Amines

3-Pyrrolidinamine dihydrochloride (3PD) is a synthetic drug that has been shown to have antimicrobial activity. 3PD has been shown to be effective against both Gram-positive and Gram-negative bacteria, such as Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa. 3PD also inhibits the growth of some fungi, such as Candida albicans. The chemical structure of 3PD includes an amine group and three pyrrolidine rings. This novel compound is able to inhibit the synthesis of proteins in bacterial cells by inhibiting ribosomal translation on the mRNA level. It also inhibits the growth of certain fungi by preventing the synthesis of their cell wall proteins. 3PD was synthesized by reacting α-aminopropionitrile with sodium cyanide in a high-salt solution at room temperature in an acidic environment.

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1-(1,3-Benzodioxol-5-ylmethyl)piperidin-4-amine dihydrochloride (1,3BDMC) is a selective soluble guanylate cyclase inhibitor. It inhibits the production of nitric oxide and guanosine 3',5'-cyclic monophosphate in vascular smooth muscle cells. This drug is used as an anesthetic agent and has been shown to have beneficial effects in animal models of hypoxemia. 1,3BDMC has also been evaluated for use in treating embolic disorders such as thrombosis and pulmonary embolism. The drug has been found to be safe when administered intravenously or intraarterially but can cause necrosis when applied directly to the artery wall. The drug can also impair blood flow by constricting vessels and inhibiting platelet aggregation.

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4-Diethylaminobenzaldehyde is an organic compound that contains a hydroxyl group. It is a fluorescent probe and can be used to measure the transcriptional regulation of genes. This molecule has been shown to be an effective fluorescence probe for the detection of cb2 receptors in Langmuir adsorption isotherms and LC-MS/MS methods. 4-Diethylaminobenzaldehyde has also been shown to have chemopreventive properties against carcinoma cells.

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2-Tetrahydrofurfurylamine (2TF) is an organic compound that belongs to the class of inorganic acids. It is a reactive and light-emitting molecule that has been used as a substrate molecule in molecular docking analysis. 2TF is also used as a reactive intermediate in the preparation of detergents. The reaction mechanism involves the formation of an ethylene diamine by nucleophilic attack on the carbonyl group, followed by oxidative addition of the hydroxyl group to the nitrogen atom. This process leads to the formation of a coordination complex with a geometry that favours two nitrogen atoms and two oxygen atoms, which are further coordinated by four carbon atoms. 2TF can be found in several infectious diseases, such as tuberculosis and leprosy, where it has been shown to inhibit cell growth through inhibition of protein synthesis and DNA replication.

4-Phenylaminobenzenediazonium hydrogensulfate is an inhibitor of tyrosinase activity. It is used to coat surfaces for the prevention of enzymatic reactions, such as the oxidation of carbohydrates and proteins. 4-Phenylaminobenzenediazonium hydrogensulfate is also used in biochemical assays, surface-enhanced Raman spectroscopy, and phosphatase inhibition assays. The IC50 value for 4-phenyaminobenzenediazonium hydrogensulfate on tyrosinase is 0.4 mM. It has been shown that this compound can inhibit the enzymatic reaction by binding to the active site on the enzyme with a higher affinity than p-nitrophenyl phosphate (Ki = 0.2 mM).

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Applications Diethylamine Hydrochloride is a secondary amine and a precursor of Atrazine (A794600). It is used as a reactant if the production of pesticides, dyes and pharmaceutical compounds. References Raghuram, P. et al.: Chromatograph., 71, 963 (2010); Smith, D. & Crowley, D.: FEMS Microbiol. Ecol., 58, 271 (2006); Asiri, A.: Dyes and Pigments., 42, 209 (1999); Rijhsinghani, K. et al.: Canc. Det. Prev., 5, 283 (1982)

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4-Aminophthalimide is a protonated aminophthalic acid derivative that is used as a fluorescence probe. It has been shown to be a photophysical and photochemical reagent that can be used in the study of intermolecular hydrogen bonding interactions. The fluorescence of 4-aminophthalimide is enhanced by the presence of epidermal growth factor (EGF) and solvents such as water, alcohols, and hydrochloric acid. The fluorescence emission from this compound is dependent on its environment, which includes the presence of hydrogen bonding interactions with fatty acids.

