Heterocycles with Nitrogen (N)

Please enquire for more information about 1-Benzylpiperazin-2-one hydrochloride including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about Ethyl6-chloro-1H-pyrrolo[2,3-b]pyridine-2-carboxylate including the price, delivery time and more detailed product information at the technical inquiry form on this page

3-Aminopiperidine-2,6-dione hydrochloride salt (3AP) is a synthetic agent that has been shown to inhibit prostate cancer cell growth. 3AP inhibits the synthesis of DNA by inhibiting the enzyme benzoate and potently inhibits the enzyme pomalidomide synthetase. This drug also has antiangiogenic properties and has been shown to reduce expression of TNF-α in human myeloid leukemia cells. 3AP is not active against HL60 cells, which are a type of white blood cell. It can be used as an alternative treatment for cancer in patients who have failed to respond to other therapies or who cannot tolerate them.

3-Nitropyridine is a nitro compound that is used in the preparation of pharmaceuticals. It has been shown to have an inhibitory effect on HIV and other viruses, which may be due to its ability to react with nucleophilic groups. 3-Nitropyridine has also been shown to have an inhibitory effect on the human immunodeficiency virus (HIV) by reacting with the acidic group of the virus. This reaction prevents the virus from binding to cells and entering them. 3-Nitropyridine is also used as a solvent for organic reactions.

Please enquire for more information about 4-(2-Quinolinyl)benzonitrile including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about 1-(Morpholin-4-ylsulfonyl)piperidine-4-carboxylic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page

5-Methoxyindole-3-acetic acid (5MI) is an endogenous indole and metabolite of melatonin that is found in high concentrations in the human serum. 5MI has been shown to inhibit the activity of cyclase enzymes and may be a specific inhibitor of the type I form of estrone sulfate, which is involved in estrogen production. This agent also inhibits matrix metalloproteinases and aminotransferases, which are enzymes that play a role in oxidative injury. 5MI also has a fluorescent derivative that can be used as a probe for biological samples or to study the target enzyme.

Please enquire for more information about 4-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)piperidine-4-carboxylic acid hydrochloride including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about 3-[(2-Chloropyridin-3-yl)amino]-5,5-dimethylcyclohex-2-en-1-one including the price, delivery time and more detailed product information at the technical inquiry form on this page

Applications N-(Benzyloxycarbonyl)-4-piperidone

Applications 1-(2,2-Dihydroxyethyl)-6-(methoxycarbonyl)-4-oxo-1,4-dihydropyridine-3-carboxylic Acid is an intermediate in the synthesis of Bictegravir-15N, d2 (B382096), which is the labeled version of Bictegravir, which is a novel, potent inhibitor of HIV-1 integrase with an IC50 of 7.5 nM. References Tsiang M. et al.: Antimicrob Agents Chemother. 2016 Nov 21;60(12):7086-7097;