Halogenated Compounds

Applications 2-(3-Bromo-4-methoxyphenyl)-5,5-dimethyl-1,3-dioxane is an intermediate in the synthesis of VP 14637 (V785000), an inhibitor used to treat respiratory syncytial virus infections. References Andries, K., et al.: Antiviral Res., 60, 209 (2003), Douglas, J., et al.: J. Virol., 77, 5054 (2003), Cianci, C., et al.: Antimicrob. Agents Chemother., 48, 413 (2004),

Applications 2-(Chloromethyl)-6-methylthieno[2,3-d]pyrimidin-4(3H)-one Hydrochloride is a salt of 2-(Chloromethyl)-6-methylthieno[2,3-d]pyrimidin-4(3H)-one (C650415 ), used in the preparation of chalcone analogs containing a thieno[2,3-d]pyrimidin-2-yl groups with cytotoxic activity towards cultured human lung cancer A549 and colorectal HCT-116 cells. References Wang, F., et al.: Bioorg. Chem., 94, 103346 (2020)

Applications 3,5-Dichlorobiphenyl-2',3',4',5',6'-d5 (CAS# 1276197-28-4) is a useful isotopically labeled research compound.

Applications 2-(Trifluoromethyl)benzamide-D4 is an isotopic labeled intermediate for organic synthesis processes.

Applications 3-((5-Chloropyridin-2-yl)carbamoyl)pyrazin-2-yl)methyl 4-methylpiperazine-1-carboxylate is a useful synthesis intermediate.

Applications 4-Chloronitrobenzene-13C6 is the labeled form of 4-Chloronitrobenzene(C373910). It is an intermediate in the synthesis of PCB 101-13C12 (P216628) which is a related compound of PCB 189-13C12(P216622), which is a flame retardant and a standard for environmental testing and research. References EPA. Method 1668, (EPA 821-R-00-002) (1999)

Applications 1-Chloro-2,4-dinitrobenzene- 13C6 is the labeled form of 1-Chloro-2,4-dinitrobenzene (C365860). It is a byproduct in the synthesis of 1,4-Dichlorobenzene-13C6(D431878) which is a versatile building block and a small bioactive molecule, used in various organic synthesis. It is also used as disinfectant, deodorant, and pesticide. References Fahey, D. R., et al.: Macromolecules, 24 (15), 4242 (1991); Rossberg, M., et al.: Ullmann's Encyclopedia of Industrial Chemistry, (2006);

Applications 4-((4-Chlorophenyl)(phenyl)methyl)-1,1-Bis(2-(2-hydroxyethoxy)ethyl)piperazin-1-ium Bromide is a useful research compound.

Applications 2-(Bromomethyl)-N,N-dimethyl-2-propenamide is used to prepare poly(cyclohexene oxide). References Gupta, M., et al.: Polym. Bull., 62, 271 (2009);

Applications 4-Bromo-2-methoxy-1-(methoxymethoxy) Benzene is an intermediate in the synthesis of Vanillactic Acid-13C3 (>85%) (V097354) which is an isotope labelled compound of Vanillactic Acid (V097350). Vanillactic Acid is a metabolite of dihydroxyphenylalanine (DOPA) (D533751, L-DOPA), which is a natural isomer of the immediate precursor of dopamine. References Tabar, et al.: Pharmacol. Biochem. Behav., 33, 139 (1989), De Souza Silva, et al.: J. Neurochem., 68, 233 (1997), Feigin, A., et al.: Neurology, 57, 2083 (2001),

Applications 4-Difluoromethoxy-1,2-phenylendiamine is used in preparation of benzimidazole derivatives as TRPC6 inhibitors References Batberger, M., et al., PCT Int. Appli, (2018),

Applications 6-Chloro-N2-methyl-1,3,5-triazine-2,4-diamine is a reagent in the synthesis of N-Methyl-6-(2,2,2-trifluoroethoxy)-1,3,5-triazine-2,4-diamine (M330478) which is a useful research chemical. References List, M., et al.: J. Org. Chem., 81(10), 4066-4075 (2016)

Applications 5-Chloro-2-hydroxybenzyl alcohol (cas# 5330-38-1) is a useful research chemical.

Applications Bromocyclopentane, is an organic reagent that can be used as both the starting material and an intermediates in the chemical synthesis. It can be used as an starting material in the synthesis of Glycopyrrolate Bromide (G656980), which is a is a medication of the muscarinic anticholinergic group. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Kaltiala, E., et al.: J. Pharm. Pharmacol., 26, 352 (1974), Kongsrud, F., et al.: Acta Anaesthesiol. Scand., 26, 620 (1982),

Applications alpha,alpha'-Dibromo-p-xylene-d8 (CAS# 74903-77-8) is a useful isotopically labeled research compound.

Applications 4-Bromo-1-butanol is a useful reactant for the synthesis of tetrasubstituted alkenes from cross-​electrophile coupling and tandem metallacycle formation. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Shimkin, K.W., et al.: J. Am. Chem. Soc., 140, 7074-78 (2018);

Applications 1,3-Dichloro-5-ethyl-5-methylhydantoin is used in method and system for autonomous self-limiting generation of Chlorine Dioxide. References Martin, Roy W., et al.: U.S. Pat. Appl. Publ., (2018);

Applications Pentachlorothiophenol is plasticizer; is used in method for preparing outer rubber hose for high performance hydraulic oil pipe. References Jun, F., et al.: Faming Zhuanli Shenqing, (2019);