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(2-Furylmethyl)methylamine is a protein inhibitor that has been shown to inhibit γ-secretase, an enzyme responsible for the cleavage of amyloid precursor protein (APP) and the production of beta-amyloid. It has also been shown to be effective in treating cancer and Alzheimer's disease when administered as an intravenous injection or oral medication. The effects on animals were observed in a study involving mice with bladder cancer. (2-Furylmethyl)methylamine was found to inhibit the growth of bladder cancer cells and induce apoptosis. This compound also inhibits glycogen synthase kinase 3 (GSK3), which is involved in cell proliferation. Trichophyton mentagrophytes, a fungus that causes athlete's foot, has also been found to be sensitive to this drug. Heterocycles are not affected by this compound because they lack nitrogen atoms at their positions corresponding to those in the amide group

Tetrabutylammonium Diiodoaurate is an organic compound that belongs to the group of polyesters. It is a liquid crystal composition that has a ring structure and can be expressed as the residue of two monomers, polycarboxylic acid and diiodoaurate. Tetrabutylammonium Diiodoaurate has shown optical activity in its Raman spectra due to its symmetries and its liquid crystal composition. This material is usually uncured, but can be cured by dehydration or thermal transfer to form a crystalline solid.

N-Phenyl-2-nitro-4-trifluoromethylphenylamine is a versatile building block. It is a fine chemical that is used in research and as a reagent, speciality chemical, or useful scaffold for the synthesis of complex compounds. This compound has CAS No. 5108-04-3 and can be used as an intermediate in reactions. It is also useful in the synthesis of various types of building blocks. N-Phenyl-2-nitro-4-trifluoromethylphenylamine has been shown to be a high quality product that can be used in various ways.

1,3-Bis(dimethylamino)-2-propanol is a polymeric compound that is soluble in water and organic solvents. It has been shown to have a viscosity of less than 2.0 centipoise (cP) at 20°C and pH 8.5. This compound also has a high solubility in buffers, carboxylates, and chloride ions. 1,3-Bis(dimethylamino)-2-propanol has been used as an additive for silicone surfactants and in the production of tetranuclear gold nanoparticles for use in chemiluminescence applications.

Methyl 3-{[(1,3-benzodioxol-5-ylmethyl)amino]sulfonyl}thiophene-2-carboxylate is a metal hydroxide that has minimal concentrations in glycol ethers. Methyl 3-{[(1,3-benzodioxol-5-ylmethyl)amino]sulfonyl}thiophene-2-carboxylate has been shown to be an effective cross linking agent for polymers and can be used as a sample preparation reagent for fatty acids.

N-(4-Aminobutyl)-2-naphthalenesulfonamide hydrochloride is a reactive sulfonyl chloride that has been shown to be an antagonist of nitric oxide. It also inhibits the activity of the enzyme calmodulin, which is involved in protein kinase C activation and gene expression. N-(4-Aminobutyl)-2-naphthalenesulfonamide hydrochloride has been shown to be carcinogenic in rats and mice and is only used for research purposes. This drug also inhibits phenothiazine synthesis, which may have therapeutic benefits for schizophrenia.

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4-Allylaminocarbonylphenylboronic acid is a chemical compound that is used as an antibiotic. It is an aminoglycoside, which inhibits bacterial growth by binding to the ribosome and preventing the formation of proteins. 4-Allylaminocarbonylphenylboronic acid has been shown to be bactericidal in vitro against both Gram-negative and Gram-positive bacteria. This drug also reversibly binds to the polymer matrix of the eye, which may help prevent bacterial keratitis. 4-Allylaminocarbonylphenylboronic acid may reduce damage caused by hydroxyl radicals, which are often associated with inflammation in infections.

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N-(Aminocarbonyl)-N-[3-(Trifluoromethyl)Phenyl]Carbamic Acid Ethyl Ester is a nature-based analog of the neurotransmitter GABA that can be used to investigate the function and regulation of the GABA receptor. It is approved for use in animals, but not humans. N-(Aminocarbonyl)-N-[3-(Trifluoromethyl)Phenyl]Carbamic Acid Ethyl Ester has been shown to inhibit nerve transmission and enhance the effectiveness of other anesthetics. It has also been shown to have an effect on brain activity and body movement, which may be due to its ability to inhibit the enzyme acetylcholinesterase.

