Heterocycles with Nitrogen (N)

4-[2-[Bis(4-Fluorophenyl)Methoxy]Ethyl]-1-(3-Phenylpropyl)Piperidine is a modulating agent that has been shown to be an antagonist at serotonin 5-HT2A receptors. It also inhibits the binding of serotonin to the receptor and prevents its release. This drug binds to the hydroxyl group on serotonin molecules, preventing it from binding to the receptor. 4-[2-[Bis(4-Fluorophenyl)Methoxy]Ethyl]-1-(3-Phenylpropyl)Piperidine has been shown to be effective in animal models of Parkinson's disease and Alzheimer's disease.

2,4-Diamino-6-hydroxypyrimidine is a potent antitumor agent that has been shown to have potent cytotoxicity against tubule cells in the kidney. It binds to DNA and inhibits transcription by interfering with polymerase chain reaction. This drug also inhibits protein synthesis and has been shown to be effective in treating diabetic patients. 2,4-Diamino-6-hydroxypyrimidine has been found to be useful in detecting high levels of c-reactive protein (CRP) in serum, which can help diagnose inflammation or myocardial infarct. 2,4-Diamino-6-hydroxypyrimidine is also used as a fluorescent probe for determining low levels of hydrogen bonds between polymers or proteins.

Please enquire for more information about N-[5-[5-(2-Methyl-1-oxoisoindolin-5-yl)thien-2-yl]pyridin-3-yl]-2-nitrobenzenesulfonamide including the price, delivery time and more detailed product information at the technical inquiry form on this page

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5-Amino-3-pyridinecarboxamide is an analog of nicotinamide that has been shown to have tumor-modulating activity. It has been shown to inhibit the growth of tumor cells in a maximally tolerated dose and inhibits hypoxic tumor growth. 5-Amino-3-pyridinecarboxamide is also structurally related to 6-methylmercaptopurine, which has been shown to induce tumor regression, but without the toxic side effects of 6-methylmercaptopurine. Studies have shown that 5-amino-3 pyridinecarboxamide inhibits the proliferation of breast cancer cells by inhibiting riboside synthesis, which may be due to its structural similarity to adriamycin, an antitumor antibiotic.

Please enquire for more information about 2-(Pyridin-4-yl)acetohydrazide including the price, delivery time and more detailed product information at the technical inquiry form on this page

Applications 2-Chloropyrimidine-d3 was used in the study of IR vibrational spectroscopy of [Ru(bpy)2(bpm)]2+ and [Ru(bpy)3]2+ in the excited triplet state. References Mukuta, T., et al.: Inorg. Chem., 53, 2481 (2014)

2,2'-Bipyridine-6,6'-dicarboxylic acid is a molecule that has an acidic functional group. It has been found to have a molecular weight of 220.2 g/mol and is soluble in water at elevated temperatures. 2,2'-Bipyridine-6,6'-dicarboxylic acid has been shown to be photoprocessable in the presence of sodium carbonate as a catalyst. The reaction rate can be increased by adding a diluent to the solution or by using linear models.

Please enquire for more information about 3-(2,6-Dioxopiperidin-1-yl)propanoic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page

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1-Methyl-4-(3-nitrophenyl)piperazine is a quaternary ammonium salt that has been used for the treatment of tuberculosis. It is an alkylating agent that inhibits bacterial growth by binding to DNA and RNA, preventing transcription and replication. Substituents on the nitrogen atom affect the potency of this drug. 1-Methyl-4-(3-nitrophenyl)piperazine binds to guanine in the DNA molecule, which causes cross linking between DNA strands, resulting in cell death. This drug also has anti-inflammatory properties, which may be due to its inhibition of prostaglandin synthesis.

Applications 4-amino-1-propylpyrrolidin-2-one hydrochloride (cas# 1255717-37-3) is a useful research chemical.

