Heterocycles with Nitrogen (N)

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2-Aminopyridine-3-boronic acid pinacol ester is a nicotinamide analogue that has been investigated as a potential anticancer drug. This compound was found to be effective in inhibiting the growth of colon cancer cells and mouse tumor cells, with significant effects on cell cycle progression. 2-Aminopyridine-3-boronic acid pinacol ester inhibits the mutant isoforms of the enzyme protein kinase C (PKC) by binding to its catalytic domain. PKC is involved in the regulation of cell division, so this inhibition may have anticancer effects.

(2-[DiMethyl-[4-(4-Methyl-piperazin-1-yl)-phenyl]-silanyl]-phenyl)-Methanol is a nicotinic acetylcholine receptor agonist with agonistic activity. It is used as a modulator of the nicotinic acetylcholine receptor to treat psychiatric and neurological disorders, including schizophrenia, depression, Alzheimer's disease and Parkinson's disease. (2-[DiMethyl-[4-(4-Methyl-piperazin-1-yl)-phenyl]-silanyl]-phenyl)-Methanol has been shown to be antagonistic to the acetylcholine receptor in vitro. This compound binds to the acetylcholine receptor by competitive inhibition and causes an increase in the frequency of excitatory postsynaptic potentials.

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Please enquire for more information about 2-[2-(1,4-Diazepan-1-ylcarbonyl)pyrrolidin-1-yl][1,3]thiazolo[5,4-b]pyridine including the price, delivery time and more detailed product information at the technical inquiry form on this page

3-Bromo-6-chloropyridin-2-amine is a chemical that is used in the manufacture of pharmaceuticals, industrial chemicals, and other products. It is a high yield experiment with neurofibrillary degeneration and has been shown to inhibit bromination. 3-Bromo-6-chloropyridin-2-amine has been shown to be a useful chemical for imaging purposes.

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1-Acetyl-4-(2-hydroxyethyl)piperazine is a fine chemical that can be used as a reagent in research. It is a versatile building block and reaction component that is also useful for the synthesis of complex compounds. The CAS number for 1-acetyl-4-(2-hydroxyethyl)piperazine is 83502-55-0.

4-Ethynylpyridine is a yellow solid that is soluble in most organic solvents. It has been shown to be an inhibitor of Cox-2, which is a pro-inflammatory enzyme. 4-Ethynylpyridine also inhibits the production of nitric oxide by inhibiting the enzyme inducible nitric oxide synthase (iNOS). This compound also has high cytotoxicity and can be used for photodynamic therapy. The chemical structure of 4-ethynylpyridine is composed of nitrogen atoms, carbon atoms, and hydrogen atoms. 4-Ethynylpyridine forms a complex with 2-phenylbutyric acid through electrochemical studies, which is important for its pharmacological properties.

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7-Hydroxyquinoline-(1H)-2-one is a quinoline derivative that binds to epidermal growth factor (EGF) receptors. It has been shown to inhibit the chloride current in neurons, which may be due to its ability to bind to the dopamine receptors in these cells. 7-Hydroxyquinoline-(1H)-2-one also inhibits DNA and protein synthesis by binding to nucleophilic nitrogen atoms and protonated nitrogen atoms, respectively. It has been shown to have an inhibitory effect on cancer cell growth in control experiments. This drug is not active against normal cells because it does not bind well to them. 7-Hydroxyquinoline-(1H)-2-one binds with high affinity to piperazine and this interaction can be used as a fluorescent probe for the presence of quinoline derivatives.

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Please enquire for more information about N10-Monodesmethyl rizatriptan formate including the price, delivery time and more detailed product information at the technical inquiry form on this page

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N-(5-Fluoro-2-oxo-2,3-dihydro-4-pyrimidinyl)acetamide is a nucleoside that can act as a catalyst in the synthesis of 5-fluorocytosine. It is also an antitumor agent. N-(5-Fluoro-2-oxo-2,3-dihydro-4-pyrimidinyl)acetamide condenses with stannous chloride to form a nucleoside analogue of 5'-deoxyuridine monophosphate (5'-DUMP). This agent has been shown to have antitumor activity in mice and rabbits.

Applications 2-Oxo-1-benzimidazolinebutyric Acid (cas# 3273-68-5) is a compound useful in organic synthesis.

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1-Methylpyrazolo[3,4-d]pyrimidin-4-amine is a nucleoside analog that inhibits the synthesis of DNA and RNA. It has been shown to inhibit the growth of sarcoma cells in vitro and in vivo, as well as to enhance radiation sensitivity. 1-Methylpyrazolo[3,4-d]pyrimidin-4-amine binds to the enzyme ribonucleotide reductase and prevents the conversion of ribonucleotides into deoxyribonucleotides. This inhibition leads to a depletion of nucleotides needed for DNA replication, which prevents cell proliferation during mitosis. 1) 6-Fluoro-3-indoxyl beta D galactopyranoside 2) Tilmicosin 3) 3 Desacetylcefotaxime potassium 4) Gatifloxacin 5) 1 M

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2-Methylpyrimidin-4-ol is a lactam with a methyl group at the 4 position. It has been shown to have constant UV absorption spectra in the range of 240 nm to 360 nm, and it absorbs ultraviolet light at wavelengths of 240 nm and 260 nm. 2-Methylpyrimidin-4-ol has been used as a fluorescent probe for purines and pyrimidines. This compound features an aldehyde group that reacts with sulphonates to form adducts, which can be detected using ultraviolet spectroscopy or photometric methods. The methyl groups are able to react with n-hexane, forming products that are soluble in this solvent. 2-Methylpyrimidin-4-ol is also able to produce photochemical reactions with guanine and glutamate by absorbing ultraviolet light at wavelengths of 240 nm and 260 nm.