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Applications 3-AZIDOPROPAN-1-AMINE (cas# 88192-19-2) is a useful research chemical.

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Applications N-[(2,4-Difluorophenyl)methylene]-2,4-difluoro-benzenemethanamine is derived from 2,4-Difluorobenzylamine (D450850), which acts as a reagent for the design of pyrazole derivatives as non-nucleoside heptatitis B virus inhibitors. It is also used as a reagent in the preparation, HIV antiviral activity, SAR, and molecular modelling of hydroxypyridonecarboxylic acids as HIV reverse transcriptase inhibitors. References Jia, H., et al.: Eur. J. Med. Chem., 123, 202 (2016); Kankanala, J., et al.: J. Med. Chem., 59, 5051 (2016)

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4,6-Diamino-2-(cyclopropylamino)pyrimidine-5-carbonitrile is a chemical compound that has been shown to have antimicrobial activity. It inhibits bacterial fatty acid synthesis and transport by binding to the enzyme acyl carrier protein (ACP). The binding of 4,6-Diamino-2-(cyclopropylamino)pyrimidine-5-carbonitrile to ACP prevents fatty acids from being transferred across the bacterial membrane. This results in an accumulation of free fatty acids inside the bacteria and eventually leads to cell death. The synergistic effect of 4,6-Diamino-2-(cyclopropylamino)pyrimidine-5-carbonitrile with sodium carbonate can be explained by the fact that both compounds inhibit the production of fatty acids by blocking enzymes which are required for this process.

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Diethyl aminoacetonitrile (DEAN) is an aliphatic hydrocarbon that has a molecular formula of C6H14N2. It is used in the preparation of hydroxamic acids and hydroxylated amines by reaction with water. The radiation-induced polymerization of DEAN yields polyimides, which have been shown to have excellent resistance to a variety of solvents and chemicals. This chemical has also been used as a precursor for the synthesis of heterocyclic amines, such as 2-aminopyridine and 4-aminopyridine. The fluorine atom on the trifluoromethyl group makes DEAN a good candidate for reactions involving sulfonic acids, such as sulfonylation reactions.

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4-(Dimethylamino)pyridine, polymer-bound (4DAP-P), is a chemical compound that belongs to the aminopyridine class of compounds. 4DAP-P has been shown to have antibacterial efficacy against bacteria such as Escherichia coli and Klebsiella pneumoniae in vitro assays. It also has anti-inflammatory properties and can be used for the treatment of inflammatory bowel disease. 4DAP-P is not absorbed through the skin or mucus membranes, but can be taken orally with food or liquid. The polymer-bound form of 4DAP-P has been shown to be more stable than its free form, which may make it a better choice for some applications.

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3,5-Diamino-1,2,4-triazole is a nitrogen heterocyclic compound that has shown to be an inhibitor of the Toll-like receptor (TLR) signaling pathway. The TLR pathway is a major regulator of the innate immune system and plays a role in the development of many infectious diseases. 3,5-Diamino-1,2,4-triazole has been shown to inhibit bacterial growth in model systems and leukemic mice. It is also shown to have high binding affinity for TLRs. 3,5-Diamino-1,2,4-triazole binds to the Toll/interleukin 1 receptor domain (TIR) by hydrogen bonding interactions with amino acid residues and competitively inhibits the binding of ligands such as lipopolysaccharide (LPS) or peptidoglycan. This inhibition leads to reduced production of proinflammatory cytokines such as IL-8 and

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Boc-D-glutamine is a small, water-soluble amino acid that has shown anticancer efficacy in vivo. It is structurally related to the cyclic peptide, glutamic acid-α-ketoglutarate (GAK). Boc-D-glutamine specifically binds to the tumor vasculature and inhibits cancer cell growth by inhibiting the uptake of essential nutrients. This drug also inhibits tumor angiogenesis and prevents metastasis by preventing the formation of new blood vessels. Boc-D-glutamine has been shown to have a greater effect on human nasopharyngeal carcinoma cells than other types of cancer cells because it targets a specific receptor found in these cells. The anticancer activity of this drug is due to its inhibition of uptake and chloride ion transport. In addition, Boc-D-glutamine has been shown to inhibit the proliferation of human embryonic kidney cells when used at high concentrations.

