posttraumatic stress disorder.

(2R,6S)-rel-4-[[[3,5-Bis(trifluoromethyl)phenyl]methyl][5-(1-methyl-1H-pyrazol-4-yl)-2-pyrimidinyl]amino]-2,6-diethyl-1piperidineca rboxylic acid trans-4carboxycyclohexyl ester (TPCA) is an antioxidant drug with a potency similar to that of vitamin E. It has been shown to be effective in lowering the level of low density lipoprotein cholesterol (LDL), which is associated with an increased risk for atherosclerosis. TPCA also has the ability to inhibit blood pressure and has been shown to have no toxicity in humans. TPCA is stable under a variety of conditions, including storage at high temperatures.

2-Amino-4-chloro-6-methylpyrimidine is an antimicrobial agent that belongs to the group of diamines tetraacetic. It is a molecule with two amine groups and four chlorine atoms, which can be found in fructus (e.g., wheat straw) and other plants. 2-Amino-4-chloro-6-methylpyrimidine has been shown to have strong antibacterial activity against Gram positive bacteria such as Staphylococcus aureus and Clostridium perfringens, but not against Gram negative bacteria such as Escherichia coli. The compound also has structural features that are similar to ethylene diamine and carbonyl group, which may account for its hydrogen bonding interactions with amino acids in proteins.

Please enquire for more information about 2-(4-Fluorophenyl)imidazo[1,2-a]pyridine-3-carbaldehyde including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about Methyl 5-benzyl-3-oxo-2-phenyl-3,5-dihydro-2H-pyrazolo[4,3-c]pyridine-7-carboxylate including the price, delivery time and more detailed product information at the technical inquiry form on this page

N-Methyl 2-pyridine ethylamine is an amine with viscosity. It has been activated to form a reactive intermediate, which can react with another molecule to form a covalent bond. The synthesised amines are not very stable and undergo hydrolysis or oxidative reactions. The activation energy of N-Methyl 2-pyridine ethylamine is 8.8 kJ/mol, which is relatively high. This compound has been shown to have anticancer properties in cancer cells and induce cell death by reactive oxygen species (ROS).

Please enquire for more information about 3-Amino-4-oxo-4-piperidin-1-ylbutanamide hydrochloride including the price, delivery time and more detailed product information at the technical inquiry form on this page

4-Hydroxypiperidine is a molecule with a carbonyl group. It is the most active and selective CCR5 receptor antagonist that has been studied to date. 4-Hydroxypiperidine inhibits HIV infection by preventing the binding of HIV to its receptor on the surface of white blood cells, thereby preventing it from entering these cells. 4-Hydroxypiperidine also acts as an anti-inflammatory agent in chronic bronchitis patients, due to its ability to inhibit prostaglandin synthesis. The chemical ionization mass spectra of this molecule show peaks for methyl ethyl, malic acid, and hydroxyl groups. These properties make 4-hydroxypiperidine a useful candidate for drug development against inflammatory diseases and several cancers.