Please enquire for more information about 2-(Methylthio)pyrimidine-5-boronic acid pinacol ester including the price, delivery time and more detailed product information at the technical inquiry form on this page

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(2-Chloropyrimidin-5-yl)boronic acid is a reactive agent that can be used for cross-coupling reactions. It has been shown to react with pinacol esters and other electrophiles to form macrocycles, which have functions such as supramolecular assembly. (2-Chloropyrimidin-5-yl)boronic acid also catalyzes the synthesis of nucleophiles, such as an alcohol or amine, by acting as a nucleophile. (2-Chloropyrimidin-5-yl)boronic acid is synthesized in a cross coupling reaction between an organoboron compound and 2 chloropyrimidine. This chemical is used in Suzuki chemistry and other synthetic processes.

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Please enquire for more information about 4-(1-Fmoc-piperidin-4-yl)butanoic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page

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Applications 3-Amino-6-chloropyridazine (cas# 5469-69-2) is a compound useful in organic synthesis.

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1-Acetylpiperidin-4-ol is a small, bioactive molecule with a catalytic activity against glycogen phosphorylase. It is an antidiabetic drug that can be used to treat type 2 diabetes mellitus. 1-Acetylpiperidin-4-ol binds to the allosteric site of glycogen phosphorylase and inhibits its activity, which prevents the breakdown of muscle glycogen. This inhibition leads to increased blood glucose levels. The crystal structure of 1-acetylpiperidin-4-ol has been determined using X-ray crystallography and unambiguously confirmed by NMR spectroscopy.

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5-Amino-2-mercaptobenzimidazole is a molecule that has been shown to have antibacterial activity. It binds to the active site of bacterial ribosomes, which prevents the synthesis of proteins. This binding also inhibits the growth of bacteria such as Staphylococcus aureus and Escherichia coli. 5-Amino-2-mercaptobenzimidazole has been studied using vibrational spectroscopy, molecular modeling and surface-enhanced Raman spectroscopy. The binding constants have been determined by measuring the dissociation constant using sodium carbonate as an electrolyte. The optimum concentration for this molecule is when it is in anhydrous sodium at a constant concentration of 0.1 M.

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Thieno[3,4-b]pyrazine is an organic compound that belongs to the heterocyclic compounds class. It is a red-shifted acceptor and has been used as a fluorescent probe in investigations of electron transfer reactions. Thieno[3,4-b]pyrazine has been found to be an efficient anticancer agent in vitro and in vivo against the Ehrlich ascites carcinoma and the sarcoma 180. The molecule is electron deficient because it lacks a hydrogen atom on its thiophene ring. This makes it susceptible to oxidation by electrophilic agents such as nitric oxide (NO). Thieno[3,4-b]pyrazine may also function as an antioxidant due to its ability to scavenge hydroxyl radicals.

3-Hydroxypyridine-2-carboxaldehyde is a novel agent that has been shown to inhibit the growth of various types of cancer cells in vitro and in vivo. It was found to be a potent inhibitor of cyclin-dependent kinases, which are proteins that regulate the cell cycle by phosphorylating other proteins and playing a role in cell proliferation. 3-Hydroxypyridine-2-carboxaldehyde has also been shown to have anti-inflammatory effects, as well as inhibit the growth and invasion of cervical cancer cells.

6-Oxo-2-thioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid is a chemical species that belongs to the class of sodium salts. It is the monosodium salt of 6-oxo-2,3,6-tetrahydropyrimidine carboxylic acid and a desulfurization agent. 6-Oxo-2-thioxo-1,2,3,6 tetrahydropyrimidine carboxylic acid has been shown to be an effective cancer treatment by inhibiting tumor growth and inducing cell death. This compound also inhibits the growth rate of bacteria such as erythromycin resistant strains of Mycobacterium tuberculosis and Mycobacterium avium complex.

Applications 1-Phenyl-1H-tetrazole-5-thiol is used as a corrosion inhibitor and as a reagent in the synthesis of Microcarpalide, a microfilament disrupting agent that is weakly cytotoxic to mammalian cells. References Chermahini, A., et al.: Struct. Chem., 22, 175 (2011); Murga, J., et al.: Org. Lett., 4, 3447 (2002); Ratnayake, A., et al.: Org. Lett., 3, 3479 (2001)