Applications (2R)-1-(9H-Purin-6-ylamino)-2-propanol is a reagent for the synthesis of tenofovir disoproxil fumarate, a medication for the treatment of hepatitis B and to prevent and treat HIV/AIDS. References Yan, N., et al.: Jingxi Huagong, 31, 983 (2014); Ripin, D. H. B., et al.: Org. Process Res. Dev., 14, 1194 (2010)

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4-Chloro-2-fluorobenzylamine hydrochloride is a chemisorption inhibitor that can be used to reduce the efficiency of hydrogen gas evolution in cooling water systems. It is also an inhibitor for hydrogen gas evolution from metal surfaces. 4-Chloro-2-fluorobenzylamine hydrochloride adsorbs on the surface of metals and prevents corrosion by reducing the availability of chlorine. This chemisorption inhibitor has a low activation energy and high efficiency, which means it can be used at lower concentrations than other inhibitors.

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5-Pyrimidinemethanamine is a synthetic chemical that belongs to the group of carbonitriles. It is used as an adsorbent and has been shown to be selective for quinoline derivatives. 5-Pyrimidinemethanamine has been shown to have high yield in reactions with trimethyl, enolate, carbonyl, high yields, and vitamin B1. The reaction product can be used at temperatures up to 150 degrees Celsius. This compound can also be prepared by reacting hydrochloric acid with alkali metal temperatures.

The ligand [4-methoxypyridin-2-yl]methanamine is an alcohol that can be used as a monomer in the polymerization of styrene. It is synthesised by the reaction of 4-methoxypyridine with methylamine and methyl methacrylate. The synthesis has been shown to proceed in high yields. The functionalised ligand was crystallised in two different crystal forms, which differed only in their orientation. These crystals were then used for x-ray crystallography studies.

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Dansyl ethylenediamine is a fluorescent probe that binds to peptides containing an amino acid with a free sulfhydryl group. It is used in the study of biological samples, such as tissue culture and blood cells, for detecting amines. Dansyl ethylenediamine has been shown to bind to α1-acid glycoprotein, which is present in human plasma and increases in concentration during congestive heart failure. This compound also exhibits conformational properties that make it ideal for analytical chemistry techniques such as high performance liquid chromatography (HPLC) and gas chromatography (GC).

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3-Iodobenzylamine HCl is a weak anion that has a moderate affinity for the adenosine A3 receptor. 3-Iodobenzylamine HCl is used in the analysis of adenosine, d-xylose and other compounds. The binding of 3-iodobenzylamine to the A3 receptor causes an increase in cyclic AMP levels and an increase in intracellular Ca2+ levels, leading to cell signaling. 3-Iodobenzylamine HCl also acts as a competitive antagonist at the A3 receptor. This drug can also act as an agonist at the A3 receptor, with binding affinities for this site comparable to those of adenosine. This drug is able to inhibit cyanamide catalysis due to its ability to bind with fluorine atoms on the acceptor site of this enzyme.

N,N-Diamylnitrosamine is a carcinogen that has been shown to cause cancer in animals. It can be metabolized by the liver and excreted into the intestine where it is absorbed and enters cells. N,N-Diamylnitrosamine has synergistic effects with other carcinogens such as cationic surfactants and alkylating agents. It also causes cross-linking of DNA strands which can lead to mutations. This chemical is used in biological products as a cross-linking agent to promote cell growth. The chemical's cancerous properties have been demonstrated through its ability to induce tumors in rats and mice, as well as through its ability to induce cancerous tumors when injected into the skin of hamsters.

Applications Tetrabutylammonium Azide (cas# 993-22-6) is a useful research chemical.

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3-Amino-4-cyano-1-phenyl-1H-pyrrole-2-carboxylic acidethylester is a catalytic, carbodiimide that has been used to synthesize amines, phenols and other organic compounds. It has been used in the synthesis of hexachloroethane and other chlorinated hydrocarbons. 3-Amino-4-cyano-1-phenyl-1H-pyrrole-2--carboxylic acid ethylester is also efficient for the synthesis of phenols from alcohols and alkoxides. This compound can be synthesized by reacting triethylamine with an alkoxide in the presence of potassium carbonate.

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