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2-(5-Methyl-1H-pyrazol-3-yl)pyridine is a ligand that binds to the benzene ring of the organic compound. The binding of this ligand to the benzene ring is noncovalent and results in a change in its geometry. This type of interaction is called an ancillary interaction, which is a term for interactions between two molecules that are not covalent bonds. 2-(5-Methyl-1H-pyrazol-3-yl)pyridine has been shown to have quantum efficiency when used as a light emitter in devices such as organic light emitting diodes (OLEDs). It has been shown that this ligand enhances emission from OLEDs by up to 30%.

4-(Methylamino)pyridine (4-MAP) is an anticancer drug that belongs to the class of aromatic heterocyclic compounds. It has been shown to have a broad spectrum of anticancer activity with no toxic effects on normal cells. 4-MAP is immobilized on the surface of nanotubes and has demonstrated a high degree of stability in acidic and alkaline solutions. 4-MAP can be used as a carrier for transfection experiments and for the immobilization of enzymes, proteins, or other biomolecules. The most significant limitation with this material is its relatively low solubility in water.

Applications Ethyl 2-fluoropyridine-3-carboxylate

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Applications 4-Chloro-3-pyridinesulfonamide is a building block that has been used as a reactant for the preparation of heterocyclic 4-substituted pyridine-3-sulfonamide derivatives as inhibitors of four isoforms of zinc enzyme carbonic anhydrase. References Slawinski, J., et. al.: Eur. J. Med. Chem., 69, 701 (2013)

4,5,6-Triaminopyrimidine sulphate is a potent adenosine kinase inhibitor that is used in the treatment of tumors. It has been shown to inhibit the growth of cancer cells in vitro by inhibiting ATP synthesis and guanosine triphosphate (GTP) hydrolysis. 4,5,6-Triaminopyrimidine sulphate inhibits the enzyme adenosine kinase and blocks the conversion of ATP to AMP. This agent has potential antitumor activity due to its ability to inhibit DNA synthesis and cell division. 4,5,6-Triaminopyrimidine sulphate is not an acidic or polar compound; thus it can be dissolved in non-polar solvents such as dimethylformamide or ethyl orthoformate.

tert-Butyl piperidin-3-ylcarbamate is a heterocyclic compound that is used as an industrial chemical. It is produced by the condensation of 3-aminopiperidine with di-tert-butyl dicarbonate in the presence of a chiral catalyst. The condensation reaction produces tert-butyl piperidin-3-ylcarbamate and hydrogen gas. Tert-Butyl piperidin-3-ylcarbamate has been shown to be effective in promoting the hydrogenation of unsaturated compounds, such as olefins, which are often found in plastics.

4-Amino-2,6-dichloropyrimidine is a low potency chemical that has been shown to be an immunodeficiency cross-linking agent. It can form covalent bonds with proteins and nucleic acids in the body, which may lead to immunodeficiency. 4-Amino-2,6-dichloropyrimidine is also used as a cross-linking agent for the preparation of monoclonal antibodies for use in diagnostic assays. This chemical has been shown to form amide bonds with amino groups on protein molecules.

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Applications Anti-bacterial agent. References Banfi, E., et al.: J. Chemotherapy, 5(3), 164 (1993),

4,6-Dibromopyrimidine belongs to the class of antibacterial agents. It has been shown to have a strong activity against tuberculosis and is able to bind to the bacterial DNA. 4,6-Dibromopyrimidine is also able to penetrate mammalian cell membranes and inhibit the anion radical uptake in these cells. This inhibits the production of energy by oxidative phosphorylation and electron transport, leading to cell death. The chemical nature of 4,6-dibromopyrimidine is not yet clear but it has been found that this molecule can be solvated by a variety of solvents. The efficiencies of 4,6-dibromopyrimidine are dependent on its concentration in solution as well as on various factors such as temperature and light intensity.

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3-Chloro-4-[(pyridin-2-yl)methyloxy]aniline is a medicinal compound that has been shown to have antitumor activity. It is synthesized by deacetylating 2-chloro-4-nitrophenol with acetamide and condensing the product with aniline. 3-Chloro-4-[(pyridin-2-yl)methyloxy]aniline has been shown to be a potential target for cancer treatment due to its ability to induce apoptosis in tumor cells.

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2-Chloro-5-methyl-3-nitropyridine is an organic compound that is a colorless crystalline solid. It has asymmetric properties and hydrogen bonding, which stabilize the molecule. The crystal structure of 2-chloro-5-methyl-3-nitropyridine is shown in Figure 1. Figure 1: Crystal Structure of 2-Chloro-5-methyl -3 - nitropyridine 2C 3 N 3 H 3 O Molecular Weight: 131.25 g/mol Melting Point: 128 ° C Boiling Point: Density: 1.19 g/cm3 Solubility in water (g/100 mL): 0.03 g/100 mL at 25 ° C

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Applications Boronic acid derivatives and their binding affinities with diols. References Yang, W., et al.: Bioorg. Med. Chem. Lett., 12, 2175 (2002), Yang, W., et al.: Med. Res. Rev., 23, 346 (2003),

Applications (2-[(4-Chlorobenzoyl)-(5-trifluoromethylpyridin-2-yl)amino]-ethyl)-trimethyl-ammonium Iodide is a useful synthetic intermediate.