Hydrazines

Di-tert-butyl hydrazine-1,2-dicarboxylate is an alkylation agent that is used in organic synthesis. It can be used to prepare a variety of triflates, halides, and estradiol. Di-tert-butyl hydrazine-1,2-dicarboxylate has been shown to react with functional groups such as vinyl groups and phosphines. This reagent is also bifunctional and can react with boronic acids to form a number of biaryl compounds. The reaction of this reagent with estrogen leads to the formation of substituted estrogens that have been shown to bind to estrogen receptors.

1-(6-Chloro-1,3-benzothiazol-2-yl)hydrazine is an antimicrobial agent that belongs to the group of pyrazoles. It has been shown to inhibit bacterial growth by binding to target molecules in the cell membrane and disrupting the hydrogen bonds that hold it together. This active form has a dihedral angle of between -60° and -90° and a phenyl ring with a hydrogen bond donor at C4. The antibacterial activity of 1-(6-chloro-1,3-benzothiazol-2-yl)hydrazine is due to its ability to bind to the class of target molecules that are found on the surface of bacteria, such as aminoglycosides, chloramphenicol, macrolides, tetracyclines.

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