Stimulants

Applications 2-(2-Fluorophenyl)-2-(methylamino)-cyclohexanone Hydrochloride is a related compound of Ketamine (K165300), an anesthetic. References Sass, W.C., et al.: Anal. Profiles Drug Subs., 6, 297 (1977); Reich, D.L., et al.: Can. J. Anaesth., 36, 186 (1989);

Applications This is a controlled substance (stimulant). Anorexic. References Netter, P., et al.: Arzneim.-Forsch., 28, 1310 (1978); Rendic, S., et al.: Eur. J. Drug Metab. Pharmacokinet., 19, 107 (1994);

Applications 1,3,7-Trimethyluric Acid is a caffeine derivative, and a methyl derivative of uric acid. Detected as a urine marker of caffeine consumption. References Rothwell, J. et al.: PLoS One, 9, e93474 (2014); Silva, C. et al.: Sci. Trans. Med., 5, 197ra04 (2013);

Applications Labelled Phencyclidine (P295500). Anesthetic (intravenous). Controlled substance (depressant). Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Chen, G., et al.: J. Pharmacol. Exp. Ther., 127, 241 (1959), Bailey, K., et al.: J. Pharm. Pharmacol., 28, 713 (1976), Balster, R.L., J. Psychedelic Drugs., 10115 (1978), Johnson, K.M., et al.: Annu. Rev. Pharmacol. Toxicol., 30, 707 (1990),

Applications The S-enantiomer metabolite of tobacco, a specific N-nitrosamines with carcinogenic activity. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Idris, A.M., et al.: Carcinogenesis, 13, 1001 (1992), Toropov, A.A., et al.: Eur. J. Med. Chem., 45, 3581 (2010),

Applications Isotope labelled analog of Xanthine (X499950), a substance that can be found in animal organs, yeast, patatoes, coffee beans, tea. Xanthine can be used to relax and widen certain breathing passages of the lungs. It is also found that a large number of derivatives that exhibits adenoside receptor antagonist properties. References Mueller, C. et. al: Handbook Exp. Pharmacol. 200,151(2011)

Applications Labelled Modafinil (M482502). Modafinil is an α-1-adrenergic agonist. Modafinil is a CNS stimulant; psychostimulant that displays neuroprotective and antiparkinsonian activity in a primate model of Parkinson's disease.This is a controlled substance (stimulant). References Saletu, B., et al.: Int. J. Clin. Pharmacol. Res., 9, 183 (1989), Chemelli, R.M., et al.: Cell, 98, 437 (1999)

Stability Hygroscopic Applications trans-3'-Hydroxy Cotinine-d3 (Racemic Mixtures) (cas# 159956-78-2) is a compound useful in organic synthesis. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Desai, D., et al.: Chem. Res. Toxicol., 3, 47 (1990)

Applications Deschloro-N-ethyl-ketamine Hydrochloride is a derivative of Ketamine (K165300), an anesthetic agent and used as a depressant. References Sass, W.C., et al.: Anal. Profiles Drug Subs., 6, 297 (1977), Reich, D.L., et al.: Can. J. Anaesth., 36, 186 (1989),

Applications Controlled substance (stimulant). CNS stimulant from the same class as methylphenidate (M325880). Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Rivier, L., et al.: Anal. Chim. Acta, 492, 69 (2003), Politi, L., et al.: J. Anal. Toxicol., 29, 1 (2005),

Applications Controlled susbtancePiperazine derivative used as reference materials for forensic laboratories. They affect the central and the autonomic nervous systems, the blood pressure, and smooth muscle. References Bannwarth, W., et al.: Bioorg. Med. Chem., Lett., 6, 1525 (1996), Greenwald, R., et al.: J. Med. Chem., 43, 475 (2000), Wills, A., et al.: Curr. Opin. Chem. Biol., 7, 346 (2003), Heidler, P., et al.: Bioorg. Med. Chem., 13, 585 (2005),

Stability Hygroscopic, Light Sensitive Applications α-Pyrrolidinovalerophenone (PVP) is a stimulant compound developed in the 1960s and related to Pyrovalerone (P99775), which has been reported as a novel designer drug. References Fleckenstein, A., et al.: Eur. J. Pharmacol., 406, 1 (2000), Meltzer, P., et al.: J. Med. Chem., 44, 2619 (2001), Gorclick, D., et al.: Drugs, 64, 1547 (20040,

Applications Paraxanthine-d3, is the labeled analogue of Paraxanthine (P192500), an adenosine receptor ligand and a major metabolite of caffeine. References Proc. Natl. Acad. Sci. USA 78, 3260 (1981); Cell Mol. Neurobiol., 3, 69 (1983); Eur. J. Pharmacol., 179, 295 (1990)

Applications Controlled substance (stimulant). CNS stimulant. Four isomers of Methylphenidate are known to exist. One pair of threo isomers and one pair of erythro are distinguished, from which only d-threo-Methylphenidate exhibits the pharmacologically desired effects. This compound is a 4:1 mixture of DL-erythro to DL-threo. References Greenblatt, E.N., et al.: J. Pharmacol. Exp. Ther., 131, 115 (1961), Padmanabhan, G.R., Anal. Profiles Drug Subs., 10, 473 (1981), Srinivas, N.R., et al.: Pharm. Res., 10, 14 (1993),

Stability Hygroscopic Applications (R,S)-Norcotinine-pyridyl-d4 (cas# 1020719-70-3) is a compound useful in organic synthesis.

Applications Higenamine acts through inhibition of middle cerebral artery occlusion (MCAO)-mediated HMGB1 release in vivo. Useful towards ischemic injuries. References Ha, Y. et al.: Apoptosis., 17, 463 (2012);

Stability Hygroscopic Applications A tobacco alkaloid as risk factor of human cancer. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Stepanov, I., et al.: Cancer Res., 69, 8236 (2009), Maertens, R., et al.: Chem. Res. Toxicol., 22, 1406 (2009), Gaworski, C., et al.: Toxicol., 269, 54 (2010),

Applications 4-[N-(Methyl-d3)-N-nitrosamino]-4-(3-pyridyl)butane-1-ol is labelled 4-(N-Methyl-N-nitrosamino)-4-(3-pyridyl)butane-1-ol (M325700) which a toxic and carcinogenic labelled agent in dry and moist snuff. References Idris, A.M., et al.: Carcinogenesis, 13, 1001 (1992), Ren Q., et al.: Drug Metab. Dispos., 28, 1352 (2000), Brown, B., et al.: Mutat. Res., 494, 21 (2001),

Applications A Pyrovalerone (P997750) analog as selective dopamine transporter inhibitors. References Meltzer, P., et al.: Bioorg. Med. Chem., 10, 3583 (2002), Madras, B., et al.: Eur. J. Pharmacol., 479, 41 (2003), Carroll, F., et al.: J. Med. Chem., 47, 296 (2004),

Applications Diclofensine is a stimulant; inhibits reuptake of dopamine and noradrenaline, is an effective antidepressant. Diclofensine exhibits significant addictive properties. References Supersaxo, A., et al.: Pharm. Res., 8, 1286 (1991), Nakachi, N., et al.: Eur. J. Pharmacol., 281, 195 (1995), Chankvetadze, B., et al.: J. Pharm. Biomed. Anal., 27, 467 (2001),

Applications (±)-Cotinine-2,4,5,6-d4 (pyridine-d4) (CAS# 350818-68-7) is a useful isotopically labeled research compound.