Cyano-, Nitrile-

2-Methoxyphenylacetonitrile is a chemical that is used in the manufacture of pharmaceuticals. It has antibacterial activity and can be used to treat typhoid fever, staphylococcal infections, and mental disorders such as schizophrenia. 2-Methoxyphenylacetonitrile is an alkylating agent that reacts with nucleophiles in proteins, DNA, and RNA. These reactions lead to the destruction of the bacterial cell wall and inhibition of protein synthesis. The mechanism by which 2-methoxyphenylacetonitrile exerts its antibacterial effect may involve formation of a reactive intermediate that inhibits bacterial ribonucleotide reductase. The addition of an electron to this intermediate leads to the formation of a covalent bond with one or more amino acids in the protein acceptor, thereby preventing further growth and division of bacteria.

1-Cyclohexenylacetonitrile (1-CHCN) is a synthetic compound with hydroxyl groups. It has been used as a radiation quencher and in the synthesis of piperazine, which is an inhibitor of plant growth. 1-CHCN has been shown to have anti-inflammatory effects in autoimmune diseases, such as arthritis and asthma. The mechanism of action is not well understood, but it may be due to its ability to inhibit the production of cytokines. A marine microorganism that produces 1-CHCN was found on the coast of Peru.

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4,4'-Dicyanostilbene is a stilbene derivative that has been used as a photoinitiator in radical polymerization. The elimination of the methyl group from 4,4'-dicyanostilbene to form 3-methyl-2-phenylindane is characterized by a mass spectrum with an m/z of 155.7 and an m/z of 112.5. This product has been shown to have a cyclohexane ring structure with phenanthrene substituents on each benzene ring. 4,4'-Dicyanostilbene can be used as an initiator for free radical polymerization reactions such as polyester synthesis or polyurethane production.

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2-Cyanophenylboronic acid is a bifunctional molecule that can be used as an antiviral drug. It binds to the benzodiazepine binding site of HIV-1 reverse transcriptase, which is required for viral replication. The 2-cyanophenylboronic acid-benzodiazepine complex was found to have a greater inhibitory effect on HIV-1 replication than the 2-cyanophenylboronic acid alone. Pharmacokinetics studies have been conducted in rats and mice and showed that the compound had good absorption, distribution, metabolism, and excretion profiles. Impurities are not usually detected in this product because it is synthetically produced. The reaction solution is acidic with a pH of about 3.5 to 4.5. This product has been shown to have immunosuppressive properties in vitro, which may be due to its ability to induce apoptosis or inhibit chemotaxis of macrophages.END>

3,4-Dimethoxybenzylamine is an amine that is used in the synthesis of pharmaceuticals. It can be polymerized by heating with aqueous formaldehyde and hydrochloric acid to form a resin. 3,4-Dimethoxybenzylamine inhibits serotonin receptors, exhibiting inhibitory properties at concentrations of 10-5 M. 3,4-Dimethoxybenzylamine also has pharmacokinetic properties that are similar to vitamin B1. This compound has been shown to inhibit homogeneous catalysts and is used for coatings for ganglion cells.

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Applications 4-cyano-N,N-dimethylbenzamide (cas# 24167-50-8) is a useful research chemical.

Applications Phenoxyacetonitrile is a building block that has been used as a reactant for the preparation of [[(oxo)pyridazinyl]phenoxy]acetonitrile derivatives to be used as vasodilators. References Bansal, R., et. al.: Drug Dev. Ind. Pharm., 74, 296 (2013)

3,4-Dihydroxybenzonitrile is a chemical compound that is found in soybean lipoxygenase. The molecule has been shown to be an excellent Michaelis-Menten substrate and hydrogen bonding partner. It also reacts with chlorine to form chlorinating agents such as 3,4-dichlorobenzonitrile and 3,4-dibromobenzonitrile. 3,4-Dihydroxybenzonitrile can act as a nucleophile and forms stable complexes when reacted with hydroxyl group compounds such as protocatechuic acid or reaction solution. This chemical is reactive and can be activated by redox cycling or light. 3,4-Dihydroxybenzonitrile has been used to treat protocatechuic acid levels in the blood of patients with chronic liver disease who are being treated for alcoholism.

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3-Fluorophenylacetonitrile is a laboratory chemical that is used as a starting material in the synthesis of 3-fluorophenylimidazole, which has been shown to have receptor modulating properties. The microwave irradiation of 3-fluorophenylacetonitrile in acetic acid leads to the formation of an analogous compound with higher yields and enhanced stability. The allosteric interactions between 3-fluorophenylacetonitrile and its analogous compound are also observed in vivo, where both compounds exhibit receptor modulating activity. This data may be useful for the development of new drugs that target G protein coupled receptors.

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